UniProtKB - Q9H7Y0 (DIK2B_HUMAN)
Protein
Divergent protein kinase domain 2B
Gene
DIPK2B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Divergent protein kinase domain 2BCuratedAlternative name(s): Deleted in autism-related protein 11 Publication |
Gene namesi | ORF Names:UNQ1862/PRO3743 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25866, DIPK2B |
MIMi | 300959, gene |
neXtProti | NX_Q9H7Y0 |
VEuPathDBi | HostDB:ENSG00000147113.16 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Genetic variations in CXorf36 may be associated with susceptibility to autism.1 Publication
Keywords - Diseasei
Autism, Autism spectrum disorderOrganism-specific databases
DisGeNETi | 79742 |
OpenTargetsi | ENSG00000147113 |
PharmGKBi | PA134972038 |
Miscellaneous databases
Pharosi | Q9H7Y0, Tdark |
Genetic variation databases
BioMutai | CXorf36 |
DMDMi | 212276509 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000019568 | 32 – 433 | Divergent protein kinase domain 2BAdd BLAST | 402 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9H7Y0 |
PaxDbi | Q9H7Y0 |
PeptideAtlasi | Q9H7Y0 |
PRIDEi | Q9H7Y0 |
ProteomicsDBi | 81157 [Q9H7Y0-1] 81158 [Q9H7Y0-2] |
TopDownProteomicsi | Q9H7Y0-1 [Q9H7Y0-1] |
PTM databases
GlyGeni | Q9H7Y0, 1 site |
iPTMneti | Q9H7Y0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147113, Expressed in adrenal gland and 172 other tissues |
Genevisiblei | Q9H7Y0, HS |
Organism-specific databases
HPAi | ENSG00000147113, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122855, 1 interactor |
STRINGi | 9606.ENSP00000381086 |
Miscellaneous databases
RNActi | Q9H7Y0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DIPK family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRQX, Eukaryota |
GeneTreei | ENSGT00520000055625 |
HOGENOMi | CLU_051861_0_0_1 |
InParanoidi | Q9H7Y0 |
OMAi | EIRFDTW |
PhylomeDBi | Q9H7Y0 |
TreeFami | TF353643 |
Family and domain databases
InterProi | View protein in InterPro IPR020519, DIPK2A/B IPR022049, FAM69_kinase_dom |
PANTHERi | PTHR32073, PTHR32073, 1 hit |
Pfami | View protein in Pfam PF12260, PIP49_C, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9H7Y0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPQLGPEAA ALRPGWLALL LWVSALSCSF SLPASSLSSL VPQVRTSYNF
60 70 80 90 100
GRTFLGLDKC NACIGTSICK KFFKEEIRSD NWLASHLGLP PDSLLSYPAN
110 120 130 140 150
YSDDSKIWRP VEIFRLVSKY QNEISDRRIC ASASAPKTCS IERVLRKTER
160 170 180 190 200
FQKWLQAKRL TPDLVQGLAS PLLRCPSQRL LDRVVRRYAE VADAGSIFMD
210 220 230 240 250
HFTDRDKLRL LYTLAVNSHP ILLQIFPGAE GWPLPKYLGS CGRFLVSTST
260 270 280 290 300
RPLQEFYDAP PDQAADLAYQ LLGVLESLRS NDLNYFFYFT HIDAGMFGVF
310 320 330 340 350
NNGHLFIRDA SAVGVIDKQE GSQEANRAGE NKDIFSCLVS GCQAQLPSCE
360 370 380 390 400
SISEKQSLVL VCQKLLPRLL QGRFPSPVQD DIDSILVQCG DSIRPDPEVL
410 420 430
GAASQLKDIL RPLRTCDSRF AYRYPDCKYN DKF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047103 | 128 | R → K2 PublicationsCorresponds to variant dbSNP:rs1132201Ensembl. | 1 | |
Natural variantiVAR_047104 | 146 | R → Q. Corresponds to variant dbSNP:rs9969Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035633 | 167 – 182 | GLASP…QRLLD → DCHQGQRELKFLCMLR in isoform 2. 3 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_035634 | 183 – 433 | Missing in isoform 2. 3 PublicationsAdd BLAST | 251 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358764 mRNA Translation: AAQ89124.1 AK024165 mRNA Translation: BAB14843.1 AC136488 Genomic DNA No translation available. BC137528 mRNA Translation: AAI37529.1 BC137529 mRNA Translation: AAI37530.1 |
CCDSi | CCDS14266.1 [Q9H7Y0-2] CCDS48096.1 [Q9H7Y0-1] |
RefSeqi | NP_078965.2, NM_024689.2 [Q9H7Y0-2] NP_789789.2, NM_176819.3 [Q9H7Y0-1] |
Genome annotation databases
Ensembli | ENST00000377934; ENSP00000367168; ENSG00000147113 [Q9H7Y0-2] ENST00000398000; ENSP00000381086; ENSG00000147113 [Q9H7Y0-1] |
GeneIDi | 79742 |
KEGGi | hsa:79742 |
UCSCi | uc004dgg.3, human [Q9H7Y0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358764 mRNA Translation: AAQ89124.1 AK024165 mRNA Translation: BAB14843.1 AC136488 Genomic DNA No translation available. BC137528 mRNA Translation: AAI37529.1 BC137529 mRNA Translation: AAI37530.1 |
CCDSi | CCDS14266.1 [Q9H7Y0-2] CCDS48096.1 [Q9H7Y0-1] |
RefSeqi | NP_078965.2, NM_024689.2 [Q9H7Y0-2] NP_789789.2, NM_176819.3 [Q9H7Y0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122855, 1 interactor |
STRINGi | 9606.ENSP00000381086 |
PTM databases
GlyGeni | Q9H7Y0, 1 site |
iPTMneti | Q9H7Y0 |
Genetic variation databases
BioMutai | CXorf36 |
DMDMi | 212276509 |
Proteomic databases
MassIVEi | Q9H7Y0 |
PaxDbi | Q9H7Y0 |
PeptideAtlasi | Q9H7Y0 |
PRIDEi | Q9H7Y0 |
ProteomicsDBi | 81157 [Q9H7Y0-1] 81158 [Q9H7Y0-2] |
TopDownProteomicsi | Q9H7Y0-1 [Q9H7Y0-1] |
Protocols and materials databases
Antibodypediai | 455, 111 antibodies |
Genome annotation databases
Ensembli | ENST00000377934; ENSP00000367168; ENSG00000147113 [Q9H7Y0-2] ENST00000398000; ENSP00000381086; ENSG00000147113 [Q9H7Y0-1] |
GeneIDi | 79742 |
KEGGi | hsa:79742 |
UCSCi | uc004dgg.3, human [Q9H7Y0-1] |
Organism-specific databases
CTDi | 79742 |
DisGeNETi | 79742 |
GeneCardsi | DIPK2B |
HGNCi | HGNC:25866, DIPK2B |
HPAi | ENSG00000147113, Low tissue specificity |
MIMi | 300959, gene |
neXtProti | NX_Q9H7Y0 |
OpenTargetsi | ENSG00000147113 |
PharmGKBi | PA134972038 |
VEuPathDBi | HostDB:ENSG00000147113.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRQX, Eukaryota |
GeneTreei | ENSGT00520000055625 |
HOGENOMi | CLU_051861_0_0_1 |
InParanoidi | Q9H7Y0 |
OMAi | EIRFDTW |
PhylomeDBi | Q9H7Y0 |
TreeFami | TF353643 |
Enzyme and pathway databases
PathwayCommonsi | Q9H7Y0 |
Miscellaneous databases
BioGRID-ORCSi | 79742, 9 hits in 505 CRISPR screens |
ChiTaRSi | CXorf36, human |
GeneWikii | CXorf36 |
GenomeRNAii | 79742 |
Pharosi | Q9H7Y0, Tdark |
PROi | PR:Q9H7Y0 |
RNActi | Q9H7Y0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147113, Expressed in adrenal gland and 172 other tissues |
Genevisiblei | Q9H7Y0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020519, DIPK2A/B IPR022049, FAM69_kinase_dom |
PANTHERi | PTHR32073, PTHR32073, 1 hit |
Pfami | View protein in Pfam PF12260, PIP49_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DIK2B_HUMAN | |
Accessioni | Q9H7Y0Primary (citable) accession number: Q9H7Y0 Secondary accession number(s): A8MUU5, B2RPN7, Q6UWJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families