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Entry version 164 (08 May 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Histone acetyltransferase KAT8

Gene

KAT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei350Proton donor/acceptor2 PublicationsCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei354Acetyl-CoA2 Publications1
Binding sitei363Acetyl-CoA2 Publications1
Binding sitei432Acetyl-CoA2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri207 – 232C2HC MYST-typePROSITE-ProRule annotation1 PublicationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.3.1.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847 HATs acetylate histones

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H7Z6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone acetyltransferase KAT8 (EC:2.3.1.481 Publication4 Publications)
Alternative name(s):
Lysine acetyltransferase 8
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
Short name:
MYST-1
Short name:
hMOF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KAT8
Synonyms:MOF, MYST1
ORF Names:PP7073
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17933 KAT8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609912 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7Z6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi274K → A: Abolishes histone acetyltransferase activity. 1 Publication1
Mutagenesisi274K → R: Abolishes histone acetyltransferase activity. 1 Publication1
Mutagenesisi316C → S: Strongly reduces histone acetyltransferase activity. 1 Publication1
Mutagenesisi350E → Q: Abolishes histone acetyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84148

Open Targets

More...
OpenTargetsi
ENSG00000103510

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38476

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1932912

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2668

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KAT8

Domain mapping of disease mutations (DMDM)

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DMDMi
68565938

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515662 – 458Histone acetyltransferase KAT8Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei113N6-acetyllysineCombined sources1
Modified residuei274N6-acetyllysine; by autocatalysis5 Publications1
Modified residuei348PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H7Z6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H7Z6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7Z6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H7Z6

PeptideAtlas

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PeptideAtlasi
Q9H7Z6

PRoteomics IDEntifications database

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PRIDEi
Q9H7Z6

ProteomicsDB human proteome resource

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ProteomicsDBi
81162
81163 [Q9H7Z6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7Z6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7Z6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000103510 Expressed in 230 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H7Z6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H7Z6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066324

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1 (PubMed:16227571, PubMed:16543150). Interacts with MSL1; the interaction is direct. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:16543150, PubMed:20018852, PubMed:22547026). Interacts with KANSL1; the interaction is direct. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct (PubMed:16543150, PubMed:20620954).10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123914, 44 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-809 NSL histone acetyltransferase complex
CPX-815 MSL histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9H7Z6

Protein interaction database and analysis system

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IntActi
Q9H7Z6, 12 interactors

Molecular INTeraction database

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MINTi
Q9H7Z6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406037

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9H7Z6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H7Z6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9H7Z6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 123ChromoAdd BLAST55
Domaini174 – 447MYST-type HATPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni174 – 458Sufficient for interaction with KANSL1Add BLAST285
Regioni317 – 319Acetyl-CoA binding2 Publications3
Regioni324 – 330Acetyl-CoA binding2 Publications7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 232C2HC MYST-typePROSITE-ProRule annotation1 PublicationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2747 Eukaryota
COG5027 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159512

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H7Z6

KEGG Orthology (KO)

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KOi
K11308

Identification of Orthologs from Complete Genome Data

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OMAi
MNMVKYW

Database of Orthologous Groups

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OrthoDBi
1373773at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H7Z6

TreeFam database of animal gene trees

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TreeFami
TF317619

Family and domain databases

Conserved Domains Database

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CDDi
cd00024 CHROMO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR002717 HAT_MYST-type
IPR037906 KAT8
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
IPR040706 Zf-MYST

The PANTHER Classification System

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PANTHERi
PTHR10615:SF82 PTHR10615:SF82, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
PF17772 zf-MYST, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00298 CHROMO, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51726 MYST_HAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7Z6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE
60 70 80 90 100
PEVTVEIGET YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL
110 120 130 140 150
DEWVDKNRLA LTKTVKDAVQ KNSEKYLSEL AEQPERKITR NQKRKHDEIN
160 170 180 190 200
HVQKTYAEMD PTTAALEKEH EAITKVKYVD KIHIGNYEID AWYFSPFPED
210 220 230 240 250
YGKQPKLWLC EYCLKYMKYE KSYRFHLGQC QWRQPPGKEI YRKSNISVYE
260 270 280 290 300
VDGKDHKIYC QNLCLLAKLF LDHKTLYFDV EPFVFYILTE VDRQGAHIVG
310 320 330 340 350
YFSKEKESPD GNNVACILTL PPYQRRGYGK FLIAFSYELS KLESTVGSPE
360 370 380 390 400
KPLSDLGKLS YRSYWSWVLL EILRDFRGTL SIKDLSQMTS ITQNDIISTL
410 420 430 440 450
QSLNMVKYWK GQHVICVTPK LVEEHLKSAQ YKKPPITVDS VCLKWAPPKH

KQVKLSKK
Length:458
Mass (Da):52,403
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66C474BE5B90E8E3
GO
Isoform 2 (identifier: Q9H7Z6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-458: VDSVCLKWAPPKHKQVKLSKK → GGWGAAVCRGRWGSVSIWTGRSQGLLIAVT

Show »
Length:467
Mass (Da):53,085
Checksum:i69AA4F8800E687E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMX5H3BMX5_HUMAN
Histone acetyltransferase
KAT8
187Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0I2A0A494C0I2_HUMAN
Histone acetyltransferase KAT8
KAT8
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55762 differs from that shown. Probable cloning artifact.Curated
The sequence AAL56648 differs from that shown. Reason: Frameshift at positions 23, 26 and 52.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222S → T in AAL55762 (PubMed:15498874).Curated1
Sequence conflicti249Y → H in BAB14827 (PubMed:14702039).Curated1
Sequence conflicti372I → N in BAB14827 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q9H7Z6-2)
Sequence conflicti454I → M in AAH37773 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014579438 – 458VDSVC…KLSKK → GGWGAAVCRGRWGSVSIWTG RSQGLLIAVT in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK021872 mRNA Translation: BAB13924.1
AK024102 mRNA Translation: BAB14827.1
AK291106 mRNA Translation: BAF83795.1
AC009088 Genomic DNA No translation available.
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52157.1
CH471192 Genomic DNA Translation: EAW52158.1
BC037773 mRNA Translation: AAH37773.1
AF217501 mRNA Translation: AAL56648.1 Frameshift.
AF260665 mRNA Translation: AAF72665.2
AF289578 mRNA Translation: AAL55762.1 Sequence problems.
AL050395 mRNA Translation: CAH56416.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10706.1 [Q9H7Z6-1]
CCDS45468.1 [Q9H7Z6-2]

NCBI Reference Sequences

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RefSeqi
NP_115564.2, NM_032188.2 [Q9H7Z6-1]
NP_892003.2, NM_182958.2 [Q9H7Z6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000219797; ENSP00000219797; ENSG00000103510 [Q9H7Z6-1]
ENST00000448516; ENSP00000406037; ENSG00000103510 [Q9H7Z6-2]
ENST00000543774; ENSP00000456933; ENSG00000103510 [Q9H7Z6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84148

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84148

UCSC genome browser

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UCSCi
uc002eax.4 human [Q9H7Z6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021872 mRNA Translation: BAB13924.1
AK024102 mRNA Translation: BAB14827.1
AK291106 mRNA Translation: BAF83795.1
AC009088 Genomic DNA No translation available.
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52157.1
CH471192 Genomic DNA Translation: EAW52158.1
BC037773 mRNA Translation: AAH37773.1
AF217501 mRNA Translation: AAL56648.1 Frameshift.
AF260665 mRNA Translation: AAF72665.2
AF289578 mRNA Translation: AAL55762.1 Sequence problems.
AL050395 mRNA Translation: CAH56416.1
CCDSiCCDS10706.1 [Q9H7Z6-1]
CCDS45468.1 [Q9H7Z6-2]
RefSeqiNP_115564.2, NM_032188.2 [Q9H7Z6-1]
NP_892003.2, NM_182958.2 [Q9H7Z6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GIVX-ray1.94A174-449[»]
2PQ8X-ray1.45A174-449[»]
2Y0MX-ray2.70A174-458[»]
3QAHX-ray2.10A174-449[»]
3TOAX-ray3.00A177-458[»]
3TOBX-ray2.70A177-458[»]
4DNCX-ray2.05A/B170-458[»]
5H43X-ray2.30B140-149[»]
C128-142[»]
5J8CX-ray2.17A177-458[»]
5J8FX-ray2.60A177-458[»]
5WCIX-ray1.78A174-449[»]
6BA2X-ray1.85A174-449[»]
6BA4X-ray1.95A174-449[»]
6CT2X-ray2.13A174-449[»]
SMRiQ9H7Z6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123914, 44 interactors
ComplexPortaliCPX-809 NSL histone acetyltransferase complex
CPX-815 MSL histone acetyltransferase complex
CORUMiQ9H7Z6
IntActiQ9H7Z6, 12 interactors
MINTiQ9H7Z6
STRINGi9606.ENSP00000406037

Chemistry databases

BindingDBiQ9H7Z6
ChEMBLiCHEMBL1932912
GuidetoPHARMACOLOGYi2668

PTM databases

iPTMnetiQ9H7Z6
PhosphoSitePlusiQ9H7Z6

Polymorphism and mutation databases

BioMutaiKAT8
DMDMi68565938

Proteomic databases

EPDiQ9H7Z6
jPOSTiQ9H7Z6
MaxQBiQ9H7Z6
PaxDbiQ9H7Z6
PeptideAtlasiQ9H7Z6
PRIDEiQ9H7Z6
ProteomicsDBi81162
81163 [Q9H7Z6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219797; ENSP00000219797; ENSG00000103510 [Q9H7Z6-1]
ENST00000448516; ENSP00000406037; ENSG00000103510 [Q9H7Z6-2]
ENST00000543774; ENSP00000456933; ENSG00000103510 [Q9H7Z6-1]
GeneIDi84148
KEGGihsa:84148
UCSCiuc002eax.4 human [Q9H7Z6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84148
DisGeNETi84148

GeneCards: human genes, protein and diseases

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GeneCardsi
KAT8
HGNCiHGNC:17933 KAT8
HPAiHPA066324
MIMi609912 gene
neXtProtiNX_Q9H7Z6
OpenTargetsiENSG00000103510
PharmGKBiPA38476

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2747 Eukaryota
COG5027 LUCA
GeneTreeiENSGT00940000159512
InParanoidiQ9H7Z6
KOiK11308
OMAiMNMVKYW
OrthoDBi1373773at2759
PhylomeDBiQ9H7Z6
TreeFamiTF317619

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones
SIGNORiQ9H7Z6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KAT8 human
EvolutionaryTraceiQ9H7Z6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYST1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84148

Protein Ontology

More...
PROi
PR:Q9H7Z6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103510 Expressed in 230 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiQ9H7Z6 baseline and differential
GenevisibleiQ9H7Z6 HS

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR002717 HAT_MYST-type
IPR037906 KAT8
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
IPR040706 Zf-MYST
PANTHERiPTHR10615:SF82 PTHR10615:SF82, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
PF17772 zf-MYST, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7Z6
Secondary accession number(s): A8K4Z1
, G5E9P2, Q659G0, Q7LC17, Q8IY59, Q8WYB4, Q8WZ14, Q9HAC5, Q9NR35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 8, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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