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Entry version 136 (31 Jul 2019)
Sequence version 2 (06 Feb 2007)
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Protein

GRB2-associated and regulator of MAPK protein 1

Gene

GAREM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • proline-rich region binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMitogen

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB2-associated and regulator of MAPK protein 1
Alternative name(s):
GRB2-associated and regulator of MAPK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAREM1
Synonyms:C18orf11, FAM59A, GAREM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26136 GAREM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617998 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H706

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi105Y → F: Does not abolish phosphorylation upon EGF stimulation. Reduces interaction with GRB2. Abolishes phosphorylation, interaction with GRB2 and ERK activation upon EGF stimulation; when associated with F-453. 1 Publication1
Mutagenesisi453Y → F: Does not abolish phosphorylation upon EGF stimulation. Abolishes interaction with PTPN11. Abolishes phosphorylation upon EGF stimulation; when associated with F-105. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64762

Open Targets

More...
OpenTargetsi
ENSG00000141441

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888032

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAREM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125991851

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776471 – 876GRB2-associated and regulator of MAPK protein 1Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105Phosphotyrosine1 Publication1
Modified residuei453Phosphotyrosine1 Publication1
Modified residuei610PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H706

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H706

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H706

PeptideAtlas

More...
PeptideAtlasi
Q9H706

PRoteomics IDEntifications database

More...
PRIDEi
Q9H706

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81068 [Q9H706-1]
81069 [Q9H706-2]
81070 [Q9H706-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H706

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H706

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141441 Expressed in 218 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H706 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H706 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040709
HPA042046

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with EGFR. Isoform 1 interacts (via proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation. Isoform 1 interacts (phosphorylated at Tyr-453) with PTPN11; the interaction increases MAPK/ERK activity and does not affect the GRB2/SOS complex formation. Isoform 2 does not interact with GRB2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122275, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H706, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000269209

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H706

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H706

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini811 – 876SAMAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 320CABITAdd BLAST309
Regioni498 – 550Necessary for interaction with GRB21 PublicationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi512 – 566Pro-richAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAREM family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II0U Eukaryota
ENOG410XSPW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063834

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074085

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H706

Identification of Orthologs from Complete Genome Data

More...
OMAi
GGEWAPF

Database of Orthologous Groups

More...
OrthoDBi
288834at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H706

TreeFam database of animal gene trees

More...
TreeFami
TF329726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025946 CABIT_dom
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12736 CABIT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H706-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPAPSLGCS LKDVKWSSVA VPLDLLVSTY RLPQIARLDN GECVEGLREN
60 70 80 90 100
DYLLIHSCRQ WTTITAHSLE EGHYVIGPKI EIPVHYAGQF KLLEQDRDIK
110 120 130 140 150
EPVQYFNSVE EVAKAFPERV YVMEDITFNV KVASGECNED TEVYNITLCT
160 170 180 190 200
GDELTLMGQA EILYAKTFKE KSRLNTIFKK IGKLNSISKL GKGKMPCLIC
210 220 230 240 250
MNHRTNESIS LPFQCKGRFS TRSPLELQMQ EGEHTIRNIV EKTRLPVNVT
260 270 280 290 300
VPSPPPRNPY DLHFIREGHR YKFVNIQTKT VVVCCVLRNN KILPMHFPLH
310 320 330 340 350
LTVPKFSLPE HLVKGESWPE TLVHHWLGIC QEQFDIDEYS RAVRDVKTDW
360 370 380 390 400
NEECKSPKKG RCSGHNHVPN SLSYARDELT QSFHRLSVCV YGNNLHGNSE
410 420 430 440 450
VNLHGCRDLG GDWAPFPHDI LPYQDSGDSG SDYLFPEASE ESAGIPGKSE
460 470 480 490 500
LPYEELWLEE GKPSHQPLTR SLSEKNRCDQ FRGSVRSKCA TSPLPIPGTL
510 520 530 540 550
GAAVKSSDTA LPPPPVPPKS EAVREECRLL NAPPVPPRSA KPLSTSPSIP
560 570 580 590 600
PRTVKPARQQ TRSPSPTLSY YSSGLHNISV TKTDTNPSES TPVSCYPCNR
610 620 630 640 650
VKTDSVDLKS PFGSPSAEAV SSRLSWPNHY SGASESQTRS DFLLDPSRSY
660 670 680 690 700
SYPRQKTPGT PKRNCPAPFD FDGCELLASP TSPVTAEFSS SVSGCPKSAS
710 720 730 740 750
YSLESTDVKS LAAGVTKQST SCPALPPRAP KLVEEKVASE TSPLPLKIDG
760 770 780 790 800
AEEDPKSGSP DLSEDQYFVK KGMQDIFSAS YPFSSPLHLQ LAPRSCGDGS
810 820 830 840 850
PWQPPADLSG LSIEEVSKSL RFIGLSEDVI SFFVTEKIDG NLLVQLTEEI
860 870
LSEDFKLSKL QVKKIMQFIN GWRPKI
Length:876
Mass (Da):97,186
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i668EBABC9CDE4CDF
GO
Isoform 2 (identifier: Q9H706-2) [UniParc]FASTAAdd to basket
Also known as: GAREM(S)

The sequence of this isoform differs from the canonical sequence as follows:
     495-563: Missing.

Show »
Length:807
Mass (Da):90,008
Checksum:i5C5DF3BFC90F1717
GO
Isoform 3 (identifier: Q9H706-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-579: Missing.

Show »
Length:875
Mass (Da):97,099
Checksum:i10A0E9147A9BFCB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRF3J3QRF3_HUMAN
GRB2-associated and regulator of MA...
GAREM1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD39149 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030580243T → N. Corresponds to variant dbSNP:rs671138Ensembl.1
Natural variantiVAR_030581291K → R. Corresponds to variant dbSNP:rs3744921Ensembl.1
Natural variantiVAR_030582490A → V. Corresponds to variant dbSNP:rs16962974Ensembl.1
Natural variantiVAR_030583580V → I. Corresponds to variant dbSNP:rs3891458Ensembl.1
Natural variantiVAR_030584720T → M. Corresponds to variant dbSNP:rs2276374Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023047495 – 563Missing in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_023048579Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025263 mRNA Translation: BAB15094.1
AL834491 mRNA Translation: CAD39149.1 Different initiation.
BC005074 mRNA Translation: AAH05074.1
BC121067 mRNA Translation: AAI21068.1
BC121068 mRNA Translation: AAI21069.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11905.1 [Q9H706-3]
CCDS56057.1 [Q9H706-1]

NCBI Reference Sequences

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RefSeqi
NP_001229338.1, NM_001242409.1 [Q9H706-1]
NP_073588.1, NM_022751.2 [Q9H706-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269209; ENSP00000269209; ENSG00000141441 [Q9H706-1]
ENST00000399218; ENSP00000382165; ENSG00000141441 [Q9H706-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64762

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64762

UCSC genome browser

More...
UCSCi
uc002kxk.3 human [Q9H706-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025263 mRNA Translation: BAB15094.1
AL834491 mRNA Translation: CAD39149.1 Different initiation.
BC005074 mRNA Translation: AAH05074.1
BC121067 mRNA Translation: AAI21068.1
BC121068 mRNA Translation: AAI21069.1
CCDSiCCDS11905.1 [Q9H706-3]
CCDS56057.1 [Q9H706-1]
RefSeqiNP_001229338.1, NM_001242409.1 [Q9H706-1]
NP_073588.1, NM_022751.2 [Q9H706-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKZNMR-A801-871[»]
SMRiQ9H706
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122275, 9 interactors
IntActiQ9H706, 7 interactors
STRINGi9606.ENSP00000269209

PTM databases

iPTMnetiQ9H706
PhosphoSitePlusiQ9H706

Polymorphism and mutation databases

BioMutaiGAREM1
DMDMi125991851

Proteomic databases

jPOSTiQ9H706
MaxQBiQ9H706
PaxDbiQ9H706
PeptideAtlasiQ9H706
PRIDEiQ9H706
ProteomicsDBi81068 [Q9H706-1]
81069 [Q9H706-2]
81070 [Q9H706-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269209; ENSP00000269209; ENSG00000141441 [Q9H706-1]
ENST00000399218; ENSP00000382165; ENSG00000141441 [Q9H706-3]
GeneIDi64762
KEGGihsa:64762
UCSCiuc002kxk.3 human [Q9H706-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64762
DisGeNETi64762

GeneCards: human genes, protein and diseases

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GeneCardsi
GAREM1
HGNCiHGNC:26136 GAREM1
HPAiHPA040709
HPA042046
MIMi617998 gene
neXtProtiNX_Q9H706
OpenTargetsiENSG00000141441
PharmGKBiPA134888032

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410II0U Eukaryota
ENOG410XSPW LUCA
GeneTreeiENSGT00530000063834
HOGENOMiHOG000074085
InParanoidiQ9H706
OMAiGGEWAPF
OrthoDBi288834at2759
PhylomeDBiQ9H706
TreeFamiTF329726

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GAREM1 human
EvolutionaryTraceiQ9H706

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64762

Protein Ontology

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PROi
PR:Q9H706

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141441 Expressed in 218 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9H706 baseline and differential
GenevisibleiQ9H706 HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR025946 CABIT_dom
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF12736 CABIT, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGARE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H706
Secondary accession number(s): Q0VAG3
, Q0VAG4, Q8ND03, Q9BSF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 31, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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