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Protein

Splicing factor, arginine/serine-rich 19

Gene

SCAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in pre-mRNA splicing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein domain specific binding Source: Ensembl
  • RNA binding Source: UniProtKB-KW
  • RNA polymerase II C-terminal domain binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 19
Alternative name(s):
SR-related C-terminal domain-associated factor 1
Short name:
SR-related and CTD-associated factor 1
SR-related-CTD-associated factor
Short name:
SCAF
Serine arginine-rich pre-mRNA splicing factor SR-A1
Short name:
SR-A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCAF1
Synonyms:SFRS19, SRA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126461.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30403 SCAF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617264 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7N4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58506

Open Targets

More...
OpenTargetsi
ENSG00000126461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402459

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCAF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994061 – 1312Splicing factor, arginine/serine-rich 19Add BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei239PhosphoserineCombined sources1
Modified residuei335PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei706PhosphothreonineCombined sources1
Modified residuei719PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei732PhosphotyrosineCombined sources1
Modified residuei734PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki865Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei872PhosphoserineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei963PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei976PhosphothreonineCombined sources1
Modified residuei989PhosphothreonineCombined sources1
Modified residuei992PhosphoserineBy similarity1
Modified residuei1001PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H7N4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7N4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7N4

PeptideAtlas

More...
PeptideAtlasi
Q9H7N4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7N4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81132

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7N4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7N4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H7N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa.4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by estrogens, androgens and glucocorticoids.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126461 Expressed in 141 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...
CleanExi
HS_SCAF1
HS_SRA1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H7N4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H7N4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046828
HPA054593

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121834, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H7N4, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H7N4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H7N4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1187 – 1312Necessary for interaction with the CTD domain of POLR2AAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi184 – 267Pro-richAdd BLAST84
Compositional biasi191 – 207Ser-richAdd BLAST17
Compositional biasi268 – 288Glu-richAdd BLAST21
Compositional biasi380 – 441Pro-richAdd BLAST62
Compositional biasi534 – 828Ser-richAdd BLAST295
Compositional biasi556 – 654Arg-richAdd BLAST99
Compositional biasi896 – 926Lys-richAdd BLAST31
Compositional biasi1009 – 1039Glu-richAdd BLAST31
Compositional biasi1284 – 1311Pro-richAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0825 Eukaryota
ENOG410YF5K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168227

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097942

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H7N4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDERAPT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05JH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7N4

TreeFam database of animal gene trees

More...
TreeFami
TF332183

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H7N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEEDESRGK TEESGEDRGD GPPDRDPTLS PSAFILRAIQ QAVGSSLQGD
60 70 80 90 100
LPNDKDGSRC HGLRWRRCRS PRSEPRSQES GGTDTATVLD MATDSFLAGL
110 120 130 140 150
VSVLDPPDTW VPSRLDLRPG ESEDMLELVA EVRIGDRDPI PLPVPSLLPR
160 170 180 190 200
LRAWRTGKTV SPQSNSSRPT CARHLTLGTG DGGPAPPPAP SSASSSPSPS
210 220 230 240 250
PSSSSPSPPP PPPPPAPPAP PAPRFDIYDP FHPTDEAYSP PPAPEQKYDP
260 270 280 290 300
FEPTGSNPSS SAGTPSPEEE EEEEEEEEEE EEDEEEEEGL SQSISRISET
310 320 330 340 350
LAGIYDDNSL SQDFPGDESP RPDAQPTQPT PAPGTPPQVD STRADGAMRR
360 370 380 390 400
RVFVVGTEAE ACREGKVSVE VVTAGGAALP PPLLPPGDSE IEEGEIVQPE
410 420 430 440 450
EEPRLALSLF RPGGRAARPT PAASATPTAQ PLPQPPAPRA PEGDDFLSLH
460 470 480 490 500
AESDGEGALQ VDLGEPAPAP PAADSRWGGL DLRRKILTQR RERYRQRSPS
510 520 530 540 550
PAPAPAPAAA AGPPTRKKSR RERKRSGEAK EAASSSSGTQ PAPPAPASPW
560 570 580 590 600
DSKKHRSRDR KPGSHASSSA RRRSRSRSRS RSTRRRSRST DRRRGGSRRS
610 620 630 640 650
RSREKRRRRR RSASPPPATS SSSSSRRERH RGKHRDGGGS KKKKKRSRSR
660 670 680 690 700
GEKRSGDGSE KAPAPAPPPS GSTSCGDRDS RRRGAVPPSI QDLTDHDLFA
710 720 730 740 750
IKRTITVGRL DKSDPRGPSP APASSPKREV LYDSEGLSGE ERGGKSSQKD
760 770 780 790 800
RRRSGAASSS SSSREKGSRR KALDGGDRDR DRDRDRDRDR SSKKARPPKE
810 820 830 840 850
SAPSSGPPPK PPVSSGSGSS SSSSSCSSRK VKLQSKVAVL IREGVSSTTP
860 870 880 890 900
AKDAASAGLG SIGVKFSRDR ESRSPFLKPD ERAPTEMAKA APGSTKPKKT
910 920 930 940 950
KVKAKAGAKK TKGTKGKTKP SKTRKKVRSG GGSGGSGGQV SLKKSKADSC
960 970 980 990 1000
SQAAGTKGAE ETSWSGEERA AKVPSTPPPK AAPPPPALTP DSQTVDSSCK
1010 1020 1030 1040 1050
TPEVSFLPEE ATEEAGVRGG AEEEEEEEEE EEEEEEEEEQ QPATTTATST
1060 1070 1080 1090 1100
AAAAPSTAPS AGSTAGDSGA EDGPASRVSQ LPTLPPPMPW NLPAGVDCTT
1110 1120 1130 1140 1150
SGVLALTALL FKMEEANLAS RAKAQELIQA TNQILSHRKP PSSLGMTPAP
1160 1170 1180 1190 1200
VPTSLGLPPG PSSYLLPGSL PLGGCGSTPP TPTGLAATSD KREGSSSSEG
1210 1220 1230 1240 1250
RGDTDKYLKK LHTQERAVEE VKLAIKPYYQ KKDITKEEYK DILRKAVHKI
1260 1270 1280 1290 1300
CHSKSGEINP VKVSNLVRAY VQRYRYFRKH GRKPGDPPGP PRPPKEPGPP
1310
DKGGPGLPLP PL
Length:1,312
Mass (Da):139,270
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CB1C87C963C52BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R3G4M0R3G4_HUMAN
Splicing factor, arginine/serine-ri...
SCAF1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2L3M0R2L3_HUMAN
Splicing factor, arginine/serine-ri...
SCAF1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R232M0R232_HUMAN
Splicing factor, arginine/serine-ri...
SCAF1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti420T → P in BAB15734 (PubMed:14702039).Curated1
Sequence conflicti420T → P in AAH53992 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052235895T → A. Corresponds to variant dbSNP:rs3745470Ensembl.1
Natural variantiVAR_0522361146M → T. Corresponds to variant dbSNP:rs2304208Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF254411 Genomic DNA Translation: AAF87552.1
AK024444 mRNA Translation: BAB15734.1 Different initiation.
BC018398 mRNA Translation: AAH18398.1
BC053992 mRNA Translation: AAH53992.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33074.1

NCBI Reference Sequences

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RefSeqi
NP_067051.2, NM_021228.2
XP_005259179.1, XM_005259122.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.103521

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360565; ENSP00000353769; ENSG00000126461

Database of genes from NCBI RefSeq genomes

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GeneIDi
58506

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:58506

UCSC genome browser

More...
UCSCi
uc002poq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254411 Genomic DNA Translation: AAF87552.1
AK024444 mRNA Translation: BAB15734.1 Different initiation.
BC018398 mRNA Translation: AAH18398.1
BC053992 mRNA Translation: AAH53992.1
CCDSiCCDS33074.1
RefSeqiNP_067051.2, NM_021228.2
XP_005259179.1, XM_005259122.4
UniGeneiHs.103521

3D structure databases

ProteinModelPortaliQ9H7N4
SMRiQ9H7N4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121834, 29 interactors
IntActiQ9H7N4, 17 interactors
STRINGi9606.ENSP00000353769

PTM databases

iPTMnetiQ9H7N4
PhosphoSitePlusiQ9H7N4
SwissPalmiQ9H7N4

Polymorphism and mutation databases

BioMutaiSCAF1
DMDMi296452955

Proteomic databases

EPDiQ9H7N4
MaxQBiQ9H7N4
PaxDbiQ9H7N4
PeptideAtlasiQ9H7N4
PRIDEiQ9H7N4
ProteomicsDBi81132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360565; ENSP00000353769; ENSG00000126461
GeneIDi58506
KEGGihsa:58506
UCSCiuc002poq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58506
DisGeNETi58506
EuPathDBiHostDB:ENSG00000126461.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SCAF1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0015337
HGNCiHGNC:30403 SCAF1
HPAiHPA046828
HPA054593
MIMi617264 gene
neXtProtiNX_Q9H7N4
OpenTargetsiENSG00000126461
PharmGKBiPA162402459

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0825 Eukaryota
ENOG410YF5K LUCA
GeneTreeiENSGT00940000154168
HOGENOMiHOG000168227
HOVERGENiHBG097942
InParanoidiQ9H7N4
OMAiPDERAPT
OrthoDBiEOG091G05JH
PhylomeDBiQ9H7N4
TreeFamiTF332183

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCAF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58506

Protein Ontology

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PROi
PR:Q9H7N4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126461 Expressed in 141 organ(s), highest expression level in heart left ventricle
CleanExiHS_SCAF1
HS_SRA1
ExpressionAtlasiQ9H7N4 baseline and differential
GenevisibleiQ9H7N4 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFR19_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7N4
Secondary accession number(s): Q7Z5V7, Q8WVA1, Q9NR59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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