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Entry version 153 (22 Apr 2020)
Sequence version 3 (12 Dec 2006)
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Protein

Dedicator of cytokinesis protein 5

Gene

DOCK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23476 DOCK5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616904 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H7D0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80005

Open Targets

More...
OpenTargetsi
ENSG00000147459

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134932307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H7D0 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DOCK5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119370380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899921 – 1870Dedicator of cytokinesis protein 5Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei365PhosphoserineCombined sources1
Modified residuei818N6-acetyllysineCombined sources1
Modified residuei1756PhosphoserineCombined sources1
Modified residuei1766PhosphoserineCombined sources1
Modified residuei1785PhosphoserineBy similarity1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1794PhosphothreonineCombined sources1
Modified residuei1814PhosphothreonineCombined sources1
Modified residuei1834PhosphoserineCombined sources1
Modified residuei1869PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H7D0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H7D0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H7D0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H7D0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H7D0

PeptideAtlas

More...
PeptideAtlasi
Q9H7D0

PRoteomics IDEntifications database

More...
PRIDEi
Q9H7D0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81105 [Q9H7D0-1]
81106 [Q9H7D0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H7D0

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H7D0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H7D0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147459 Expressed in corpus callosum and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H7D0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H7D0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147459 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CRK and CRKL.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123062, 70 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9H7D0

Protein interaction database and analysis system

More...
IntActi
Q9H7D0, 74 interactors

Molecular INTeraction database

More...
MINTi
Q9H7D0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H7D0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H7D0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 69SH3PROSITE-ProRule annotationAdd BLAST62
Domaini443 – 627C2 DOCK-typePROSITE-ProRule annotationAdd BLAST185
Domaini1231 – 1642DOCKERPROSITE-ProRule annotationAdd BLAST412

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1782 – 1855Pro-richAdd BLAST74

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain may mediate some GEF activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1998 Eukaryota
ENOG410XQH7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157734

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039802_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H7D0

KEGG Orthology (KO)

More...
KOi
K17707

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRPLPRI

Database of Orthologous Groups

More...
OrthoDBi
102580at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H7D0

TreeFam database of animal gene trees

More...
TreeFami
TF300423

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.350, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR030717 DOCK1/DOCK5
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR042455 DOCK_N_sub1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR45653 PTHR45653, 1 hit
PTHR45653:SF3 PTHR45653:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 C2_DOCK, 1 hit
PS51651 DOCKER, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL
60 70 80 90 100
QNKSKKGIFP ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV
110 120 130 140 150
IWRKLYVNNK LTLFRQLQQM TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA
160 170 180 190 200
KIDHGNRMLG LDLVVRDDNG NILDPDETST IALFKAHEVA SKRIEEKIQE
210 220 230 240 250
EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE LFMALYDPDQ
260 270 280 290 300
STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI
310 320 330 340 350
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ
360 370 380 390 400
IAMETYIRQR QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW
410 420 430 440 450
VSLKLLPGDL TQVQKNFSHL VDRSTAIARK MGFPEIILPG DVRNDIYVTL
460 470 480 490 500
IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL EKAIHPGAGY EGISEYKSVV
510 520 530 540 550
YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR DKSERAFGVA
560 570 580 590 600
FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL
610 620 630 640 650
QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI
660 670 680 690 700
KHNLKKLMEV DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI
710 720 730 740 750
ISLIGDIKFQ HFNPVLETYI YKHFSATLAY VKLSKVLNFY VANADDSSKT
760 770 780 790 800
ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ SKDGDEFNNS IRQLFLAFNM
810 820 830 840 850
LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF CKFIQSIPDN
860 870 880 890 900
QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE
910 920 930 940 950
ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI
960 970 980 990 1000
GSFVACMIAL LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN
1010 1020 1030 1040 1050
VYAKDWMVMN MTQNRVFLRA INQFAEVLTR FFMDQASFEL QLWNNYFHLA
1060 1070 1080 1090 1100
VAFLTHESLQ LETFSQAKRN KIVKKYGDMR KEIGFRIRDM WYNLGPHKIK
1110 1120 1130 1140 1150
FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG NGNFHMFENE
1160 1170 1180 1190 1200
LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
1210 1220 1230 1240 1250
LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL
1260 1270 1280 1290 1300
HRDCENYTEA AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL
1310 1320 1330 1340 1350
YQEIISYFDK GKMWEKAIKL SKELAETYES KVFDYEGLGN LLKKRASFYE
1360 1370 1380 1390 1400
NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI FIYRGKEYER REDFSLRLLT
1410 1420 1430 1440 1450
QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS YKDKPVPEQI
1460 1470 1480 1490 1500
LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
1510 1520 1530 1540 1550
WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML
1560 1570 1580 1590 1600
LSGIVDPAVM GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL
1610 1620 1630 1640 1650
TEGIRIHGEK LTEQLKPLHE RLSSCFRELK EKVEKHYGVI TLPPNLTERK
1660 1670 1680 1690 1700
QSRTGSIVLP YIMSSTLRRL SITSVTSSVV STSSNSSDNA PSRPGSDGSI
1710 1720 1730 1740 1750
LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS KSQVIAEKAP
1760 1770 1780 1790 1800
EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT
1810 1820 1830 1840 1850
LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP
1860 1870
PPPPPKARKS GIPTSEPGSQ
Length:1,870
Mass (Da):215,309
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i947A3DC1190EF7A9
GO
Isoform 2 (identifier: Q9H7D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-1870: Missing.

Show »
Length:350
Mass (Da):40,421
Checksum:iCFC696403289D76F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7N4H0Y7N4_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
1,090Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9A015B9A015_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB14H0YB14_HUMAN
Dedicator of cytokinesis protein 5
DOCK5
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14962 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti987M → L in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1161G → E in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1548S → Y in CAH10503 (PubMed:17974005).Curated1
Sequence conflicti1833N → S in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1842P → S in CAH10503 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033886250Q → R. Corresponds to variant dbSNP:rs17053341Ensembl.1
Natural variantiVAR_0530651023Q → R. Corresponds to variant dbSNP:rs2271111Ensembl.1
Natural variantiVAR_0530661285K → R2 PublicationsCorresponds to variant dbSNP:rs2659585Ensembl.1
Natural variantiVAR_0338871836E → K. Corresponds to variant dbSNP:rs35688737Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021868351 – 1870Missing in isoform 2. 1 PublicationAdd BLAST1520

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC041005 Genomic DNA No translation available.
AC091185 Genomic DNA No translation available.
BC011877 mRNA Translation: AAH11877.1
BC041761 mRNA Translation: AAH41761.2
BC137175 mRNA Translation: AAI37176.1
BC137176 mRNA Translation: AAI37177.1
AK024687 mRNA Translation: BAB14962.1 Different initiation.
AK126249 mRNA Translation: BAC86503.1 Different initiation.
CR627414 mRNA Translation: CAH10503.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6047.1 [Q9H7D0-1]

NCBI Reference Sequences

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RefSeqi
NP_079216.4, NM_024940.7 [Q9H7D0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000276440; ENSP00000276440; ENSG00000147459 [Q9H7D0-1]
ENST00000481100; ENSP00000429737; ENSG00000147459 [Q9H7D0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80005

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80005

UCSC genome browser

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UCSCi
uc003xef.4 human [Q9H7D0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC041005 Genomic DNA No translation available.
AC091185 Genomic DNA No translation available.
BC011877 mRNA Translation: AAH11877.1
BC041761 mRNA Translation: AAH41761.2
BC137175 mRNA Translation: AAI37176.1
BC137176 mRNA Translation: AAI37177.1
AK024687 mRNA Translation: BAB14962.1 Different initiation.
AK126249 mRNA Translation: BAC86503.1 Different initiation.
CR627414 mRNA Translation: CAH10503.1
CCDSiCCDS6047.1 [Q9H7D0-1]
RefSeqiNP_079216.4, NM_024940.7 [Q9H7D0-1]

3D structure databases

SMRiQ9H7D0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123062, 70 interactors
ELMiQ9H7D0
IntActiQ9H7D0, 74 interactors
MINTiQ9H7D0
STRINGi9606.ENSP00000276440

PTM databases

iPTMnetiQ9H7D0
MetOSiteiQ9H7D0
PhosphoSitePlusiQ9H7D0

Polymorphism and mutation databases

BioMutaiDOCK5
DMDMi119370380

Proteomic databases

EPDiQ9H7D0
jPOSTiQ9H7D0
MassIVEiQ9H7D0
MaxQBiQ9H7D0
PaxDbiQ9H7D0
PeptideAtlasiQ9H7D0
PRIDEiQ9H7D0
ProteomicsDBi81105 [Q9H7D0-1]
81106 [Q9H7D0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2898 82 antibodies

Genome annotation databases

EnsembliENST00000276440; ENSP00000276440; ENSG00000147459 [Q9H7D0-1]
ENST00000481100; ENSP00000429737; ENSG00000147459 [Q9H7D0-2]
GeneIDi80005
KEGGihsa:80005
UCSCiuc003xef.4 human [Q9H7D0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80005
DisGeNETi80005

GeneCards: human genes, protein and diseases

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GeneCardsi
DOCK5
HGNCiHGNC:23476 DOCK5
HPAiENSG00000147459 Low tissue specificity
MIMi616904 gene
neXtProtiNX_Q9H7D0
OpenTargetsiENSG00000147459
PharmGKBiPA134932307

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00940000157734
HOGENOMiCLU_039802_0_0_1
InParanoidiQ9H7D0
KOiK17707
OMAiWRPLPRI
OrthoDBi102580at2759
PhylomeDBiQ9H7D0
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DOCK5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dock5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80005
PharosiQ9H7D0 Tbio

Protein Ontology

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PROi
PR:Q9H7D0
RNActiQ9H7D0 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147459 Expressed in corpus callosum and 198 other tissues
ExpressionAtlasiQ9H7D0 baseline and differential
GenevisibleiQ9H7D0 HS

Family and domain databases

Gene3Di1.20.1270.350, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR030717 DOCK1/DOCK5
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR042455 DOCK_N_sub1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR45653 PTHR45653, 1 hit
PTHR45653:SF3 PTHR45653:SF3, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 C2_DOCK, 1 hit
PS51651 DOCKER, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H7D0
Secondary accession number(s): B2RNY0
, Q5XKD5, Q6AI11, Q6PJS6, Q6ZTS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: December 12, 2006
Last modified: April 22, 2020
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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