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Entry version 152 (13 Nov 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Tudor domain-containing protein 3

Gene

TDRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H7E2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20612 TDRD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614392 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7E2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi598E → K: Abolishes interaction with dimethylarginine-containing protein motifs and reduces association with mRNA stress granules. 1 Publication1
Mutagenesisi638 – 644RPTQQFY → EPTQQFE: Loss of interaction with the EJC. 1 Publication7

Organism-specific databases

DisGeNET

More...
DisGeNETi
81550

Open Targets

More...
OpenTargetsi
ENSG00000083544

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134962690

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H7E2

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879852

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29337133

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831631 – 651Tudor domain-containing protein 3Add BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki470Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H7E2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H7E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7E2

PeptideAtlas

More...
PeptideAtlasi
Q9H7E2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7E2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81113 [Q9H7E2-1]
81114 [Q9H7E2-2]
81115 [Q9H7E2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H7E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000083544 Expressed in 221 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H7E2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H7E2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034925
HPA067153

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of mRNA stress granules.

Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN.

Interacts with 'Lys-48'-linked tetra-ubiquitin, but not with monoubiquitin or 'Lys-63'-linked ubiquitin chains. May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A.

Interacts with POLR2A (via the C-terminal domain (CTD)).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123514, 41 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1621 TDRD3-TOP3B type IA topoisomerase complex [Q9H7E2-3]

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H7E2

Database of interacting proteins

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DIPi
DIP-61935N

Protein interaction database and analysis system

More...
IntActi
Q9H7E2, 19 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000440190

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1651
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H7E2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H7E2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini193 – 233UBAPROSITE-ProRule annotationAdd BLAST41
Domaini555 – 615TudorPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni631 – 651EBM motif; may mediate interaction with the EJCAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3683 Eukaryota
ENOG4111KPK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155487

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154539

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H7E2

KEGG Orthology (KO)

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KOi
K18404

Identification of Orthologs from Complete Genome Data

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OMAi
FYHARID

Database of Orthologous Groups

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OrthoDBi
914913at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7E2

TreeFam database of animal gene trees

More...
TreeFami
TF316491

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14282 UBA_TDRD3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.50.770, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013894 RMI1_N
IPR042470 RMI1_N_2
IPR002999 Tudor
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041915 UBA_TDRD3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08585 RMI1_N, 1 hit
PF00567 TUDOR, 1 hit
PF00627 UBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333 TUDOR, 1 hit
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304 TUDOR, 1 hit
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRLQMTDGH ISCTAVEFSY MSKISLNTPP GTKVKLSGIV DIKNGFLLLN
60 70 80 90 100
DSNTTVLGGE VEHLIEKWEL QRSLSKHNRS NIGTEGGPPP FVPFGQKCVS
110 120 130 140 150
HVQVDSRELD RRKTLQVTMP VKPTNDNDEF EKQRTAAIAE VAKSKETKTF
160 170 180 190 200
GGGGGGARSN LNMNAAGNRN REVLQKEKST KSEGKHEGVY RELVDEKALK
210 220 230 240 250
HITEMGFSKE ASRQALMDNG NNLEAALNVL LTSNKQKPVM GPPLRGRGKG
260 270 280 290 300
RGRIRSEDEE DLGNARPSAP STLFDFLESK MGTLNVEEPK SQPQQLHQGQ
310 320 330 340 350
YRSSNTEQNG VKDNNHLRHP PRNDTRQPRN EKPPRFQRDS QNSKSVLEGS
360 370 380 390 400
GLPRNRGSER PSTSSVSEVW AEDRIKCDRP YSRYDRTKDT SYPLGSQHSD
410 420 430 440 450
GAFKKRDNSM QSRSGKGPSF AEAKENPLPQ GSVDYNNQKR GKRESQTSIP
460 470 480 490 500
DYFYDRKSQT INNEAFSGIK IEKHFNVNTD YQNPVRSNSF IGVPNGEVEM
510 520 530 540 550
PLKGRRIGPI KPAGPVTAVP CDDKIFYNSG PKRRSGPIKP EKILESSIPM
560 570 580 590 600
EYAKMWKPGD ECFALYWEDN KFYRAEVEAL HSSGMTAVVK FIDYGNYEEV
610 620 630 640 650
LLSNIKPIQT EAWEEEGTYD QTLEFRRGGD GQPRRSTRPT QQFYQPPRAR

N
Length:651
Mass (Da):73,185
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D82F323F6EF4B05
GO
Isoform 2 (identifier: Q9H7E2-2) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     97-97: Missing.

Show »
Length:650
Mass (Da):73,057
Checksum:i997FB4382F678469
GO
Isoform 3 (identifier: Q9H7E2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAQVAGAALS...NEESQAAPRM

Show »
Length:744
Mass (Da):83,103
Checksum:iCF27720025EFBD81
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMN9B1AMN9_HUMAN
Tudor domain-containing protein 3
TDRD3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Y2F2Z2Y2_HUMAN
Tudor domain-containing protein 3
TDRD3
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101H → R in AAH60876 (PubMed:15489334).Curated1
Sequence conflicti509P → H in AAH60876 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0370521M → MAQVAGAALSQAGWYLSDEG IEACTSSPDKVNVNDIILIA LNTDLRTIGKKFLPSDINSG KVEKLEGPCVLQIQKIRNVA APKDNEESQAAPRM in isoform 3. 1 Publication1
Alternative sequenceiVSP_03705397Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
EU643838 mRNA Translation: ACC94142.1
AK024660 mRNA Translation: BAB14950.1
BX537910 mRNA Translation: CAD97894.1
AL354764 Genomic DNA No translation available.
AL512666 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52079.1
BC030514 mRNA Translation: AAH30514.1
BC060876 mRNA Translation: AAH60876.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53872.1 [Q9H7E2-3]
CCDS9441.1 [Q9H7E2-1]

NCBI Reference Sequences

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RefSeqi
NP_001139542.1, NM_001146070.1 [Q9H7E2-3]
NP_001139543.1, NM_001146071.1 [Q9H7E2-1]
NP_110421.1, NM_030794.2 [Q9H7E2-1]
XP_016876266.1, XM_017020777.1 [Q9H7E2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000196169; ENSP00000196169; ENSG00000083544 [Q9H7E2-1]
ENST00000377881; ENSP00000367113; ENSG00000083544 [Q9H7E2-1]
ENST00000377894; ENSP00000367126; ENSG00000083544 [Q9H7E2-1]
ENST00000535286; ENSP00000440190; ENSG00000083544 [Q9H7E2-3]
ENST00000621840; ENSP00000477993; ENSG00000083544 [Q9H7E2-2]
ENST00000648252; ENSP00000498191; ENSG00000083544 [Q9H7E2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81550

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81550

UCSC genome browser

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UCSCi
uc001vhz.5 human [Q9H7E2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU643838 mRNA Translation: ACC94142.1
AK024660 mRNA Translation: BAB14950.1
BX537910 mRNA Translation: CAD97894.1
AL354764 Genomic DNA No translation available.
AL512666 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52079.1
BC030514 mRNA Translation: AAH30514.1
BC060876 mRNA Translation: AAH60876.1
CCDSiCCDS53872.1 [Q9H7E2-3]
CCDS9441.1 [Q9H7E2-1]
RefSeqiNP_001139542.1, NM_001146070.1 [Q9H7E2-3]
NP_001139543.1, NM_001146071.1 [Q9H7E2-1]
NP_110421.1, NM_030794.2 [Q9H7E2-1]
XP_016876266.1, XM_017020777.1 [Q9H7E2-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJINMR-A194-243[»]
2LTONMR-A554-608[»]
3PMTX-ray1.80A553-611[»]
3PNWX-ray2.05C/F/I/L/O/R/U/X540-615[»]
3S6WX-ray1.78A555-608[»]
5GVDX-ray1.62A/B1-68[»]
5GVEX-ray3.61B1-68[»]
5YJ8X-ray1.76A555-608[»]
SMRiQ9H7E2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123514, 41 interactors
ComplexPortaliCPX-1621 TDRD3-TOP3B type IA topoisomerase complex [Q9H7E2-3]
CORUMiQ9H7E2
DIPiDIP-61935N
IntActiQ9H7E2, 19 interactors
STRINGi9606.ENSP00000440190

Chemistry databases

ChEMBLiCHEMBL3879852

PTM databases

iPTMnetiQ9H7E2
PhosphoSitePlusiQ9H7E2

Polymorphism and mutation databases

BioMutaiTDRD3
DMDMi29337133

Proteomic databases

jPOSTiQ9H7E2
MassIVEiQ9H7E2
MaxQBiQ9H7E2
PaxDbiQ9H7E2
PeptideAtlasiQ9H7E2
PRIDEiQ9H7E2
ProteomicsDBi81113 [Q9H7E2-1]
81114 [Q9H7E2-2]
81115 [Q9H7E2-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9H7E2

The DNASU plasmid repository

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DNASUi
81550

Genome annotation databases

EnsembliENST00000196169; ENSP00000196169; ENSG00000083544 [Q9H7E2-1]
ENST00000377881; ENSP00000367113; ENSG00000083544 [Q9H7E2-1]
ENST00000377894; ENSP00000367126; ENSG00000083544 [Q9H7E2-1]
ENST00000535286; ENSP00000440190; ENSG00000083544 [Q9H7E2-3]
ENST00000621840; ENSP00000477993; ENSG00000083544 [Q9H7E2-2]
ENST00000648252; ENSP00000498191; ENSG00000083544 [Q9H7E2-1]
GeneIDi81550
KEGGihsa:81550
UCSCiuc001vhz.5 human [Q9H7E2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81550
DisGeNETi81550

GeneCards: human genes, protein and diseases

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GeneCardsi
TDRD3
HGNCiHGNC:20612 TDRD3
HPAiCAB034925
HPA067153
MIMi614392 gene
neXtProtiNX_Q9H7E2
OpenTargetsiENSG00000083544
PharmGKBiPA134962690

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3683 Eukaryota
ENOG4111KPK LUCA
GeneTreeiENSGT00940000155487
HOGENOMiHOG000154539
InParanoidiQ9H7E2
KOiK18404
OMAiFYHARID
OrthoDBi914913at2759
PhylomeDBiQ9H7E2
TreeFamiTF316491

Enzyme and pathway databases

SIGNORiQ9H7E2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TDRD3 human
EvolutionaryTraceiQ9H7E2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TDRD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81550
PharosiQ9H7E2

Protein Ontology

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PROi
PR:Q9H7E2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000083544 Expressed in 221 organ(s), highest expression level in heart
ExpressionAtlasiQ9H7E2 baseline and differential
GenevisibleiQ9H7E2 HS

Family and domain databases

CDDicd14282 UBA_TDRD3, 1 hit
Gene3Di2.40.50.770, 1 hit
InterProiView protein in InterPro
IPR013894 RMI1_N
IPR042470 RMI1_N_2
IPR002999 Tudor
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041915 UBA_TDRD3
PfamiView protein in Pfam
PF08585 RMI1_N, 1 hit
PF00567 TUDOR, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00333 TUDOR, 1 hit
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50304 TUDOR, 1 hit
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7E2
Secondary accession number(s): B2MWP9, Q53XA6, Q6P992
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2001
Last modified: November 13, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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