UniProtKB - Q9H7F0 (AT133_HUMAN)
Protein
Probable cation-transporting ATPase 13A3
Gene
ATP13A3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 498 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 883 | MagnesiumBy similarity | 1 | |
Metal bindingi | 887 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cation transport Source: InterPro
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Molecular function | Translocase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H7F0 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable cation-transporting ATPase 13A3 (EC:7.2.2.-)Alternative name(s): ATPase family homolog up-regulated in senescence cells 1 |
Gene namesi | Name:ATP13A3 Synonyms:AFURS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24113, ATP13A3 |
MIMi | 610232, gene |
neXtProti | NX_Q9H7F0 |
VEuPathDBi | HostDB:ENSG00000133657.14 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 233 – 253 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 449 – 469 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 941 – 961 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 963 – 983 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1000 – 1020 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1074 – 1094 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1106 – 1126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1144 – 1164 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79572 |
OpenTargetsi | ENSG00000133657 |
PharmGKBi | PA134971145 |
Miscellaneous databases
Pharosi | Q9H7F0, Tdark |
Genetic variation databases
BioMutai | ATP13A3 |
DMDMi | 223590262 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046425 | 1 – 1226 | Probable cation-transporting ATPase 13A3Add BLAST | 1226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 98 | PhosphoserineCombined sources | 1 | |
Modified residuei | 817 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H7F0 |
jPOSTi | Q9H7F0 |
MassIVEi | Q9H7F0 |
MaxQBi | Q9H7F0 |
PaxDbi | Q9H7F0 |
PeptideAtlasi | Q9H7F0 |
PRIDEi | Q9H7F0 |
ProteomicsDBi | 81118 [Q9H7F0-1] 81119 [Q9H7F0-2] |
PTM databases
iPTMneti | Q9H7F0 |
PhosphoSitePlusi | Q9H7F0 |
SwissPalmi | Q9H7F0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133657, Expressed in heart and 240 other tissues |
ExpressionAtlasi | Q9H7F0, baseline and differential |
Genevisiblei | Q9H7F0, HS |
Organism-specific databases
HPAi | ENSG00000133657, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122719, 38 interactors |
IntActi | Q9H7F0, 23 interactors |
MINTi | Q9H7F0 |
STRINGi | 9606.ENSP00000416508 |
Miscellaneous databases
RNActi | Q9H7F0, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 231 – 234 | Poly-Tyr | 4 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0208, Eukaryota |
GeneTreei | ENSGT00940000155941 |
HOGENOMi | CLU_001828_0_0_1 |
InParanoidi | Q9H7F0 |
OMAi | GINRYEK |
OrthoDBi | 172453at2759 |
PhylomeDBi | Q9H7F0 |
TreeFami | TF300331 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006544, P-type_TPase_V IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit PF12409, P5-ATPase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 3 hits TIGR01657, P-ATPase-V, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H7F0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDREERKTIN QGQEDEMEIY GYNLSRWKLA IVSLGVICSG GFLLLLLYWM
60 70 80 90 100
PEWRVKATCV RAAIKDCEVV LLRTTDEFKM WFCAKIRVLS LETYPVSSPK
110 120 130 140 150
SMSNKLSNGH AVCLIENPTE ENRHRISKYS QTESQQIRYF THHSVKYFWN
160 170 180 190 200
DTIHNFDFLK GLDEGVSCTS IYEKHSAGLT KGMHAYRKLL YGVNEIAVKV
210 220 230 240 250
PSVFKLLIKE VLNPFYIFQL FSVILWSTDE YYYYALAIVV MSIVSIVSSL
260 270 280 290 300
YSIRKQYVML HDMVATHSTV RVSVCRVNEE IEEIFSTDLV PGDVMVIPLN
310 320 330 340 350
GTIMPCDAVL INGTCIVNES MLTGESVPVT KTNLPNPSVD VKGIGDELYN
360 370 380 390 400
PETHKRHTLF CGTTVIQTRF YTGELVKAIV VRTGFSTSKG QLVRSILYPK
410 420 430 440 450
PTDFKLYRDA YLFLLCLVAV AGIGFIYTII NSILNEVQVG VIIIESLDII
460 470 480 490 500
TITVPPALPA AMTAGIVYAQ RRLKKIGIFC ISPQRINICG QLNLVCFDKT
510 520 530 540 550
GTLTEDGLDL WGIQRVENAR FLSPEENVCN EMLVKSQFVA CMATCHSLTK
560 570 580 590 600
IEGVLSGDPL DLKMFEAIGW ILEEATEEET ALHNRIMPTV VRPPKQLLPE
610 620 630 640 650
STPAGNQEME LFELPATYEI GIVRQFPFSS ALQRMSVVAR VLGDRKMDAY
660 670 680 690 700
MKGAPEAIAG LCKPETVPVD FQNVLEDFTK QGFRVIALAH RKLESKLTWH
710 720 730 740 750
KVQNISRDAI ENNMDFMGLI IMQNKLKQET PAVLEDLHKA NIRTVMVTGD
760 770 780 790 800
SMLTAVSVAR DCGMILPQDK VIIAEALPPK DGKVAKINWH YADSLTQCSH
810 820 830 840 850
PSAIDPEAIP VKLVHDSLED LQMTRYHFAM NGKSFSVILE HFQDLVPKLM
860 870 880 890 900
LHGTVFARMA PDQKTQLIEA LQNVDYFVGM CGDGANDCGA LKRAHGGISL
910 920 930 940 950
SELEASVASP FTSKTPSISC VPNLIREGRA ALITSFCVFK FMALYSIIQY
960 970 980 990 1000
FSVTLLYSIL SNLGDFQFLF IDLAIILVVV FTMSLNPAWK ELVAQRPPSG
1010 1020 1030 1040 1050
LISGALLFSV LSQIIICIGF QSLGFFWVKQ QPWYEVWHPK SDACNTTGSG
1060 1070 1080 1090 1100
FWNSSHVDNE TELDEHNIQN YENTTVFFIS SFQYLIVAIA FSKGKPFRQP
1110 1120 1130 1140 1150
CYKNYFFVFS VIFLYIFILF IMLYPVASVD QVLQIVCVPY QWRVTMLIIV
1160 1170 1180 1190 1200
LVNAFVSITV EESVDRWGKC CLPWALGCRK KTPKAKYMYL AQELLVDPEW
1210 1220
PPKPQTTTEA KALVKENGSC QIITIT
Isoform 2 (identifier: Q9H7F0-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-277: Missing.
278-279: NE → MS
936-978: FCVFKFMALY...LFIDLAIILV → SCELALFSIV...FHNCAFYSLV
979-1226: Missing.
Note: Dubious isoform produced through aberrant splice sites.Curated
Show »Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y635 | A0A2R8Y635_HUMAN | Cation-transporting ATPase | ATP13A3 | 1,256 | Annotation score: | ||
A0A2R8YDN7 | A0A2R8YDN7_HUMAN | Cation-transporting ATPase | ATP13A3 | 1,229 | Annotation score: | ||
C9JAP7 | C9JAP7_HUMAN | Probable cation-transporting ATPase... | ATP13A3 | 46 | Annotation score: | ||
H7C1U7 | H7C1U7_HUMAN | Probable cation-transporting ATPase... | ATP13A3 | 344 | Annotation score: |
Sequence cautioni
The sequence BAB14942 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14942 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC11398 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 347 | E → Q in CAC84902 (PubMed:11867234).Curated | 1 | |
Sequence conflicti | 730 | T → P in CAC84902 (PubMed:11867234).Curated | 1 | |
Sequence conflicti | 784 | V → F in BAC11398 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 807 | E → G in BAC11398 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 964 | G → R in BAC11398 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007314 | 1 – 277 | Missing in isoform 2. 1 PublicationAdd BLAST | 277 | |
Alternative sequenceiVSP_036300 | 278 – 279 | NE → MS in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_007315 | 936 – 978 | FCVFK…AIILV → SCELALFSIVTYSLDHFIIS ILISSMLVLFFSDFHNCAFY SLV in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_007316 | 979 – 1226 | Missing in isoform 2. 1 PublicationAdd BLAST | 248 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306929 mRNA Translation: CAC84902.1 AC108676 Genomic DNA No translation available. AC125362 Genomic DNA No translation available. AK024639 mRNA Translation: BAB14942.1 Sequence problems. AK075094 mRNA Translation: BAC11398.1 Different initiation. |
CCDSi | CCDS43187.1 [Q9H7F0-1] |
RefSeqi | NP_078800.3, NM_024524.3 [Q9H7F0-1] XP_011511425.1, XM_011513123.2 [Q9H7F0-1] |
Genome annotation databases
Ensembli | ENST00000439040; ENSP00000416508; ENSG00000133657 [Q9H7F0-1] ENST00000645538; ENSP00000494471; ENSG00000133657 [Q9H7F0-1] |
GeneIDi | 79572 |
KEGGi | hsa:79572 |
UCSCi | uc003fty.5, human [Q9H7F0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ306929 mRNA Translation: CAC84902.1 AC108676 Genomic DNA No translation available. AC125362 Genomic DNA No translation available. AK024639 mRNA Translation: BAB14942.1 Sequence problems. AK075094 mRNA Translation: BAC11398.1 Different initiation. |
CCDSi | CCDS43187.1 [Q9H7F0-1] |
RefSeqi | NP_078800.3, NM_024524.3 [Q9H7F0-1] XP_011511425.1, XM_011513123.2 [Q9H7F0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122719, 38 interactors |
IntActi | Q9H7F0, 23 interactors |
MINTi | Q9H7F0 |
STRINGi | 9606.ENSP00000416508 |
PTM databases
iPTMneti | Q9H7F0 |
PhosphoSitePlusi | Q9H7F0 |
SwissPalmi | Q9H7F0 |
Genetic variation databases
BioMutai | ATP13A3 |
DMDMi | 223590262 |
Proteomic databases
EPDi | Q9H7F0 |
jPOSTi | Q9H7F0 |
MassIVEi | Q9H7F0 |
MaxQBi | Q9H7F0 |
PaxDbi | Q9H7F0 |
PeptideAtlasi | Q9H7F0 |
PRIDEi | Q9H7F0 |
ProteomicsDBi | 81118 [Q9H7F0-1] 81119 [Q9H7F0-2] |
Protocols and materials databases
Antibodypediai | 33892, 65 antibodies |
DNASUi | 79572 |
Genome annotation databases
Ensembli | ENST00000439040; ENSP00000416508; ENSG00000133657 [Q9H7F0-1] ENST00000645538; ENSP00000494471; ENSG00000133657 [Q9H7F0-1] |
GeneIDi | 79572 |
KEGGi | hsa:79572 |
UCSCi | uc003fty.5, human [Q9H7F0-1] |
Organism-specific databases
CTDi | 79572 |
DisGeNETi | 79572 |
GeneCardsi | ATP13A3 |
HGNCi | HGNC:24113, ATP13A3 |
HPAi | ENSG00000133657, Low tissue specificity |
MIMi | 610232, gene |
neXtProti | NX_Q9H7F0 |
OpenTargetsi | ENSG00000133657 |
PharmGKBi | PA134971145 |
VEuPathDBi | HostDB:ENSG00000133657.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0208, Eukaryota |
GeneTreei | ENSGT00940000155941 |
HOGENOMi | CLU_001828_0_0_1 |
InParanoidi | Q9H7F0 |
OMAi | GINRYEK |
OrthoDBi | 172453at2759 |
PhylomeDBi | Q9H7F0 |
TreeFami | TF300331 |
Enzyme and pathway databases
PathwayCommonsi | Q9H7F0 |
Miscellaneous databases
BioGRID-ORCSi | 79572, 1 hit in 875 CRISPR screens |
ChiTaRSi | ATP13A3, human |
GeneWikii | ATP13A3 |
GenomeRNAii | 79572 |
Pharosi | Q9H7F0, Tdark |
PROi | PR:Q9H7F0 |
RNActi | Q9H7F0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133657, Expressed in heart and 240 other tissues |
ExpressionAtlasi | Q9H7F0, baseline and differential |
Genevisiblei | Q9H7F0, HS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006544, P-type_TPase_V IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit PF12409, P5-ATPase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 3 hits TIGR01657, P-ATPase-V, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AT133_HUMAN | |
Accessioni | Q9H7F0Primary (citable) accession number: Q9H7F0 Secondary accession number(s): Q8NC11, Q96KS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | February 10, 2009 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families