Probable cation-transporting ATPase 13A3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• calcium-transporting ATPase activity Source: GO_Central
• metal ion binding Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cellular calcium ion homeostasis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MDREERKTIN QGQEDEMEIY GYNLSRWKLA IVSLGVICSG GFLLLLLYWM 
        60         70         80         90        100
PEWRVKATCV RAAIKDCEVV LLRTTDEFKM WFCAKIRVLS LETYPVSSPK 
       110        120        130        140        150
SMSNKLSNGH AVCLIENPTE ENRHRISKYS QTESQQIRYF THHSVKYFWN 
       160        170        180        190        200
DTIHNFDFLK GLDEGVSCTS IYEKHSAGLT KGMHAYRKLL YGVNEIAVKV 
       210        220        230        240        250
PSVFKLLIKE VLNPFYIFQL FSVILWSTDE YYYYALAIVV MSIVSIVSSL 
       260        270        280        290        300
YSIRKQYVML HDMVATHSTV RVSVCRVNEE IEEIFSTDLV PGDVMVIPLN 
       310        320        330        340        350
GTIMPCDAVL INGTCIVNES MLTGESVPVT KTNLPNPSVD VKGIGDELYN 
       360        370        380        390        400
PETHKRHTLF CGTTVIQTRF YTGELVKAIV VRTGFSTSKG QLVRSILYPK 
       410        420        430        440        450
PTDFKLYRDA YLFLLCLVAV AGIGFIYTII NSILNEVQVG VIIIESLDII 
       460        470        480        490        500
TITVPPALPA AMTAGIVYAQ RRLKKIGIFC ISPQRINICG QLNLVCFDKT 
       510        520        530        540        550
GTLTEDGLDL WGIQRVENAR FLSPEENVCN EMLVKSQFVA CMATCHSLTK 
       560        570        580        590        600
IEGVLSGDPL DLKMFEAIGW ILEEATEEET ALHNRIMPTV VRPPKQLLPE 
       610        620        630        640        650
STPAGNQEME LFELPATYEI GIVRQFPFSS ALQRMSVVAR VLGDRKMDAY 
       660        670        680        690        700
MKGAPEAIAG LCKPETVPVD FQNVLEDFTK QGFRVIALAH RKLESKLTWH 
       710        720        730        740        750
KVQNISRDAI ENNMDFMGLI IMQNKLKQET PAVLEDLHKA NIRTVMVTGD 
       760        770        780        790        800
SMLTAVSVAR DCGMILPQDK VIIAEALPPK DGKVAKINWH YADSLTQCSH 
       810        820        830        840        850
PSAIDPEAIP VKLVHDSLED LQMTRYHFAM NGKSFSVILE HFQDLVPKLM 
       860        870        880        890        900
LHGTVFARMA PDQKTQLIEA LQNVDYFVGM CGDGANDCGA LKRAHGGISL 
       910        920        930        940        950
SELEASVASP FTSKTPSISC VPNLIREGRA ALITSFCVFK FMALYSIIQY 
       960        970        980        990       1000
FSVTLLYSIL SNLGDFQFLF IDLAIILVVV FTMSLNPAWK ELVAQRPPSG 
      1010       1020       1030       1040       1050
LISGALLFSV LSQIIICIGF QSLGFFWVKQ QPWYEVWHPK SDACNTTGSG 
      1060       1070       1080       1090       1100
FWNSSHVDNE TELDEHNIQN YENTTVFFIS SFQYLIVAIA FSKGKPFRQP 
      1110       1120       1130       1140       1150
CYKNYFFVFS VIFLYIFILF IMLYPVASVD QVLQIVCVPY QWRVTMLIIV 
      1160       1170       1180       1190       1200
LVNAFVSITV EESVDRWGKC CLPWALGCRK KTPKAKYMYL AQELLVDPEW 
      1210       1220 
PPKPQTTTEA KALVKENGSC QIITIT                           

        10         20         30         40         50
MSEIEEIFST DLVPGDVMVI PLNGTIMPCD AVLINGTCIV NESMLTGESV 
        60         70         80         90        100
PVTKTNLPNP SVDVKGIGDE LYNPETHKRH TLFCGTTVIQ TRFYTGELVK 
       110        120        130        140        150
AIVVRTGFST SKGQLVRSIL YPKPTDFKLY RDAYLFLLCL VAVAGIGFIY 
       160        170        180        190        200
TIINSILNEV QVGVIIIESL DIITITVPPA LPAAMTAGIV YAQRRLKKIG 
       210        220        230        240        250
IFCISPQRIN ICGQLNLVCF DKTGTLTEDG LDLWGIQRVE NARFLSPEEN 
       260        270        280        290        300
VCNEMLVKSQ FVACMATCHS LTKIEGVLSG DPLDLKMFEA IGWILEEATE 
       310        320        330        340        350
EETALHNRIM PTVVRPPKQL LPESTPAGNQ EMELFELPAT YEIGIVRQFP 
       360        370        380        390        400
FSSALQRMSV VARVLGDRKM DAYMKGAPEA IAGLCKPETV PVDFQNVLED 
       410        420        430        440        450
FTKQGFRVIA LAHRKLESKL TWHKVQNISR DAIENNMDFM GLIIMQNKLK 
       460        470        480        490        500
QETPAVLEDL HKANIRTVMV TGDSMLTAVS VARDCGMILP QDKVIIAEAL 
       510        520        530        540        550
PPKDGKVAKI NWHYADSLTQ CSHPSAIDPE AIPVKLVHDS LEDLQMTRYH 
       560        570        580        590        600
FAMNGKSFSV ILEHFQDLVP KLMLHGTVFA RMAPDQKTQL IEALQNVDYF 
       610        620        630        640        650
VGMCGDGAND CGALKRAHGG ISLSELEASV ASPFTSKTPS ISCVPNLIRE 
       660        670        680        690        700
GRAALITSSC ELALFSIVTY SLDHFIISIL ISSMLVLFFS DFHNCAFYSL 

V                                                      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families