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Protein

Aurora kinase A and ninein-interacting protein

Gene

AUNIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670).2 Publications

GO - Molecular functioni

  • damaged DNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase A and ninein-interacting protein1 Publication
Short name:
AIBp1 Publication
Gene namesi
Name:AUNIP1 PublicationImported
Synonyms:C1orf135Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000127423.10
HGNCiHGNC:28363 AUNIP
neXtProtiNX_Q9H7T9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127423
PharmGKBiPA142672453

Polymorphism and mutation databases

DMDMi74733700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845721 – 357Aurora kinase A and ninein-interacting proteinAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H7T9
PaxDbiQ9H7T9
PeptideAtlasiQ9H7T9
PRIDEiQ9H7T9
ProteomicsDBi81147

PTM databases

iPTMnetiQ9H7T9
PhosphoSitePlusiQ9H7T9

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscles, placenta and testis.

Inductioni

Overexpressed in brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000127423 Expressed in 110 organ(s), highest expression level in oocyte
CleanExiHS_C1orf135
GenevisibleiQ9H7T9 HS

Organism-specific databases

HPAiHPA028730

Interactioni

Subunit structurei

Interacts (via C-terminus) with AURKA (via C-terminus) (PubMed:20596670). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B (PubMed:20596670). Identified in a complex with NIN and AURKA (PubMed:20596670). Interacts with RBBP8/CtIP (PubMed:29042561).2 Publications

Protein-protein interaction databases

BioGridi122471, 8 interactors
IntActiQ9H7T9, 4 interactors
STRINGi9606.ENSP00000363416

Structurei

3D structure databases

ProteinModelPortaliQ9H7T9
SMRiQ9H7T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 357Interaction with AURKA1 PublicationAdd BLAST171
Regioni281 – 357Interaction with RBBP8/CtIP1 PublicationAdd BLAST77

Sequence similaritiesi

Belongs to the AUNIP family.Curated

Phylogenomic databases

eggNOGiENOG410IJFA Eukaryota
ENOG41113GP LUCA
GeneTreeiENSGT00390000003280
HOGENOMiHOG000261642
HOVERGENiHBG101165
InParanoidiQ9H7T9
KOiK16800
OMAiEEACGVW
OrthoDBiEOG091G08VG
PhylomeDBiQ9H7T9
TreeFamiTF337334

Family and domain databases

InterProiView protein in InterPro
IPR029286 AUNIP
PANTHERiPTHR14526 PTHR14526, 1 hit
PfamiView protein in Pfam
PF15334 AIB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H7T9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRTGPEEEA CGVWLDAAAL KRRKVQTHLI KPGTKMLTLL PGERKANIYF
60 70 80 90 100
TQRRAPSTGI HQRSIASFFT LQPGKTNGSD QKSVSSHTES QINKESKKNA
110 120 130 140 150
TQLDHLIPGL AHDCMASPLA TSTTADIQEA GLSPQSLQTS GHHRMKTPFS
160 170 180 190 200
TELSLLQPDT PDCAGDSHTP LAFSFTEDLE SSCLLDRKEE KGDSARKWEW
210 220 230 240 250
LHESKKNYQS MEKHTKLPGD KCCQPLGKTK LERKVSAKEN RQAPVLLQTY
260 270 280 290 300
RESWNGENIE SVKQSRSPVS VFSWDNEKND KDSWSQLFTE DSQGQRVIAH
310 320 330 340 350
NTRAPFQDVT NNWNWDLGPF PNSPWAQCQE DGPTQNLKPD LLFTQDSEGN

QVIRHQF
Length:357
Mass (Da):40,253
Last modified:March 1, 2001 - v1
Checksum:i8080DCF2E3CAB569
GO
Isoform 2 (identifier: Q9H7T9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-357: GNQVIRHQF → VQALACQQDCCRRSILKRQKHLR

Show »
Length:371
Mass (Da):41,909
Checksum:iF9A649D1518BABD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177682K → T1 PublicationCorresponds to variant dbSNP:rs34449716Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044288349 – 357GNQVIRHQF → VQALACQQDCCRRSILKRQK HLR in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ844687 mRNA Translation: ACV90488.1
AK024326 mRNA Translation: BAB14886.1
AK223419 mRNA Translation: BAD97139.1
AL020996 Genomic DNA No translation available.
AL033528 Genomic DNA No translation available.
BC000209 mRNA Translation: AAH00209.1
CCDSiCCDS266.1 [Q9H7T9-1]
CCDS72731.1 [Q9H7T9-2]
RefSeqiNP_001274419.1, NM_001287490.1 [Q9H7T9-2]
NP_076942.1, NM_024037.2 [Q9H7T9-1]
UniGeneiHs.149305
Hs.725400

Genome annotation databases

EnsembliENST00000374298; ENSP00000363416; ENSG00000127423 [Q9H7T9-1]
ENST00000538789; ENSP00000443647; ENSG00000127423 [Q9H7T9-2]
GeneIDi79000
KEGGihsa:79000
UCSCiuc001bkw.3 human [Q9H7T9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ844687 mRNA Translation: ACV90488.1
AK024326 mRNA Translation: BAB14886.1
AK223419 mRNA Translation: BAD97139.1
AL020996 Genomic DNA No translation available.
AL033528 Genomic DNA No translation available.
BC000209 mRNA Translation: AAH00209.1
CCDSiCCDS266.1 [Q9H7T9-1]
CCDS72731.1 [Q9H7T9-2]
RefSeqiNP_001274419.1, NM_001287490.1 [Q9H7T9-2]
NP_076942.1, NM_024037.2 [Q9H7T9-1]
UniGeneiHs.149305
Hs.725400

3D structure databases

ProteinModelPortaliQ9H7T9
SMRiQ9H7T9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122471, 8 interactors
IntActiQ9H7T9, 4 interactors
STRINGi9606.ENSP00000363416

PTM databases

iPTMnetiQ9H7T9
PhosphoSitePlusiQ9H7T9

Polymorphism and mutation databases

DMDMi74733700

Proteomic databases

MaxQBiQ9H7T9
PaxDbiQ9H7T9
PeptideAtlasiQ9H7T9
PRIDEiQ9H7T9
ProteomicsDBi81147

Protocols and materials databases

DNASUi79000
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374298; ENSP00000363416; ENSG00000127423 [Q9H7T9-1]
ENST00000538789; ENSP00000443647; ENSG00000127423 [Q9H7T9-2]
GeneIDi79000
KEGGihsa:79000
UCSCiuc001bkw.3 human [Q9H7T9-1]

Organism-specific databases

CTDi79000
EuPathDBiHostDB:ENSG00000127423.10
GeneCardsiAUNIP
HGNCiHGNC:28363 AUNIP
HPAiHPA028730
neXtProtiNX_Q9H7T9
OpenTargetsiENSG00000127423
PharmGKBiPA142672453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJFA Eukaryota
ENOG41113GP LUCA
GeneTreeiENSGT00390000003280
HOGENOMiHOG000261642
HOVERGENiHBG101165
InParanoidiQ9H7T9
KOiK16800
OMAiEEACGVW
OrthoDBiEOG091G08VG
PhylomeDBiQ9H7T9
TreeFamiTF337334

Miscellaneous databases

ChiTaRSiAUNIP human
GenomeRNAii79000
PROiPR:Q9H7T9

Gene expression databases

BgeeiENSG00000127423 Expressed in 110 organ(s), highest expression level in oocyte
CleanExiHS_C1orf135
GenevisibleiQ9H7T9 HS

Family and domain databases

InterProiView protein in InterPro
IPR029286 AUNIP
PANTHERiPTHR14526 PTHR14526, 1 hit
PfamiView protein in Pfam
PF15334 AIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAUNIP_HUMAN
AccessioniPrimary (citable) accession number: Q9H7T9
Secondary accession number(s): C9EI59, Q53F70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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