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Protein

Syncoilin

Gene

SYNC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Syncoilin
Alternative name(s):
Syncoilin intermediate filament 1
Syncoilin-1
Gene namesi
Name:SYNC
Synonyms:SYNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162520.14
HGNCiHGNC:28897 SYNC
MIMi611750 gene
neXtProtiNX_Q9H7C4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162520
PharmGKBiPA164726395

Polymorphism and mutation databases

BioMutaiSYNC
DMDMi300669677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061801 – 482SyncoilinAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei325PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H7C4
PaxDbiQ9H7C4
PeptideAtlasiQ9H7C4
PRIDEiQ9H7C4
ProteomicsDBi81100
81101 [Q9H7C4-2]

PTM databases

iPTMnetiQ9H7C4
PhosphoSitePlusiQ9H7C4

Expressioni

Inductioni

Up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease.1 Publication

Gene expression databases

BgeeiENSG00000162520 Expressed in 206 organ(s), highest expression level in biceps brachii
CleanExiHS_SYNC
ExpressionAtlasiQ9H7C4 baseline and differential
GenevisibleiQ9H7C4 HS

Organism-specific databases

HPAiHPA028311

Interactioni

Subunit structurei

May link the dystrophin-associated glycoprotein complex (DAPC) to intracellular desmin (DES) filaments. Interacts with DES and DTNA.By similarity

Protein-protein interaction databases

BioGridi123502, 49 interactors
IntActiQ9H7C4, 3 interactors
STRINGi9606.ENSP00000386439

Structurei

3D structure databases

ProteinModelPortaliQ9H7C4
SMRiQ9H7C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 463IF rodPROSITE-ProRule annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 161HeadAdd BLAST161
Regioni170 – 204Coil 1AAdd BLAST35
Regioni205 – 231Linker 1Add BLAST27
Regioni232 – 309Coil 1bAdd BLAST78
Regioni310 – 349Linker 2Add BLAST40
Regioni350 – 458Coil 2Add BLAST109
Regioni459 – 482TailAdd BLAST24

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKIK Eukaryota
ENOG410Y2YI LUCA
GeneTreeiENSGT00390000018108
HOGENOMiHOG000010275
HOVERGENiHBG108528
InParanoidiQ9H7C4
KOiK10377
OMAiQLECRRQ
OrthoDBiEOG091G0V3M
PhylomeDBiQ9H7C4

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR027702 Syncoilin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF216 PTHR23239:SF216, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H7C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPEPRRGG DGAAQAARKT RVEANSPLPK NSGSLNEAEA LNPEVTLSSE
60 70 80 90 100
GSLNLEDILY LEDTGDLDET LYVQETEKAE EALYIEEAMQ PDEALHVEEP
110 120 130 140 150
GNPEETVCVE ETTEPDRIQF VEGPVEPGKP TSPEHVVYEG ETVTRAEKSN
160 170 180 190 200
PEESLRAEQS PSMEENLSIE DLELLEGRFQ QCVQAVAQLE EERDQLIHEL
210 220 230 240 250
VLLREPALQE VQQVHQDILA AYKLHAQAEL ERDGLREEIR LVKQKLFKVT
260 270 280 290 300
KECVAYQYQL ECRQQDVAQF ADFREVLTTR ATQLSEELAQ LRDAYQKQKE
310 320 330 340 350
QLRQQLEAPP SQRDGHFLQE SRRLSAQFEN LMAESRQDLE EEYEPQFLRL
360 370 380 390 400
LERKEAGTKA LQRTQAEIQE MKEALRPLQA EARQLRLQNR NLEDQIALVR
410 420 430 440 450
QKRDEEVQQY REQLEEMEER QRQLRNGVQL QQQKNKEMEQ LRLSLAEELS
460 470 480
TYKAMLLPKS LEQADAPTSQ AGGMETQSQG AV
Length:482
Mass (Da):55,299
Last modified:July 13, 2010 - v3
Checksum:i969F2DA9C48C858B
GO
Isoform 2 (identifier: Q9H7C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-482: AMLLPKSLEQADAPTSQAGGMETQSQGAV → GCLEIYGQICNPETAKNFLAKDH

Show »
Length:476
Mass (Da):54,947
Checksum:i2B3ADA20445CCE58
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTN4C9JTN4_HUMAN
Syncoilin
SYNC
70Annotation score:
C9JSS1C9JSS1_HUMAN
Syncoilin
SYNC
89Annotation score:

Sequence cautioni

The sequence AAI19701 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI19702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14970 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58I → T in BAG60270 (PubMed:14702039).Curated1
Sequence conflicti163M → V in BAG63620 (PubMed:14702039).Curated1
Sequence conflicti163M → V in BAG60270 (PubMed:14702039).Curated1
Sequence conflicti274R → Q in BAG63620 (PubMed:14702039).Curated1
Sequence conflicti274R → Q in BAG60270 (PubMed:14702039).Curated1
Sequence conflicti328F → S in BAG60270 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039404454 – 482AMLLP…SQGAV → GCLEIYGQICNPETAKNFLA KDH in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024707 mRNA Translation: BAB14970.1 Different initiation.
AK297958 mRNA Translation: BAG60270.1
AK302275 mRNA Translation: BAG63620.1
AC114489 Genomic DNA No translation available.
BC119700 mRNA Translation: AAI19701.1 Different initiation.
BC119701 mRNA Translation: AAI19702.1 Different initiation.
CCDSiCCDS367.2 [Q9H7C4-1]
CCDS53294.1 [Q9H7C4-2]
RefSeqiNP_001155180.1, NM_001161708.1
NP_110413.2, NM_030786.2
UniGeneiHs.712631

Genome annotation databases

EnsembliENST00000373484; ENSP00000362583; ENSG00000162520 [Q9H7C4-2]
ENST00000409190; ENSP00000386439; ENSG00000162520 [Q9H7C4-1]
GeneIDi81493
KEGGihsa:81493
UCSCiuc001bvt.3 human [Q9H7C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024707 mRNA Translation: BAB14970.1 Different initiation.
AK297958 mRNA Translation: BAG60270.1
AK302275 mRNA Translation: BAG63620.1
AC114489 Genomic DNA No translation available.
BC119700 mRNA Translation: AAI19701.1 Different initiation.
BC119701 mRNA Translation: AAI19702.1 Different initiation.
CCDSiCCDS367.2 [Q9H7C4-1]
CCDS53294.1 [Q9H7C4-2]
RefSeqiNP_001155180.1, NM_001161708.1
NP_110413.2, NM_030786.2
UniGeneiHs.712631

3D structure databases

ProteinModelPortaliQ9H7C4
SMRiQ9H7C4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123502, 49 interactors
IntActiQ9H7C4, 3 interactors
STRINGi9606.ENSP00000386439

PTM databases

iPTMnetiQ9H7C4
PhosphoSitePlusiQ9H7C4

Polymorphism and mutation databases

BioMutaiSYNC
DMDMi300669677

Proteomic databases

MaxQBiQ9H7C4
PaxDbiQ9H7C4
PeptideAtlasiQ9H7C4
PRIDEiQ9H7C4
ProteomicsDBi81100
81101 [Q9H7C4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373484; ENSP00000362583; ENSG00000162520 [Q9H7C4-2]
ENST00000409190; ENSP00000386439; ENSG00000162520 [Q9H7C4-1]
GeneIDi81493
KEGGihsa:81493
UCSCiuc001bvt.3 human [Q9H7C4-1]

Organism-specific databases

CTDi81493
EuPathDBiHostDB:ENSG00000162520.14
GeneCardsiSYNC
H-InvDBiHIX0000378
HGNCiHGNC:28897 SYNC
HPAiHPA028311
MIMi611750 gene
neXtProtiNX_Q9H7C4
OpenTargetsiENSG00000162520
PharmGKBiPA164726395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIK Eukaryota
ENOG410Y2YI LUCA
GeneTreeiENSGT00390000018108
HOGENOMiHOG000010275
HOVERGENiHBG108528
InParanoidiQ9H7C4
KOiK10377
OMAiQLECRRQ
OrthoDBiEOG091G0V3M
PhylomeDBiQ9H7C4

Miscellaneous databases

ChiTaRSiSYNC human
GenomeRNAii81493
PROiPR:Q9H7C4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162520 Expressed in 206 organ(s), highest expression level in biceps brachii
CleanExiHS_SYNC
ExpressionAtlasiQ9H7C4 baseline and differential
GenevisibleiQ9H7C4 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR027702 Syncoilin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF216 PTHR23239:SF216, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYNCI_HUMAN
AccessioniPrimary (citable) accession number: Q9H7C4
Secondary accession number(s): B4DNK8, B4DY58, C9IY41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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