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Protein

Inactive tyrosine-protein kinase PEAK1

Gene

PEAK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654).3 Publications

Caution

Has been the subject of controversy surrounding its catalytic capabilities. Early characterization of PEAK1 gave a weak in vitro tyrosine kinase activity (PubMed:20534451). The crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft that in this conformation may deleteriously affect nucleotide binding (PubMed:29212708). Furthermore PEAK1 is devoid of nucleotide binding activity, as detected by a thermal-shift assay (PubMed:24107129). So it seems probable that PEAK1 is an inactive kinase.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
  • protein kinase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H792

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive tyrosine-protein kinase PEAK1Curated
Alternative name(s):
Pseudopodium-enriched atypical kinase 11 Publication
Sugen kinase 2691 Publication
Tyrosine-protein kinase SgK269
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEAK1
Synonyms:KIAA2002
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173517.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29431 PEAK1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614248 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H792

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi665Y → E: No effect on localization with actin. Decreases localization in focal adhesion. Fails to regulate focal adhesion dynamics. Decreases cell migration. 1 Publication1
Mutagenesisi665Y → F: No effect on focal adhesion subcellular localization. Does not affect colocalization with F-actin. 1 Publication1
Mutagenesisi1188Y → F: Fails to bind SHC1. 1 Publication1
Mutagenesisi1609F → A: No effect on interaction with PRAG1. 1 Publication1
Mutagenesisi1707A → D: Disrupts homodimerization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79834

Open Targets

More...
OpenTargetsi
ENSG00000173517

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3627585

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEAK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223634730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002505891 – 1746Inactive tyrosine-protein kinase PEAK1Add BLAST1746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei281PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei635PhosphotyrosineCombined sources1
Modified residuei641PhosphotyrosineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei665Phosphotyrosine1 Publication1
Modified residuei826PhosphoserineBy similarity1
Modified residuei854PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineCombined sources1
Modified residuei1188Phosphotyrosine1 Publication1
Modified residuei1374PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation (PubMed:20534451). Phosphorylation at Tyr-665 by a Src family kinase controls subcellular localization to focal adhesion and focal adhesion dynamics (PubMed:20534451). Phosphorylation at Tyr-1188 is essential for binding to SHC1 (PubMed:23846654).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H792

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H792

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H792

PeptideAtlas

More...
PeptideAtlasi
Q9H792

PRoteomics IDEntifications database

More...
PRIDEi
Q9H792

ProteomicsDB human proteome resource

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ProteomicsDBi
81090

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1692

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H792

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H792

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000173517 Expressed in 206 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H792 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H792 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026313
HPA026517

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:29212708). Interacts with BCAR1 and CRK (PubMed:20534451). Interacts with PRAG1 (PubMed:29079850). Interacts (when phosphorylated at Tyr-1188) with SHC1 (via PID domain) (PubMed:23846654). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BCAR1P569453EBI-2609701,EBI-702093

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122926, 34 interactors

Database of interacting proteins

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DIPi
DIP-56276N

Protein interaction database and analysis system

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IntActi
Q9H792, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11746
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H792

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H792

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1313 – 1675Protein kinasePROSITE-ProRule annotationAdd BLAST363

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1285 – 1311Required for homodimerization1 PublicationAdd BLAST27
Regioni1670 – 1743Required for homodimerization1 PublicationAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 120Poly-Asn4
Compositional biasi324 – 406Ser-richAdd BLAST83
Compositional biasi500 – 503Poly-Ser4
Compositional biasi776 – 873Pro-richAdd BLAST98
Compositional biasi964 – 967Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The dimerization region encompasses helices both from the N- and C-terminal of the protein kinase domain.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJMD Eukaryota
ENOG4110SRP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157591

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG093946

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H792

KEGG Orthology (KO)

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KOi
K17538

Identification of Orthologs from Complete Genome Data

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OMAi
PRKNCHK

Database of Orthologous Groups

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OrthoDBi
EOG091G03K2

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H792

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDPEKAPITH GNVKTNANHS
60 70 80 90 100
NNHRIRNTGN FRPPVAKKPT IAVKPTMIVA DGQSICGELS IQEHCENKPV
110 120 130 140 150
IIGWNRNRAA LSQKPLNNNN EDDEGISHVP KPYGNNDSAK KMSDNNNGLT
160 170 180 190 200
EVLKEIAGLD TAPQIRGNET NSRETFLGRI NDCYKRSLER KLPPSCMIGG
210 220 230 240 250
IKETQGKHVI LSGSTEVISN EGGRFCYPEF SSGEESEEDV LFSNMEEEHE
260 270 280 290 300
SWDESDEELL AMEIRMRGQP RFANFRANTL SPVRFFVDKK WNTIPLRNKS
310 320 330 340 350
LQRICAVDYD DSYDEILNGY EENSVVSYGQ GSIQSMVSSD STSPDSSLTE
360 370 380 390 400
ESRSETASSL SQKICNGGLS PGNPGDSKDM KEIEPNYESP SSNNQDKDSS
410 420 430 440 450
QASKSSIKVP ETHKAVLALR LEEKDGKIAV QTEKEESKAS TDVAGQAVTI
460 470 480 490 500
NLVPTEEQAK PYRVVNLEQP LCKPYTVVDV SAAMASEHLE GPVNSPKTKS
510 520 530 540 550
SSSTPNSPVT SSSLTPGQIS AHFQKSSAIR YQEVWTSSTS PRQKIPKVEL
560 570 580 590 600
ITSGTGPNVP PRKNCHKSAP TSPTATNISS KTIPVKSPNL SEIKFNSYNN
610 620 630 640 650
AGMPPFPIII HDEPTYARSS KNAIKVPIVI NPNAYDNLAI YKSFLGTSGE
660 670 680 690 700
LSVKEKTTSV ISHTYEEIET ESKVPDNTTS KTTDCLQTKG FSNSTEHKRG
710 720 730 740 750
SVAQKVQEFN NCLNRGQSSP QRSYSSSHSS PAKIQRATQE PVAKIEGTQE
760 770 780 790 800
SQMVGSSSTR EKASTVLSQI VASIQPPQSP PETPQSGPKA CSVEELYAIP
810 820 830 840 850
PDADVAKSTP KSTPVRPKSL FTSQPSGEAE APQTTDSPTT KVQKDPSIKP
860 870 880 890 900
VTPSPSKLVT SPQSEPPAPF PPPRSTSSPY HAGNLLQRHF TNWTKPTSPT
910 920 930 940 950
RSTEAESVLH SEGSRRAADA KPKRWISFKS FFRRRKTDEE DDKEKEREKG
960 970 980 990 1000
KLVGLDGTVI HMLPPPPVQR HHWFTEAKGE SSEKPAIVFM YRCDPAQGQL
1010 1020 1030 1040 1050
SVDQSKARTD QAAVMEKGRA ENALLQDSEK KRSHSSPSQI PKKILSHMTH
1060 1070 1080 1090 1100
EVTEDFSPRD PRTVVGKQDG RGCTSVTTAL SLPELEREDG KEDISDPMDP
1110 1120 1130 1140 1150
NPCSATYSNL GQSRAAMIPP KQPRQPKGAV DDAIAFGGKT DQEAPNASQP
1160 1170 1180 1190 1200
TPPPLPKKMI IRANTEPISK DLQKSMESSL CVMANPTYDI DPNWDASSAG
1210 1220 1230 1240 1250
SSISYELKGL DIESYDSLER PLRKERPVPS AANSISSLTT LSIKDRFSNS
1260 1270 1280 1290 1300
MESLSSRRGP SCRQGRGIQK PQRQALYRGL ENREEVVGKI RSLHTDALKK
1310 1320 1330 1340 1350
LAVKCEDLFM AGQKDQLRFG VDSWSDFRLT SDKPCCEAGD AVYYTASYAK
1360 1370 1380 1390 1400
DPLNNYAVKI CKSKAKESQQ YYHSLAVRQS LAVHFNIQQD CGHFLAEVPN
1410 1420 1430 1440 1450
RLLPWEDPDD PEKDEDDMEE TEEDAKGETD GKNPKPCSEA ASSQKENQGV
1460 1470 1480 1490 1500
MSKKQRSHVV VITREVPCLT VADFVRDSLA QHGKSPDLYE RQVCLLLLQL
1510 1520 1530 1540 1550
CSGLEHLKPY HVTHCDLRLE NLLLVHYQPG GTAQGFGPAE PSPTSSYPTR
1560 1570 1580 1590 1600
LIVSNFSQAK QKSHLVDPEI LRDQSRLAPE IITATQYKKC DEFQTGILIY
1610 1620 1630 1640 1650
EMLHLPNPFD ENPELKEREY TRADLPRIPF RSPYSRGLQQ LASCLLNPNP
1660 1670 1680 1690 1700
SERILISDAK GILQCLLWGP REDLFQTFTA CPSLVQRNTL LQNWLDIKRT
1710 1720 1730 1740
LLMIKFAEKS LDREGGISLE DWLCAQYLAF ATTDSLSCIV KILQHR
Length:1,746
Mass (Da):193,106
Last modified:February 10, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C9A9F60BBCF6C61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN99H0YN99_HUMAN
Inactive tyrosine-protein kinase PE...
PEAK1
1,049Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ5H3BUZ5_HUMAN
Inactive tyrosine-protein kinase PE...
PEAK1
656Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUE6H3BUE6_HUMAN
Inactive tyrosine-protein kinase PE...
PEAK1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15006 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87076 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti779S → F in BAC87076 (PubMed:14702039).Curated1
Sequence conflicti1046 – 1049SHMT → RYVK in AK091802 (PubMed:14702039).Curated4
Sequence conflicti1112 – 1120QSRAAMIPP → KCKCPISSI in BAB84983 (Ref. 3) Curated9
Sequence conflicti1375 – 1378LAVR → SQEF in BAC87076 (PubMed:14702039).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041817213G → R1 PublicationCorresponds to variant dbSNP:rs35459975Ensembl.1
Natural variantiVAR_041818240V → I1 PublicationCorresponds to variant dbSNP:rs56129428Ensembl.1
Natural variantiVAR_041819440S → P1 PublicationCorresponds to variant dbSNP:rs35335169Ensembl.1
Natural variantiVAR_041820611H → Q in a bladder carcinoma NOS sample; somatic mutation. 1 Publication1
Natural variantiVAR_041821792S → I1 PublicationCorresponds to variant dbSNP:rs34885462Ensembl.1
Natural variantiVAR_041822836D → E1 PublicationCorresponds to variant dbSNP:rs56388121Ensembl.1
Natural variantiVAR_0418231035S → F in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0418241071R → K1 PublicationCorresponds to variant dbSNP:rs12909704Ensembl.1
Natural variantiVAR_0418251077T → P1 PublicationCorresponds to variant dbSNP:rs56133554Ensembl.1
Natural variantiVAR_0418261145P → L in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0418271408P → Q1 PublicationCorresponds to variant dbSNP:rs56079860Ensembl.1
Natural variantiVAR_0418281542S → T1 PublicationCorresponds to variant dbSNP:rs1867780Ensembl.1
Natural variantiVAR_0418291699R → G1 PublicationCorresponds to variant dbSNP:rs34004337Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC087465 Genomic DNA No translation available.
AC107883 Genomic DNA No translation available.
AK024793 mRNA Translation: BAB15006.1 Different initiation.
AK091802 mRNA No translation available.
AK127658 mRNA Translation: BAC87076.1 Different initiation.
AK074157 mRNA Translation: BAB84983.1
AB082533 mRNA Translation: BAC02711.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42062.1

NCBI Reference Sequences

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RefSeqi
NP_079052.2, NM_024776.3
XP_005254727.1, XM_005254670.2
XP_005254728.1, XM_005254671.2
XP_005254730.1, XM_005254673.2
XP_005254731.1, XM_005254674.2
XP_005254732.1, XM_005254675.4
XP_011520335.1, XM_011522033.2
XP_011520336.1, XM_011522034.2
XP_011520337.1, XM_011522035.2
XP_011520338.1, XM_011522036.2
XP_011520339.1, XM_011522037.2
XP_011520340.1, XM_011522038.2
XP_011520341.1, XM_011522039.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.731402
Hs.9587

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000312493; ENSP00000309230; ENSG00000173517
ENST00000560626; ENSP00000452796; ENSG00000173517

Database of genes from NCBI RefSeq genomes

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GeneIDi
79834

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79834

UCSC genome browser

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UCSCi
uc059lyw.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087465 Genomic DNA No translation available.
AC107883 Genomic DNA No translation available.
AK024793 mRNA Translation: BAB15006.1 Different initiation.
AK091802 mRNA No translation available.
AK127658 mRNA Translation: BAC87076.1 Different initiation.
AK074157 mRNA Translation: BAB84983.1
AB082533 mRNA Translation: BAC02711.1
CCDSiCCDS42062.1
RefSeqiNP_079052.2, NM_024776.3
XP_005254727.1, XM_005254670.2
XP_005254728.1, XM_005254671.2
XP_005254730.1, XM_005254673.2
XP_005254731.1, XM_005254674.2
XP_005254732.1, XM_005254675.4
XP_011520335.1, XM_011522033.2
XP_011520336.1, XM_011522034.2
XP_011520337.1, XM_011522035.2
XP_011520338.1, XM_011522036.2
XP_011520339.1, XM_011522037.2
XP_011520340.1, XM_011522038.2
XP_011520341.1, XM_011522039.2
UniGeneiHs.731402
Hs.9587

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BHCX-ray2.30A1272-1743[»]
ProteinModelPortaliQ9H792
SMRiQ9H792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122926, 34 interactors
DIPiDIP-56276N
IntActiQ9H792, 17 interactors
STRINGi9606.ENSP00000309230

Chemistry databases

ChEMBLiCHEMBL3627585

PTM databases

GlyConnecti1692
iPTMnetiQ9H792
PhosphoSitePlusiQ9H792

Polymorphism and mutation databases

BioMutaiPEAK1
DMDMi223634730

Proteomic databases

EPDiQ9H792
MaxQBiQ9H792
PaxDbiQ9H792
PeptideAtlasiQ9H792
PRIDEiQ9H792
ProteomicsDBi81090

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79834
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312493; ENSP00000309230; ENSG00000173517
ENST00000560626; ENSP00000452796; ENSG00000173517
GeneIDi79834
KEGGihsa:79834
UCSCiuc059lyw.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79834
DisGeNETi79834
EuPathDBiHostDB:ENSG00000173517.10

GeneCards: human genes, protein and diseases

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GeneCardsi
PEAK1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012463
HGNCiHGNC:29431 PEAK1
HPAiHPA026313
HPA026517
MIMi614248 gene
neXtProtiNX_Q9H792
OpenTargetsiENSG00000173517

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJMD Eukaryota
ENOG4110SRP LUCA
GeneTreeiENSGT00940000157591
HOVERGENiHBG093946
InParanoidiQ9H792
KOiK17538
OMAiPRKNCHK
OrthoDBiEOG091G03K2
PhylomeDBiQ9H792

Enzyme and pathway databases

SignaLinkiQ9H792

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PEAK1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79834

Protein Ontology

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PROi
PR:Q9H792

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173517 Expressed in 206 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9H792 baseline and differential
GenevisibleiQ9H792 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEAK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H792
Secondary accession number(s): Q6ZS78
, Q8NAZ4, Q8NCM3, Q8TEG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 10, 2009
Last modified: December 5, 2018
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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