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Entry version 178 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Prostaglandin E synthase 2

Gene

PTGES2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783).

The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783).

In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity).

By similarity3 Publications

Caution

It is not known if heme and GST are required for prostaglandin synthase activity. The protein copurifies with heme and GST when DTT is omitted during the purification procedure. The GSH-heme complex-bound enzyme has been proposed to act as a lyase and catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). According to PubMed:18198127, boiling the enzyme leads to loss of prostaglandin synthase activity, but does not eliminate the lyase activity. Besides, free heme can catalyze the formation of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) (PubMed:18198127). A more recent study demonstrates the GSH-dependent property of PTGES2, DTT dissociates the bound heme to produce active PGE2 synthase in vitro (By similarity). PTGES2 can only catalyzes PGE2 synthesis in the free state as an enzyme, while in vivo it forms a complex with heme and does not participate in PGE2 synthesis (By similarity). In agreement with this study, the in vivo evidence from PTGES2 deficient mice do not show that this protein is responsible for the PGE2 production under basal or pathophysiological conditions (By similarity).By similarityCurated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=56 µM for PGH2 (for the GSH-heme complex-bound enzyme)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: prostaglandin biosynthesis

    This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.
    View all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei148Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase
    Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS07514-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    5.3.99.3, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q9H7Z7

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    R-HSA-6798695, Neutrophil degranulation

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00662

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001095

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Prostaglandin E synthase 2 (EC:5.3.99.33 Publications)
    Alternative name(s):
    Membrane-associated prostaglandin E synthase-21 Publication
    Short name:
    mPGE synthase-21 Publication
    Microsomal prostaglandin E synthase 2
    Short name:
    mPGES-2
    Prostaglandin-H(2) E-isomerase
    Cleaved into the following chain:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PTGES2
    Synonyms:C9orf15, PGES2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17822, PTGES2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608152, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H7Z7

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000148334.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57LumenalSequence analysisAdd BLAST57
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 74HelicalSequence analysisAdd BLAST17
    Topological domaini75 – 377CytoplasmicSequence analysisAdd BLAST303

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi110C → S: Loss of prostaglandin-E synthase activity. Can bind glutathione-heme and exhibits PGH2 degradation activity. 2 Publications1
    Mutagenesisi113C → S: Slightly decreased prostaglandin-E synthase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    80142

    Open Targets

    More...
    OpenTargetsi
    ENSG00000148334

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33949

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9H7Z7, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4411

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1378

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PTGES2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    73921741

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000131271 – 377Prostaglandin E synthase 2Add BLAST377
    ChainiPRO_000001312888 – 377Prostaglandin E synthase 2 truncated formBy similarityAdd BLAST290

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei95PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei87 – 88CleavageBy similarity2

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9H7Z7

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9H7Z7

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9H7Z7

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H7Z7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H7Z7

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H7Z7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H7Z7

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    81164

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q9H7Z7

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H7Z7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H7Z7

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9H7Z7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000148334, Expressed in apex of heart and 218 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H7Z7, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H7Z7, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000148334, Tissue enhanced (skeletal)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer. May interact with CEBPB (By similarity).

    Interacts with EXOSC10.

    By similarity1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    123135, 60 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H7Z7, 28 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9H7Z7

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000345341

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9H7Z7

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9H7Z7, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9H7Z7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini90 – 193GlutaredoxinPROSITE-ProRule annotationAdd BLAST104
    Domaini263 – 377GST C-terminalAdd BLAST115

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni164 – 165Glutathione bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the GST superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3029, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000000224

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_011226_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H7Z7

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LWTGGCA

    Database of Orthologous Groups

    More...
    OrthoDBi
    1042777at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H7Z7

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314304

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03197, GST_C_mPGES2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.30.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002109, Glutaredoxin
    IPR010987, Glutathione-S-Trfase_C-like
    IPR036282, Glutathione-S-Trfase_C_sf
    IPR040079, Glutathione_S-Trfase
    IPR004045, Glutathione_S-Trfase_N
    IPR034334, PGES2
    IPR034335, PGES2_C
    IPR036249, Thioredoxin-like_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13417, GST_N_3, 1 hit

    Structure-Function Linkage Database

    More...
    SFLDi
    SFLDS00019, Glutathione_Transferase_(cytos, 1 hit
    SFLDG01203, Prostaglandin_E_synthase_like1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47616, SSF47616, 1 hit
    SSF52833, SSF52833, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00195, GLUTAREDOXIN_1, 1 hit
    PS51354, GLUTAREDOXIN_2, 1 hit
    PS50405, GST_CTER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

    Q9H7Z7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDPAARVVRA LWPGGCALAW RLGGRPQPLL PTQSRAGFAG AAGGPSPVAA
    60 70 80 90 100
    ARKGSPRLLG AAALALGGAL GLYHTARWHL RAQDLHAERS AAQLSLSSRL
    110 120 130 140 150
    QLTLYQYKTC PFCSKVRAFL DFHALPYQVV EVNPVRRAEI KFSSYRKVPI
    160 170 180 190 200
    LVAQEGESSQ QLNDSSVIIS ALKTYLVSGQ PLEEIITYYP AMKAVNEQGK
    210 220 230 240 250
    EVTEFGNKYW LMLNEKEAQQ VYGGKEARTE EMKWRQWADD WLVHLISPNV
    260 270 280 290 300
    YRTPTEALAS FDYIVREGKF GAVEGAVAKY MGAAAMYLIS KRLKSRHRLQ
    310 320 330 340 350
    DNVREDLYEA ADKWVAAVGK DRPFMGGQKP NLADLAVYGV LRVMEGLDAF
    360 370
    DDLMQHTHIQ PWYLRVERAI TEASPAH
    Length:377
    Mass (Da):41,943
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82F2DF867BB8337C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A7I2V5T7A0A7I2V5T7_HUMAN
    Microsomal prostaglandin E synthase...
    PTGES2
    369Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A6NHH0A6NHH0_HUMAN
    Prostaglandin E synthase 2
    PTGES2 hCG_1785478
    186Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    X6RJ95X6RJ95_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    265Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V5X6A0A7I2V5X6_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    310Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V308A0A7I2V308_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    190Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2YQ70A0A7I2YQ70_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    163Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V460A0A7I2V460_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    105Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7I2V4L3A0A7I2V4L3_HUMAN
    Prostaglandin E synthase 2
    PTGES2
    170Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319G → S in BAD97240 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049494298R → H. Corresponds to variant dbSNP:rs13283456Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK024100 mRNA Translation: BAB14826.1
    AK223520 mRNA Translation: BAD97240.1
    AL590708 Genomic DNA No translation available.
    BC009397 mRNA Translation: AAH09397.2
    BC009456 mRNA Translation: AAH09456.1
    BC011613 mRNA Translation: AAH11613.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6891.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001243264.1, NM_001256335.1
    NP_079348.1, NM_025072.6
    NP_945176.1, NM_198938.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000338961; ENSP00000345341; ENSG00000148334

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    80142

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:80142

    UCSC genome browser

    More...
    UCSCi
    uc004bti.4, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK024100 mRNA Translation: BAB14826.1
    AK223520 mRNA Translation: BAD97240.1
    AL590708 Genomic DNA No translation available.
    BC009397 mRNA Translation: AAH09397.2
    BC009456 mRNA Translation: AAH09456.1
    BC011613 mRNA Translation: AAH11613.1
    CCDSiCCDS6891.1
    RefSeqiNP_001243264.1, NM_001256335.1
    NP_079348.1, NM_025072.6
    NP_945176.1, NM_198938.2

    3D structure databases

    SMRiQ9H7Z7
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi123135, 60 interactors
    IntActiQ9H7Z7, 28 interactors
    MINTiQ9H7Z7
    STRINGi9606.ENSP00000345341

    Chemistry databases

    BindingDBiQ9H7Z7
    ChEMBLiCHEMBL4411
    GuidetoPHARMACOLOGYi1378
    SwissLipidsiSLP:000001095

    PTM databases

    iPTMnetiQ9H7Z7
    PhosphoSitePlusiQ9H7Z7
    SwissPalmiQ9H7Z7

    Genetic variation databases

    BioMutaiPTGES2
    DMDMi73921741

    Proteomic databases

    EPDiQ9H7Z7
    jPOSTiQ9H7Z7
    MassIVEiQ9H7Z7
    MaxQBiQ9H7Z7
    PaxDbiQ9H7Z7
    PeptideAtlasiQ9H7Z7
    PRIDEiQ9H7Z7
    ProteomicsDBi81164
    TopDownProteomicsiQ9H7Z7

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    17330, 317 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    80142

    Genome annotation databases

    EnsembliENST00000338961; ENSP00000345341; ENSG00000148334
    GeneIDi80142
    KEGGihsa:80142
    UCSCiuc004bti.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    80142
    DisGeNETi80142

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PTGES2
    HGNCiHGNC:17822, PTGES2
    HPAiENSG00000148334, Tissue enhanced (skeletal)
    MIMi608152, gene
    neXtProtiNX_Q9H7Z7
    OpenTargetsiENSG00000148334
    PharmGKBiPA33949
    VEuPathDBiHostDB:ENSG00000148334.14

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3029, Eukaryota
    GeneTreeiENSGT00390000000224
    HOGENOMiCLU_011226_0_0_1
    InParanoidiQ9H7Z7
    OMAiLWTGGCA
    OrthoDBi1042777at2759
    PhylomeDBiQ9H7Z7
    TreeFamiTF314304

    Enzyme and pathway databases

    UniPathwayiUPA00662
    BioCyciMetaCyc:HS07514-MONOMER
    BRENDAi5.3.99.3, 2681
    PathwayCommonsiQ9H7Z7
    ReactomeiR-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    R-HSA-6798695, Neutrophil degranulation

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    80142, 13 hits in 1004 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PTGES2, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PTGES2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    80142
    PharosiQ9H7Z7, Tchem

    Protein Ontology

    More...
    PROi
    PR:Q9H7Z7
    RNActiQ9H7Z7, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000148334, Expressed in apex of heart and 218 other tissues
    ExpressionAtlasiQ9H7Z7, baseline and differential
    GenevisibleiQ9H7Z7, HS

    Family and domain databases

    CDDicd03197, GST_C_mPGES2, 1 hit
    Gene3Di3.40.30.10, 1 hit
    InterProiView protein in InterPro
    IPR002109, Glutaredoxin
    IPR010987, Glutathione-S-Trfase_C-like
    IPR036282, Glutathione-S-Trfase_C_sf
    IPR040079, Glutathione_S-Trfase
    IPR004045, Glutathione_S-Trfase_N
    IPR034334, PGES2
    IPR034335, PGES2_C
    IPR036249, Thioredoxin-like_sf
    PfamiView protein in Pfam
    PF13417, GST_N_3, 1 hit
    SFLDiSFLDS00019, Glutathione_Transferase_(cytos, 1 hit
    SFLDG01203, Prostaglandin_E_synthase_like1, 1 hit
    SUPFAMiSSF47616, SSF47616, 1 hit
    SSF52833, SSF52833, 1 hit
    PROSITEiView protein in PROSITE
    PS00195, GLUTAREDOXIN_1, 1 hit
    PS51354, GLUTAREDOXIN_2, 1 hit
    PS50405, GST_CTER, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGES2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7Z7
    Secondary accession number(s): Q53EW9
    , Q5SYV6, Q96GI0, Q96GL2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2001
    Last modified: June 2, 2021
    This is version 178 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families
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