RANBP3

Functionⁱ

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.5 Publications

GO - Molecular functionⁱ

Ran GTPase binding
Source: GO_Central
Inferred from physical interactionⁱ
- 9637251
R-SMAD binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19289081

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of GTPase activity Source: GOC
protein export from nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

SignaLinkⁱ	Q9H6Z4
SIGNORⁱ	Q9H6Z4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ran-binding protein 3 Short name: RanBP3
Gene namesⁱ	Name:RANBP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000031823.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9850 RANBP3
MIMⁱ	603327 gene
neXtProtⁱ	NX_Q9H6Z4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8498
Open Targets More...OpenTargetsⁱ	ENSG00000031823
PharmGKBⁱ	PA34211

Polymorphism and mutation databases

BioMutaⁱ	RANBP3
DMDMⁱ	51316528

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000097165	2 – 567	Ran-binding protein 3Add BLAST		566

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	9	N6-acetyllysineBy similarity	1
Modified residueⁱ	21	N6-acetyllysineCombined sources	1
Modified residueⁱ	75	PhosphothreonineCombined sources	1
Modified residueⁱ	100	PhosphoserineCombined sources	1
Modified residueⁱ	101	PhosphoserineCombined sources	1
Modified residueⁱ	108	PhosphoserineCombined sources	1
Modified residueⁱ	124	PhosphothreonineCombined sources	1
Modified residueⁱ	126	PhosphoserineCombined sources	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	333	PhosphoserineCombined sources	1
Modified residueⁱ	353	PhosphoserineCombined sources	1
Modified residueⁱ	355	PhosphoserineCombined sources	1
Modified residueⁱ	372	PhosphoserineCombined sources	1
Modified residueⁱ	539	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H6Z4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H6Z4
PaxDbⁱ	Q9H6Z4
PeptideAtlas More...PeptideAtlasⁱ	Q9H6Z4
PRIDEⁱ	Q9H6Z4
ProteomicsDBⁱ	81064 81065 [Q9H6Z4-2] 81066 [Q9H6Z4-3]

PTM databases

iPTMnetⁱ	Q9H6Z4
PhosphoSitePlusⁱ	Q9H6Z4

Expressionⁱ

Tissue specificityⁱ

Widely expressed with high levels in testis and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000031823 Expressed in 225 organ(s), highest expression level in testis
CleanExⁱ	HS_RANBP3
ExpressionAtlasⁱ	Q9H6Z4 baseline and differential
Genevisibleⁱ	Q9H6Z4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043375 HPA043389

HPAⁱ

HPA043375
HPA043389

Interactionⁱ

Subunit structureⁱ

Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PPM1A	P35813	4	EBI-992681,EBI-989143
RCC1	P18754	2	EBI-992681,EBI-992720
SMAD2	Q15796	2	EBI-992681,EBI-1040141

GO - Molecular functionⁱ

Ran GTPase binding
Source: GO_Central
Inferred from physical interactionⁱ
- 9637251
R-SMAD binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19289081

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114070, 48 interactors
IntActⁱ	Q9H6Z4, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9H6Z4
STRINGⁱ	9606.ENSP00000341483

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	389 – 391	Combined sources	3
Beta strandⁱ	399 – 412	Combined sources	14
Turnⁱ	413 – 416	Combined sources	4
Beta strandⁱ	417 – 432	Combined sources	16
Turnⁱ	434 – 436	Combined sources	3
Beta strandⁱ	439 – 447	Combined sources	9
Turnⁱ	448 – 450	Combined sources	3
Beta strandⁱ	453 – 458	Combined sources	6
Beta strandⁱ	465 – 469	Combined sources	5
Beta strandⁱ	472 – 476	Combined sources	5
Beta strandⁱ	487 – 491	Combined sources	5
Helixⁱ	494 – 519	Combined sources	26

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H6Z4
SMRⁱ	Q9H6Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H6Z4

EvolutionaryTraceⁱ

Q9H6Z4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	378 – 518	RanBD1PROSITE-ProRule annotationAdd BLAST		141

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	76 – 81	Poly-Pro		6
Compositional biasⁱ	537 – 543	Poly-Asp		7

Phylogenomic databases

eggNOGⁱ	KOG0866 Eukaryota ENOG4111NCK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063644
HOVERGENⁱ	HBG061383
InParanoidⁱ	Q9H6Z4
KEGG Orthology (KO) More...KOⁱ	K15304
OMAⁱ	PQPKAFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G076E
PhylomeDBⁱ	Q9H6Z4
TreeFamⁱ	TF313181

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR000156 Ran_bind_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00638 Ran_BP1, 1 hit
SMARTⁱ	View protein in SMART SM00160 RanBD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50196 RANBD1, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H6Z4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH 
        60         70         80         90        100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS 
       110        120        130        140        150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI 
       160        170        180        190        200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP 
       210        220        230        240        250
ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE 
       260        270        280        290        300
KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL 
       310        320        330        340        350
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA 
       360        370        380        390        400
AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN 
       410        420        430        440        450
VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS 
       460        470        480        490        500
LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL 
       510        520        530        540        550
YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA 
       560 
TAAGAGDEGD GQTTGST

Length:567

Mass (Da):60,210

Last modified:March 1, 2001 - v1

Checksum:ⁱ203B5A900512743C

GO

Isoform 2 (identifier: Q9H6Z4-2) [UniParc]FASTA Add to basket

Also known as: Ranbp3-a

The sequence of this isoform differs from the canonical sequence as follows:
226-230: Missing.

« Hide

        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH 
        60         70         80         90        100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS 
       110        120        130        140        150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI 
       160        170        180        190        200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP 
       210        220        230        240        250
ADCTGAVPAA SPDTAAWRSP SEAADEEKEP QKNESSNASE EEACEKKDPA 
       260        270        280        290        300
TQQAFVFGQN LRDRVKLINE SVDEADMENA GHPSADTPTA TNYFLQYISS 
       310        320        330        340        350
SLENSTNSAD ASSNKFVFGQ NMSERVLSPP KLNEVSSDAN RENAAAESGS 
       360        370        380        390        400
ESSSQEATPE KESLAESAAA YTKATARKCL LEKVEVITGE EAESNVLQMQ 
       410        420        430        440        450
CKLFVFDKTS QSWVERGRGL LRLNDMASTD DGTLQSRLVM RTQGSLRLIL 
       460        470        480        490        500
NTKLWAQMQI DKASEKSIRI TAMDTEDQGV KVFLISASSK DTGQLYAALH 
       510        520        530        540        550
HRILALRSRV EQEQEAKMPA PEPGAAPSNE EDDSDDDDVL APSGATAAGA 
       560 
GDEGDGQTTG ST

Show »

Length:562

Mass (Da):59,694

Checksum:ⁱ453AF2CD380BA7F1

GO

Isoform 3 (identifier: Q9H6Z4-3) [UniParc]FASTA Add to basket

Also known as: Ranbp3-b

The sequence of this isoform differs from the canonical sequence as follows:
27-94: Missing.

« Hide

        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKRSAG GSSPEGGEDS DREDGNYCPP 
        60         70         80         90        100
VKRERTSSLT QFPPSQSEER SSGFRLKPPT LIHGQAPSAG LPSQKPKEQQ 
       110        120        130        140        150
RSVLRPAVLQ APQPKALSQT VPSSGTNGVS LPADCTGAVP AASPDTAAWR 
       160        170        180        190        200
SPSEAADEVC ALEEKEPQKN ESSNASEEEA CEKKDPATQQ AFVFGQNLRD 
       210        220        230        240        250
RVKLINESVD EADMENAGHP SADTPTATNY FLQYISSSLE NSTNSADASS 
       260        270        280        290        300
NKFVFGQNMS ERVLSPPKLN EVSSDANREN AAAESGSESS SQEATPEKES 
       310        320        330        340        350
LAESAAAYTK ATARKCLLEK VEVITGEEAE SNVLQMQCKL FVFDKTSQSW 
       360        370        380        390        400
VERGRGLLRL NDMASTDDGT LQSRLVMRTQ GSLRLILNTK LWAQMQIDKA 
       410        420        430        440        450
SEKSIRITAM DTEDQGVKVF LISASSKDTG QLYAALHHRI LALRSRVEQE 
       460        470        480        490 
QEAKMPAPEP GAAPSNEEDD SDDDDVLAPS GATAAGAGDE GDGQTTGST

Show »

Length:499

Mass (Da):53,411

Checksum:ⁱ3356FC66E6A21796

GO

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	B7Z7F3	B7Z7F3_HUMAN	cDNA FLJ58549, highly similar to Ra... cDNA FLJ58549, highly similar to Ran-binding protein 3	RANBP3	494	Annotation score:
	K7EIJ4	K7EIJ4_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	155	Annotation score:
	K7ESQ0	K7ESQ0_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	122	Annotation score:
	K7ENB9	K7ENB9_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	74	Annotation score:
	K7ENJ2	K7ENJ2_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	62	Annotation score:
	K7EPW1	K7EPW1_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	108	Annotation score:
	K7EN31	K7EN31_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	171	Annotation score:
	K7EID7	K7EID7_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	73	Annotation score:
	K7EMH9	K7EMH9_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	51	Annotation score:
	K7EMT3	K7EMT3_HUMAN	Ran-binding protein 3 Ran-binding protein 3	RANBP3	139	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAH04349 differs from that shown. Aberrant splicing.Curated

The sequence CAB43293 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	358 – 359	SS → PF in CAA69956 (PubMed:9637251).Curated		2
Sequence conflictⁱ	367	E → G in CAA69957 (PubMed:9637251).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051303	314	A → V. Corresponds to variant dbSNP:rs10417885Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011163	27 – 94	Missing in isoform 3. 3 PublicationsAdd BLAST		68
Alternative sequenceⁱVSP_011162	226 – 230	Missing in isoform 2. 1 Publication		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08697 mRNA Translation: CAA69956.1 Y08698 mRNA Translation: CAA69957.1 AK025300 mRNA Translation: BAB15106.1 AK314343 mRNA Translation: BAG36985.1 AL050149 mRNA Translation: CAB43293.1 Different initiation. AC004602 Genomic DNA Translation: AAC14485.1 AC104532 Genomic DNA No translation available. AC093050 Genomic DNA No translation available. AC005784 Genomic DNA No translation available. BC004349 mRNA Translation: AAH04349.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42477.1 [Q9H6Z4-3] CCDS42478.1 [Q9H6Z4-1] CCDS45935.1 [Q9H6Z4-2]
PIRⁱ	T08778
NCBI Reference Sequences More...RefSeqⁱ	NP_001287794.1, NM_001300865.1 NP_003615.2, NM_003624.2 [Q9H6Z4-2] NP_015559.2, NM_007320.2 [Q9H6Z4-3] NP_015561.1, NM_007322.2 [Q9H6Z4-1]
UniGeneⁱ	Hs.531752

Genome annotation databases

Ensemblⁱ	ENST00000034275; ENSP00000034275; ENSG00000031823 [Q9H6Z4-3] ENST00000340578; ENSP00000341483; ENSG00000031823 [Q9H6Z4-1] ENST00000439268; ENSP00000404837; ENSG00000031823 [Q9H6Z4-2]
GeneIDⁱ	8498
KEGGⁱ	hsa:8498
UCSC genome browser More...UCSCⁱ	uc002mdw.4 human [Q9H6Z4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H6Z4	Ran-binding protein 3		MACFA		499	UniRef90_Q9H6Z4
Ran-binding protein 3		PONAB		494
Uncharacterized protein		CALJA		576
Uncharacterized protein		RHIRO		576
Uncharacterized protein		RHIBE		576
+181

Protein	Similar proteins		Species	Score	Length	Source
Q9H6Z4	Ran-binding protein 3		MACFA		499	UniRef50_Q9H6Z4
Ran-binding protein 3		PONAB		494
Uncharacterized protein		CALJA		576
Uncharacterized protein		RHIRO		576
Uncharacterized protein		RHIBE		576
+395

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08697 mRNA Translation: CAA69956.1 Y08698 mRNA Translation: CAA69957.1 AK025300 mRNA Translation: BAB15106.1 AK314343 mRNA Translation: BAG36985.1 AL050149 mRNA Translation: CAB43293.1 Different initiation. AC004602 Genomic DNA Translation: AAC14485.1 AC104532 Genomic DNA No translation available. AC093050 Genomic DNA No translation available. AC005784 Genomic DNA No translation available. BC004349 mRNA Translation: AAH04349.1 Sequence problems.
CCDSⁱ	CCDS42477.1 [Q9H6Z4-3] CCDS42478.1 [Q9H6Z4-1] CCDS45935.1 [Q9H6Z4-2]
PIRⁱ	T08778
RefSeqⁱ	NP_001287794.1, NM_001300865.1 NP_003615.2, NM_003624.2 [Q9H6Z4-2] NP_015559.2, NM_007320.2 [Q9H6Z4-3] NP_015561.1, NM_007322.2 [Q9H6Z4-1]
UniGeneⁱ	Hs.531752

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CRF	NMR	-	A	380-516	[»]
	2Y8F	X-ray	2.10	A/B/C/D	388-522	[»]
	2Y8G	X-ray	1.61	A/B	388-522	[»]
	5XZX	X-ray	3.00	B	99-128	[»]
ProteinModelPortalⁱ	Q9H6Z4
SMRⁱ	Q9H6Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114070, 48 interactors
IntActⁱ	Q9H6Z4, 9 interactors
MINTⁱ	Q9H6Z4
STRINGⁱ	9606.ENSP00000341483

PTM databases

iPTMnetⁱ	Q9H6Z4
PhosphoSitePlusⁱ	Q9H6Z4

Polymorphism and mutation databases

BioMutaⁱ	RANBP3
DMDMⁱ	51316528

Proteomic databases

EPDⁱ	Q9H6Z4
MaxQBⁱ	Q9H6Z4
PaxDbⁱ	Q9H6Z4
PeptideAtlasⁱ	Q9H6Z4
PRIDEⁱ	Q9H6Z4
ProteomicsDBⁱ	81064 81065 [Q9H6Z4-2] 81066 [Q9H6Z4-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000034275; ENSP00000034275; ENSG00000031823 [Q9H6Z4-3] ENST00000340578; ENSP00000341483; ENSG00000031823 [Q9H6Z4-1] ENST00000439268; ENSP00000404837; ENSG00000031823 [Q9H6Z4-2]
GeneIDⁱ	8498
KEGGⁱ	hsa:8498
UCSCⁱ	uc002mdw.4 human [Q9H6Z4-1]

Organism-specific databases

CTDⁱ	8498
DisGeNETⁱ	8498
EuPathDBⁱ	HostDB:ENSG00000031823.14
GeneCardsⁱ	RANBP3
HGNCⁱ	HGNC:9850 RANBP3
HPAⁱ	HPA043375 HPA043389
MIMⁱ	603327 gene
neXtProtⁱ	NX_Q9H6Z4
OpenTargetsⁱ	ENSG00000031823
PharmGKBⁱ	PA34211
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0866 Eukaryota ENOG4111NCK LUCA
GeneTreeⁱ	ENSGT00530000063644
HOVERGENⁱ	HBG061383
InParanoidⁱ	Q9H6Z4
KOⁱ	K15304
OMAⁱ	PQPKAFS
OrthoDBⁱ	EOG091G076E
PhylomeDBⁱ	Q9H6Z4
TreeFamⁱ	TF313181

Enzyme and pathway databases

SignaLinkⁱ	Q9H6Z4
SIGNORⁱ	Q9H6Z4

Miscellaneous databases

ChiTaRSⁱ	RANBP3 human
EvolutionaryTraceⁱ	Q9H6Z4
GeneWikiⁱ	RANBP3
GenomeRNAiⁱ	8498
Protein Ontology More...PROⁱ	PR:Q9H6Z4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000031823 Expressed in 225 organ(s), highest expression level in testis
CleanExⁱ	HS_RANBP3
ExpressionAtlasⁱ	Q9H6Z4 baseline and differential
Genevisibleⁱ	Q9H6Z4 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR000156 Ran_bind_dom
Pfamⁱ	View protein in Pfam PF00638 Ran_BP1, 1 hit
SMARTⁱ	View protein in SMART SM00160 RanBD, 1 hit
PROSITEⁱ	View protein in PROSITE PS50196 RANBD1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RANB3_HUMAN
Accessionⁱ	Q9H6Z4Primary (citable) accession number: Q9H6Z4 Secondary accession number(s): B2RAT8 , O60405, O75759, O75760, Q9BT47, Q9UG74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q9H6Z4 (RANB3_HUMAN)

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Ran-binding protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ