UniProtKB - Q9H756 (LRC19_HUMAN)
Protein
Leucine-rich repeat-containing protein 19
Gene
LRRC19
Organism
Homo sapiens (Human)
Status
Functioni
Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of proinflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity).By similarity2 Publications
Activity regulationi
Activated by TLR ligands such as LPS, bacterial DNA and peptidoglycan.By similarity
GO - Molecular functioni
- signaling receptor activity Source: GO_Central
GO - Biological processi
- host-mediated regulation of intestinal microbiota composition Source: UniProtKB
- interleukin-8 production Source: GO_Central
- positive regulation of NIK/NF-kappaB signaling Source: MGI
- regulation of cytokine production Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- toll-like receptor signaling pathway Source: Ensembl
- TRAF-mediated signal transduction Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9H756 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 19Curated |
Gene namesi | Name:LRRC19Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184434.7 |
HGNCi | HGNC:23379, LRRC19 |
neXtProti | NX_Q9H756 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 270 | ExtracellularSequence analysisAdd BLAST | 246 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 370 | CytoplasmicSequence analysisAdd BLAST | 79 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000184434 |
PharmGKBi | PA134892454 |
Miscellaneous databases
Pharosi | Q9H756, Tdark |
Polymorphism and mutation databases
BioMutai | LRRC19 |
DMDMi | 51701695 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000021610 | 25 – 370 | Leucine-rich repeat-containing protein 19Add BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9H756 |
MassIVEi | Q9H756 |
PaxDbi | Q9H756 |
PeptideAtlasi | Q9H756 |
PRIDEi | Q9H756 |
ProteomicsDBi | 81081 |
PTM databases
GlyGeni | Q9H756, 10 sites |
iPTMneti | Q9H756 |
PhosphoSitePlusi | Q9H756 |
Expressioni
Tissue specificityi
Expressed in renal collecting duct epithelial cells.1 Publication
Gene expression databases
Bgeei | ENSG00000184434, Expressed in colon and 94 other tissues |
Genevisiblei | Q9H756, HS |
Organism-specific databases
HPAi | ENSG00000184434, Group enriched (intestine, kidney) |
Interactioni
Subunit structurei
Interacts with TRAF2 and TRAF6.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000369395 |
Miscellaneous databases
RNActi | Q9H756, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 71 | LRR 1Sequence analysisAdd BLAST | 26 | |
Repeati | 72 – 95 | LRR 2Sequence analysisAdd BLAST | 24 | |
Repeati | 96 – 119 | LRR 3Sequence analysisAdd BLAST | 24 | |
Repeati | 120 – 143 | LRR 4Sequence analysisAdd BLAST | 24 | |
Repeati | 145 – 168 | LRR 5Sequence analysisAdd BLAST | 24 | |
Domaini | 176 – 227 | LRRCTSequence analysisAdd BLAST | 52 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000161278 |
HOGENOMi | CLU_063696_1_0_1 |
InParanoidi | Q9H756 |
OMAi | WYNFLLS |
OrthoDBi | 622935at2759 |
PhylomeDBi | Q9H756 |
TreeFami | TF335466 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR039489, LRRC19 |
PANTHERi | PTHR31450:SF4, PTHR31450:SF4, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9H756-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVTGITILF WPLSMILLSD KIQSSKREVQ CNFTEKNYTL IPADIKKDVT
60 70 80 90 100
ILDLSYNQIT LNGTDTRVLQ TYFLLTELYL IENKVTILHN NGFGNLSSLE
110 120 130 140 150
ILNICRNSIY VIQQGAFLGL NKLKQLYLCQ NKIEQLNADV FVPLRSLKLL
160 170 180 190 200
NLQGNLISYL DVPPLFHLEL ITLYGNLWNC SCSLFNLQNW LNTSNVTLEN
210 220 230 240 250
ENITMCSYPN SLQSYNIKTV PHKAECHSKF PSSVTEDLYI HFQPISNSIF
260 270 280 290 300
NSSSNNLTRN SEHEPLGKSW AFLVGVVVTV LTTSLLIFIA IKCPIWYNIL
310 320 330 340 350
LSYNHHRLEE HEAETYEDGF TGNPSSLSQI PETNSEETTV IFEQLHSFVV
360 370
DDDGFIEDKY IDIHELCEEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024955 mRNA Translation: BAB15042.1 BC126156 mRNA Translation: AAI26157.1 BC136298 mRNA Translation: AAI36299.1 |
CCDSi | CCDS6518.1 |
RefSeqi | NP_075052.1, NM_022901.2 |
Genome annotation databases
Ensembli | ENST00000380055; ENSP00000369395; ENSG00000184434 |
GeneIDi | 64922 |
KEGGi | hsa:64922 |
UCSCi | uc003zqh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024955 mRNA Translation: BAB15042.1 BC126156 mRNA Translation: AAI26157.1 BC136298 mRNA Translation: AAI36299.1 |
CCDSi | CCDS6518.1 |
RefSeqi | NP_075052.1, NM_022901.2 |
3D structure databases
SMRi | Q9H756 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000369395 |
PTM databases
GlyGeni | Q9H756, 10 sites |
iPTMneti | Q9H756 |
PhosphoSitePlusi | Q9H756 |
Polymorphism and mutation databases
BioMutai | LRRC19 |
DMDMi | 51701695 |
Proteomic databases
jPOSTi | Q9H756 |
MassIVEi | Q9H756 |
PaxDbi | Q9H756 |
PeptideAtlasi | Q9H756 |
PRIDEi | Q9H756 |
ProteomicsDBi | 81081 |
Protocols and materials databases
Antibodypediai | 2688, 136 antibodies |
DNASUi | 64922 |
Genome annotation databases
Ensembli | ENST00000380055; ENSP00000369395; ENSG00000184434 |
GeneIDi | 64922 |
KEGGi | hsa:64922 |
UCSCi | uc003zqh.4, human |
Organism-specific databases
CTDi | 64922 |
EuPathDBi | HostDB:ENSG00000184434.7 |
GeneCardsi | LRRC19 |
HGNCi | HGNC:23379, LRRC19 |
HPAi | ENSG00000184434, Group enriched (intestine, kidney) |
neXtProti | NX_Q9H756 |
OpenTargetsi | ENSG00000184434 |
PharmGKBi | PA134892454 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000161278 |
HOGENOMi | CLU_063696_1_0_1 |
InParanoidi | Q9H756 |
OMAi | WYNFLLS |
OrthoDBi | 622935at2759 |
PhylomeDBi | Q9H756 |
TreeFami | TF335466 |
Enzyme and pathway databases
PathwayCommonsi | Q9H756 |
Miscellaneous databases
BioGRID-ORCSi | 64922, 0 hits in 818 CRISPR screens |
GenomeRNAii | 64922 |
Pharosi | Q9H756, Tdark |
PROi | PR:Q9H756 |
RNActi | Q9H756, protein |
Gene expression databases
Bgeei | ENSG00000184434, Expressed in colon and 94 other tissues |
Genevisiblei | Q9H756, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR039489, LRRC19 |
PANTHERi | PTHR31450:SF4, PTHR31450:SF4, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 4 hits SM00082, LRRCT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRC19_HUMAN | |
Accessioni | Q9H756Primary (citable) accession number: Q9H756 Secondary accession number(s): A0AV00, B9EG91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM