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Protein

DnaJ homolog subfamily C member 18

Gene

DNAJC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 18
Gene namesi
Name:DNAJC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170464.9
HGNCiHGNC:28429 DNAJC18
neXtProtiNX_Q9H819

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi202052
OpenTargetsiENSG00000170464
PharmGKBiPA142671966

Polymorphism and mutation databases

BioMutaiDNAJC18
DMDMi74733748

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440851 – 358DnaJ homolog subfamily C member 18Add BLAST358

Proteomic databases

EPDiQ9H819
PaxDbiQ9H819
PeptideAtlasiQ9H819
PRIDEiQ9H819
ProteomicsDBi81170

PTM databases

iPTMnetiQ9H819
PhosphoSitePlusiQ9H819

Expressioni

Gene expression databases

BgeeiENSG00000170464 Expressed in 151 organ(s), highest expression level in right testis
CleanExiHS_DNAJC18
ExpressionAtlasiQ9H819 baseline and differential
GenevisibleiQ9H819 HS

Organism-specific databases

HPAiHPA036538
HPA060154

Interactioni

Protein-protein interaction databases

BioGridi128416, 28 interactors
STRINGi9606.ENSP00000302843

Structurei

3D structure databases

ProteinModelPortaliQ9H819
SMRiQ9H819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 146JPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 220Poly-Glu5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000233608
HOVERGENiHBG051373
InParanoidiQ9H819
KOiK09538
OMAiMATNPPY
OrthoDBiEOG091G0CE9
PhylomeDBiQ9H819
TreeFamiTF105145

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR015399 DUF1977_DnaJ-like
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF09320 DUF1977, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9H819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATLGSGER WTEAYIDAVR RNKYPEDTPP ESHDPCGCCN CMKAQKEKKS
60 70 80 90 100
ENEWTQTRQG EGNSTYSEEQ LLGVQRIKKC RNYYEILGVS RDASDEELKK
110 120 130 140 150
AYRKLALKFH PDKNCAPGAT DAFKAIGNAF AVLSNPDKRL RYDEYGDEQV
160 170 180 190 200
TFTAPRARPY NYYRDFEADI TPEELFNVFF GGHFPTGNIH MFSNVTDDTY
210 220 230 240 250
YYRRRHRHER TQTQKEEEEE KPQTTYSAFI QLLPVLVIVI ISVITQLLAT
260 270 280 290 300
NPPYSLFYKS TLGYTISRET QNLQVPYFVD KNFDKAYRGA SLHDLEKTIE
310 320 330 340 350
KDYIDYIQTS CWKEKQQKSE LTNLAGLYRD ERLKQKAESL KLENCEKLSK

LIGLRRGG
Length:358
Mass (Da):41,551
Last modified:March 1, 2001 - v1
Checksum:iBF8864DAB6D7695A
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9V6H0Y9V6_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
121Annotation score:
H0YA78H0YA78_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
177Annotation score:
D6RCS7D6RCS7_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
173Annotation score:
D6RB03D6RB03_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
181Annotation score:
D6RHF6D6RHF6_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
87Annotation score:
D6REJ9D6REJ9_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
25Annotation score:
D6RB44D6RB44_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
44Annotation score:
A0A096LP15A0A096LP15_HUMAN
DnaJ homolog subfamily C member 18
DNAJC18
30Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024054 mRNA Translation: BAB14804.1
BC030162 mRNA Translation: AAH30162.1
CCDSiCCDS4214.1
RefSeqiNP_689899.1, NM_152686.3
UniGeneiHs.483537

Genome annotation databases

EnsembliENST00000302060; ENSP00000302843; ENSG00000170464
GeneIDi202052
KEGGihsa:202052
UCSCiuc003len.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024054 mRNA Translation: BAB14804.1
BC030162 mRNA Translation: AAH30162.1
CCDSiCCDS4214.1
RefSeqiNP_689899.1, NM_152686.3
UniGeneiHs.483537

3D structure databases

ProteinModelPortaliQ9H819
SMRiQ9H819
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128416, 28 interactors
STRINGi9606.ENSP00000302843

PTM databases

iPTMnetiQ9H819
PhosphoSitePlusiQ9H819

Polymorphism and mutation databases

BioMutaiDNAJC18
DMDMi74733748

Proteomic databases

EPDiQ9H819
PaxDbiQ9H819
PeptideAtlasiQ9H819
PRIDEiQ9H819
ProteomicsDBi81170

Protocols and materials databases

DNASUi202052
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302060; ENSP00000302843; ENSG00000170464
GeneIDi202052
KEGGihsa:202052
UCSCiuc003len.4 human

Organism-specific databases

CTDi202052
DisGeNETi202052
EuPathDBiHostDB:ENSG00000170464.9
GeneCardsiDNAJC18
HGNCiHGNC:28429 DNAJC18
HPAiHPA036538
HPA060154
neXtProtiNX_Q9H819
OpenTargetsiENSG00000170464
PharmGKBiPA142671966
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000233608
HOVERGENiHBG051373
InParanoidiQ9H819
KOiK09538
OMAiMATNPPY
OrthoDBiEOG091G0CE9
PhylomeDBiQ9H819
TreeFamiTF105145

Miscellaneous databases

ChiTaRSiDNAJC18 human
GenomeRNAii202052
PROiPR:Q9H819

Gene expression databases

BgeeiENSG00000170464 Expressed in 151 organ(s), highest expression level in right testis
CleanExiHS_DNAJC18
ExpressionAtlasiQ9H819 baseline and differential
GenevisibleiQ9H819 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR015399 DUF1977_DnaJ-like
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF09320 DUF1977, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC18_HUMAN
AccessioniPrimary (citable) accession number: Q9H819
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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