UniProtKB - Q9H816 (DCR1B_HUMAN)

BLAST

>sp|Q9H816|DCR1B_HUMAN 5' exonuclease Apollo OS=Homo sapiens OX=9606 GN=DCLRE1B PE=1 SV=1
MNGVLIPHTPIAVDFWSLRRAGTARLFFLSHMHSDHTVGLSSTWARPLYCSPITAHLLHR
HLQVSKQWIQALEVGESHVLPLDEIGQETMTVTLLDANHCPGSVMFLFEGYFGTILYTGD
FRYTPSMLKEPALTLGKQIHTLYLDNTNCNPALVLPSRQEAAHQIVQLIRKHPQHNIKIG
LYSLGKESLLEQLALEFQTWVVLSPRRLELVQLLGLADVFTVEEKAGRIHAVDHMEICHS
NMLRWNQTHPTIAILPTSRKIHSSHPDIHVIPYSDHSSYSELRAFVAALKPCQVVPIVSR
RPCGGFQDSLSPRISVPLIPDSVQQYMSSSSRKPSLLWLLERRLKRPRTQGVVFESPEES
ADQSQADRDSKKAKKEKLSPWPADLEKQPSHHPLRIKKQLFPDLYSKEWNKAVPFCESQK
RVTMLTAPLGFSVHLRSTDEEFISQKTREEIGLGSPLVPMGDDDGGPEATGNQSAWMGHG
SPLSHSSKGTPLLATEFRGLALKYLLTPVNFFQAGYSSRRFDQQVEKYHKPC

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History
Entry version 140 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

5' exonuclease Apollo

Gene

DCLRE1B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.9 Publications

Miscellaneous

Was named 'Apollo' in reference to the twin brother of 'Artemis' in Greek mythology (PubMed:16730175 and PubMed:16730176). Artemis/DCLRE1C is a related nuclease.

GO - Molecular functionⁱ

5'-3' exodeoxyribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
5'-3' exonuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16730175
- 20655466
damaged DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18202258
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20479256

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

double-strand break repair via nonhomologous end joining
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interstrand cross-link repair
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20479256
mitotic cell cycle checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19197158
protection from non-homologous end joining at telomere
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16730175
telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20479256
telomere maintenance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20655466
telomere maintenance via telomere lengthening
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20479256
telomeric 3' overhang formation Source: UniProtKB
telomeric loop formation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Exonuclease, Hydrolase, Nuclease
Biological process	DNA damage, DNA repair

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783310 Fanconi Anemia Pathway

Reactomeⁱ

R-HSA-6783310 Fanconi Anemia Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5' exonuclease Apollo (EC:3.1.-.-) Alternative name(s): DNA cross-link repair 1B protein SNM1 homolog B Short name: SNMIB Short name: hSNM1B
Gene namesⁱ	Name:DCLRE1B Synonyms:SNM1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118655.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17641 DCLRE1B
MIMⁱ	609683 gene
neXtProtⁱ	NX_Q9H816

Keywords - Cellular componentⁱ

Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hoyeraal-Hreidarsson syndrome (HHS)1 Publication

The gene represented in this entry may be involved in disease pathogenesis. An aberrant splice variant of DCLRE1B, designated Apollo-Delta, has been found in a patient with Hoyeraal-Hreidarsson syndrome (PubMed:20479256). Apollo-Delta hampers the proper replication of telomeres, leading to major telomeric dysfunction and cellular senescence, but maintains its DNA interstrand cross-link repair function in the whole genome.1 Publication

Disease descriptionA clinically severe variant of dyskeratosis congenita that is characterized by multisystem involvement, early onset in utero, and often results in death in childhood. Affected individuals show intrauterine growth retardation, microcephaly, cerebellar hypoplasia, delayed development, and bone marrow failure resulting in immunodeficiency.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	D → N in Apm3; abolishes exonuclease activity and function on telomere maintenance. Impairs interaction with SPAG5. 2 Publications	1
Mutagenesisⁱ	33	H → A in Apm1; abolishes exonuclease activity and function on telomere maintenance; when associated with N-35. 1 Publication	1
Mutagenesisⁱ	35	D → N in Apm2; abolishes exonuclease activity and function on telomere maintenance. In Apm1; abolishes exonuclease activity and function on telomere maintenance; when associated with A-33. 1 Publication	1
Mutagenesisⁱ	276	H → A: Slightly affects interaction with SPAG5. 1 Publication	1
Mutagenesisⁱ	504	Y → A: Abolishes interaction with TERF2. 1 Publication	1
Mutagenesisⁱ	506	L → A: Abolishes interaction with TERF2. 1 Publication	1
Mutagenesisⁱ	508	P → A: Abolishes interaction with TERF2. 1 Publication	1

Keywords - Diseaseⁱ

Dyskeratosis congenita

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64858
MIMⁱ	305000 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000118655
PharmGKBⁱ	PA27175

Polymorphism and mutation databases

BioMutaⁱ	DCLRE1B
DMDMⁱ	73620756

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209119	1 – 532	5' exonuclease ApolloAdd BLAST		532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	333	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H816
PaxDbⁱ	Q9H816
PeptideAtlas More...PeptideAtlasⁱ	Q9H816
PRIDEⁱ	Q9H816
ProteomicsDBⁱ	81169

PTM databases

iPTMnetⁱ	Q9H816
PhosphoSitePlusⁱ	Q9H816

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118655 Expressed in 169 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_DCLRE1B
Genevisibleⁱ	Q9H816 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064934

HPAⁱ

HPA064934

Interactionⁱ

Subunit structureⁱ

Interacts with TERF2; the interaction is direct. Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2, HSPA8 and HSPA14. Interacts with SPAG5.10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TERF2	Q15554	9	EBI-3508943,EBI-706637

With

Entry

#Exp.

IntAct

Notes

TERF2

Q15554

EBI-3508943,EBI-706637

GO - Molecular functionⁱ

protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20479256

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122331, 16 interactors
Database of interacting proteins More...DIPⁱ	DIP-42669N
ELMⁱ	Q9H816
IntActⁱ	Q9H816, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q9H816
STRINGⁱ	9606.ENSP00000358576

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 6	Combined sources	3
Turnⁱ	7 – 10	Combined sources	4
Beta strandⁱ	11 – 14	Combined sources	4
Helixⁱ	18 – 21	Combined sources	4
Beta strandⁱ	26 – 28	Combined sources	3
Helixⁱ	34 – 36	Combined sources	3
Beta strandⁱ	48 – 50	Combined sources	3
Helixⁱ	52 – 61	Combined sources	10
Turnⁱ	66 – 68	Combined sources	3
Beta strandⁱ	69 – 71	Combined sources	3
Beta strandⁱ	76 – 86	Combined sources	11
Beta strandⁱ	89 – 96	Combined sources	8
Beta strandⁱ	98 – 100	Combined sources	3
Beta strandⁱ	104 – 110	Combined sources	7
Beta strandⁱ	113 – 117	Combined sources	5
Helixⁱ	125 – 129	Combined sources	5
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	140 – 144	Combined sources	5
Helixⁱ	158 – 170	Combined sources	13
Beta strandⁱ	175 – 181	Combined sources	7
Beta strandⁱ	183 – 185	Combined sources	3
Helixⁱ	187 – 196	Combined sources	10
Helixⁱ	205 – 214	Combined sources	10
Beta strandⁱ	220 – 222	Combined sources	3
Helixⁱ	224 – 226	Combined sources	3
Beta strandⁱ	228 – 233	Combined sources	6
Helixⁱ	234 – 236	Combined sources	3
Helixⁱ	239 – 246	Combined sources	8
Beta strandⁱ	251 – 256	Combined sources	6
Beta strandⁱ	268 – 271	Combined sources	4
Helixⁱ	279 – 289	Combined sources	11
Beta strandⁱ	294 – 298	Combined sources	5
Helixⁱ	307 – 309	Combined sources	3
Helixⁱ	500 – 503	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H816
SMRⁱ	Q9H816
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9H816

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	496 – 511	TBMAdd BLAST		16

Domainⁱ

The TBM domain mediates interaction with TERF2.

Sequence similaritiesⁱ

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1361 Eukaryota COG1236 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063183
HOGENOMⁱ	HOG000043118
HOVERGENⁱ	HBG081420
KEGG Orthology (KO) More...KOⁱ	K15341
OMAⁱ	HPDIHII
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DBZ
PhylomeDBⁱ	Q9H816
TreeFamⁱ	TF329572

Family and domain databases

Gene3Dⁱ	3.60.15.10, 1 hit
InterProⁱ	View protein in InterPro IPR011084 DRMBL IPR036866 RibonucZ/Hydroxyglut_hydro
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07522 DRMBL, 1 hit
SUPFAMⁱ	SSF56281 SSF56281, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H816-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNGVLIPHTP IAVDFWSLRR AGTARLFFLS HMHSDHTVGL SSTWARPLYC 
        60         70         80         90        100
SPITAHLLHR HLQVSKQWIQ ALEVGESHVL PLDEIGQETM TVTLLDANHC 
       110        120        130        140        150
PGSVMFLFEG YFGTILYTGD FRYTPSMLKE PALTLGKQIH TLYLDNTNCN 
       160        170        180        190        200
PALVLPSRQE AAHQIVQLIR KHPQHNIKIG LYSLGKESLL EQLALEFQTW 
       210        220        230        240        250
VVLSPRRLEL VQLLGLADVF TVEEKAGRIH AVDHMEICHS NMLRWNQTHP 
       260        270        280        290        300
TIAILPTSRK IHSSHPDIHV IPYSDHSSYS ELRAFVAALK PCQVVPIVSR 
       310        320        330        340        350
RPCGGFQDSL SPRISVPLIP DSVQQYMSSS SRKPSLLWLL ERRLKRPRTQ 
       360        370        380        390        400
GVVFESPEES ADQSQADRDS KKAKKEKLSP WPADLEKQPS HHPLRIKKQL 
       410        420        430        440        450
FPDLYSKEWN KAVPFCESQK RVTMLTAPLG FSVHLRSTDE EFISQKTREE 
       460        470        480        490        500
IGLGSPLVPM GDDDGGPEAT GNQSAWMGHG SPLSHSSKGT PLLATEFRGL 
       510        520        530 
ALKYLLTPVN FFQAGYSSRR FDQQVEKYHK PC

Length:532

Mass (Da):60,002

Last modified:March 1, 2001 - v1

Checksum:ⁱ601A800CCD43CFDA

Sequence cautionⁱ

The sequence BAB14284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	237	I → T in BAB14284 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023292	46	R → L1 PublicationCorresponds to variant dbSNP:rs28381069Ensembl.	1
Natural variantⁱVAR_023293	61	H → Y1 PublicationCorresponds to variant dbSNP:rs11552449Ensembl.	1
Natural variantⁱVAR_023294	462	D → N1 PublicationCorresponds to variant dbSNP:rs28381079EnsemblClinVar.	1
Natural variantⁱVAR_048891	510	N → Y. Corresponds to variant dbSNP:rs35397235EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022872 mRNA Translation: BAB14284.1 Different initiation. AK024060 mRNA Translation: BAB14807.1 AY849379 Genomic DNA Translation: AAV97812.1 AL137856 Genomic DNA No translation available. BC029687 mRNA Translation: AAH29687.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS866.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001306876.1, NM_001319947.1 NP_073747.1, NM_022836.3
UniGeneⁱ	Hs.591412 Hs.628365

Genome annotation databases

Ensemblⁱ	ENST00000369563; ENSP00000358576; ENSG00000118655
GeneIDⁱ	64858
KEGGⁱ	hsa:64858
UCSC genome browser More...UCSCⁱ	uc001eeg.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H816	Uncharacterized protein		CALJA		545	UniRef90_Q9H816
Uncharacterized protein		Cebus capucinus imitator		540
5' exonuclease Apollo		MACMU		532
Uncharacterized protein		MACFA		532
Uncharacterized protein		MACNE		532
+25

Protein	Similar proteins		Species	Score	Length	Source
Q9H816	5' exonuclease Apollo		AILME		529	UniRef50_Q9H816
5' exonuclease Apollo		RAT		541
5' exonuclease Apollo		MOUSE		541
Uncharacterized protein		CALJA		545
Uncharacterized protein		Cebus capucinus imitator		540
+168

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022872 mRNA Translation: BAB14284.1 Different initiation. AK024060 mRNA Translation: BAB14807.1 AY849379 Genomic DNA Translation: AAV97812.1 AL137856 Genomic DNA No translation available. BC029687 mRNA Translation: AAH29687.1
CCDSⁱ	CCDS866.1
RefSeqⁱ	NP_001306876.1, NM_001319947.1 NP_073747.1, NM_022836.3
UniGeneⁱ	Hs.591412 Hs.628365

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3BUA	X-ray	2.50	E/F/G/H	495-530	[»]
	5AHO	X-ray	2.16	A	1-335	[»]
ProteinModelPortalⁱ	Q9H816
SMRⁱ	Q9H816
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122331, 16 interactors
DIPⁱ	DIP-42669N
ELMⁱ	Q9H816
IntActⁱ	Q9H816, 16 interactors
MINTⁱ	Q9H816
STRINGⁱ	9606.ENSP00000358576

PTM databases

iPTMnetⁱ	Q9H816
PhosphoSitePlusⁱ	Q9H816

Polymorphism and mutation databases

BioMutaⁱ	DCLRE1B
DMDMⁱ	73620756

Proteomic databases

EPDⁱ	Q9H816
PaxDbⁱ	Q9H816
PeptideAtlasⁱ	Q9H816
PRIDEⁱ	Q9H816
ProteomicsDBⁱ	81169

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64858
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369563; ENSP00000358576; ENSG00000118655
GeneIDⁱ	64858
KEGGⁱ	hsa:64858
UCSCⁱ	uc001eeg.4 human

Organism-specific databases

CTDⁱ	64858
DisGeNETⁱ	64858
EuPathDBⁱ	HostDB:ENSG00000118655.4
GeneCardsⁱ	DCLRE1B
HGNCⁱ	HGNC:17641 DCLRE1B
HPAⁱ	HPA064934
MIMⁱ	305000 phenotype 609683 gene
neXtProtⁱ	NX_Q9H816
OpenTargetsⁱ	ENSG00000118655
PharmGKBⁱ	PA27175
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1361 Eukaryota COG1236 LUCA
GeneTreeⁱ	ENSGT00530000063183
HOGENOMⁱ	HOG000043118
HOVERGENⁱ	HBG081420
KOⁱ	K15341
OMAⁱ	HPDIHII
OrthoDBⁱ	EOG091G0DBZ
PhylomeDBⁱ	Q9H816
TreeFamⁱ	TF329572

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6783310 Fanconi Anemia Pathway

Reactomeⁱ

R-HSA-6783310 Fanconi Anemia Pathway

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H816
GeneWikiⁱ	DCLRE1B
GenomeRNAiⁱ	64858
Protein Ontology More...PROⁱ	PR:Q9H816
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118655 Expressed in 169 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_DCLRE1B
Genevisibleⁱ	Q9H816 HS

Family and domain databases

Gene3Dⁱ	3.60.15.10, 1 hit
InterProⁱ	View protein in InterPro IPR011084 DRMBL IPR036866 RibonucZ/Hydroxyglut_hydro
Pfamⁱ	View protein in Pfam PF07522 DRMBL, 1 hit
SUPFAMⁱ	SSF56281 SSF56281, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCR1B_HUMAN
Accessionⁱ	Q9H816Primary (citable) accession number: Q9H816 Secondary accession number(s): Q9H9E5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H816 (DCR1B_HUMAN)

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5' exonuclease Apollo

DCLRE1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ