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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

UBE2Z

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.PROSITE-ProRule annotation2 Publications

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei188Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cysteine-type endopeptidase inhibitor activity Source: GO_Central
  • ubiquitin conjugating enzyme activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9H832
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme Z
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:UBE2Z
ORF Names:HOYS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000159202.17
HGNCiHGNC:25847 UBE2Z
MIMi611362 gene
neXtProtiNX_Q9H832

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi65264
OpenTargetsiENSG00000159202
PharmGKBiPA142670659

Polymorphism and mutation databases

BioMutaiUBE2Z
DMDMi134035344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805151 – 354Ubiquitin-conjugating enzyme E2 ZAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H832
MaxQBiQ9H832
PaxDbiQ9H832
PeptideAtlasiQ9H832
PRIDEiQ9H832
ProteomicsDBi81173
81174 [Q9H832-2]

PTM databases

iPTMnetiQ9H832
PhosphoSitePlusiQ9H832

Expressioni

Tissue specificityi

Widely expressed. Highly in placenta, pancreas, spleen and testis.2 Publications

Gene expression databases

BgeeiENSG00000159202 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExiHS_UBE2Z
ExpressionAtlasiQ9H832 baseline and differential
GenevisibleiQ9H832 HS

Organism-specific databases

HPAiHPA007922

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122419, 36 interactors
IntActiQ9H832, 40 interactors
MINTiQ9H832
STRINGi9606.ENSP00000354201

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00953
ProteinModelPortaliQ9H832
SMRiQ9H832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITJE Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110680
HOGENOMiHOG000233451
HOVERGENiHBG083204
InParanoidiQ9H832
KOiK10585
OMAiHETMRVA
OrthoDBiEOG091G0K0Y
PhylomeDBiQ9H832
TreeFamiTF354204

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESPTEEAA TAGAGAAGPG ASSVAGVVGV SGSGGGFGPP FLPDVWAAAA
60 70 80 90 100
AAGGAGGPGS GLAPLPGLPP SAAAHGAALL SHWDPTLSSD WDGERTAPQC
110 120 130 140 150
LLRIKRDIMS IYKEPPPGMF VVPDTVDMTK IHALITGPFD TPYEGGFFLF
160 170 180 190 200
VFRCPPDYPI HPPRVKLMTT GNNTVRFNPN FYRNGKVCLS ILGTWTGPAW
210 220 230 240 250
SPAQSISSVL ISIQSLMTEN PYHNEPGFEQ ERHPGDSKNY NECIRHETIR
260 270 280 290 300
VAVCDMMEGK CPCPEPLRGV MEKSFLEYYD FYEVACKDRL HLQGQTMQDP
310 320 330 340 350
FGEKRGHFDY QSLLMRLGLI RQKVLERLHN ENAEMDSDSS SSGTETDLHG

SLRV
Length:354
Mass (Da):38,210
Last modified:March 20, 2007 - v2
Checksum:i5AFC148BD8D31356
GO
Isoform 2 (identifier: Q9H832-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):28,075
Checksum:iA0AE68FB9430ACDB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9X8H0Y9X8_HUMAN
Ubiquitin-conjugating enzyme E2 Z
UBE2Z
129Annotation score:
D6RB11D6RB11_HUMAN
Ubiquitin-conjugating enzyme E2 Z
UBE2Z
180Annotation score:
I3L4C5I3L4C5_HUMAN
Ubiquitin-conjugating enzyme E2 Z
UBE2Z
100Annotation score:
I3L3V3I3L3V3_HUMAN
Ubiquitin-conjugating enzyme E2 Z
UBE2Z
47Annotation score:
I3L286I3L286_HUMAN
Ubiquitin-conjugating enzyme E2 Z
UBE2Z
70Annotation score:

Sequence cautioni

The sequence AAH15890 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14724 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0237471 – 108Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF623992 mRNA Translation: ABR25252.1
AK023917 mRNA Translation: BAB14724.1 Different initiation.
AK024030 mRNA Translation: BAB14789.1
AC091133 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94703.1
BC015169 mRNA Translation: AAH15169.2
BC015890 mRNA Translation: AAH15890.1 Different initiation.
AB025426 mRNA Translation: BAB87810.1
CR457322 mRNA Translation: CAG33603.1
AL713782 mRNA Translation: CAD28542.1
CCDSiCCDS11540.2 [Q9H832-1]
RefSeqiNP_075567.2, NM_023079.4 [Q9H832-1]
UniGeneiHs.514297

Genome annotation databases

EnsembliENST00000360943; ENSP00000354201; ENSG00000159202 [Q9H832-1]
GeneIDi65264
KEGGihsa:65264
UCSCiuc002ioi.4 human [Q9H832-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF623992 mRNA Translation: ABR25252.1
AK023917 mRNA Translation: BAB14724.1 Different initiation.
AK024030 mRNA Translation: BAB14789.1
AC091133 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94703.1
BC015169 mRNA Translation: AAH15169.2
BC015890 mRNA Translation: AAH15890.1 Different initiation.
AB025426 mRNA Translation: BAB87810.1
CR457322 mRNA Translation: CAG33603.1
AL713782 mRNA Translation: CAD28542.1
CCDSiCCDS11540.2 [Q9H832-1]
RefSeqiNP_075567.2, NM_023079.4 [Q9H832-1]
UniGeneiHs.514297

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A4PX-ray2.10A1-354[»]
DisProtiDP00953
ProteinModelPortaliQ9H832
SMRiQ9H832
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122419, 36 interactors
IntActiQ9H832, 40 interactors
MINTiQ9H832
STRINGi9606.ENSP00000354201

PTM databases

iPTMnetiQ9H832
PhosphoSitePlusiQ9H832

Polymorphism and mutation databases

BioMutaiUBE2Z
DMDMi134035344

Proteomic databases

EPDiQ9H832
MaxQBiQ9H832
PaxDbiQ9H832
PeptideAtlasiQ9H832
PRIDEiQ9H832
ProteomicsDBi81173
81174 [Q9H832-2]

Protocols and materials databases

DNASUi65264
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360943; ENSP00000354201; ENSG00000159202 [Q9H832-1]
GeneIDi65264
KEGGihsa:65264
UCSCiuc002ioi.4 human [Q9H832-1]

Organism-specific databases

CTDi65264
DisGeNETi65264
EuPathDBiHostDB:ENSG00000159202.17
GeneCardsiUBE2Z
HGNCiHGNC:25847 UBE2Z
HPAiHPA007922
MIMi611362 gene
neXtProtiNX_Q9H832
OpenTargetsiENSG00000159202
PharmGKBiPA142670659
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJE Eukaryota
COG5078 LUCA
GeneTreeiENSGT00730000110680
HOGENOMiHOG000233451
HOVERGENiHBG083204
InParanoidiQ9H832
KOiK10585
OMAiHETMRVA
OrthoDBiEOG091G0K0Y
PhylomeDBiQ9H832
TreeFamiTF354204

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ9H832

Miscellaneous databases

ChiTaRSiUBE2Z human
GenomeRNAii65264
PROiPR:Q9H832
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159202 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExiHS_UBE2Z
ExpressionAtlasiQ9H832 baseline and differential
GenevisibleiQ9H832 HS

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBE2Z_HUMAN
AccessioniPrimary (citable) accession number: Q9H832
Secondary accession number(s): A6N8M6
, A6NC60, Q7L354, Q8TCM4, Q9H893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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