UniProtKB - Q9H7X7 (IFT22_HUMAN)
Protein
Intraflagellar transport protein 22 homolog
Gene
IFT22
Organism
Homo sapiens (Human)
Status
Functioni
Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTPBy similarity | 8 | |
Nucleotide bindingi | 63 – 67 | GTPBy similarity | 5 | |
Nucleotide bindingi | 123 – 126 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- intracellular protein transport Source: GO_Central
- intraciliary transport involved in cilium assembly Source: Reactome
- Rab protein signal transduction Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-5620924 Intraflagellar transport |
Names & Taxonomyi
Protein namesi | Recommended name: Intraflagellar transport protein 22 homologAlternative name(s): Rab-like protein 5 |
Gene namesi | Name:IFT22 Synonyms:RABL5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21895 IFT22 |
neXtProti | NX_Q9H7X7 |
Subcellular locationi
Other locations
- cilium By similarity
Cytoskeleton
- centrosome Source: Ensembl
Other locations
- ciliary tip Source: Reactome
- cilium Source: Reactome
- intraciliary transport particle B Source: UniProtKB
Keywords - Cellular componenti
Cell projection, CiliumPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000128581 |
PharmGKBi | PA134871769 |
Miscellaneous databases
Pharosi | Q9H7X7 |
Polymorphism and mutation databases
BioMutai | IFT22 |
DMDMi | 74733725 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253733 | 1 – 185 | Intraflagellar transport protein 22 homologAdd BLAST | 185 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 137 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H7X7 |
jPOSTi | Q9H7X7 |
MassIVEi | Q9H7X7 |
MaxQBi | Q9H7X7 |
PaxDbi | Q9H7X7 |
PeptideAtlasi | Q9H7X7 |
PRIDEi | Q9H7X7 |
ProteomicsDBi | 62041 81155 [Q9H7X7-1] 81156 [Q9H7X7-2] |
PTM databases
iPTMneti | Q9H7X7 |
PhosphoSitePlusi | Q9H7X7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128581 Expressed in 215 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9H7X7 baseline and differential |
Genevisiblei | Q9H7X7 HS |
Organism-specific databases
HPAi | HPA042930 |
Interactioni
Subunit structurei
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88.
Interacts with IFT88 (By similarity).
By similarityProtein-protein interaction databases
BioGridi | 122300, 42 interactors |
CORUMi | Q9H7X7 |
IntActi | Q9H7X7, 25 interactors |
STRINGi | 9606.ENSP00000320359 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IVWX Eukaryota ENOG4111FYS LUCA |
GeneTreei | ENSGT00390000013187 |
HOGENOMi | HOG000232131 |
InParanoidi | Q9H7X7 |
KOi | K07935 |
OMAi | GDQKFET |
OrthoDBi | 1428809at2759 |
PhylomeDBi | Q9H7X7 |
TreeFami | TF313208 |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase |
SUPFAMi | SSF52540 SSF52540, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS
60 70 80 90 100
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME
110 120 130 140 150
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL
160 170 180
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WDY0 | F8WDY0_HUMAN | Intraflagellar transport protein 22... | IFT22 | 37 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045182 | 1 – 77 | Missing in isoform 3. 2 PublicationsAdd BLAST | 77 | |
Alternative sequenceiVSP_021112 | 40 – 69 | Missing in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023287 mRNA Translation: BAG51181.1 AK024179 mRNA Translation: BAB14846.1 AK298888 mRNA Translation: BAH12896.1 AC006329 Genomic DNA No translation available. CH471197 Genomic DNA Translation: EAW50217.1 BC004522 mRNA Translation: AAH04522.1 BC009823 mRNA Translation: AAH09823.1 BC038668 mRNA Translation: AAH38668.1 AL157469 mRNA Translation: CAH10693.1 |
CCDSi | CCDS47670.1 [Q9H7X7-2] CCDS47671.1 [Q9H7X7-3] CCDS5719.1 [Q9H7X7-1] |
RefSeqi | NP_001124292.1, NM_001130820.2 [Q9H7X7-2] NP_001124293.1, NM_001130821.2 [Q9H7X7-3] NP_001124294.1, NM_001130822.2 [Q9H7X7-3] NP_001274454.1, NM_001287525.1 [Q9H7X7-3] NP_001274455.1, NM_001287526.1 [Q9H7X7-3] NP_073614.1, NM_022777.3 [Q9H7X7-1] |
Genome annotation databases
Ensembli | ENST00000315322; ENSP00000320359; ENSG00000128581 [Q9H7X7-1] ENST00000422177; ENSP00000392087; ENSG00000128581 [Q9H7X7-1] ENST00000437644; ENSP00000390770; ENSG00000128581 [Q9H7X7-2] ENST00000498704; ENSP00000429648; ENSG00000128581 [Q9H7X7-3] ENST00000517481; ENSP00000429202; ENSG00000128581 [Q9H7X7-3] ENST00000621899; ENSP00000478948; ENSG00000128581 [Q9H7X7-3] |
GeneIDi | 64792 |
KEGGi | hsa:64792 |
UCSCi | uc003uyl.5 human [Q9H7X7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023287 mRNA Translation: BAG51181.1 AK024179 mRNA Translation: BAB14846.1 AK298888 mRNA Translation: BAH12896.1 AC006329 Genomic DNA No translation available. CH471197 Genomic DNA Translation: EAW50217.1 BC004522 mRNA Translation: AAH04522.1 BC009823 mRNA Translation: AAH09823.1 BC038668 mRNA Translation: AAH38668.1 AL157469 mRNA Translation: CAH10693.1 |
CCDSi | CCDS47670.1 [Q9H7X7-2] CCDS47671.1 [Q9H7X7-3] CCDS5719.1 [Q9H7X7-1] |
RefSeqi | NP_001124292.1, NM_001130820.2 [Q9H7X7-2] NP_001124293.1, NM_001130821.2 [Q9H7X7-3] NP_001124294.1, NM_001130822.2 [Q9H7X7-3] NP_001274454.1, NM_001287525.1 [Q9H7X7-3] NP_001274455.1, NM_001287526.1 [Q9H7X7-3] NP_073614.1, NM_022777.3 [Q9H7X7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 122300, 42 interactors |
CORUMi | Q9H7X7 |
IntActi | Q9H7X7, 25 interactors |
STRINGi | 9606.ENSP00000320359 |
PTM databases
iPTMneti | Q9H7X7 |
PhosphoSitePlusi | Q9H7X7 |
Polymorphism and mutation databases
BioMutai | IFT22 |
DMDMi | 74733725 |
Proteomic databases
EPDi | Q9H7X7 |
jPOSTi | Q9H7X7 |
MassIVEi | Q9H7X7 |
MaxQBi | Q9H7X7 |
PaxDbi | Q9H7X7 |
PeptideAtlasi | Q9H7X7 |
PRIDEi | Q9H7X7 |
ProteomicsDBi | 62041 81155 [Q9H7X7-1] 81156 [Q9H7X7-2] |
Protocols and materials databases
DNASUi | 64792 |
Genome annotation databases
Ensembli | ENST00000315322; ENSP00000320359; ENSG00000128581 [Q9H7X7-1] ENST00000422177; ENSP00000392087; ENSG00000128581 [Q9H7X7-1] ENST00000437644; ENSP00000390770; ENSG00000128581 [Q9H7X7-2] ENST00000498704; ENSP00000429648; ENSG00000128581 [Q9H7X7-3] ENST00000517481; ENSP00000429202; ENSG00000128581 [Q9H7X7-3] ENST00000621899; ENSP00000478948; ENSG00000128581 [Q9H7X7-3] |
GeneIDi | 64792 |
KEGGi | hsa:64792 |
UCSCi | uc003uyl.5 human [Q9H7X7-1] |
Organism-specific databases
CTDi | 64792 |
GeneCardsi | IFT22 |
HGNCi | HGNC:21895 IFT22 |
HPAi | HPA042930 |
neXtProti | NX_Q9H7X7 |
OpenTargetsi | ENSG00000128581 |
PharmGKBi | PA134871769 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IVWX Eukaryota ENOG4111FYS LUCA |
GeneTreei | ENSGT00390000013187 |
HOGENOMi | HOG000232131 |
InParanoidi | Q9H7X7 |
KOi | K07935 |
OMAi | GDQKFET |
OrthoDBi | 1428809at2759 |
PhylomeDBi | Q9H7X7 |
TreeFami | TF313208 |
Enzyme and pathway databases
Reactomei | R-HSA-5620924 Intraflagellar transport |
Miscellaneous databases
ChiTaRSi | IFT22 human |
GenomeRNAii | 64792 |
Pharosi | Q9H7X7 |
PROi | PR:Q9H7X7 |
Gene expression databases
Bgeei | ENSG00000128581 Expressed in 215 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9H7X7 baseline and differential |
Genevisiblei | Q9H7X7 HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase |
SUPFAMi | SSF52540 SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFT22_HUMAN | |
Accessioni | Q9H7X7Primary (citable) accession number: Q9H7X7 Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families