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Protein

dCTP pyrophosphatase 1

Gene

DCTPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Probably binds two or three Mg2+ ions per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the reaction end product PPi. Inhibited by dCDP. Inhibited by triptolide.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=47.6 µM for dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  2. KM=65 µM for dTTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  3. KM=79.3 µM for dATP (at pH 8.0 and 25 degrees Celsius)1 Publication
  4. KM=75.9 µM for dUTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  5. KM=16.8 µM for 5I-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  6. KM=36.5 µM for 5Br-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  7. KM=33.3 µM for 5me-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  8. KM=62.9 µM for 5hme-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  9. KM=9.2 µM for 5fo-dCTP (at pH 8.0 and 25 degrees Celsius)1 Publication
  10. KM=142.9 µM for CTP (at pH 8.0 and 25 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38SubstrateBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63MagnesiumBy similarity1
    Metal bindingi66MagnesiumBy similarity1
    Binding sitei73SubstrateBy similarity1
    Metal bindingi95MagnesiumBy similarity1
    Metal bindingi98MagnesiumBy similarity1
    Binding sitei102SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • dCTP catabolic process Source: UniProtKB
    • DNA protection Source: UniProtKB
    • nucleoside triphosphate catabolic process Source: UniProtKB
    • protein homotetramerization Source: Ensembl

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandMagnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-499943 Interconversion of nucleotide di- and triphosphates

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    dCTP pyrophosphatase 1Curated (EC:3.6.1.121 Publication)
    Alternative name(s):
    Deoxycytidine-triphosphatase 1
    Short name:
    dCTPase 1
    RS21C6Imported
    XTP3-transactivated gene A proteinImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DCTPP1Imported
    Synonyms:XTP3TPAImported
    ORF Names:CDA03Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000179958.8

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:28777 DCTPP1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    615840 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H773

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63E → Q: Loss of dCTP diphosphatase activity. 1 Publication1

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000179958

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA164718733

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3769292

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DCTPP1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74733624

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002917692 – 170dCTP pyrophosphatase 1Add BLAST169

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
    Modified residuei2PhosphoserineCombined sources1
    Modified residuei12PhosphothreonineCombined sources1
    Modified residuei85PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9H773

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9H773

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H773

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H773

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H773

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H773

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    81085

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q9H773

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H773

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H773

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9H773

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expression increases during mitosis (at protein level).1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by an increase in cellular dCTP pool.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000179958 Expressed in 223 organ(s), highest expression level in mucosa of transverse colon

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H773 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H773 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA002832

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer.By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    122527, 35 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H773, 13 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000322524

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9H773

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9H773

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9H773

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 51Substrate bindingBy similarity5

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IXWQ Eukaryota
    ENOG4111PYX LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000017709

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000056700

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H773

    KEGG Orthology (KO)

    More...
    KOi
    K16904

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EPGPQAW

    Database of Orthologous Groups

    More...
    OrthoDBi
    1472354at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H773

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300237

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd11537 NTP-PPase_RS21-C6_like, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR025984 DCTPP

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF12643 MazG-like, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF029826 UCP029826_pph, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9H773-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF
    60 70 80 90 100
    HQPRNLLLAL VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL
    110 120 130 140 150
    IYLVALAARC RVDLPLAVLS KMDINRRRYP AHLARSSSRK YTELPHGAIS
    160 170
    EDQAVGPADI PCDSTGQTST
    Length:170
    Mass (Da):18,681
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23BC932D5461320B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H3BSA6H3BSA6_HUMAN
    dCTP pyrophosphatase 1
    DCTPP1
    71Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BPN2H3BPN2_HUMAN
    dCTP pyrophosphatase 1
    DCTPP1
    49Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY453409 mRNA Translation: AAR26724.1
    AF212242 mRNA Translation: AAK14927.1
    AF210430 mRNA Translation: AAK48422.1
    CR457335 mRNA Translation: CAG33616.1
    AK024843 mRNA Translation: BAB15025.1
    BC001344 mRNA Translation: AAH01344.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10680.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_077001.1, NM_024096.1

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.632191

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000319285; ENSP00000322524; ENSG00000179958

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    79077

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:79077

    UCSC genome browser

    More...
    UCSCi
    uc002dyf.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY453409 mRNA Translation: AAR26724.1
    AF212242 mRNA Translation: AAK14927.1
    AF210430 mRNA Translation: AAK48422.1
    CR457335 mRNA Translation: CAG33616.1
    AK024843 mRNA Translation: BAB15025.1
    BC001344 mRNA Translation: AAH01344.1
    CCDSiCCDS10680.1
    RefSeqiNP_077001.1, NM_024096.1
    UniGeneiHs.632191

    3D structure databases

    ProteinModelPortaliQ9H773
    SMRiQ9H773
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi122527, 35 interactors
    IntActiQ9H773, 13 interactors
    STRINGi9606.ENSP00000322524

    Chemistry databases

    BindingDBiQ9H773
    ChEMBLiCHEMBL3769292

    PTM databases

    iPTMnetiQ9H773
    PhosphoSitePlusiQ9H773
    SwissPalmiQ9H773

    Polymorphism and mutation databases

    BioMutaiDCTPP1
    DMDMi74733624

    Proteomic databases

    EPDiQ9H773
    jPOSTiQ9H773
    MaxQBiQ9H773
    PaxDbiQ9H773
    PeptideAtlasiQ9H773
    PRIDEiQ9H773
    ProteomicsDBi81085
    TopDownProteomicsiQ9H773

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000319285; ENSP00000322524; ENSG00000179958
    GeneIDi79077
    KEGGihsa:79077
    UCSCiuc002dyf.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    79077
    EuPathDBiHostDB:ENSG00000179958.8

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    DCTPP1
    HGNCiHGNC:28777 DCTPP1
    HPAiHPA002832
    MIMi615840 gene
    neXtProtiNX_Q9H773
    OpenTargetsiENSG00000179958
    PharmGKBiPA164718733

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiENOG410IXWQ Eukaryota
    ENOG4111PYX LUCA
    GeneTreeiENSGT00390000017709
    HOGENOMiHOG000056700
    InParanoidiQ9H773
    KOiK16904
    OMAiEPGPQAW
    OrthoDBi1472354at2759
    PhylomeDBiQ9H773
    TreeFamiTF300237

    Enzyme and pathway databases

    ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    XTP3-transactivated_gene_A_protein

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    79077

    Protein Ontology

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    PROi
    PR:Q9H773

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
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    Gene expression databases

    BgeeiENSG00000179958 Expressed in 223 organ(s), highest expression level in mucosa of transverse colon
    ExpressionAtlasiQ9H773 baseline and differential
    GenevisibleiQ9H773 HS

    Family and domain databases

    CDDicd11537 NTP-PPase_RS21-C6_like, 1 hit
    InterProiView protein in InterPro
    IPR025984 DCTPP
    PfamiView protein in Pfam
    PF12643 MazG-like, 1 hit
    PIRSFiPIRSF029826 UCP029826_pph, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCTP1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H773
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: March 1, 2001
    Last modified: January 16, 2019
    This is version 141 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
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