UniProtKB - Q9H7L9 (SDS3_HUMAN)
Sin3 histone deacetylase corepressor complex component SDS3
SUDS3
Functioni
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
2 PublicationsGO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- histone deacetylation Source: UniProtKB
- negative regulation of cell migration Source: ComplexPortal
- negative regulation of stem cell population maintenance Source: ComplexPortal
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ComplexPortal
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of stem cell population maintenance Source: ComplexPortal
- substantia nigra development Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9H7L9 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5689880, Ub-specific processing proteases R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q9H7L9 |
SIGNORi | Q9H7L9 |
Names & Taxonomyi
Protein namesi | Recommended name: Sin3 histone deacetylase corepressor complex component SDS3Alternative name(s): 45 kDa Sin3-associated polypeptide Suppressor of defective silencing 3 protein homolog |
Gene namesi | Name:SUDS3 Synonyms:SAP45, SDS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29545, SUDS3 |
MIMi | 608250, gene |
neXtProti | NX_Q9H7L9 |
VEuPathDBi | HostDB:ENSG00000111707 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- Sin3 complex Source: UniProtKB
- Sin3-type complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 64426 |
OpenTargetsi | ENSG00000111707 |
PharmGKBi | PA143485626 |
Miscellaneous databases
Pharosi | Q9H7L9, Tbio |
Genetic variation databases
BioMutai | SUDS3 |
DMDMi | 68053233 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000097652 | 2 – 328 | Sin3 histone deacetylase corepressor complex component SDS3Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 49 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Cross-linki | 69 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 201 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 228 | PhosphoserineCombined sources | 1 | |
Modified residuei | 234 | PhosphoserineCombined sources | 1 | |
Modified residuei | 237 | PhosphoserineCombined sources | 1 | |
Modified residuei | 244 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9H7L9 |
jPOSTi | Q9H7L9 |
MassIVEi | Q9H7L9 |
MaxQBi | Q9H7L9 |
PaxDbi | Q9H7L9 |
PeptideAtlasi | Q9H7L9 |
PRIDEi | Q9H7L9 |
ProteomicsDBi | 81128 |
PTM databases
iPTMneti | Q9H7L9 |
PhosphoSitePlusi | Q9H7L9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000111707, Expressed in oviduct epithelium and 218 other tissues |
Genevisiblei | Q9H7L9, HS |
Organism-specific databases
HPAi | ENSG00000111707, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Component of the SIN3 histone deacetylase (HDAC) corepressor complex.
Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity).
Interacts with HCFC1.
Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.
Interacts with USP17L2; the interaction is direct.
Interacts with FOXK2 (PubMed:25805136).
By similarity4 PublicationsBinary interactionsi
Q9H7L9
With | #Exp. | IntAct |
---|---|---|
BRMS1 [Q9HCU9] | 2 | EBI-540496,EBI-714781 |
GOLGA2 [Q08379] | 3 | EBI-540496,EBI-618309 |
HCFC1 [P51610] | 2 | EBI-540496,EBI-396176 |
LDOC1 [O95751] | 3 | EBI-540496,EBI-740738 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 122174, 99 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9H7L9 |
IntActi | Q9H7L9, 44 interactors |
MINTi | Q9H7L9 |
STRINGi | 9606.ENSP00000443988 |
Miscellaneous databases
RNActi | Q9H7L9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 65 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 2 – 170 | Mediates interaction with USP17L21 PublicationAdd BLAST | 169 | |
Regioni | 188 – 226 | Sin3 interaction domain (SID)By similarityAdd BLAST | 39 | |
Regioni | 226 – 252 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 66 – 171 | Sequence analysisAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 65 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00910000144281 |
HOGENOMi | CLU_050862_0_1_1 |
InParanoidi | Q9H7L9 |
OMAi | IGTEAIW |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q9H7L9 |
TreeFami | TF323740 |
Family and domain databases
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE
60 70 80 90 100
DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK
110 120 130 140 150
KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL
160 170 180 190 200
IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR
210 220 230 240 250
KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA
260 270 280 290 300
QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR
310 320
KTSDSTKMRI YLGQLQRGLF VIRRRSAA
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 – 171 | EKLTMELT → HASAHASA in AAH30252 (PubMed:12724404).Curated | 8 | |
Sequence conflicti | 286 | S → R in BAB14685 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024460 mRNA Translation: BAB15750.1 Different initiation. BC030252 mRNA Translation: AAH30252.1 BC098404 mRNA Translation: AAH98404.1 AK023801 mRNA Translation: BAB14685.1 Different initiation. |
CCDSi | CCDS44993.1 |
RefSeqi | NP_071936.2, NM_022491.2 |
Genome annotation databases
Ensembli | ENST00000543473.2; ENSP00000443988.1; ENSG00000111707.12 |
GeneIDi | 64426 |
KEGGi | hsa:64426 |
MANE-Selecti | ENST00000543473.2; ENSP00000443988.1; NM_022491.3; NP_071936.2 |
UCSCi | uc001twz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024460 mRNA Translation: BAB15750.1 Different initiation. BC030252 mRNA Translation: AAH30252.1 BC098404 mRNA Translation: AAH98404.1 AK023801 mRNA Translation: BAB14685.1 Different initiation. |
CCDSi | CCDS44993.1 |
RefSeqi | NP_071936.2, NM_022491.2 |
3D structure databases
AlphaFoldDBi | Q9H7L9 |
SMRi | Q9H7L9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122174, 99 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9H7L9 |
IntActi | Q9H7L9, 44 interactors |
MINTi | Q9H7L9 |
STRINGi | 9606.ENSP00000443988 |
PTM databases
iPTMneti | Q9H7L9 |
PhosphoSitePlusi | Q9H7L9 |
Genetic variation databases
BioMutai | SUDS3 |
DMDMi | 68053233 |
Proteomic databases
EPDi | Q9H7L9 |
jPOSTi | Q9H7L9 |
MassIVEi | Q9H7L9 |
MaxQBi | Q9H7L9 |
PaxDbi | Q9H7L9 |
PeptideAtlasi | Q9H7L9 |
PRIDEi | Q9H7L9 |
ProteomicsDBi | 81128 |
Protocols and materials databases
Antibodypediai | 31389, 105 antibodies from 20 providers |
DNASUi | 64426 |
Genome annotation databases
Ensembli | ENST00000543473.2; ENSP00000443988.1; ENSG00000111707.12 |
GeneIDi | 64426 |
KEGGi | hsa:64426 |
MANE-Selecti | ENST00000543473.2; ENSP00000443988.1; NM_022491.3; NP_071936.2 |
UCSCi | uc001twz.4, human |
Organism-specific databases
CTDi | 64426 |
DisGeNETi | 64426 |
GeneCardsi | SUDS3 |
HGNCi | HGNC:29545, SUDS3 |
HPAi | ENSG00000111707, Low tissue specificity |
MIMi | 608250, gene |
neXtProti | NX_Q9H7L9 |
OpenTargetsi | ENSG00000111707 |
PharmGKBi | PA143485626 |
VEuPathDBi | HostDB:ENSG00000111707 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4466, Eukaryota |
GeneTreei | ENSGT00910000144281 |
HOGENOMi | CLU_050862_0_1_1 |
InParanoidi | Q9H7L9 |
OMAi | IGTEAIW |
OrthoDBi | 1456563at2759 |
PhylomeDBi | Q9H7L9 |
TreeFami | TF323740 |
Enzyme and pathway databases
PathwayCommonsi | Q9H7L9 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5689880, Ub-specific processing proteases R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q9H7L9 |
SIGNORi | Q9H7L9 |
Miscellaneous databases
BioGRID-ORCSi | 64426, 389 hits in 1083 CRISPR screens |
ChiTaRSi | SUDS3, human |
GeneWikii | SUDS3 |
GenomeRNAii | 64426 |
Pharosi | Q9H7L9, Tbio |
PROi | PR:Q9H7L9 |
RNActi | Q9H7L9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111707, Expressed in oviduct epithelium and 218 other tissues |
Genevisiblei | Q9H7L9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013907, Sds3 |
PANTHERi | PTHR21964, PTHR21964, 1 hit |
Pfami | View protein in Pfam PF08598, Sds3, 1 hit |
SMARTi | View protein in SMART SM01401, Sds3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDS3_HUMAN | |
Accessioni | Q9H7L9Primary (citable) accession number: Q9H7L9 Secondary accession number(s): Q4KMQ5, Q8N6H0, Q9H8D2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families