Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 552

Gene

ZNF552

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri91 – 113C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 552
Gene namesi
Name:ZNF552
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178935.5
HGNCiHGNC:26135 ZNF552
neXtProtiNX_Q9H707

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178935
PharmGKBiPA134986961

Polymorphism and mutation databases

BioMutaiZNF552
DMDMi147742907

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868101 – 407Zinc finger protein 552Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9H707
MaxQBiQ9H707
PaxDbiQ9H707
PeptideAtlasiQ9H707
PRIDEiQ9H707
ProteomicsDBi81071

PTM databases

iPTMnetiQ9H707
PhosphoSitePlusiQ9H707

Expressioni

Gene expression databases

BgeeiENSG00000178935 Expressed in 168 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF552
ExpressionAtlasiQ9H707 baseline and differential
GenevisibleiQ9H707 HS

Organism-specific databases

HPAiHPA043800
HPA053762
HPA072145

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122913, 2 interactors
IntActiQ9H707, 36 interactors
STRINGi9606.ENSP00000375582

Structurei

3D structure databases

ProteinModelPortaliQ9H707
SMRiQ9H707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 90KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri91 – 113C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H707
KOiK09228
OMAiCEYGKSF
OrthoDBiEOG091G02KC
PhylomeDBiQ9H707
TreeFamiTF341078

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H707-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAALRFPV QGTVTFEDVA VKFTQEEWNL LSEAQRCLYR DVTLENLALM
60 70 80 90 100
SSLGCWCGVE DEAAPSKQSI YIQRETQVRT PMAGVSPKKA HPCEMCGPIL
110 120 130 140 150
GDILHVADHQ GTHHKQKLHR CEAWGNKLYD SGNFHQHQNE HIGEKPYRGS
160 170 180 190 200
VEEALFAKRC KLHVSGESSV FSESGKDFLL RSGLLQQEAT HTGKSNSKTE
210 220 230 240 250
CVSLFHGGKS HYSCGGCMKH FSTKDILSQH ERLLPTEEPS VWCECGKSSS
260 270 280 290 300
KYDSFSNHQG VHTREKPYTC GICGKLFNSK SHLLVHQRIH TGEKPYECEV
310 320 330 340 350
CQKFFRHKYH LIAHQRVHTG ERPYECSDCG KSFTHSSTFR VHKRVHTGQK
360 370 380 390 400
PYECSECGKS FAESSSLTKH RRVHTGEKPY GCSECEKKFR QISSLRHHQR

VHKRKGL
Length:407
Mass (Da):46,198
Last modified:May 15, 2007 - v2
Checksum:iA2D6783033EEDC61
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2C3M0R2C3_HUMAN
Zinc finger protein 552
ZNF552
62Annotation score:
M0QZ81M0QZ81_HUMAN
Zinc finger protein 552
ZNF552
49Annotation score:

Sequence cautioni

The sequence BAB15093 differs from that shown. Reason: Frameshift at position 388.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286H → R in BAB15093 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032177242W → C. Corresponds to variant dbSNP:rs2288538Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010645 Genomic DNA No translation available.
DA345819 mRNA No translation available.
AK025256 mRNA Translation: BAB15093.1 Sequence problems.
AK097041 mRNA Translation: BAG53411.1
CH471135 Genomic DNA Translation: EAW72535.1
BC046237 mRNA Translation: AAH46237.1
BC062982 mRNA Translation: AAH62982.1
BC082767 mRNA Translation: AAH82767.1
CCDSiCCDS12963.1
RefSeqiNP_079038.2, NM_024762.3
UniGeneiHs.560727

Genome annotation databases

EnsembliENST00000391701; ENSP00000375582; ENSG00000178935
GeneIDi79818
KEGGihsa:79818
UCSCiuc002qqg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010645 Genomic DNA No translation available.
DA345819 mRNA No translation available.
AK025256 mRNA Translation: BAB15093.1 Sequence problems.
AK097041 mRNA Translation: BAG53411.1
CH471135 Genomic DNA Translation: EAW72535.1
BC046237 mRNA Translation: AAH46237.1
BC062982 mRNA Translation: AAH62982.1
BC082767 mRNA Translation: AAH82767.1
CCDSiCCDS12963.1
RefSeqiNP_079038.2, NM_024762.3
UniGeneiHs.560727

3D structure databases

ProteinModelPortaliQ9H707
SMRiQ9H707
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122913, 2 interactors
IntActiQ9H707, 36 interactors
STRINGi9606.ENSP00000375582

PTM databases

iPTMnetiQ9H707
PhosphoSitePlusiQ9H707

Polymorphism and mutation databases

BioMutaiZNF552
DMDMi147742907

Proteomic databases

EPDiQ9H707
MaxQBiQ9H707
PaxDbiQ9H707
PeptideAtlasiQ9H707
PRIDEiQ9H707
ProteomicsDBi81071

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391701; ENSP00000375582; ENSG00000178935
GeneIDi79818
KEGGihsa:79818
UCSCiuc002qqg.3 human

Organism-specific databases

CTDi79818
EuPathDBiHostDB:ENSG00000178935.5
GeneCardsiZNF552
HGNCiHGNC:26135 ZNF552
HPAiHPA043800
HPA053762
HPA072145
neXtProtiNX_Q9H707
OpenTargetsiENSG00000178935
PharmGKBiPA134986961
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H707
KOiK09228
OMAiCEYGKSF
OrthoDBiEOG091G02KC
PhylomeDBiQ9H707
TreeFamiTF341078

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii79818
PROiPR:Q9H707

Gene expression databases

BgeeiENSG00000178935 Expressed in 168 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF552
ExpressionAtlasiQ9H707 baseline and differential
GenevisibleiQ9H707 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN552_HUMAN
AccessioniPrimary (citable) accession number: Q9H707
Secondary accession number(s): B3KUE9, Q6P5A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again