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Entry version 123 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Exonuclease V

Gene

EXO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.1 Publication

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi92Iron-sulfur (4Fe-4S)1
Metal bindingi343Iron-sulfur (4Fe-4S)1
Metal bindingi346Iron-sulfur (4Fe-4S)1
Metal bindingi352Iron-sulfur (4Fe-4S)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • interstrand cross-link repair Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
Ligand4Fe-4S, Iron, Iron-sulfur, Magnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H790

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exonuclease V (EC:3.1.-.-)
Short name:
Exo V
Short name:
hExo5
Alternative name(s):
Defects in morphology protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXO5
Synonyms:C1orf176, DEM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000164002.11

Human Gene Nomenclature Database

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HGNCi
HGNC:26115, EXO5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618601, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi196E → A: Nearly abolishes exonuclease activity. 1 Publication1
Mutagenesisi343C → A: Abolishes iron-sulfur-binding and affects exonuclease activity; when associated with A-346. 1 Publication1
Mutagenesisi346C → A: Abolishes iron-sulfur-binding and affects exonuclease activity; when associated with A-343. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64789

Open Targets

More...
OpenTargetsi
ENSG00000164002

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164718736

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H790, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
EXO5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752706

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073201 – 373Exonuclease VAdd BLAST373

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H790

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H790

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H790

PeptideAtlas

More...
PeptideAtlasi
Q9H790

PRoteomics IDEntifications database

More...
PRIDEi
Q9H790

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81089

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H790

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H790

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164002, Expressed in secondary oocyte and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H790, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H790, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164002, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer; monomeric form has weak exonuclease activity. Homodimer; homodimeric form is unsure but has much higher exonuclease activity, suggesting that it could homodimerize upon DNA-binding.

Interacts with the replication protein A (RPA) complex.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122299, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361788

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H790, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EXO5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4760, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000015205

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013225_0_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H790

Identification of Orthologs from Complete Genome Data

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OMAi
STQNWCE

Database of Orthologous Groups

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OrthoDBi
1601909at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H790

TreeFam database of animal gene trees

More...
TreeFami
TF332529

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019190, EXOV

The PANTHER Classification System

More...
PANTHERi
PTHR14464, PTHR14464, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09810, Exo5, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9H790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETREEETV SAEASGFSDL SDSEFLEFLD LEDAQESKAL VNMPGPSSES
60 70 80 90 100
LGKDDKPISL QNWKRGLDIL SPMERFHLKY LYVTDLATQN WCELQTAYGK
110 120 130 140 150
ELPGFLAPEK AAVLDTGASI HLARELELHD LVTVPVTTKE DAWAIKFLNI
160 170 180 190 200
LLLIPTLQSE GHIREFPVFG EGEGVLLVGV IDELHYTAKG ELELAELKTR
210 220 230 240 250
RRPMLPLEAQ KKKDCFQVSL YKYIFDAMVQ GKVTPASLIH HTKLCLEKPL
260 270 280 290 300
GPSVLRHAQQ GGFSVKSLGD LMELVFLSLT LSDLPVIDIL KIEYIHQETA
310 320 330 340 350
TVLGTEIVAF KEKEVRAKVQ HYMAYWMGHR EPQGVDVEEA WKCRTCTYAD
360 370
ICEWRKGSGV LSSTLAPQVK KAK
Length:373
Mass (Da):41,816
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAFB31099EA40FAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RCL8X6RCL8_HUMAN
Exonuclease V
EXO5
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RF29X6RF29_HUMAN
Exonuclease V
EXO5
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RCY3X6RCY3_HUMAN
Exonuclease V
EXO5
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RK18X6RK18_HUMAN
Exonuclease V
EXO5
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RLK1X6RLK1_HUMAN
Exonuclease V
EXO5
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035407115D → N Polymorphism; does not affect exonuclease activity. 1 PublicationCorresponds to variant dbSNP:rs1134586Ensembl.1
Natural variantiVAR_035408172G → V Polymorphism; does not affect exonuclease activity. 2 PublicationsCorresponds to variant dbSNP:rs11208299Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024797 mRNA Translation: BAB15008.1
AL603839 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07210.1
CH471059 Genomic DNA Translation: EAX07211.1
CH471059 Genomic DNA Translation: EAX07212.1
CH471059 Genomic DNA Translation: EAX07213.1
CH471059 Genomic DNA Translation: EAX07214.1
BC021969 mRNA Translation: AAH21969.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS453.1

NCBI Reference Sequences

More...
RefSeqi
NP_001333875.1, NM_001346946.1
NP_001333876.1, NM_001346947.1
NP_001333877.1, NM_001346948.1
NP_001333878.1, NM_001346949.1
NP_001333879.1, NM_001346950.1
NP_001333880.1, NM_001346951.1
NP_001333881.1, NM_001346952.1
NP_001333882.1, NM_001346953.1
NP_001333883.1, NM_001346954.1
NP_001333884.1, NM_001346955.1
NP_001333885.1, NM_001346956.1
NP_073611.1, NM_022774.2
XP_016857588.1, XM_017002099.1
XP_016857591.1, XM_017002102.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296380; ENSP00000296380; ENSG00000164002
ENST00000358527; ENSP00000351328; ENSG00000164002
ENST00000372703; ENSP00000361788; ENSG00000164002

Database of genes from NCBI RefSeq genomes

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GeneIDi
64789

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64789

UCSC genome browser

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UCSCi
uc001cfp.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024797 mRNA Translation: BAB15008.1
AL603839 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07210.1
CH471059 Genomic DNA Translation: EAX07211.1
CH471059 Genomic DNA Translation: EAX07212.1
CH471059 Genomic DNA Translation: EAX07213.1
CH471059 Genomic DNA Translation: EAX07214.1
BC021969 mRNA Translation: AAH21969.1
CCDSiCCDS453.1
RefSeqiNP_001333875.1, NM_001346946.1
NP_001333876.1, NM_001346947.1
NP_001333877.1, NM_001346948.1
NP_001333878.1, NM_001346949.1
NP_001333879.1, NM_001346950.1
NP_001333880.1, NM_001346951.1
NP_001333881.1, NM_001346952.1
NP_001333882.1, NM_001346953.1
NP_001333883.1, NM_001346954.1
NP_001333884.1, NM_001346955.1
NP_001333885.1, NM_001346956.1
NP_073611.1, NM_022774.2
XP_016857588.1, XM_017002099.1
XP_016857591.1, XM_017002102.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122299, 2 interactors
STRINGi9606.ENSP00000361788

PTM databases

iPTMnetiQ9H790
PhosphoSitePlusiQ9H790

Polymorphism and mutation databases

BioMutaiEXO5
DMDMi74752706

Proteomic databases

MassIVEiQ9H790
MaxQBiQ9H790
PaxDbiQ9H790
PeptideAtlasiQ9H790
PRIDEiQ9H790
ProteomicsDBi81089

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32100, 83 antibodies

The DNASU plasmid repository

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DNASUi
64789

Genome annotation databases

EnsembliENST00000296380; ENSP00000296380; ENSG00000164002
ENST00000358527; ENSP00000351328; ENSG00000164002
ENST00000372703; ENSP00000361788; ENSG00000164002
GeneIDi64789
KEGGihsa:64789
UCSCiuc001cfp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64789
DisGeNETi64789
EuPathDBiHostDB:ENSG00000164002.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXO5
HGNCiHGNC:26115, EXO5
HPAiENSG00000164002, Low tissue specificity
MIMi618601, gene
neXtProtiNX_Q9H790
OpenTargetsiENSG00000164002
PharmGKBiPA164718736

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4760, Eukaryota
GeneTreeiENSGT00390000015205
HOGENOMiCLU_013225_0_2_1
InParanoidiQ9H790
OMAiSTQNWCE
OrthoDBi1601909at2759
PhylomeDBiQ9H790
TreeFamiTF332529

Enzyme and pathway databases

PathwayCommonsiQ9H790

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
64789, 5 hits in 848 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64789
PharosiQ9H790, Tbio

Protein Ontology

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PROi
PR:Q9H790
RNActiQ9H790, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164002, Expressed in secondary oocyte and 167 other tissues
ExpressionAtlasiQ9H790, baseline and differential
GenevisibleiQ9H790, HS

Family and domain databases

InterProiView protein in InterPro
IPR019190, EXOV
PANTHERiPTHR14464, PTHR14464, 1 hit
PfamiView protein in Pfam
PF09810, Exo5, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXO5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H790
Secondary accession number(s): D3DPV4
, Q5SWM7, Q5SWM8, Q5SWM9, Q5SWN0, Q5SWN1, Q8WTW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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