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UniProtKB - Q9H6Z4 (RANB3_HUMAN)

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Protein

Ran-binding protein 3

Gene

RANBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.5 Publications

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • R-SMAD binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9H6Z4
SIGNORiQ9H6Z4

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3
Short name:
RanBP3
Gene namesi
Name:RANBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000031823.14
HGNCiHGNC:9850 RANBP3
MIMi603327 gene
neXtProtiNX_Q9H6Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8498
OpenTargetsiENSG00000031823
PharmGKBiPA34211

Polymorphism and mutation databases

BioMutaiRANBP3
DMDMi51316528

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000971652 – 567Ran-binding protein 3Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei219PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H6Z4
MaxQBiQ9H6Z4
PaxDbiQ9H6Z4
PeptideAtlasiQ9H6Z4
PRIDEiQ9H6Z4
ProteomicsDBi81064
81065 [Q9H6Z4-2]
81066 [Q9H6Z4-3]

PTM databases

iPTMnetiQ9H6Z4
PhosphoSitePlusiQ9H6Z4

Expressioni

Tissue specificityi

Widely expressed with high levels in testis and heart.1 Publication

Gene expression databases

BgeeiENSG00000031823
CleanExiHS_RANBP3
ExpressionAtlasiQ9H6Z4 baseline and differential
GenevisibleiQ9H6Z4 HS

Organism-specific databases

HPAiHPA043375
HPA043389

Interactioni

Subunit structurei

Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • R-SMAD binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114070, 48 interactors
IntActiQ9H6Z4, 11 interactors
MINTiQ9H6Z4
STRINGi9606.ENSP00000341483

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni389 – 391Combined sources3
Beta strandi399 – 412Combined sources14
Turni413 – 416Combined sources4
Beta strandi417 – 432Combined sources16
Turni434 – 436Combined sources3
Beta strandi439 – 447Combined sources9
Turni448 – 450Combined sources3
Beta strandi453 – 458Combined sources6
Beta strandi465 – 469Combined sources5
Beta strandi472 – 476Combined sources5
Beta strandi487 – 491Combined sources5
Helixi494 – 519Combined sources26

3D structure databases

ProteinModelPortaliQ9H6Z4
SMRiQ9H6Z4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H6Z4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini378 – 518RanBD1PROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Poly-Pro6
Compositional biasi537 – 543Poly-Asp7

Phylogenomic databases

eggNOGiKOG0866 Eukaryota
ENOG4111NCK LUCA
GeneTreeiENSGT00530000063644
HOVERGENiHBG061383
InParanoidiQ9H6Z4
KOiK15304
OMAiLWAQMQM
OrthoDBiEOG091G076E
PhylomeDBiQ9H6Z4
TreeFamiTF313181

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
PfamiView protein in Pfam
PF00638 Ran_BP1, 1 hit
SMARTiView protein in SMART
SM00160 RanBD, 1 hit
PROSITEiView protein in PROSITE
PS50196 RANBD1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH 
        60         70         80         90        100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS 
       110        120        130        140        150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI 
       160        170        180        190        200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP 
       210        220        230        240        250
ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE 
       260        270        280        290        300
KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL 
       310        320        330        340        350
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA 
       360        370        380        390        400
AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN 
       410        420        430        440        450
VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS 
       460        470        480        490        500
LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL 
       510        520        530        540        550
YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA 
       560 
TAAGAGDEGD GQTTGST
Length:567
Mass (Da):60,210
Last modified:March 1, 2001 - v1
Checksum:i203B5A900512743C
GO
Isoform 2 (identifier: Q9H6Z4-2) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-a

The sequence of this isoform differs from the canonical sequence as follows:
     226-230: Missing.

Show »
Length:562
Mass (Da):59,694
Checksum:i453AF2CD380BA7F1
GO
Isoform 3 (identifier: Q9H6Z4-3) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-b

The sequence of this isoform differs from the canonical sequence as follows:
     27-94: Missing.

Show »
Length:499
Mass (Da):53,411
Checksum:i3356FC66E6A21796
GO

Sequence cautioni

The sequence AAH04349 differs from that shown. Aberrant splicing.Curated
The sequence CAB43293 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358 – 359SS → PF in CAA69956 (PubMed:9637251).Curated2
Sequence conflicti367E → G in CAA69957 (PubMed:9637251).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051303314A → V. Corresponds to variant dbSNP:rs10417885Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01116327 – 94Missing in isoform 3. 3 PublicationsAdd BLAST68
Alternative sequenceiVSP_011162226 – 230Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08697 mRNA Translation: CAA69956.1
Y08698 mRNA Translation: CAA69957.1
AK025300 mRNA Translation: BAB15106.1
AK314343 mRNA Translation: BAG36985.1
AL050149 mRNA Translation: CAB43293.1 Different initiation.
AC004602 Genomic DNA Translation: AAC14485.1
AC104532 Genomic DNA No translation available.
AC093050 Genomic DNA No translation available.
AC005784 Genomic DNA No translation available.
BC004349 mRNA Translation: AAH04349.1 Sequence problems.
CCDSiCCDS42477.1 [Q9H6Z4-3]
CCDS42478.1 [Q9H6Z4-1]
CCDS45935.1 [Q9H6Z4-2]
PIRiT08778
RefSeqiNP_001287794.1, NM_001300865.1
NP_003615.2, NM_003624.2 [Q9H6Z4-2]
NP_015559.2, NM_007320.2 [Q9H6Z4-3]
NP_015561.1, NM_007322.2 [Q9H6Z4-1]
UniGeneiHs.531752

Genome annotation databases

EnsembliENST00000034275; ENSP00000034275; ENSG00000031823 [Q9H6Z4-3]
ENST00000340578; ENSP00000341483; ENSG00000031823 [Q9H6Z4-1]
ENST00000439268; ENSP00000404837; ENSG00000031823 [Q9H6Z4-2]
GeneIDi8498
KEGGihsa:8498
UCSCiuc002mdw.4 human [Q9H6Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRANB3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6Z4
Secondary accession number(s): B2RAT8
, O60405, O75759, O75760, Q9BT47, Q9UG74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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