SUDS3

Functionⁱ

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.2 Publications

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21239494
histone deacetylase activity Source: Reactome
histone deacetylase binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11909966

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
histone deacetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 21239494
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11909966
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22783022
positive regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21239494
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Repressor
Biological process	Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5689880 Ub-specific processing proteases

Reactomeⁱ

R-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sin3 histone deacetylase corepressor complex component SDS3 Alternative name(s): 45 kDa Sin3-associated polypeptide Suppressor of defective silencing 3 protein homolog
Gene namesⁱ	Name:SUDS3 Synonyms:SAP45, SDS3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111707.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29545 SUDS3
MIMⁱ	608250 gene
neXtProtⁱ	NX_Q9H7L9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64426
Open Targets More...OpenTargetsⁱ	ENSG00000111707
PharmGKBⁱ	PA143485626

Polymorphism and mutation databases

BioMutaⁱ	SUDS3
DMDMⁱ	68053233

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000097652	2 – 328	Sin3 histone deacetylase corepressor complex component SDS3Add BLAST		327

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	32	PhosphoserineCombined sources	1
Modified residueⁱ	45	PhosphoserineCombined sources	1
Modified residueⁱ	49	PhosphothreonineCombined sources	1
Modified residueⁱ	53	PhosphoserineCombined sources	1
Cross-linkⁱ	69	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	201	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	228	PhosphoserineCombined sources	1
Modified residueⁱ	234	PhosphoserineCombined sources	1
Modified residueⁱ	237	PhosphoserineCombined sources	1
Modified residueⁱ	244	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H7L9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H7L9
PaxDbⁱ	Q9H7L9
PeptideAtlas More...PeptideAtlasⁱ	Q9H7L9
PRIDEⁱ	Q9H7L9
ProteomicsDBⁱ	81128

PTM databases

iPTMnetⁱ	Q9H7L9
PhosphoSitePlusⁱ	Q9H7L9

Expressionⁱ

Tissue specificityⁱ

Expressed in various cancer cell ines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111707 Expressed in 203 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SUDS3
Genevisibleⁱ	Q9H7L9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040402 HPA041972

HPAⁱ

HPA040402
HPA041972

Interactionⁱ

Subunit structureⁱ

Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct. Interacts with FOXK2 (PubMed:25805136).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BRMS1	Q9HCU9	2	EBI-540496,EBI-714781
HCFC1	P51610	2	EBI-540496,EBI-396176

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21239494
histone deacetylase binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11909966

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122174, 33 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9H7L9
IntActⁱ	Q9H7L9, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q9H7L9
STRINGⁱ	9606.ENSP00000443988

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H7L9
SMRⁱ	Q9H7L9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 170	Mediates interaction with USP17L21 PublicationAdd BLAST		169
Regionⁱ	188 – 226	Sin3 interaction domain (SID)By similarityAdd BLAST		39

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	66 – 171	Sequence analysisAdd BLAST		106

Domainⁱ

The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.

Sequence similaritiesⁱ

Belongs to the SDS3 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4466 Eukaryota ENOG410Y9N9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144281
HOGENOMⁱ	HOG000007054
HOVERGENⁱ	HBG108465
InParanoidⁱ	Q9H7L9
KEGG Orthology (KO) More...KOⁱ	K19201
OMAⁱ	NDSMEIK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MS7
PhylomeDBⁱ	Q9H7L9
TreeFamⁱ	TF323740

Family and domain databases

InterProⁱ	View protein in InterPro IPR013907 Sds3
PANTHERⁱ	PTHR21964 PTHR21964, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08598 Sds3, 1 hit
SMARTⁱ	View protein in SMART SM01401 Sds3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H7L9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE 
        60         70         80         90        100
DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK 
       110        120        130        140        150
KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL 
       160        170        180        190        200
IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR 
       210        220        230        240        250
KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA 
       260        270        280        290        300
QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR 
       310        320 
KTSDSTKMRI YLGQLQRGLF VIRRRSAA

Length:328

Mass (Da):38,136

Last modified:June 21, 2005 - v2

Checksum:ⁱ10A7393B607117EB

GO

Sequence cautionⁱ

The sequence BAB14685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAB15750 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	164 – 171	EKLTMELT → HASAHASA in AAH30252 (PubMed:12724404).Curated		8
Sequence conflictⁱ	286	S → R in BAB14685 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024460 mRNA Translation: BAB15750.1 Different initiation. BC030252 mRNA Translation: AAH30252.1 BC098404 mRNA Translation: AAH98404.1 AK023801 mRNA Translation: BAB14685.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44993.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071936.2, NM_022491.2
UniGeneⁱ	Hs.416630 Hs.602312

Genome annotation databases

Ensemblⁱ	ENST00000543473; ENSP00000443988; ENSG00000111707
GeneIDⁱ	64426
KEGGⁱ	hsa:64426
UCSC genome browser More...UCSCⁱ	uc001twz.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3		MACMU		328	UniRef100_Q9H7L9
SDS3 homolog, SIN3A corepressor complex component		PANTR		328
Uncharacterized protein		CERAT		328
Uncharacterized protein		RHIRO		328
Uncharacterized protein		PAPAN		328
+7

Protein	Similar proteins		Species	Score	Length	Source
Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3		BOVIN		328	UniRef90_Q9H7L9
Sin3 histone deacetylase corepressor complex component SDS3		MACMU		328
SDS3 homolog, SIN3A corepressor complex component		PANTR		328
Uncharacterized protein		CERAT		328
Uncharacterized protein		RHIRO		328
+39

Protein	Similar proteins		Species	Score	Length	Source
Q9H7L9	Sin3 histone deacetylase corepressor complex component SDS3		BOVIN		328	UniRef50_Q9H7L9
Sin3 histone deacetylase corepressor complex component SDS3		PONAB		328
Sin3 histone deacetylase corepressor complex component SDS3	)	MOUSE		328
Sin3 histone deacetylase corepressor complex component SDS3		MACMU		328
SDS3 homolog, SIN3A corepressor complex component		PANTR		328
+145

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024460 mRNA Translation: BAB15750.1 Different initiation. BC030252 mRNA Translation: AAH30252.1 BC098404 mRNA Translation: AAH98404.1 AK023801 mRNA Translation: BAB14685.1 Different initiation.
CCDSⁱ	CCDS44993.1
RefSeqⁱ	NP_071936.2, NM_022491.2
UniGeneⁱ	Hs.416630 Hs.602312

3D structure databases

ProteinModelPortalⁱ	Q9H7L9
SMRⁱ	Q9H7L9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122174, 33 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9H7L9
IntActⁱ	Q9H7L9, 19 interactors
MINTⁱ	Q9H7L9
STRINGⁱ	9606.ENSP00000443988

PTM databases

iPTMnetⁱ	Q9H7L9
PhosphoSitePlusⁱ	Q9H7L9

Polymorphism and mutation databases

BioMutaⁱ	SUDS3
DMDMⁱ	68053233

Proteomic databases

EPDⁱ	Q9H7L9
MaxQBⁱ	Q9H7L9
PaxDbⁱ	Q9H7L9
PeptideAtlasⁱ	Q9H7L9
PRIDEⁱ	Q9H7L9
ProteomicsDBⁱ	81128

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000543473; ENSP00000443988; ENSG00000111707
GeneIDⁱ	64426
KEGGⁱ	hsa:64426
UCSCⁱ	uc001twz.4 human

Organism-specific databases

CTDⁱ	64426
DisGeNETⁱ	64426
EuPathDBⁱ	HostDB:ENSG00000111707.11
GeneCardsⁱ	SUDS3
HGNCⁱ	HGNC:29545 SUDS3
HPAⁱ	HPA040402 HPA041972
MIMⁱ	608250 gene
neXtProtⁱ	NX_Q9H7L9
OpenTargetsⁱ	ENSG00000111707
PharmGKBⁱ	PA143485626
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4466 Eukaryota ENOG410Y9N9 LUCA
GeneTreeⁱ	ENSGT00910000144281
HOGENOMⁱ	HOG000007054
HOVERGENⁱ	HBG108465
InParanoidⁱ	Q9H7L9
KOⁱ	K19201
OMAⁱ	NDSMEIK
OrthoDBⁱ	EOG091G0MS7
PhylomeDBⁱ	Q9H7L9
TreeFamⁱ	TF323740

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3214815 HDACs deacetylate histones R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5689880 Ub-specific processing proteases

Reactomeⁱ

R-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSⁱ	SUDS3 human
GeneWikiⁱ	SUDS3
GenomeRNAiⁱ	64426
Protein Ontology More...PROⁱ	PR:Q9H7L9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111707 Expressed in 203 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SUDS3
Genevisibleⁱ	Q9H7L9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013907 Sds3
PANTHERⁱ	PTHR21964 PTHR21964, 1 hit
Pfamⁱ	View protein in Pfam PF08598 Sds3, 1 hit
SMARTⁱ	View protein in SMART SM01401 Sds3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDS3_HUMAN
Accessionⁱ	Q9H7L9Primary (citable) accession number: Q9H7L9 Secondary accession number(s): Q4KMQ5, Q8N6H0, Q9H8D2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
	Last sequence update:	June 21, 2005
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - Q9H7L9 (SDS3_HUMAN)

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Sin3 histone deacetylase corepressor complex component SDS3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ