Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 163 (13 Feb 2019)
Sequence version 3 (20 Mar 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

WD repeat-containing protein 26

Gene

WDR26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).By similarity6 Publications

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H7D7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 26
Alternative name(s):
CUL4- and DDB1-associated WDR protein 2
Myocardial ischemic preconditioning up-regulated protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR26
Synonyms:CDW2, MIP2
ORF Names:PRO0852
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162923.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21208 WDR26

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7D7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Skraban-Deardorff syndrome (SKDEAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized by psychomotor developmental delay, intellectual disability with delayed speech, febrile and non-febrile seizures, abnormal gait, and facial dysmorphism. Facial features include a prominent maxilla and upper lip that readily reveal the upper gingiva, widely spaced teeth, and a broad nasal tip.
See also OMIM:617616
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07929746 – 661Missing in SKDEAS. 1 PublicationAdd BLAST616
Natural variantiVAR_079298172W → R in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079299215L → P in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079300254S → R in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079301279 – 661Missing in SKDEAS; unknown pathological significance. 1 PublicationAdd BLAST383
Natural variantiVAR_079302284D → N in SKDEAS; unknown pathological significance; slightly decreased protein expression;. 1 Publication1
Natural variantiVAR_079303426 – 661Missing in SKDEAS. 1 PublicationAdd BLAST236
Natural variantiVAR_079304428 – 661Missing in SKDEAS. 1 PublicationAdd BLAST234
Natural variantiVAR_079305524 – 661Missing in SKDEAS. 1 PublicationAdd BLAST138

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
80232

MalaCards human disease database

More...
MalaCardsi
WDR26
MIMi617616 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000162923

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
513456 Intellectual disability-seizures-abnormal gait-facial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907873

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134047967

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513731 – 661WD repeat-containing protein 26Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei121PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H7D7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H7D7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7D7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7D7

PeptideAtlas

More...
PeptideAtlasi
Q9H7D7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7D7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81109
81110 [Q9H7D7-2]
81111 [Q9H7D7-3]
81112 [Q9H7D7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed, with highest levels in heart and skeletal muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is significantly up-regulated by oxidative stress (PubMed:19446606).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162923 Expressed in 225 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H7D7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H7D7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028539
HPA061094

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers (PubMed:23625927). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with DDB1-CUL4A/B E3 ligase complexes (PubMed:17041588). Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:22065575, PubMed:23625927). Interacts with AXIN1 (PubMed:27098453).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AXIN1O151694EBI-1046864,EBI-710484

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123195, 104 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H7D7

Protein interaction database and analysis system

More...
IntActi
Q9H7D7, 38 interactors

Molecular INTeraction database

More...
MINTi
Q9H7D7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000408108

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H7D7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 155LisHPROSITE-ProRule annotationAdd BLAST33
Domaini156 – 231CTLHPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati353 – 392WD 1Add BLAST40
Repeati399 – 438WD 2Add BLAST40
Repeati444 – 484WD 3Add BLAST41
Repeati524 – 563WD 4Add BLAST40
Repeati566 – 608WD 5Add BLAST43
Repeati611 – 651WD 6Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0293 Eukaryota
ENOG410XQ2U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153634

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG083958

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H7D7

KEGG Orthology (KO)

More...
KOi
K22382

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCLYHNT

Database of Orthologous Groups

More...
OrthoDBi
349428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7D7

TreeFam database of animal gene trees

More...
TreeFami
TF314869

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00668 CTLH, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA
60 70 80 90 100
GDLAHANGLL PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA
110 120 130 140 150
ASSSLATPEL GSSLKKKKRL SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE
160 170 180 190 200
SGCRLEHPSA TKFRNHVMEG DWDKAENDLN ELKPLVHSPH AIVVRGALEI
210 220 230 240 250
SQTLLGIIVR MKFLLLQQKY LEYLEDGKVL EALQVLRCEL TPLKYNTERI
260 270 280 290 300
HVLSGYLMCS HAEDLRAKAE WEGKGTASRS KLLDKLQTYL PPSVMLPPRR
310 320 330 340 350
LQTLLRQAVE LQRDRCLYHN TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI
360 370 380 390 400
LTEHCNEVWF CKFSNDGTKL ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH
410 420 430 440 450
AYGVSYIAWS PDDNYLVACG PDDCSELWLW NVQTGELRTK MSQSHEDSLT
460 470 480 490 500
SVAWNPDGKR FVTGGQRGQF YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV
510 520 530 540 550
LASDTHQRIR GYNFEDLTDR NIVQEDHPIM SFTISKNGRL ALLNVATQGV
560 570 580 590 600
HLWDLQDRVL VRKYQGVTQG FYTIHSCFGG HNEDFIASGS EDHKVYIWHK
610 620 630 640 650
RSELPIAELT GHTRTVNCVS WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ
660
NIEEECSSMD S
Length:661
Mass (Da):72,124
Last modified:March 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0B8AAFF44CB7DF7
GO
Isoform 2 (identifier: Q9H7D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-207: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):70,460
Checksum:i664C8EA291526315
GO
Isoform 3 (identifier: Q9H7D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-216: VRGALEISQTLLGIIVRMKFLLL → AQTFSETSINFFPLTAAFCHVRG
     217-661: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):21,314
Checksum:i0CA772E9A8A59012
GO
Isoform 4 (identifier: Q9H7D7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-223: RMKFLLLQQKYLEY → VNTLLFLVSHLCLF
     224-661: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):22,052
Checksum:i7880CBDF91D06DA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9R3H0Y9R3_HUMAN
WD repeat-containing protein 26
WDR26
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCS7C9JCS7_HUMAN
WD repeat-containing protein 26
WDR26
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y917H0Y917_HUMAN
WD repeat-containing protein 26
WDR26
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG35477 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH52301 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH63817 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO67709 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ74770 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABK41102 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14955 differs from that shown. Reason: Erroneous termination at position 274. Translated as Lys.Curated
The sequence BAD93124 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8G → A in AAH34498 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07929746 – 661Missing in SKDEAS. 1 PublicationAdd BLAST616
Natural variantiVAR_079298172W → R in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079299215L → P in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079300254S → R in SKDEAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_079301279 – 661Missing in SKDEAS; unknown pathological significance. 1 PublicationAdd BLAST383
Natural variantiVAR_079302284D → N in SKDEAS; unknown pathological significance; slightly decreased protein expression;. 1 Publication1
Natural variantiVAR_079303426 – 661Missing in SKDEAS. 1 PublicationAdd BLAST236
Natural variantiVAR_079304428 – 661Missing in SKDEAS. 1 PublicationAdd BLAST234
Natural variantiVAR_079305524 – 661Missing in SKDEAS. 1 PublicationAdd BLAST138

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023895192 – 207Missing in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_023896194 – 216VRGAL…KFLLL → AQTFSETSINFFPLTAAFCH VRG in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_023897210 – 223RMKFL…KYLEY → VNTLLFLVSHLCLF in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_023898217 – 661Missing in isoform 3. 1 PublicationAdd BLAST445
Alternative sequenceiVSP_023899224 – 661Missing in isoform 4. 1 PublicationAdd BLAST438

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209887 mRNA Translation: BAD93124.1 Different initiation.
AC099790 Genomic DNA No translation available.
BC031471 mRNA Translation: AAH31471.2
BC034498 mRNA Translation: AAH34498.1
BC052301 mRNA Translation: AAH52301.2 Different initiation.
BC063817 mRNA Translation: AAH63817.2 Different initiation.
AY221751 mRNA Translation: AAO67709.1 Different initiation.
AY304473 mRNA Translation: AAQ74770.1 Different initiation.
AF130049 mRNA Translation: AAG35477.1 Different initiation.
EF011612 mRNA Translation: ABK41102.1 Different initiation.
AK024669 mRNA Translation: BAB14955.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31037.2 [Q9H7D7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001108585.2, NM_001115113.2 [Q9H7D7-2]
NP_079436.4, NM_025160.6 [Q9H7D7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497873
Hs.729289

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000414423; ENSP00000408108; ENSG00000162923 [Q9H7D7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80232

UCSC genome browser

More...
UCSCi
uc001hop.4 human [Q9H7D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209887 mRNA Translation: BAD93124.1 Different initiation.
AC099790 Genomic DNA No translation available.
BC031471 mRNA Translation: AAH31471.2
BC034498 mRNA Translation: AAH34498.1
BC052301 mRNA Translation: AAH52301.2 Different initiation.
BC063817 mRNA Translation: AAH63817.2 Different initiation.
AY221751 mRNA Translation: AAO67709.1 Different initiation.
AY304473 mRNA Translation: AAQ74770.1 Different initiation.
AF130049 mRNA Translation: AAG35477.1 Different initiation.
EF011612 mRNA Translation: ABK41102.1 Different initiation.
AK024669 mRNA Translation: BAB14955.1 Sequence problems.
CCDSiCCDS31037.2 [Q9H7D7-1]
RefSeqiNP_001108585.2, NM_001115113.2 [Q9H7D7-2]
NP_079436.4, NM_025160.6 [Q9H7D7-1]
UniGeneiHs.497873
Hs.729289

3D structure databases

ProteinModelPortaliQ9H7D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123195, 104 interactors
CORUMiQ9H7D7
IntActiQ9H7D7, 38 interactors
MINTiQ9H7D7
STRINGi9606.ENSP00000408108

PTM databases

iPTMnetiQ9H7D7
PhosphoSitePlusiQ9H7D7

Polymorphism and mutation databases

BioMutaiWDR26
DMDMi134047967

Proteomic databases

EPDiQ9H7D7
jPOSTiQ9H7D7
MaxQBiQ9H7D7
PaxDbiQ9H7D7
PeptideAtlasiQ9H7D7
PRIDEiQ9H7D7
ProteomicsDBi81109
81110 [Q9H7D7-2]
81111 [Q9H7D7-3]
81112 [Q9H7D7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414423; ENSP00000408108; ENSG00000162923 [Q9H7D7-1]
GeneIDi80232
KEGGihsa:80232
UCSCiuc001hop.4 human [Q9H7D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80232
DisGeNETi80232
EuPathDBiHostDB:ENSG00000162923.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR26
HGNCiHGNC:21208 WDR26
HPAiHPA028539
HPA061094
MalaCardsiWDR26
MIMi617424 gene
617616 phenotype
neXtProtiNX_Q9H7D7
OpenTargetsiENSG00000162923
Orphaneti513456 Intellectual disability-seizures-abnormal gait-facial dysmorphism syndrome
PharmGKBiPA134907873

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0293 Eukaryota
ENOG410XQ2U LUCA
GeneTreeiENSGT00940000153634
HOVERGENiHBG083958
InParanoidiQ9H7D7
KOiK22382
OMAiQCLYHNT
OrthoDBi349428at2759
PhylomeDBiQ9H7D7
TreeFamiTF314869

Enzyme and pathway databases

SignaLinkiQ9H7D7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR26 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WDR26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80232

Protein Ontology

More...
PROi
PR:Q9H7D7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162923 Expressed in 225 organ(s), highest expression level in sperm
ExpressionAtlasiQ9H7D7 baseline and differential
GenevisibleiQ9H7D7 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR26_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7D7
Secondary accession number(s): A0MNN3
, Q4G100, Q59EC4, Q5GLZ9, Q86UY4, Q9H3C2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 20, 2007
Last modified: February 13, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again