Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H7F0 (AT133_HUMAN)

Protein

Probable cation-transporting ATPase 13A3

Gene

ATP13A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4984-aspartylphosphate intermediateBy similarity1
Metal bindingi883MagnesiumBy similarity1
Metal bindingi887MagnesiumBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cation transport Source: InterPro
  • cellular calcium ion homeostasis Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A3 (EC:3.6.3.-)
Alternative name(s):
ATPase family homolog up-regulated in senescence cells 1
Gene namesi
Name:ATP13A3
Synonyms:AFURS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000133657.14
HGNCiHGNC:24113 ATP13A3
MIMi610232 gene
neXtProtiNX_Q9H7F0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Transmembranei941 – 961HelicalSequence analysisAdd BLAST21
Transmembranei963 – 983HelicalSequence analysisAdd BLAST21
Transmembranei1000 – 1020HelicalSequence analysisAdd BLAST21
Transmembranei1074 – 1094HelicalSequence analysisAdd BLAST21
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Transmembranei1144 – 1164HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79572
OpenTargetsiENSG00000133657
PharmGKBiPA134971145

Polymorphism and mutation databases

BioMutaiATP13A3
DMDMi223590262

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464251 – 1226Probable cation-transporting ATPase 13A3Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7F0
MaxQBiQ9H7F0
PaxDbiQ9H7F0
PeptideAtlasiQ9H7F0
PRIDEiQ9H7F0
ProteomicsDBi81118
81119 [Q9H7F0-2]

PTM databases

iPTMnetiQ9H7F0
PhosphoSitePlusiQ9H7F0
SwissPalmiQ9H7F0

Expressioni

Gene expression databases

BgeeiENSG00000133657 Expressed in 230 organ(s), highest expression level in heart
CleanExiHS_ATP13A3
ExpressionAtlasiQ9H7F0 baseline and differential
GenevisibleiQ9H7F0 HS

Organism-specific databases

HPAiHPA029471

Interactioni

Protein-protein interaction databases

BioGridi122719, 21 interactors
IntActiQ9H7F0, 5 interactors
MINTiQ9H7F0
STRINGi9606.ENSP00000256031

Structurei

3D structure databases

ProteinModelPortaliQ9H7F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 234Poly-Tyr4

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208 Eukaryota
ENOG410XRCA LUCA
GeneTreeiENSGT00530000063001
HOGENOMiHOG000171813
HOVERGENiHBG065757
InParanoidiQ9H7F0
KOiK14951
OMAiDYYYYAF
OrthoDBiEOG091G01IL
PhylomeDBiQ9H7F0
TreeFamiTF300331

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 3 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7F0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDREERKTIN QGQEDEMEIY GYNLSRWKLA IVSLGVICSG GFLLLLLYWM 
        60         70         80         90        100
PEWRVKATCV RAAIKDCEVV LLRTTDEFKM WFCAKIRVLS LETYPVSSPK 
       110        120        130        140        150
SMSNKLSNGH AVCLIENPTE ENRHRISKYS QTESQQIRYF THHSVKYFWN 
       160        170        180        190        200
DTIHNFDFLK GLDEGVSCTS IYEKHSAGLT KGMHAYRKLL YGVNEIAVKV 
       210        220        230        240        250
PSVFKLLIKE VLNPFYIFQL FSVILWSTDE YYYYALAIVV MSIVSIVSSL 
       260        270        280        290        300
YSIRKQYVML HDMVATHSTV RVSVCRVNEE IEEIFSTDLV PGDVMVIPLN 
       310        320        330        340        350
GTIMPCDAVL INGTCIVNES MLTGESVPVT KTNLPNPSVD VKGIGDELYN 
       360        370        380        390        400
PETHKRHTLF CGTTVIQTRF YTGELVKAIV VRTGFSTSKG QLVRSILYPK 
       410        420        430        440        450
PTDFKLYRDA YLFLLCLVAV AGIGFIYTII NSILNEVQVG VIIIESLDII 
       460        470        480        490        500
TITVPPALPA AMTAGIVYAQ RRLKKIGIFC ISPQRINICG QLNLVCFDKT 
       510        520        530        540        550
GTLTEDGLDL WGIQRVENAR FLSPEENVCN EMLVKSQFVA CMATCHSLTK 
       560        570        580        590        600
IEGVLSGDPL DLKMFEAIGW ILEEATEEET ALHNRIMPTV VRPPKQLLPE 
       610        620        630        640        650
STPAGNQEME LFELPATYEI GIVRQFPFSS ALQRMSVVAR VLGDRKMDAY 
       660        670        680        690        700
MKGAPEAIAG LCKPETVPVD FQNVLEDFTK QGFRVIALAH RKLESKLTWH 
       710        720        730        740        750
KVQNISRDAI ENNMDFMGLI IMQNKLKQET PAVLEDLHKA NIRTVMVTGD 
       760        770        780        790        800
SMLTAVSVAR DCGMILPQDK VIIAEALPPK DGKVAKINWH YADSLTQCSH 
       810        820        830        840        850
PSAIDPEAIP VKLVHDSLED LQMTRYHFAM NGKSFSVILE HFQDLVPKLM 
       860        870        880        890        900
LHGTVFARMA PDQKTQLIEA LQNVDYFVGM CGDGANDCGA LKRAHGGISL 
       910        920        930        940        950
SELEASVASP FTSKTPSISC VPNLIREGRA ALITSFCVFK FMALYSIIQY 
       960        970        980        990       1000
FSVTLLYSIL SNLGDFQFLF IDLAIILVVV FTMSLNPAWK ELVAQRPPSG 
      1010       1020       1030       1040       1050
LISGALLFSV LSQIIICIGF QSLGFFWVKQ QPWYEVWHPK SDACNTTGSG 
      1060       1070       1080       1090       1100
FWNSSHVDNE TELDEHNIQN YENTTVFFIS SFQYLIVAIA FSKGKPFRQP 
      1110       1120       1130       1140       1150
CYKNYFFVFS VIFLYIFILF IMLYPVASVD QVLQIVCVPY QWRVTMLIIV 
      1160       1170       1180       1190       1200
LVNAFVSITV EESVDRWGKC CLPWALGCRK KTPKAKYMYL AQELLVDPEW 
      1210       1220 
PPKPQTTTEA KALVKENGSC QIITIT
Length:1,226
Mass (Da):138,043
Last modified:February 10, 2009 - v4
Checksum:i8DD1C0451223C7AB
GO
Isoform 2 (identifier: Q9H7F0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     278-279: NE → MS
     936-978: FCVFKFMALY...LFIDLAIILV → SCELALFSIV...FHNCAFYSLV
     979-1226: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:701
Mass (Da):77,310
Checksum:i7927AFFE8413247F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYY3A0A087WYY3_HUMAN
Cation-transporting ATPase
ATP13A3
701Annotation score:
A0A2R8YDN7A0A2R8YDN7_HUMAN
Cation-transporting ATPase
ATP13A3
1,229Annotation score:
A0A2R8Y635A0A2R8Y635_HUMAN
Cation-transporting ATPase
ATP13A3
1,164Annotation score:
C9JAP7C9JAP7_HUMAN
Probable cation-transporting ATPase...
ATP13A3
46Annotation score:
C9J7Z7C9J7Z7_HUMAN
Probable cation-transporting ATPase...
ATP13A3
102Annotation score:
H7C1U7H7C1U7_HUMAN
Probable cation-transporting ATPase...
ATP13A3
344Annotation score:

Sequence cautioni

The sequence BAB14942 differs from that shown. Reason: Frameshift at position 1065.Curated
The sequence BAB14942 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11398 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347E → Q in CAC84902 (PubMed:11867234).Curated1
Sequence conflicti730T → P in CAC84902 (PubMed:11867234).Curated1
Sequence conflicti784V → F in BAC11398 (PubMed:14702039).Curated1
Sequence conflicti807E → G in BAC11398 (PubMed:14702039).Curated1
Sequence conflicti964G → R in BAC11398 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0073141 – 277Missing in isoform 2. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_036300278 – 279NE → MS in isoform 2. 1 Publication2
Alternative sequenceiVSP_007315936 – 978FCVFK…AIILV → SCELALFSIVTYSLDHFIIS ILISSMLVLFFSDFHNCAFY SLV in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_007316979 – 1226Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306929 mRNA Translation: CAC84902.1
AC108676 Genomic DNA No translation available.
AC125362 Genomic DNA No translation available.
AK024639 mRNA Translation: BAB14942.1 Sequence problems.
AK075094 mRNA Translation: BAC11398.1 Different initiation.
CCDSiCCDS43187.1 [Q9H7F0-1]
RefSeqiNP_078800.3, NM_024524.3 [Q9H7F0-1]
XP_011511425.1, XM_011513123.2 [Q9H7F0-1]
UniGeneiHs.529609

Genome annotation databases

EnsembliENST00000256031; ENSP00000256031; ENSG00000133657 [Q9H7F0-1]
ENST00000439040; ENSP00000416508; ENSG00000133657 [Q9H7F0-1]
ENST00000645538; ENSP00000494471; ENSG00000133657 [Q9H7F0-1]
GeneIDi79572
KEGGihsa:79572
UCSCiuc003fty.5 human [Q9H7F0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306929 mRNA Translation: CAC84902.1
AC108676 Genomic DNA No translation available.
AC125362 Genomic DNA No translation available.
AK024639 mRNA Translation: BAB14942.1 Sequence problems.
AK075094 mRNA Translation: BAC11398.1 Different initiation.
CCDSiCCDS43187.1 [Q9H7F0-1]
RefSeqiNP_078800.3, NM_024524.3 [Q9H7F0-1]
XP_011511425.1, XM_011513123.2 [Q9H7F0-1]
UniGeneiHs.529609

3D structure databases

ProteinModelPortaliQ9H7F0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122719, 21 interactors
IntActiQ9H7F0, 5 interactors
MINTiQ9H7F0
STRINGi9606.ENSP00000256031

PTM databases

iPTMnetiQ9H7F0
PhosphoSitePlusiQ9H7F0
SwissPalmiQ9H7F0

Polymorphism and mutation databases

BioMutaiATP13A3
DMDMi223590262

Proteomic databases

EPDiQ9H7F0
MaxQBiQ9H7F0
PaxDbiQ9H7F0
PeptideAtlasiQ9H7F0
PRIDEiQ9H7F0
ProteomicsDBi81118
81119 [Q9H7F0-2]

Protocols and materials databases

DNASUi79572
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256031; ENSP00000256031; ENSG00000133657 [Q9H7F0-1]
ENST00000439040; ENSP00000416508; ENSG00000133657 [Q9H7F0-1]
ENST00000645538; ENSP00000494471; ENSG00000133657 [Q9H7F0-1]
GeneIDi79572
KEGGihsa:79572
UCSCiuc003fty.5 human [Q9H7F0-1]

Organism-specific databases

CTDi79572
DisGeNETi79572
EuPathDBiHostDB:ENSG00000133657.14
GeneCardsiATP13A3
HGNCiHGNC:24113 ATP13A3
HPAiHPA029471
MIMi610232 gene
neXtProtiNX_Q9H7F0
OpenTargetsiENSG00000133657
PharmGKBiPA134971145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0208 Eukaryota
ENOG410XRCA LUCA
GeneTreeiENSGT00530000063001
HOGENOMiHOG000171813
HOVERGENiHBG065757
InParanoidiQ9H7F0
KOiK14951
OMAiDYYYYAF
OrthoDBiEOG091G01IL
PhylomeDBiQ9H7F0
TreeFamiTF300331

Miscellaneous databases

ChiTaRSiATP13A3 human
GeneWikiiATP13A3
GenomeRNAii79572
PROiPR:Q9H7F0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133657 Expressed in 230 organ(s), highest expression level in heart
CleanExiHS_ATP13A3
ExpressionAtlasiQ9H7F0 baseline and differential
GenevisibleiQ9H7F0 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 3 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT133_HUMAN
AccessioniPrimary (citable) accession number: Q9H7F0
Secondary accession number(s): Q8NC11, Q96KS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 10, 2009
Last modified: November 7, 2018
This is version 150 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again