Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H7Z3 (NRDE2_HUMAN)

Entry version 154 (10 Feb 2021)
Sequence version 3 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Nuclear exosome regulator NRDE2

Gene

NRDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H7Z3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear exosome regulator NRDE21 Publication
Alternative name(s):
Protein NRDE2 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRDE2Imported
Synonyms:C14orf102Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20186, NRDE2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618631, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H7Z3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000119720.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163F → A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with R-166; A-187 and E-189. 1 Publication1
Mutagenesisi166D → R: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; A-187 and E-189. 1 Publication1
Mutagenesisi187Y → A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and E-189. 1 Publication1
Mutagenesisi189R → E: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and A-187. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55051

Open Targets

More...OpenTargetsi		ENSG00000119720

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134926790

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H7Z3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NRDE2

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899072 – 1164Nuclear exosome regulator NRDE2Add BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H7Z3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H7Z3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H7Z3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H7Z3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H7Z3

PeptideAtlas

More...PeptideAtlasi		Q9H7Z3

PRoteomics IDEntifications database

More...PRIDEi		Q9H7Z3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81161

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H7Z3

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H7Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H7Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000119720, Expressed in sural nerve and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H7Z3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H7Z3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000119720, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTREX; the interaction is direct and stabilizes NRDE2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120373, 20 interactors

Protein interaction database and analysis system

More...IntActi		Q9H7Z3, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346335

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H7Z3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H7Z3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati305 – 337HAT 1Add BLAST33
Repeati395 – 427HAT 2Add BLAST33
Repeati758 – 792HAT 3Add BLAST35
Repeati978 – 1010HAT 4Add BLAST33
Repeati1067 – 1101HAT 5Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni163 – 266MID/MTR4-interacting domain1 PublicationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 383Sequence analysisAdd BLAST323

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi73 – 101Lys-richAdd BLAST29
Compositional biasi81 – 91Poly-LysAdd BLAST11
Compositional biasi105 – 110Poly-Ser6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRDE2 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1972, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005524

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007550_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H7Z3

Identification of Orthologs from Complete Genome Data

More...OMAi		VQVEFFE

Database of Orthologous Groups

More...OrthoDBi		833360at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H7Z3

TreeFam database of animal gene trees

More...TreeFami		TF323791

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013633, NRDE-2
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13471, PTHR13471, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08424, NRDE-2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H7Z3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV 
        60         70         80         90        100
SEGLPLTRSH LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR 
       110        120        130        140        150
KHGPSSSSRS ETDTDSEKDK PSRGVGGSKK ESEEPNQGNN AAADTGHRFV 
       160        170        180        190        200
WLEDIQAVTG ETFRTDKKPD PANWEYKSLY RGDIARYKRK GDSCLGINPK 
       210        220        230        240        250
KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS SKTEPPSSEP 
       260        270        280        290        300
ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP 
       310        320        330        340        350
DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG 
       360        370        380        390        400
EQEKRKRSLK LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL 
       410        420        430        440        450
VKEWQKLIFL HPNNTALWQK YLLFCQSQFS TFSISKIHSL YGKCLSTLSA 
       460        470        480        490        500
VKDGSILSHP ALPGTEEAMF ALFLQQCHFL RQAGHSEKAI SLFQAMVDFT 
       510        520        530        540        550
FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA WMHQQERGGW 
       560        570        580        590        600
VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT 
       610        620        630        640        650
KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF 
       660        670        680        690        700
TPPASCLYLA MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR 
       710        720        730        740        750
WTRGQNREGE EFIRNVFHLV MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT 
       760        770        780        790        800
KNKKRLKSQG KNCKKLAKNL LKEPENCNNF CLWKQYAHLE WLLGNTEDAR 
       810        820        830        840        850
KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR AATARAVHIL 
       860        870        880        890        900
TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC 
       910        920        930        940        950
SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS 
       960        970        980        990       1000
SQSWTSVLEA ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL 
      1010       1020       1030       1040       1050
WRSYVQIQNK SHSASKTRRF FDTITRSAKP LEPWLFAIEA EKLRKRLVET 
      1060       1070       1080       1090       1100
VQRLDGREIH ATIPETGLMH RIQALFENAM RSDSGSQCPL LWRMYLNFLV 
      1110       1120       1130       1140       1150
SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI LDLMTEKELR 
      1160 
VRLPLEELEL LLED
Length:1,164
Mass (Da):132,673
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i343D0CF623AE2E83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJT0H0YJT0_HUMAN
Nuclear exosome regulator NRDE2
NRDE2
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJT6H0YJT6_HUMAN
Nuclear exosome regulator NRDE2
NRDE2
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V338G3V338_HUMAN
Nuclear exosome regulator NRDE2
NRDE2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14830 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117E → G in BAA91404 (PubMed:14702039).Curated1
Sequence conflicti357R → G in BAA91404 (PubMed:14702039).Curated1
Sequence conflicti694D → G in BAB14830 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05781332C → F. Corresponds to variant dbSNP:rs7140914Ensembl.1
Natural variantiVAR_062239928E → K. Corresponds to variant dbSNP:rs59039343EnsemblClinVar.1
Natural variantiVAR_0603431118N → S2 PublicationsCorresponds to variant dbSNP:rs3737035Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000870 mRNA Translation: BAA91404.1
AK024113 mRNA Translation: BAB14830.1 Different initiation.
AK294958 mRNA Translation: BAG58032.1
AL161662 Genomic DNA No translation available.
BC098568 mRNA Translation: AAH98568.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9890.1

NCBI Reference Sequences

More...RefSeqi		NP_060440.2, NM_017970.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354366; ENSP00000346335; ENSG00000119720

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55051

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55051

UCSC genome browser

More...UCSCi		uc001xyi.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000870 mRNA Translation: BAA91404.1
AK024113 mRNA Translation: BAB14830.1 Different initiation.
AK294958 mRNA Translation: BAG58032.1
AL161662 Genomic DNA No translation available.
BC098568 mRNA Translation: AAH98568.1
CCDSiCCDS9890.1
RefSeqiNP_060440.2, NM_017970.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6IEHX-ray2.89A163-266[»]
SMRiQ9H7Z3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120373, 20 interactors
IntActiQ9H7Z3, 14 interactors
STRINGi9606.ENSP00000346335

PTM databases

iPTMnetiQ9H7Z3
MetOSiteiQ9H7Z3
PhosphoSitePlusiQ9H7Z3

Genetic variation databases

BioMutaiNRDE2
DMDMi296439394

Proteomic databases

EPDiQ9H7Z3
jPOSTiQ9H7Z3
MassIVEiQ9H7Z3
MaxQBiQ9H7Z3
PaxDbiQ9H7Z3
PeptideAtlasiQ9H7Z3
PRIDEiQ9H7Z3
ProteomicsDBi81161

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26518, 25 antibodies

Genome annotation databases

EnsembliENST00000354366; ENSP00000346335; ENSG00000119720
GeneIDi55051
KEGGihsa:55051
UCSCiuc001xyi.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55051
DisGeNETi55051

GeneCards: human genes, protein and diseases

More...GeneCardsi		NRDE2
HGNCiHGNC:20186, NRDE2
HPAiENSG00000119720, Low tissue specificity
MIMi618631, gene
neXtProtiNX_Q9H7Z3
OpenTargetsiENSG00000119720
PharmGKBiPA134926790
VEuPathDBiHostDB:ENSG00000119720.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1972, Eukaryota
GeneTreeiENSGT00390000005524
HOGENOMiCLU_007550_1_0_1
InParanoidiQ9H7Z3
OMAiVQVEFFE
OrthoDBi833360at2759
PhylomeDBiQ9H7Z3
TreeFamiTF323791

Enzyme and pathway databases

PathwayCommonsiQ9H7Z3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55051, 727 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NRDE2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55051
PharosiQ9H7Z3, Tdark

Protein Ontology

More...PROi		PR:Q9H7Z3
RNActiQ9H7Z3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000119720, Expressed in sural nerve and 194 other tissues
ExpressionAtlasiQ9H7Z3, baseline and differential
GenevisibleiQ9H7Z3, HS

Family and domain databases

InterProiView protein in InterPro
IPR013633, NRDE-2
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR13471, PTHR13471, 1 hit
PfamiView protein in Pfam
PF08424, NRDE-2, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRDE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7Z3
Secondary accession number(s): B4DH71, Q4G0A7, Q9NWH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: February 10, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again