UniProtKB - Q9H7U1 (CCSE2_HUMAN)
Protein
Serine-rich coiled-coil domain-containing protein 2
Gene
CCSER2
Organism
Homo sapiens (Human)
Status
Functioni
Microtubule-binding protein which might play a role in microtubule bundling.By similarity
GO - Molecular functioni
- microtubule binding Source: Ensembl
GO - Biological processi
- microtubule bundle formation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9H7U1 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine-rich coiled-coil domain-containing protein 2Alternative name(s): Coiled-coil serine-rich protein 2 Protein GCAP14 homolog |
Gene namesi | Name:CCSER2 Synonyms:FAM190B, KIAA1128 ORF Names:NPD012 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29197, CCSER2 |
neXtProti | NX_Q9H7U1 |
VEuPathDBi | HostDB:ENSG00000107771.15 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Note: Associates with microtubules in interphase. Has diffuse expression throughout the cell during mitosis.By similarity
Cytoskeleton
- microtubule cytoskeleton Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000107771 |
PharmGKBi | PA165548597 |
Miscellaneous databases
Pharosi | Q9H7U1, Tdark |
Genetic variation databases
BioMutai | CCSER2 |
DMDMi | 160386966 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309461 | 1 – 834 | Serine-rich coiled-coil domain-containing protein 2Add BLAST | 834 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 223 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H7U1 |
jPOSTi | Q9H7U1 |
MassIVEi | Q9H7U1 |
MaxQBi | Q9H7U1 |
PaxDbi | Q9H7U1 |
PeptideAtlasi | Q9H7U1 |
PRIDEi | Q9H7U1 |
ProteomicsDBi | 4088 81148 [Q9H7U1-1] 81149 [Q9H7U1-2] 81150 [Q9H7U1-3] |
PTM databases
iPTMneti | Q9H7U1 |
PhosphoSitePlusi | Q9H7U1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000107771, Expressed in sperm and 246 other tissues |
ExpressionAtlasi | Q9H7U1, baseline and differential |
Genevisiblei | Q9H7U1, HS |
Organism-specific databases
HPAi | ENSG00000107771, Low tissue specificity |
Interactioni
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 119968, 27 interactors |
IntActi | Q9H7U1, 22 interactors |
MINTi | Q9H7U1 |
STRINGi | 9606.ENSP00000361160 |
Miscellaneous databases
RNActi | Q9H7U1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 712 – 749 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 604 – 616 | His-richAdd BLAST | 13 |
Sequence similaritiesi
Belongs to the CCSER family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QV4S, Eukaryota |
GeneTreei | ENSGT00940000153912 |
HOGENOMi | CLU_499291_0_0_1 |
InParanoidi | Q9H7U1 |
OMAi | NCHQNSK |
OrthoDBi | 1263802at2759 |
PhylomeDBi | Q9H7U1 |
TreeFami | TF331021 |
Family and domain databases
InterProi | View protein in InterPro IPR029627, CCSER IPR029629, CCSER2 |
PANTHERi | PTHR22461, PTHR22461, 1 hit PTHR22461:SF2, PTHR22461:SF2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H7U1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEKTQIKTF LGSKLPKYGT KSVRSTLQPM PNGTPVNLLG TSKNSNVKSY
60 70 80 90 100
IKNNGSDCPS SHSFNWRKAN KYQLCAQGVE EPNNTQNSHD KIIDPEKRVP
110 120 130 140 150
TQGMFDKNGI KGGLKSVSLF TSKLAKPSTM FVSSTEELNQ KSFSGPSNLG
160 170 180 190 200
KFTKGTLLGR TSYSSINTPK SQLNGFYGNR SAGSMQRPRA NSCATRSSSG
210 220 230 240 250
ESLAQSPDSS KSINCEKMVR SQSFSHSIQN SFLPPSSITR SHSFNRAVDL
260 270 280 290 300
TKPYQNQQLS IRVPLRSSML TRNSRQPEVL NGNEHLGYGF NRPYAAGGKK
310 320 330 340 350
LALPNGPGVT STLGYRMVHP SLLKSSRSPF SGTMTVDGNK NSPADTCVEE
360 370 380 390 400
DATVLAKDRA ANKDQELIEN ESYRTKNNQT MKHDAKMRYL SDDVDDISLS
410 420 430 440 450
SLSSSDKNDL SEDFSDDFID IEDSNRTRIT PEEMSLKEEK HENGPPQDMF
460 470 480 490 500
DSPKENEKAF SKTDEWIDIS VSDRSECTKH TSGNNLVSPD TDYRAGSSFE
510 520 530 540 550
LSPSDSSDGT YMWDEEGLEP IGNVHPVGSY ESSEMNSIDI LNNLESCDLE
560 570 580 590 600
DDDLMLDVDL PEDAPLENVE CDNMNRFDRP DRNVRQPQEG FWKRPPQRWS
610 620 630 640 650
GQEHYHLSHP DHYHHHGKSD LSRGSPYRES PLGHFESYGG MPFFQAQKMF
660 670 680 690 700
VDVPENTVIL DEMTLRHMVQ DCTAVKTQLL KLKRLLHQHD GSGSLHDIQL
710 720 730 740 750
SLPSSPEPED GDKVYKNEDL LNEIKQLKDE IKKKDEKIQL LELQLATQHI
760 770 780 790 800
CHQKCKEEKC TYADKYTQTP WRRIPGGYSA PSFSPWQGSF QGIPRTVPPH
810 820 830
RRQTSSTTAF QQPSQTHRSH PGKTNKATTY RGPQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y7M2 | A0A2R8Y7M2_HUMAN | Serine-rich coiled-coil domain-cont... | CCSER2 | 251 | Annotation score: | ||
A0A2R8YGU6 | A0A2R8YGU6_HUMAN | Serine-rich coiled-coil domain-cont... | CCSER2 | 273 | Annotation score: | ||
A0A2R8Y6V5 | A0A2R8Y6V5_HUMAN | Serine-rich coiled-coil domain-cont... | CCSER2 | 119 | Annotation score: | ||
A0A2R8YGE2 | A0A2R8YGE2_HUMAN | Serine-rich coiled-coil domain-cont... | CCSER2 | 87 | Annotation score: |
Sequence cautioni
The sequence AAG44473 differs from that shown. Reason: Frameshift.Curated
The sequence AAH30528 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 155 | G → C in AAG44473 (Ref. 5) Curated | 1 | ||
Sequence conflicti | 215 | C → Y in BAB14884 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 457 | E → G in BAB14884 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 524 | V → A in BAG61061 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 540 | I → V in BAG61061 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 667 | H → R in BAG61061 (PubMed:14702039).Curated | 1 | ||
Isoform 3 (identifier: Q9H7U1-3) | |||||
Sequence conflicti | 782 | S → F in BAG61061 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 881 | M → I in BAG61061 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036952 | 84 | N → S. Corresponds to variant dbSNP:rs3814205Ensembl. | 1 | |
Natural variantiVAR_036953 | 755 | C → Y. Corresponds to variant dbSNP:rs11201058Ensembl. | 1 | |
Natural variantiVAR_036954 | 819 | S → P. Corresponds to variant dbSNP:rs11557865Ensembl. | 1 | |
Natural variantiVAR_036955 | 821 | P → S. Corresponds to variant dbSNP:rs12569751Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054560 | 1 – 573 | Missing in isoform 4. 1 PublicationAdd BLAST | 573 | |
Alternative sequenceiVSP_029180 | 539 – 567 | DILNN…DAPLE → VCMDLYTLGIFCLPYYRETC DMIDFVKNL in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_029181 | 568 – 834 | Missing in isoform 2. 1 PublicationAdd BLAST | 267 | |
Alternative sequenceiVSP_040287 | 776 – 834 | GGYSA…YRGPQ → PQVLQPSSSLPRPTDHTQGK LIKPQRIEARSECSIQDMHQ GGAHPEESFTHVLHQESNYG LEEQPFSSGPQLTMDVAKST PSEANLNITVNAQEPYHLAN NQISDMQFIPTSLQTPPESS TVDQAKRVGRNQSPPVGYMS QPKSLQLLKPSILSSLVPPP VSESSPSRTPTCKKSPIITT CNSAKLQPTSSQTNLANNQN LKASKLRPPSGSFKQKQTNS PQLEPQSFQAKTSIPRPLTQ RKEIMQNPNGNLHSGDCLAS NRYSRLPKPKIH in isoform 3. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024324 mRNA Translation: BAB14884.1 AK294321 mRNA Translation: BAG57595.1 AK298966 mRNA Translation: BAG61061.1 DC366088 mRNA No translation available. AC074321 Genomic DNA No translation available. AL356115 Genomic DNA No translation available. CH471142 Genomic DNA Translation: EAW80350.1 CH471142 Genomic DNA Translation: EAW80352.1 BC030528 mRNA Translation: AAH30528.1 Different initiation. AF241785 mRNA Translation: AAG44473.1 Frameshift. AB032954 mRNA Translation: BAA86442.1 |
CCDSi | CCDS31235.1 [Q9H7U1-1] CCDS60582.1 [Q9H7U1-3] CCDS60583.1 [Q9H7U1-4] CCDS73159.1 [Q9H7U1-2] |
RefSeqi | NP_001271169.1, NM_001284240.1 [Q9H7U1-3] NP_001271170.1, NM_001284241.1 [Q9H7U1-2] NP_001271171.1, NM_001284242.1 NP_001271172.1, NM_001284243.1 [Q9H7U1-4] NP_061872.2, NM_018999.3 [Q9H7U1-1] XP_016871829.1, XM_017016340.1 [Q9H7U1-3] |
Genome annotation databases
Ensembli | ENST00000224756; ENSP00000224756; ENSG00000107771 [Q9H7U1-1] ENST00000359979; ENSP00000353068; ENSG00000107771 [Q9H7U1-2] ENST00000372088; ENSP00000361160; ENSG00000107771 [Q9H7U1-3] ENST00000543283; ENSP00000439944; ENSG00000107771 [Q9H7U1-4] |
GeneIDi | 54462 |
KEGGi | hsa:54462 |
UCSCi | uc001kdg.3, human [Q9H7U1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024324 mRNA Translation: BAB14884.1 AK294321 mRNA Translation: BAG57595.1 AK298966 mRNA Translation: BAG61061.1 DC366088 mRNA No translation available. AC074321 Genomic DNA No translation available. AL356115 Genomic DNA No translation available. CH471142 Genomic DNA Translation: EAW80350.1 CH471142 Genomic DNA Translation: EAW80352.1 BC030528 mRNA Translation: AAH30528.1 Different initiation. AF241785 mRNA Translation: AAG44473.1 Frameshift. AB032954 mRNA Translation: BAA86442.1 |
CCDSi | CCDS31235.1 [Q9H7U1-1] CCDS60582.1 [Q9H7U1-3] CCDS60583.1 [Q9H7U1-4] CCDS73159.1 [Q9H7U1-2] |
RefSeqi | NP_001271169.1, NM_001284240.1 [Q9H7U1-3] NP_001271170.1, NM_001284241.1 [Q9H7U1-2] NP_001271171.1, NM_001284242.1 NP_001271172.1, NM_001284243.1 [Q9H7U1-4] NP_061872.2, NM_018999.3 [Q9H7U1-1] XP_016871829.1, XM_017016340.1 [Q9H7U1-3] |
3D structure databases
SMRi | Q9H7U1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119968, 27 interactors |
IntActi | Q9H7U1, 22 interactors |
MINTi | Q9H7U1 |
STRINGi | 9606.ENSP00000361160 |
PTM databases
iPTMneti | Q9H7U1 |
PhosphoSitePlusi | Q9H7U1 |
Genetic variation databases
BioMutai | CCSER2 |
DMDMi | 160386966 |
Proteomic databases
EPDi | Q9H7U1 |
jPOSTi | Q9H7U1 |
MassIVEi | Q9H7U1 |
MaxQBi | Q9H7U1 |
PaxDbi | Q9H7U1 |
PeptideAtlasi | Q9H7U1 |
PRIDEi | Q9H7U1 |
ProteomicsDBi | 4088 81148 [Q9H7U1-1] 81149 [Q9H7U1-2] 81150 [Q9H7U1-3] |
Protocols and materials databases
Antibodypediai | 48922, 35 antibodies |
DNASUi | 54462 |
Genome annotation databases
Ensembli | ENST00000224756; ENSP00000224756; ENSG00000107771 [Q9H7U1-1] ENST00000359979; ENSP00000353068; ENSG00000107771 [Q9H7U1-2] ENST00000372088; ENSP00000361160; ENSG00000107771 [Q9H7U1-3] ENST00000543283; ENSP00000439944; ENSG00000107771 [Q9H7U1-4] |
GeneIDi | 54462 |
KEGGi | hsa:54462 |
UCSCi | uc001kdg.3, human [Q9H7U1-1] |
Organism-specific databases
CTDi | 54462 |
GeneCardsi | CCSER2 |
HGNCi | HGNC:29197, CCSER2 |
HPAi | ENSG00000107771, Low tissue specificity |
neXtProti | NX_Q9H7U1 |
OpenTargetsi | ENSG00000107771 |
PharmGKBi | PA165548597 |
VEuPathDBi | HostDB:ENSG00000107771.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV4S, Eukaryota |
GeneTreei | ENSGT00940000153912 |
HOGENOMi | CLU_499291_0_0_1 |
InParanoidi | Q9H7U1 |
OMAi | NCHQNSK |
OrthoDBi | 1263802at2759 |
PhylomeDBi | Q9H7U1 |
TreeFami | TF331021 |
Enzyme and pathway databases
PathwayCommonsi | Q9H7U1 |
Miscellaneous databases
BioGRID-ORCSi | 54462, 6 hits in 875 CRISPR screens |
ChiTaRSi | CCSER2, human |
GenomeRNAii | 54462 |
Pharosi | Q9H7U1, Tdark |
PROi | PR:Q9H7U1 |
RNActi | Q9H7U1, protein |
Gene expression databases
Bgeei | ENSG00000107771, Expressed in sperm and 246 other tissues |
ExpressionAtlasi | Q9H7U1, baseline and differential |
Genevisiblei | Q9H7U1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029627, CCSER IPR029629, CCSER2 |
PANTHERi | PTHR22461, PTHR22461, 1 hit PTHR22461:SF2, PTHR22461:SF2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCSE2_HUMAN | |
Accessioni | Q9H7U1Primary (citable) accession number: Q9H7U1 Secondary accession number(s): B4DFY4 Q9ULU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families