Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H7U1 (CCSE2_HUMAN)

Entry version 135 (10 Feb 2021)
Sequence version 2 (13 Nov 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Serine-rich coiled-coil domain-containing protein 2

Gene

CCSER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding protein which might play a role in microtubule bundling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H7U1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine-rich coiled-coil domain-containing protein 2
Alternative name(s):
Coiled-coil serine-rich protein 2
Protein GCAP14 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCSER2
Synonyms:FAM190B, KIAA1128
ORF Names:NPD012
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29197, CCSER2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H7U1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000107771.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000107771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165548597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H7U1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCSER2

Domain mapping of disease mutations (DMDM)

More...DMDMi		160386966

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003094611 – 834Serine-rich coiled-coil domain-containing protein 2Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei223PhosphoserineCombined sources1
Modified residuei452PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H7U1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H7U1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H7U1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H7U1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H7U1

PeptideAtlas

More...PeptideAtlasi		Q9H7U1

PRoteomics IDEntifications database

More...PRIDEi		Q9H7U1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4088
81148 [Q9H7U1-1]
81149 [Q9H7U1-2]
81150 [Q9H7U1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H7U1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H7U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107771, Expressed in sperm and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H7U1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H7U1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107771, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119968, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q9H7U1, 22 interactors

Molecular INTeraction database

More...MINTi		Q9H7U1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361160

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H7U1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H7U1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili712 – 749Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi604 – 616His-richAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCSER family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV4S, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153912

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_499291_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H7U1

Identification of Orthologs from Complete Genome Data

More...OMAi		NCHQNSK

Database of Orthologous Groups

More...OrthoDBi		1263802at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H7U1

TreeFam database of animal gene trees

More...TreeFami		TF331021

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029627, CCSER
IPR029629, CCSER2

The PANTHER Classification System

More...PANTHERi		PTHR22461, PTHR22461, 1 hit
PTHR22461:SF2, PTHR22461:SF2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKTQIKTF LGSKLPKYGT KSVRSTLQPM PNGTPVNLLG TSKNSNVKSY 
        60         70         80         90        100
IKNNGSDCPS SHSFNWRKAN KYQLCAQGVE EPNNTQNSHD KIIDPEKRVP 
       110        120        130        140        150
TQGMFDKNGI KGGLKSVSLF TSKLAKPSTM FVSSTEELNQ KSFSGPSNLG 
       160        170        180        190        200
KFTKGTLLGR TSYSSINTPK SQLNGFYGNR SAGSMQRPRA NSCATRSSSG 
       210        220        230        240        250
ESLAQSPDSS KSINCEKMVR SQSFSHSIQN SFLPPSSITR SHSFNRAVDL 
       260        270        280        290        300
TKPYQNQQLS IRVPLRSSML TRNSRQPEVL NGNEHLGYGF NRPYAAGGKK 
       310        320        330        340        350
LALPNGPGVT STLGYRMVHP SLLKSSRSPF SGTMTVDGNK NSPADTCVEE 
       360        370        380        390        400
DATVLAKDRA ANKDQELIEN ESYRTKNNQT MKHDAKMRYL SDDVDDISLS 
       410        420        430        440        450
SLSSSDKNDL SEDFSDDFID IEDSNRTRIT PEEMSLKEEK HENGPPQDMF 
       460        470        480        490        500
DSPKENEKAF SKTDEWIDIS VSDRSECTKH TSGNNLVSPD TDYRAGSSFE 
       510        520        530        540        550
LSPSDSSDGT YMWDEEGLEP IGNVHPVGSY ESSEMNSIDI LNNLESCDLE 
       560        570        580        590        600
DDDLMLDVDL PEDAPLENVE CDNMNRFDRP DRNVRQPQEG FWKRPPQRWS 
       610        620        630        640        650
GQEHYHLSHP DHYHHHGKSD LSRGSPYRES PLGHFESYGG MPFFQAQKMF 
       660        670        680        690        700
VDVPENTVIL DEMTLRHMVQ DCTAVKTQLL KLKRLLHQHD GSGSLHDIQL 
       710        720        730        740        750
SLPSSPEPED GDKVYKNEDL LNEIKQLKDE IKKKDEKIQL LELQLATQHI 
       760        770        780        790        800
CHQKCKEEKC TYADKYTQTP WRRIPGGYSA PSFSPWQGSF QGIPRTVPPH 
       810        820        830 
RRQTSSTTAF QQPSQTHRSH PGKTNKATTY RGPQ
Length:834
Mass (Da):93,548
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i036713F1975242A3
GO
Isoform 2 (identifier: Q9H7U1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-567: DILNNLESCDLEDDDLMLDVDLPEDAPLE → VCMDLYTLGIFCLPYYRETCDMIDFVKNL
     568-834: Missing.

Show »
Length:567
Mass (Da):62,760
Checksum:i5326DD577A85F838
GO
Isoform 3 (identifier: Q9H7U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-834: GGYSAPSFSP...NKATTYRGPQ → PQVLQPSSSL...YSRLPKPKIH

Show »
Length:1,047
Mass (Da):116,913
Checksum:iE7C0A74671809440
GO
Isoform 4 (identifier: Q9H7U1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-573: Missing.

Show »
Length:261
Mass (Da):30,337
Checksum:i2AFAD6F347B4F273
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7M2A0A2R8Y7M2_HUMAN
Serine-rich coiled-coil domain-cont...
CCSER2
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGU6A0A2R8YGU6_HUMAN
Serine-rich coiled-coil domain-cont...
CCSER2
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6V5A0A2R8Y6V5_HUMAN
Serine-rich coiled-coil domain-cont...
CCSER2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGE2A0A2R8YGE2_HUMAN
Serine-rich coiled-coil domain-cont...
CCSER2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44473 differs from that shown. Reason: Frameshift.Curated
The sequence AAH30528 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155G → C in AAG44473 (Ref. 5) Curated1
Sequence conflicti215C → Y in BAB14884 (PubMed:15489334).Curated1
Sequence conflicti457E → G in BAB14884 (PubMed:15489334).Curated1
Sequence conflicti524V → A in BAG61061 (PubMed:14702039).Curated1
Sequence conflicti540I → V in BAG61061 (PubMed:14702039).Curated1
Sequence conflicti667H → R in BAG61061 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9H7U1-3)
Sequence conflicti782S → F in BAG61061 (PubMed:14702039).Curated1
Sequence conflicti881M → I in BAG61061 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03695284N → S. Corresponds to variant dbSNP:rs3814205Ensembl.1
Natural variantiVAR_036953755C → Y. Corresponds to variant dbSNP:rs11201058Ensembl.1
Natural variantiVAR_036954819S → P. Corresponds to variant dbSNP:rs11557865Ensembl.1
Natural variantiVAR_036955821P → S. Corresponds to variant dbSNP:rs12569751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545601 – 573Missing in isoform 4. 1 PublicationAdd BLAST573
Alternative sequenceiVSP_029180539 – 567DILNN…DAPLE → VCMDLYTLGIFCLPYYRETC DMIDFVKNL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_029181568 – 834Missing in isoform 2. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_040287776 – 834GGYSA…YRGPQ → PQVLQPSSSLPRPTDHTQGK LIKPQRIEARSECSIQDMHQ GGAHPEESFTHVLHQESNYG LEEQPFSSGPQLTMDVAKST PSEANLNITVNAQEPYHLAN NQISDMQFIPTSLQTPPESS TVDQAKRVGRNQSPPVGYMS QPKSLQLLKPSILSSLVPPP VSESSPSRTPTCKKSPIITT CNSAKLQPTSSQTNLANNQN LKASKLRPPSGSFKQKQTNS PQLEPQSFQAKTSIPRPLTQ RKEIMQNPNGNLHSGDCLAS NRYSRLPKPKIH in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK024324 mRNA Translation: BAB14884.1
AK294321 mRNA Translation: BAG57595.1
AK298966 mRNA Translation: BAG61061.1
DC366088 mRNA No translation available.
AC074321 Genomic DNA No translation available.
AL356115 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80350.1
CH471142 Genomic DNA Translation: EAW80352.1
BC030528 mRNA Translation: AAH30528.1 Different initiation.
AF241785 mRNA Translation: AAG44473.1 Frameshift.
AB032954 mRNA Translation: BAA86442.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31235.1 [Q9H7U1-1]
CCDS60582.1 [Q9H7U1-3]
CCDS60583.1 [Q9H7U1-4]
CCDS73159.1 [Q9H7U1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001271169.1, NM_001284240.1 [Q9H7U1-3]
NP_001271170.1, NM_001284241.1 [Q9H7U1-2]
NP_001271171.1, NM_001284242.1
NP_001271172.1, NM_001284243.1 [Q9H7U1-4]
NP_061872.2, NM_018999.3 [Q9H7U1-1]
XP_016871829.1, XM_017016340.1 [Q9H7U1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000224756; ENSP00000224756; ENSG00000107771 [Q9H7U1-1]
ENST00000359979; ENSP00000353068; ENSG00000107771 [Q9H7U1-2]
ENST00000372088; ENSP00000361160; ENSG00000107771 [Q9H7U1-3]
ENST00000543283; ENSP00000439944; ENSG00000107771 [Q9H7U1-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54462

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54462

UCSC genome browser

More...UCSCi		uc001kdg.3, human [Q9H7U1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024324 mRNA Translation: BAB14884.1
AK294321 mRNA Translation: BAG57595.1
AK298966 mRNA Translation: BAG61061.1
DC366088 mRNA No translation available.
AC074321 Genomic DNA No translation available.
AL356115 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80350.1
CH471142 Genomic DNA Translation: EAW80352.1
BC030528 mRNA Translation: AAH30528.1 Different initiation.
AF241785 mRNA Translation: AAG44473.1 Frameshift.
AB032954 mRNA Translation: BAA86442.1
CCDSiCCDS31235.1 [Q9H7U1-1]
CCDS60582.1 [Q9H7U1-3]
CCDS60583.1 [Q9H7U1-4]
CCDS73159.1 [Q9H7U1-2]
RefSeqiNP_001271169.1, NM_001284240.1 [Q9H7U1-3]
NP_001271170.1, NM_001284241.1 [Q9H7U1-2]
NP_001271171.1, NM_001284242.1
NP_001271172.1, NM_001284243.1 [Q9H7U1-4]
NP_061872.2, NM_018999.3 [Q9H7U1-1]
XP_016871829.1, XM_017016340.1 [Q9H7U1-3]

3D structure databases

SMRiQ9H7U1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119968, 27 interactors
IntActiQ9H7U1, 22 interactors
MINTiQ9H7U1
STRINGi9606.ENSP00000361160

PTM databases

iPTMnetiQ9H7U1
PhosphoSitePlusiQ9H7U1

Genetic variation databases

BioMutaiCCSER2
DMDMi160386966

Proteomic databases

EPDiQ9H7U1
jPOSTiQ9H7U1
MassIVEiQ9H7U1
MaxQBiQ9H7U1
PaxDbiQ9H7U1
PeptideAtlasiQ9H7U1
PRIDEiQ9H7U1
ProteomicsDBi4088
81148 [Q9H7U1-1]
81149 [Q9H7U1-2]
81150 [Q9H7U1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48922, 35 antibodies

The DNASU plasmid repository

More...DNASUi		54462

Genome annotation databases

EnsembliENST00000224756; ENSP00000224756; ENSG00000107771 [Q9H7U1-1]
ENST00000359979; ENSP00000353068; ENSG00000107771 [Q9H7U1-2]
ENST00000372088; ENSP00000361160; ENSG00000107771 [Q9H7U1-3]
ENST00000543283; ENSP00000439944; ENSG00000107771 [Q9H7U1-4]
GeneIDi54462
KEGGihsa:54462
UCSCiuc001kdg.3, human [Q9H7U1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54462

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCSER2
HGNCiHGNC:29197, CCSER2
HPAiENSG00000107771, Low tissue specificity
neXtProtiNX_Q9H7U1
OpenTargetsiENSG00000107771
PharmGKBiPA165548597
VEuPathDBiHostDB:ENSG00000107771.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV4S, Eukaryota
GeneTreeiENSGT00940000153912
HOGENOMiCLU_499291_0_0_1
InParanoidiQ9H7U1
OMAiNCHQNSK
OrthoDBi1263802at2759
PhylomeDBiQ9H7U1
TreeFamiTF331021

Enzyme and pathway databases

PathwayCommonsiQ9H7U1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54462, 6 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCSER2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54462
PharosiQ9H7U1, Tdark

Protein Ontology

More...PROi		PR:Q9H7U1
RNActiQ9H7U1, protein

Gene expression databases

BgeeiENSG00000107771, Expressed in sperm and 246 other tissues
ExpressionAtlasiQ9H7U1, baseline and differential
GenevisibleiQ9H7U1, HS

Family and domain databases

InterProiView protein in InterPro
IPR029627, CCSER
IPR029629, CCSER2
PANTHERiPTHR22461, PTHR22461, 1 hit
PTHR22461:SF2, PTHR22461:SF2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCSE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7U1
Secondary accession number(s): B4DFY4
, B4DQU9, B7WPE8, D3DWE2, Q8N6E9, Q9H2S0, Q9ULU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 10, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again