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Entry version 156 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

dCTP pyrophosphatase 1

Gene

DCTPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Probably binds two or three Mg2+ ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the reaction end product PPi. Inhibited by dCDP. Inhibited by triptolide.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=47.6 µM for dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  2. KM=65 µM for dTTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  3. KM=79.3 µM for dATP (at pH 8.0 and 25 degrees Celsius)1 Publication
  4. KM=75.9 µM for dUTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  5. KM=16.8 µM for 5I-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  6. KM=36.5 µM for 5Br-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  7. KM=33.3 µM for 5me-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  8. KM=62.9 µM for 5hme-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  9. KM=9.2 µM for 5fo-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  10. KM=142.9 µM for CTP (at pH 8.0 and 25 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63MagnesiumBy similarity1
Metal bindingi66MagnesiumBy similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi95MagnesiumBy similarity1
Metal bindingi98MagnesiumBy similarity1
Binding sitei102SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.12, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H773

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-499943, Interconversion of nucleotide di- and triphosphates

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9H773

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
dCTP pyrophosphatase 1Curated (EC:3.6.1.121 Publication)
Alternative name(s):
Deoxycytidine-triphosphatase 1
Short name:
dCTPase 1
RS21C6Imported
XTP3-transactivated gene A proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCTPP1Imported
Synonyms:XTP3TPAImported
ORF Names:CDA03Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28777, DCTPP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615840, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H773

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000179958

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63E → Q: Loss of dCTP diphosphatase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79077

Open Targets

More...
OpenTargetsi
ENSG00000179958

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164718733

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H773, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3769292

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCTPP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002917692 – 170dCTP pyrophosphatase 1Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H773

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H773

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H773

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H773

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H773

PeptideAtlas

More...
PeptideAtlasi
Q9H773

PRoteomics IDEntifications database

More...
PRIDEi
Q9H773

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
81085

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H773

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H773, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H773

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H773

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H773

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression increases during mitosis (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by an increase in cellular dCTP pool.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179958, Expressed in mucosa of transverse colon and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H773, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H773, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000179958, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122527, 45 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H773, 23 interactors

Molecular INTeraction database

More...
MINTi
Q9H773

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322524

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9H773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H773, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H773

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni47 – 51Substrate bindingBy similarity5
Regioni147 – 170DisorderedSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S210, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000017709

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_110454_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H773

Identification of Orthologs from Complete Genome Data

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OMAi
RKMALNR

Database of Orthologous Groups

More...
OrthoDBi
1472354at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H773

TreeFam database of animal gene trees

More...
TreeFami
TF300237

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11537, NTP-PPase_RS21-C6_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025984, DCTPP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12643, MazG-like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H773-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF
60 70 80 90 100
HQPRNLLLAL VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL
110 120 130 140 150
IYLVALAARC RVDLPLAVLS KMDINRRRYP AHLARSSSRK YTELPHGAIS
160 170
EDQAVGPADI PCDSTGQTST
Length:170
Mass (Da):18,681
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23BC932D5461320B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSA6H3BSA6_HUMAN
dCTP pyrophosphatase 1
DCTPP1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPN2H3BPN2_HUMAN
dCTP pyrophosphatase 1
DCTPP1
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY453409 mRNA Translation: AAR26724.1
AF212242 mRNA Translation: AAK14927.1
AF210430 mRNA Translation: AAK48422.1
CR457335 mRNA Translation: CAG33616.1
AK024843 mRNA Translation: BAB15025.1
BC001344 mRNA Translation: AAH01344.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10680.1

NCBI Reference Sequences

More...
RefSeqi
NP_077001.1, NM_024096.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319285; ENSP00000322524; ENSG00000179958

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79077

UCSC genome browser

More...
UCSCi
uc002dyf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453409 mRNA Translation: AAR26724.1
AF212242 mRNA Translation: AAK14927.1
AF210430 mRNA Translation: AAK48422.1
CR457335 mRNA Translation: CAG33616.1
AK024843 mRNA Translation: BAB15025.1
BC001344 mRNA Translation: AAH01344.1
CCDSiCCDS10680.1
RefSeqiNP_077001.1, NM_024096.1

3D structure databases

SMRiQ9H773
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122527, 45 interactors
IntActiQ9H773, 23 interactors
MINTiQ9H773
STRINGi9606.ENSP00000322524

Chemistry databases

BindingDBiQ9H773
ChEMBLiCHEMBL3769292

PTM databases

GlyGeniQ9H773, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9H773
PhosphoSitePlusiQ9H773
SwissPalmiQ9H773

Genetic variation databases

BioMutaiDCTPP1
DMDMi74733624

Proteomic databases

EPDiQ9H773
jPOSTiQ9H773
MassIVEiQ9H773
MaxQBiQ9H773
PaxDbiQ9H773
PeptideAtlasiQ9H773
PRIDEiQ9H773
ProteomicsDBi81085
TopDownProteomicsiQ9H773

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1233, 118 antibodies

The DNASU plasmid repository

More...
DNASUi
79077

Genome annotation databases

EnsembliENST00000319285; ENSP00000322524; ENSG00000179958
GeneIDi79077
KEGGihsa:79077
UCSCiuc002dyf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79077
DisGeNETi79077

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCTPP1
HGNCiHGNC:28777, DCTPP1
HPAiENSG00000179958, Low tissue specificity
MIMi615840, gene
neXtProtiNX_Q9H773
OpenTargetsiENSG00000179958
PharmGKBiPA164718733
VEuPathDBiHostDB:ENSG00000179958

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502S210, Eukaryota
GeneTreeiENSGT00390000017709
HOGENOMiCLU_110454_0_1_1
InParanoidiQ9H773
OMAiRKMALNR
OrthoDBi1472354at2759
PhylomeDBiQ9H773
TreeFamiTF300237

Enzyme and pathway databases

BRENDAi3.6.1.12, 2681
PathwayCommonsiQ9H773
ReactomeiR-HSA-499943, Interconversion of nucleotide di- and triphosphates
SIGNORiQ9H773

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79077, 3 hits in 1023 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCTPP1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
XTP3-transactivated_gene_A_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79077
PharosiQ9H773, Tchem

Protein Ontology

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PROi
PR:Q9H773
RNActiQ9H773, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000179958, Expressed in mucosa of transverse colon and 237 other tissues
ExpressionAtlasiQ9H773, baseline and differential
GenevisibleiQ9H773, HS

Family and domain databases

CDDicd11537, NTP-PPase_RS21-C6_like, 1 hit
InterProiView protein in InterPro
IPR025984, DCTPP
PfamiView protein in Pfam
PF12643, MazG-like, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCTP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H773
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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