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Entry version 133 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

N-alpha-acetyltransferase 60

Gene

NAA60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917).1 Publication4 Publications

Caution

According to a report, displays histone acetyltransferase activity while localized in the Golgi apparatus (PubMed:21981917). May mediate acetylation of free histone H4 and promote nucleosome assembly (PubMed:21981917). Such results are however unclear in vivo and recent reports strongly suggest that it acts as a N-alpha-acetyltransferase that specifically targets N-terminal residues of transmembrane proteins (PubMed:21750686, PubMed:25732826).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei34Required to position thioacetyl group1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38Substrate1 PublicationImported1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei972 Publications1
Binding sitei99Substrate; via carbonyl oxygen1 PublicationImported1
Active sitei1382 Publications1
Binding sitei143Acetyl-CoA2 PublicationsImported1
Binding sitei165Substrate1 PublicationImported1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processChromosome partition

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000122390-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-alpha-acetyltransferase 601 PublicationImported (EC:2.3.1.2591 Publication)
Short name:
hNaa602 Publications
Alternative name(s):
Histone acetyltransferase type B protein 41 Publication (EC:2.3.1.481 Publication)
Short name:
HAT41 Publication
N-acetyltransferase 15
N-alpha-acetyltransferase F
Short name:
NatF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAA601 PublicationImported
Synonyms:HAT41 Publication, NAT15
ORF Names:UNQ2771/PRO7155
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122390.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25875 NAA60

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614246 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7X0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 192Cytoplasmic1 PublicationAdd BLAST192
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei193 – 236Helical1 PublicationAdd BLAST44
Topological domaini237 – 242Cytoplasmic1 Publication6

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19C → S: Does not affect localization to the Golgi apparatus; when associated with S-30; S-132; S-207 and S-222. 1 Publication1
Mutagenesisi30C → S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-132; S-207 and S-222. 1 Publication1
Mutagenesisi34F → A: Abolished acetyltransferase activity. 1 Publication1
Mutagenesisi35P → A: Reduced acetyltransferase activity. 1 Publication1
Mutagenesisi36I → A: Reduced acetyltransferase activity. 1 Publication1
Mutagenesisi37E → A or F: Only slightly affects acetyltransferase activity. 1 Publication1
Mutagenesisi38Y → A: Strongly reduced acetyltransferase activity. 2 Publications1
Mutagenesisi79K → A: Slightly reduced acetyltransferase activity. 1 Publication1
Mutagenesisi79K → R or Q: Increased acetyltransferase activity. 1 Publication1
Mutagenesisi79K → R: Decreased acetyltransferase activity; when associated with R-105, R-109, R-121 and R-156. 1 Publication1
Mutagenesisi80E → A: Slightly increased acetyltransferase activity. 1 Publication1
Mutagenesisi81D → A: Slightly increased acetyltransferase activity. 2 Publications1
Mutagenesisi83D → A: Slightly increased acetyltransferase activity. 1 Publication1
Mutagenesisi84I → A: Slightly altered acetyltransferase activity. 1 Publication1
Mutagenesisi97Y → A or F: Abolished acetyltransferase activity. 2 Publications1
Mutagenesisi105K → R: Decreased acetyltransferase activity; when associated with R-79, R-109, R-121 and R-156. 1 Publication1
Mutagenesisi109K → R: Decreased acetyltransferase activity; when associated with R-79, R-105, R-121 and R-156. 1 Publication1
Mutagenesisi111G → A: Abolishes acetyltransferase activity. 1 Publication1
Mutagenesisi121K → R: Decreased acetyltransferase activity; when associated with R-79, R-105, R-109 and R-156. 1 Publication1
Mutagenesisi132C → S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-207 and S-222. 1 Publication1
Mutagenesisi138H → A or F: Abolished acetyltransferase activity. 2 Publications1
Mutagenesisi140L → A: Decreased acetyltransferase activity. 1 Publication1
Mutagenesisi143N → A: Strongly reduced acetyltransferase activity. 1 Publication1
Mutagenesisi156K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-121. 1 Publication1
Mutagenesisi164Y → A or F: Slightly altered acetyltransferase activity. 1 Publication1
Mutagenesisi165Y → A or F: Strongly reduced acetyltransferase activity. 2 Publications1
Mutagenesisi167I → A: Reduced acetyltransferase activity. 1 Publication1
Mutagenesisi207C → S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-132 and S-222. 1 Publication1
Mutagenesisi220 – 221LL → AA: Does not affect localization to the Golgi apparatus. 1 Publication2
Mutagenesisi222C → S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-132 and S-207. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000122390

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164723438

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H7X0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NAA60

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003215661 – 242N-alpha-acetyltransferase 60Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei79N6-acetyllysine; by autocatalysis1 Publication1
Modified residuei105N6-acetyllysine; by autocatalysis1 Publication1
Modified residuei109N6-acetyllysine; by autocatalysis1 Publication1
Modified residuei121N6-acetyllysine; by autocatalysis1 Publication1
Modified residuei156N6-acetyllysine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated: autoacetylation is required for optimal acetyltransferase activity.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H7X0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H7X0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7X0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7X0

PeptideAtlas

More...
PeptideAtlasi
Q9H7X0

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7X0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17514
3609
4572
5517
81152 [Q9H7X0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 2: Imprinted (PubMed:21593219). Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes (PubMed:21593219). Isoform 1: Biallelically expressed (PubMed:21593219).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122390 Expressed in 229 organ(s), highest expression level in fundus of stomach

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H7X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H7X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer; monomer in presence of substrate and homodimer in its absence (PubMed:27320834).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-62077N

Protein interaction database and analysis system

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IntActi
Q9H7X0, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000385903

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H7X0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H7X0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 182N-acetyltransferasePROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 103Acetyl-CoA binding2 PublicationsImported3
Regioni109 – 114Acetyl-CoA binding2 PublicationsImported6
Regioni150 – 153Acetyl-CoA binding2 PublicationsImported4
Regioni162 – 173Required for homodimerization1 PublicationAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQK0 Eukaryota
ENOG410Y94A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280717

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H7X0

KEGG Orthology (KO)

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KOi
K21121

Identification of Orthologs from Complete Genome Data

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OMAi
SIPQRLY

Database of Orthologous Groups

More...
OrthoDBi
1619974at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7X0

TreeFam database of animal gene trees

More...
TreeFami
TF323980

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00583 Acetyltransf_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55729 SSF55729, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51186 GNAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK
60 70 80 90 100
KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASNFS VDTQVAYILS
110 120 130 140 150
LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY
160 170 180 190 200
ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA
210 220 230 240
LASLSPCSIP HRVYRQAHSL LCSFLPWSGI SSKSGIEYSR TM
Length:242
Mass (Da):27,451
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11234F2C51DF55DE
GO
Isoform 2 (identifier: Q9H7X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MTEVVPSSAL...KHLCGDWFPI → MFPRRRTERR...ASLSWEKSSR

Note: In placenta and leukocytes, expressed from the maternal allele, due to imprinting of the paternal allele.Curated
Show »
Length:249
Mass (Da):28,375
Checksum:iE049FDCDA8FD6ECC
GO
Isoform 3 (identifier: Q9H7X0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:177
Mass (Da):20,103
Checksum:i32C31E8C2E777D5D
GO
Isoform 4 (identifier: Q9H7X0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-242: GSLLLESLKD...KSGIEYSRTM → ESTARPTACS...SVFCKELPAI

Note: Produced by alternative splicing.Curated
Show »
Length:179
Mass (Da):19,493
Checksum:i806EE0412C45F54C
GO
Isoform 5 (identifier: Q9H7X0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-242: GSLLLESLKD...KSGIEYSRTM → EPHGLHPAPG...PPAEPAFLSI

Note: Produced by alternative splicing.Curated
Show »
Length:190
Mass (Da):20,911
Checksum:iC82D743C3A3F0776
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1T4I3L1T4_HUMAN
N-alpha-acetyltransferase 60
NAA60
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2B4I3L2B4_HUMAN
N-alpha-acetyltransferase 60
NAA60
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2K7I3L2K7_HUMAN
N-alpha-acetyltransferase 60
NAA60
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2M6I3L2M6_HUMAN
N-alpha-acetyltransferase 60
NAA60
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L153I3L153_HUMAN
N-alpha-acetyltransferase 60
NAA60
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1X5I3L1X5_HUMAN
N-alpha-acetyltransferase 60
NAA60
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L205I3L205_HUMAN
N-alpha-acetyltransferase 60
NAA60
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4Q3I3L4Q3_HUMAN
N-alpha-acetyltransferase 60
NAA60
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4Q5I3L4Q5_HUMAN
N-alpha-acetyltransferase 60
NAA60
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4T5I3L4T5_HUMAN
N-alpha-acetyltransferase 60
NAA60
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87S → T in AAQ88907 (PubMed:12975309).Curated1
Sequence conflicti242M → I in CAG33605 (Ref. 3) Curated1
Isoform 5 (identifier: Q9H7X0-5)
Sequence conflicti180R → Q in BAG60760 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060995218H → Q. Corresponds to variant dbSNP:rs34464545Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441221 – 65Missing in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_0441231 – 36MTEVV…DWFPI → MFPRRRTERRLGDTGTRKKI AYRKAVPGGRKCGASLSWEK SSR in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_044124113 – 242GSLLL…YSRTM → ESTARPTACSAASCHGRASL PRVASSTAGPCDVGWAAATR PHPSAARRARLPVHLTPSVF CKELPAI in isoform 4. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_044125113 – 242GSLLL…YSRTM → EPHGLHPAPGLCTSQPEPLL HSAQSLPPGPQPALQLPAMV GHLFQEWHRVQPDHVMSAGQ PPPGPTLRPPAEPAFLSI in isoform 5. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358543 mRNA Translation: AAQ88907.1
AK024216 mRNA Translation: BAB14853.1
AK092005 mRNA Translation: BAG52462.1
AK297219 mRNA Translation: BAG59702.1
AK298566 mRNA Translation: BAG60760.1
AK302361 mRNA Translation: BAG63686.1
CR457324 mRNA Translation: CAG33605.1
AC004224 Genomic DNA No translation available.
AC025283 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85358.1
CH471112 Genomic DNA Translation: EAW85359.1
CH471112 Genomic DNA Translation: EAW85360.1
CH471112 Genomic DNA Translation: EAW85361.1
CH471112 Genomic DNA Translation: EAW85362.1
CH471112 Genomic DNA Translation: EAW85363.1
CH471112 Genomic DNA Translation: EAW85364.1
BC011267 mRNA Translation: AAH11267.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45396.1 [Q9H7X0-1]
CCDS81937.1 [Q9H7X0-2]
CCDS81938.1 [Q9H7X0-5]
CCDS81939.1 [Q9H7X0-4]
CCDS81941.1 [Q9H7X0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001077069.1, NM_001083600.2 [Q9H7X0-1]
NP_001077070.1, NM_001083601.2 [Q9H7X0-1]
NP_001304022.1, NM_001317093.1 [Q9H7X0-2]
NP_001304023.1, NM_001317094.1
NP_001304024.1, NM_001317095.1 [Q9H7X0-3]
NP_001304025.1, NM_001317096.1 [Q9H7X0-5]
NP_001304026.1, NM_001317097.1 [Q9H7X0-4]
NP_001304027.1, NM_001317098.1 [Q9H7X0-4]
NP_079121.1, NM_024845.3 [Q9H7X0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360862; ENSP00000354108; ENSG00000122390 [Q9H7X0-3]
ENST00000407558; ENSP00000385903; ENSG00000122390 [Q9H7X0-1]
ENST00000414063; ENSP00000393224; ENSG00000122390 [Q9H7X0-1]
ENST00000421765; ENSP00000405873; ENSG00000122390 [Q9H7X0-5]
ENST00000424546; ENSP00000401237; ENSG00000122390 [Q9H7X0-2]
ENST00000570819; ENSP00000460763; ENSG00000122390 [Q9H7X0-4]
ENST00000572169; ENSP00000458928; ENSG00000122390 [Q9H7X0-1]
ENST00000572584; ENSP00000459057; ENSG00000122390 [Q9H7X0-1]
ENST00000572942; ENSP00000461730; ENSG00000122390 [Q9H7X0-4]
ENST00000573580; ENSP00000459055; ENSG00000122390 [Q9H7X0-3]
ENST00000575076; ENSP00000458667; ENSG00000122390 [Q9H7X0-1]
ENST00000577013; ENSP00000458575; ENSG00000122390 [Q9H7X0-3]
ENST00000649205; ENSP00000497988; ENSG00000122390 [Q9H7X0-1]
ENST00000649360; ENSP00000497411; ENSG00000122390 [Q9H7X0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79903

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79903

UCSC genome browser

More...
UCSCi
uc002cvg.3 human [Q9H7X0-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358543 mRNA Translation: AAQ88907.1
AK024216 mRNA Translation: BAB14853.1
AK092005 mRNA Translation: BAG52462.1
AK297219 mRNA Translation: BAG59702.1
AK298566 mRNA Translation: BAG60760.1
AK302361 mRNA Translation: BAG63686.1
CR457324 mRNA Translation: CAG33605.1
AC004224 Genomic DNA No translation available.
AC025283 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85358.1
CH471112 Genomic DNA Translation: EAW85359.1
CH471112 Genomic DNA Translation: EAW85360.1
CH471112 Genomic DNA Translation: EAW85361.1
CH471112 Genomic DNA Translation: EAW85362.1
CH471112 Genomic DNA Translation: EAW85363.1
CH471112 Genomic DNA Translation: EAW85364.1
BC011267 mRNA Translation: AAH11267.1
CCDSiCCDS45396.1 [Q9H7X0-1]
CCDS81937.1 [Q9H7X0-2]
CCDS81938.1 [Q9H7X0-5]
CCDS81939.1 [Q9H7X0-4]
CCDS81941.1 [Q9H7X0-3]
RefSeqiNP_001077069.1, NM_001083600.2 [Q9H7X0-1]
NP_001077070.1, NM_001083601.2 [Q9H7X0-1]
NP_001304022.1, NM_001317093.1 [Q9H7X0-2]
NP_001304023.1, NM_001317094.1
NP_001304024.1, NM_001317095.1 [Q9H7X0-3]
NP_001304025.1, NM_001317096.1 [Q9H7X0-5]
NP_001304026.1, NM_001317097.1 [Q9H7X0-4]
NP_001304027.1, NM_001317098.1 [Q9H7X0-4]
NP_079121.1, NM_024845.3 [Q9H7X0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HGZX-ray1.38A4-242[»]
5HH0X-ray1.60A4-199[»]
5HH1X-ray1.80A4-199[»]
5ICVX-ray1.53A/B5-184[»]
5ICWX-ray1.95A/B/C/D3-184[»]
SMRiQ9H7X0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-62077N
IntActiQ9H7X0, 1 interactor
STRINGi9606.ENSP00000385903

PTM databases

iPTMnetiQ9H7X0
PhosphoSitePlusiQ9H7X0

Polymorphism and mutation databases

BioMutaiNAA60
DMDMi74733721

Proteomic databases

EPDiQ9H7X0
MassIVEiQ9H7X0
MaxQBiQ9H7X0
PaxDbiQ9H7X0
PeptideAtlasiQ9H7X0
PRIDEiQ9H7X0
ProteomicsDBi17514
3609
4572
5517
81152 [Q9H7X0-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79903

Genome annotation databases

EnsembliENST00000360862; ENSP00000354108; ENSG00000122390 [Q9H7X0-3]
ENST00000407558; ENSP00000385903; ENSG00000122390 [Q9H7X0-1]
ENST00000414063; ENSP00000393224; ENSG00000122390 [Q9H7X0-1]
ENST00000421765; ENSP00000405873; ENSG00000122390 [Q9H7X0-5]
ENST00000424546; ENSP00000401237; ENSG00000122390 [Q9H7X0-2]
ENST00000570819; ENSP00000460763; ENSG00000122390 [Q9H7X0-4]
ENST00000572169; ENSP00000458928; ENSG00000122390 [Q9H7X0-1]
ENST00000572584; ENSP00000459057; ENSG00000122390 [Q9H7X0-1]
ENST00000572942; ENSP00000461730; ENSG00000122390 [Q9H7X0-4]
ENST00000573580; ENSP00000459055; ENSG00000122390 [Q9H7X0-3]
ENST00000575076; ENSP00000458667; ENSG00000122390 [Q9H7X0-1]
ENST00000577013; ENSP00000458575; ENSG00000122390 [Q9H7X0-3]
ENST00000649205; ENSP00000497988; ENSG00000122390 [Q9H7X0-1]
ENST00000649360; ENSP00000497411; ENSG00000122390 [Q9H7X0-1]
GeneIDi79903
KEGGihsa:79903
UCSCiuc002cvg.3 human [Q9H7X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79903
EuPathDBiHostDB:ENSG00000122390.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NAA60
HGNCiHGNC:25875 NAA60
HPAiHPA040916
MIMi614246 gene
neXtProtiNX_Q9H7X0
OpenTargetsiENSG00000122390
PharmGKBiPA164723438

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQK0 Eukaryota
ENOG410Y94A LUCA
GeneTreeiENSGT00390000008314
HOGENOMiHOG000280717
InParanoidiQ9H7X0
KOiK21121
OMAiSIPQRLY
OrthoDBi1619974at2759
PhylomeDBiQ9H7X0
TreeFamiTF323980

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000122390-MONOMER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NAA60 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79903
PharosiQ9H7X0 Tbio

Protein Ontology

More...
PROi
PR:Q9H7X0
RNActiQ9H7X0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122390 Expressed in 229 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiQ9H7X0 baseline and differential
GenevisibleiQ9H7X0 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAA60_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7X0
Secondary accession number(s): B3KRQ0
, B4DLZ0, B4DPZ8, B4DYC4, D3DUC2, E7EQ65, Q6IA31, Q6UX26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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