UniProtKB - Q9H7Z3 (NRDE2_HUMAN)
Protein
Nuclear exosome regulator NRDE2
Gene
NRDE2
Organism
Homo sapiens (Human)
Status
Functioni
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217).1 Publication
GO - Biological processi
- heterochromatin assembly by small RNA Source: GO_Central
- negative regulation of RNA catabolic process Source: UniProtKB
- positive regulation of RNA export from nucleus Source: UniProtKB
- RNA interference Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9H7Z3 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear exosome regulator NRDE21 PublicationAlternative name(s): Protein NRDE2 homologCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20186, NRDE2 |
MIMi | 618631, gene |
neXtProti | NX_Q9H7Z3 |
VEuPathDBi | HostDB:ENSG00000119720.17 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- nucleolus 1 Publication
- nucleoplasm 1 Publication
Nucleus
- nuclear speck Source: UniProtKB
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 163 | F → A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with R-166; A-187 and E-189. 1 Publication | 1 | |
Mutagenesisi | 166 | D → R: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; A-187 and E-189. 1 Publication | 1 | |
Mutagenesisi | 187 | Y → A: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and E-189. 1 Publication | 1 | |
Mutagenesisi | 189 | R → E: Loss of interaction with MTREX associated with decreased RNAs stability; when associated with A-163; R-166 and A-187. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55051 |
OpenTargetsi | ENSG00000119720 |
PharmGKBi | PA134926790 |
Miscellaneous databases
Pharosi | Q9H7Z3, Tdark |
Genetic variation databases
BioMutai | NRDE2 |
DMDMi | 296439394 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000089907 | 2 – 1164 | Nuclear exosome regulator NRDE2Add BLAST | 1163 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9H7Z3 |
jPOSTi | Q9H7Z3 |
MassIVEi | Q9H7Z3 |
MaxQBi | Q9H7Z3 |
PaxDbi | Q9H7Z3 |
PeptideAtlasi | Q9H7Z3 |
PRIDEi | Q9H7Z3 |
ProteomicsDBi | 81161 |
PTM databases
iPTMneti | Q9H7Z3 |
MetOSitei | Q9H7Z3 |
PhosphoSitePlusi | Q9H7Z3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119720, Expressed in sural nerve and 194 other tissues |
ExpressionAtlasi | Q9H7Z3, baseline and differential |
Genevisiblei | Q9H7Z3, HS |
Organism-specific databases
HPAi | ENSG00000119720, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MTREX; the interaction is direct and stabilizes NRDE2.
1 PublicationBinary interactionsi
Hide detailsQ9H7Z3
Protein-protein interaction databases
BioGRIDi | 120373, 20 interactors |
IntActi | Q9H7Z3, 14 interactors |
STRINGi | 9606.ENSP00000346335 |
Miscellaneous databases
RNActi | Q9H7Z3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9H7Z3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 305 – 337 | HAT 1Add BLAST | 33 | |
Repeati | 395 – 427 | HAT 2Add BLAST | 33 | |
Repeati | 758 – 792 | HAT 3Add BLAST | 35 | |
Repeati | 978 – 1010 | HAT 4Add BLAST | 33 | |
Repeati | 1067 – 1101 | HAT 5Add BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 163 – 266 | MID/MTR4-interacting domain1 PublicationAdd BLAST | 104 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 61 – 383 | Sequence analysisAdd BLAST | 323 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 73 – 101 | Lys-richAdd BLAST | 29 | |
Compositional biasi | 81 – 91 | Poly-LysAdd BLAST | 11 | |
Compositional biasi | 105 – 110 | Poly-Ser | 6 |
Domaini
The MID/MTR4-interacting domain is necessary and sufficient to mediate interaction with MTREX.1 Publication
Sequence similaritiesi
Belongs to the NRDE2 family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1972, Eukaryota |
GeneTreei | ENSGT00390000005524 |
HOGENOMi | CLU_007550_1_0_1 |
InParanoidi | Q9H7Z3 |
OMAi | VQVEFFE |
OrthoDBi | 833360at2759 |
PhylomeDBi | Q9H7Z3 |
TreeFami | TF323791 |
Family and domain databases
InterProi | View protein in InterPro IPR013633, NRDE-2 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13471, PTHR13471, 1 hit |
Pfami | View protein in Pfam PF08424, NRDE-2, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9H7Z3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV
60 70 80 90 100
SEGLPLTRSH LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR
110 120 130 140 150
KHGPSSSSRS ETDTDSEKDK PSRGVGGSKK ESEEPNQGNN AAADTGHRFV
160 170 180 190 200
WLEDIQAVTG ETFRTDKKPD PANWEYKSLY RGDIARYKRK GDSCLGINPK
210 220 230 240 250
KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS SKTEPPSSEP
260 270 280 290 300
ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP
310 320 330 340 350
DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG
360 370 380 390 400
EQEKRKRSLK LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL
410 420 430 440 450
VKEWQKLIFL HPNNTALWQK YLLFCQSQFS TFSISKIHSL YGKCLSTLSA
460 470 480 490 500
VKDGSILSHP ALPGTEEAMF ALFLQQCHFL RQAGHSEKAI SLFQAMVDFT
510 520 530 540 550
FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA WMHQQERGGW
560 570 580 590 600
VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT
610 620 630 640 650
KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF
660 670 680 690 700
TPPASCLYLA MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR
710 720 730 740 750
WTRGQNREGE EFIRNVFHLV MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT
760 770 780 790 800
KNKKRLKSQG KNCKKLAKNL LKEPENCNNF CLWKQYAHLE WLLGNTEDAR
810 820 830 840 850
KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR AATARAVHIL
860 870 880 890 900
TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC
910 920 930 940 950
SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS
960 970 980 990 1000
SQSWTSVLEA ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL
1010 1020 1030 1040 1050
WRSYVQIQNK SHSASKTRRF FDTITRSAKP LEPWLFAIEA EKLRKRLVET
1060 1070 1080 1090 1100
VQRLDGREIH ATIPETGLMH RIQALFENAM RSDSGSQCPL LWRMYLNFLV
1110 1120 1130 1140 1150
SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI LDLMTEKELR
1160
VRLPLEELEL LLED
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YJT0 | H0YJT0_HUMAN | Nuclear exosome regulator NRDE2 | NRDE2 | 204 | Annotation score: | ||
H0YJT6 | H0YJT6_HUMAN | Nuclear exosome regulator NRDE2 | NRDE2 | 227 | Annotation score: | ||
G3V338 | G3V338_HUMAN | Nuclear exosome regulator NRDE2 | NRDE2 | 43 | Annotation score: |
Sequence cautioni
The sequence BAB14830 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 117 | E → G in BAA91404 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 357 | R → G in BAA91404 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 694 | D → G in BAB14830 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057813 | 32 | C → F. Corresponds to variant dbSNP:rs7140914Ensembl. | 1 | |
Natural variantiVAR_062239 | 928 | E → K. Corresponds to variant dbSNP:rs59039343EnsemblClinVar. | 1 | |
Natural variantiVAR_060343 | 1118 | N → S2 PublicationsCorresponds to variant dbSNP:rs3737035Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000870 mRNA Translation: BAA91404.1 AK024113 mRNA Translation: BAB14830.1 Different initiation. AK294958 mRNA Translation: BAG58032.1 AL161662 Genomic DNA No translation available. BC098568 mRNA Translation: AAH98568.1 |
CCDSi | CCDS9890.1 |
RefSeqi | NP_060440.2, NM_017970.3 |
Genome annotation databases
Ensembli | ENST00000354366; ENSP00000346335; ENSG00000119720 |
GeneIDi | 55051 |
KEGGi | hsa:55051 |
UCSCi | uc001xyi.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000870 mRNA Translation: BAA91404.1 AK024113 mRNA Translation: BAB14830.1 Different initiation. AK294958 mRNA Translation: BAG58032.1 AL161662 Genomic DNA No translation available. BC098568 mRNA Translation: AAH98568.1 |
CCDSi | CCDS9890.1 |
RefSeqi | NP_060440.2, NM_017970.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6IEH | X-ray | 2.89 | A | 163-266 | [»] | |
SMRi | Q9H7Z3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120373, 20 interactors |
IntActi | Q9H7Z3, 14 interactors |
STRINGi | 9606.ENSP00000346335 |
PTM databases
iPTMneti | Q9H7Z3 |
MetOSitei | Q9H7Z3 |
PhosphoSitePlusi | Q9H7Z3 |
Genetic variation databases
BioMutai | NRDE2 |
DMDMi | 296439394 |
Proteomic databases
EPDi | Q9H7Z3 |
jPOSTi | Q9H7Z3 |
MassIVEi | Q9H7Z3 |
MaxQBi | Q9H7Z3 |
PaxDbi | Q9H7Z3 |
PeptideAtlasi | Q9H7Z3 |
PRIDEi | Q9H7Z3 |
ProteomicsDBi | 81161 |
Protocols and materials databases
Antibodypediai | 26518, 25 antibodies |
Genome annotation databases
Ensembli | ENST00000354366; ENSP00000346335; ENSG00000119720 |
GeneIDi | 55051 |
KEGGi | hsa:55051 |
UCSCi | uc001xyi.3, human |
Organism-specific databases
CTDi | 55051 |
DisGeNETi | 55051 |
GeneCardsi | NRDE2 |
HGNCi | HGNC:20186, NRDE2 |
HPAi | ENSG00000119720, Low tissue specificity |
MIMi | 618631, gene |
neXtProti | NX_Q9H7Z3 |
OpenTargetsi | ENSG00000119720 |
PharmGKBi | PA134926790 |
VEuPathDBi | HostDB:ENSG00000119720.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1972, Eukaryota |
GeneTreei | ENSGT00390000005524 |
HOGENOMi | CLU_007550_1_0_1 |
InParanoidi | Q9H7Z3 |
OMAi | VQVEFFE |
OrthoDBi | 833360at2759 |
PhylomeDBi | Q9H7Z3 |
TreeFami | TF323791 |
Enzyme and pathway databases
PathwayCommonsi | Q9H7Z3 |
Miscellaneous databases
BioGRID-ORCSi | 55051, 727 hits in 876 CRISPR screens |
ChiTaRSi | NRDE2, human |
GenomeRNAii | 55051 |
Pharosi | Q9H7Z3, Tdark |
PROi | PR:Q9H7Z3 |
RNActi | Q9H7Z3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119720, Expressed in sural nerve and 194 other tissues |
ExpressionAtlasi | Q9H7Z3, baseline and differential |
Genevisiblei | Q9H7Z3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013633, NRDE-2 IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13471, PTHR13471, 1 hit |
Pfami | View protein in Pfam PF08424, NRDE-2, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NRDE2_HUMAN | |
Accessioni | Q9H7Z3Primary (citable) accession number: Q9H7Z3 Secondary accession number(s): B4DH71, Q4G0A7, Q9NWH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants