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Entry version 113 (03 Jul 2019)
Sequence version 3 (18 May 2010)
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Protein

Zinc finger SWIM domain-containing protein 4

Gene

ZSWIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri139 – 176SWIM-typePROSITE-ProRule annotationAdd BLAST38

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25704 ZSWIM4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7M6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000132003

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134975055

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSWIM4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002231011 – 989Zinc finger SWIM domain-containing protein 4Add BLAST989

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H7M6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7M6

PeptideAtlas

More...
PeptideAtlasi
Q9H7M6

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7M6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81129

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7M6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7M6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132003 Expressed in 86 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H7M6 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042084

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122412, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254323

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 176SWIM-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3615 Eukaryota
ENOG410XPZG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162102

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231419

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H7M6

Database of Orthologous Groups

More...
OrthoDBi
58074at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7M6

TreeFam database of animal gene trees

More...
TreeFami
TF324881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007527 Znf_SWIM

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50966 ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H7M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPAAKRSR GCPAGPEERD AGAGAARGRG RPEALLDLSA KRVAESWAFE
60 70 80 90 100
QVEERFSRVP EPVQKRIVFW SFPRSEREIC MYSSLGYPPP EGEHDARVPF
110 120 130 140 150
TRGLHLLQSG AVDRVLQVGF HLSGNIREPG SPGEPERLYH VSISFDRCKI
160 170 180 190 200
TSVSCGCDNR DLFYCAHVVA LSLYRIRHAH QVELRLPISE TLSQMNRDQL
210 220 230 240 250
QKFVQYLISA HHTEVLPTAQ RLADEILLLG SEINLVNGAP DPTAGAGIED
260 270 280 290 300
ANCWHLDEEQ IQEQVKQLLS NGGYYGASQQ LRSMFSKVRE MLRMRDSNGA
310 320 330 340 350
RMLILMTEQF LQDTRLALWR QQGAGMTDKC RQLWDELGAL WVCVVLSPHC
360 370 380 390 400
KPEERAGWLQ LLSRWDKLDV CPLEEGNYSF DGPSLQPTMA PAPELLQKGS
410 420 430 440 450
TCITNTEGWV GHPLDPIGCL CRALLEACRL EEETLTLYPD SGPEKRKVAY
460 470 480 490 500
QHVPVPGSPG ESYLVLALEV ALLGLGQQRA LPEGLYAQDK VVRNEEQLLA
510 520 530 540 550
LLEEVELDER LVQVLRKQAG LLLEGGPFSG FGEVLFRESV PMHTCARYLF
560 570 580 590 600
TALLPHDPDL AYRLALRAMR LPILETAFPA GEPHPSPLDS IMSNRFPRWF
610 620 630 640 650
ILGHLETRQC ELASTMLTAA KGDPKWLHTV LGSIQQNIHS PALLFKLAQD
660 670 680 690 700
ACKTATPVSA PPDTTLLGIA LELGLQVMRM TLNVMTWRRR EMVRWLVSCA
710 720 730 740 750
TEIGPQALMN IMQNWYSLFT PVEAATIVAV TGTTHATLLR LQLDTSRREE
760 770 780 790 800
LWACARTLAL QCAMKDPQNC ALPALTLCEK NHSAFEAAYQ IVLDAAAGGL
810 820 830 840 850
GHAHLFTVAR YMEHRGLPLR AYKLATLALA QLSIAFNQDS HPAVNDVLWA
860 870 880 890 900
CSLSHSLGRH ELSAIVPLII RSIHCAPMLS DILRRWTLSA PGLGPLGARR
910 920 930 940 950
AAKPLGADRA PLCQLLDAAV TAYITTSHSR LTHISPRHYG DFIEFLGKAR
960 970 980
ETFLLAPDGH LQFSQFLENL KQTYKGKKKL MLLVRERFG
Length:989
Mass (Da):110,138
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BFDAF8291131A2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERJ6K7ERJ6_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM4
898Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJI0K7EJI0_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM4
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15742 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti629T → M in BAB15742 (PubMed:11214971).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024452 mRNA Translation: BAB15742.1 Different initiation.
AC020916 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32924.1

NCBI Reference Sequences

More...
RefSeqi
NP_075560.2, NM_023072.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254323; ENSP00000254323; ENSG00000132003

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65249

UCSC genome browser

More...
UCSCi
uc002mxh.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024452 mRNA Translation: BAB15742.1 Different initiation.
AC020916 Genomic DNA No translation available.
CCDSiCCDS32924.1
RefSeqiNP_075560.2, NM_023072.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122412, 1 interactor
STRINGi9606.ENSP00000254323

PTM databases

iPTMnetiQ9H7M6
PhosphoSitePlusiQ9H7M6

Polymorphism and mutation databases

BioMutaiZSWIM4
DMDMi296453063

Proteomic databases

EPDiQ9H7M6
PaxDbiQ9H7M6
PeptideAtlasiQ9H7M6
PRIDEiQ9H7M6
ProteomicsDBi81129

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254323; ENSP00000254323; ENSG00000132003
GeneIDi65249
KEGGihsa:65249
UCSCiuc002mxh.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65249

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZSWIM4
HGNCiHGNC:25704 ZSWIM4
HPAiHPA042084
neXtProtiNX_Q9H7M6
OpenTargetsiENSG00000132003
PharmGKBiPA134975055

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3615 Eukaryota
ENOG410XPZG LUCA
GeneTreeiENSGT00940000162102
HOGENOMiHOG000231419
InParanoidiQ9H7M6
OrthoDBi58074at2759
PhylomeDBiQ9H7M6
TreeFamiTF324881

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZSWIM4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65249

Protein Ontology

More...
PROi
PR:Q9H7M6

Gene expression databases

BgeeiENSG00000132003 Expressed in 86 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ9H7M6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR007527 Znf_SWIM
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7M6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 18, 2010
Last modified: July 3, 2019
This is version 113 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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