UniProtKB - Q9H6Z4 (RANB3_HUMAN)
Ran-binding protein 3
RANBP3
Functioni
GO - Molecular functioni
- R-SMAD binding Source: UniProtKB
- small GTPase binding Source: GO_Central
GO - Biological processi
- positive regulation of GTPase activity Source: GOC
- protein export from nucleus Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9H6Z4 |
SignaLinki | Q9H6Z4 |
SIGNORi | Q9H6Z4 |
Names & Taxonomyi
Protein namesi | Recommended name: Ran-binding protein 3Short name: RanBP3 |
Gene namesi | Name:RANBP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9850, RANBP3 |
MIMi | 603327, gene |
neXtProti | NX_Q9H6Z4 |
VEuPathDBi | HostDB:ENSG00000031823.14 |
Subcellular locationi
Nucleus
- nuclear pore Source: GO_Central
- nucleoplasm Source: HPA
- nucleus Source: LIFEdb
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8498 |
OpenTargetsi | ENSG00000031823 |
PharmGKBi | PA34211 |
Miscellaneous databases
Pharosi | Q9H6Z4, Tbio |
Genetic variation databases
BioMutai | RANBP3 |
DMDMi | 51316528 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000097165 | 2 – 567 | Ran-binding protein 3Add BLAST | 566 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 9 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 21 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 75 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineCombined sources | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 126 | PhosphoserineCombined sources | 1 | |
Modified residuei | 219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 333 | PhosphoserineCombined sources | 1 | |
Modified residuei | 353 | PhosphoserineCombined sources | 1 | |
Modified residuei | 355 | PhosphoserineCombined sources | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources | 1 | |
Modified residuei | 539 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H6Z4 |
jPOSTi | Q9H6Z4 |
MassIVEi | Q9H6Z4 |
MaxQBi | Q9H6Z4 |
PaxDbi | Q9H6Z4 |
PeptideAtlasi | Q9H6Z4 |
PRIDEi | Q9H6Z4 |
ProteomicsDBi | 81064 [Q9H6Z4-1] 81065 [Q9H6Z4-2] 81066 [Q9H6Z4-3] |
PTM databases
iPTMneti | Q9H6Z4 |
MetOSitei | Q9H6Z4 |
PhosphoSitePlusi | Q9H6Z4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000031823, Expressed in testis and 234 other tissues |
ExpressionAtlasi | Q9H6Z4, baseline and differential |
Genevisiblei | Q9H6Z4, HS |
Organism-specific databases
HPAi | ENSG00000031823, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CHC1 in a Ran-stimulated manner.
Interacts with XPO1.
Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling.
Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.
5 PublicationsBinary interactionsi
Hide detailsQ9H6Z4
With | #Exp. | IntAct |
---|---|---|
PPM1A [P35813] | 4 | EBI-992681,EBI-989143 |
RCC1 [P18754] | 2 | EBI-992681,EBI-992720 |
SMAD2 [Q15796] | 2 | EBI-992681,EBI-1040141 |
GO - Molecular functioni
- R-SMAD binding Source: UniProtKB
- small GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114070, 67 interactors |
IntActi | Q9H6Z4, 12 interactors |
MINTi | Q9H6Z4 |
STRINGi | 9606.ENSP00000341483 |
Miscellaneous databases
RNActi | Q9H6Z4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9H6Z4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9H6Z4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 378 – 518 | RanBD1PROSITE-ProRule annotationAdd BLAST | 141 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 76 – 81 | Poly-Pro | 6 | |
Compositional biasi | 537 – 543 | Poly-Asp | 7 |
Phylogenomic databases
eggNOGi | KOG0866, Eukaryota |
GeneTreei | ENSGT00940000158588 |
InParanoidi | Q9H6Z4 |
OMAi | PHHGMGH |
OrthoDBi | 918488at2759 |
PhylomeDBi | Q9H6Z4 |
TreeFami | TF313181 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH
60 70 80 90 100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS
110 120 130 140 150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI
160 170 180 190 200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP
210 220 230 240 250
ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE
260 270 280 290 300
KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL
310 320 330 340 350
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA
360 370 380 390 400
AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN
410 420 430 440 450
VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS
460 470 480 490 500
LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL
510 520 530 540 550
YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA
560
TAAGAGDEGD GQTTGST
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z7F3 | B7Z7F3_HUMAN | Ran-binding protein 3 | RANBP3 | 494 | Annotation score: | ||
K7ESQ0 | K7ESQ0_HUMAN | Ran-binding protein 3 | RANBP3 | 122 | Annotation score: | ||
K7EIJ4 | K7EIJ4_HUMAN | Ran-binding protein 3 | RANBP3 | 155 | Annotation score: | ||
K7EMT3 | K7EMT3_HUMAN | Ran-binding protein 3 | RANBP3 | 139 | Annotation score: | ||
K7EN31 | K7EN31_HUMAN | Ran-binding protein 3 | RANBP3 | 171 | Annotation score: | ||
K7ENB9 | K7ENB9_HUMAN | Ran-binding protein 3 | RANBP3 | 74 | Annotation score: | ||
K7EID7 | K7EID7_HUMAN | Ran-binding protein 3 | RANBP3 | 73 | Annotation score: | ||
K7EPW1 | K7EPW1_HUMAN | Ran-binding protein 3 | RANBP3 | 108 | Annotation score: | ||
K7EJ17 | K7EJ17_HUMAN | Ran-binding protein 3 | RANBP3 | 81 | Annotation score: | ||
K7EMH9 | K7EMH9_HUMAN | Ran-binding protein 3 | RANBP3 | 51 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 358 – 359 | SS → PF in CAA69956 (PubMed:9637251).Curated | 2 | |
Sequence conflicti | 367 | E → G in CAA69957 (PubMed:9637251).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051303 | 314 | A → V. Corresponds to variant dbSNP:rs10417885EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011163 | 27 – 94 | Missing in isoform 3. 3 PublicationsAdd BLAST | 68 | |
Alternative sequenceiVSP_011162 | 226 – 230 | Missing in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08697 mRNA Translation: CAA69956.1 Y08698 mRNA Translation: CAA69957.1 AK025300 mRNA Translation: BAB15106.1 AK314343 mRNA Translation: BAG36985.1 AL050149 mRNA Translation: CAB43293.1 Different initiation. AC004602 Genomic DNA Translation: AAC14485.1 AC104532 Genomic DNA No translation available. AC093050 Genomic DNA No translation available. AC005784 Genomic DNA No translation available. BC004349 mRNA Translation: AAH04349.1 Sequence problems. |
CCDSi | CCDS42477.1 [Q9H6Z4-3] CCDS42478.1 [Q9H6Z4-1] CCDS45935.1 [Q9H6Z4-2] |
PIRi | T08778 |
RefSeqi | NP_001287794.1, NM_001300865.1 NP_003615.2, NM_003624.2 [Q9H6Z4-2] NP_015559.2, NM_007320.2 [Q9H6Z4-3] NP_015561.1, NM_007322.2 [Q9H6Z4-1] |
Genome annotation databases
Ensembli | ENST00000034275; ENSP00000034275; ENSG00000031823 [Q9H6Z4-3] ENST00000340578; ENSP00000341483; ENSG00000031823 [Q9H6Z4-1] ENST00000439268; ENSP00000404837; ENSG00000031823 [Q9H6Z4-2] |
GeneIDi | 8498 |
KEGGi | hsa:8498 |
UCSCi | uc002mdw.4, human [Q9H6Z4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08697 mRNA Translation: CAA69956.1 Y08698 mRNA Translation: CAA69957.1 AK025300 mRNA Translation: BAB15106.1 AK314343 mRNA Translation: BAG36985.1 AL050149 mRNA Translation: CAB43293.1 Different initiation. AC004602 Genomic DNA Translation: AAC14485.1 AC104532 Genomic DNA No translation available. AC093050 Genomic DNA No translation available. AC005784 Genomic DNA No translation available. BC004349 mRNA Translation: AAH04349.1 Sequence problems. |
CCDSi | CCDS42477.1 [Q9H6Z4-3] CCDS42478.1 [Q9H6Z4-1] CCDS45935.1 [Q9H6Z4-2] |
PIRi | T08778 |
RefSeqi | NP_001287794.1, NM_001300865.1 NP_003615.2, NM_003624.2 [Q9H6Z4-2] NP_015559.2, NM_007320.2 [Q9H6Z4-3] NP_015561.1, NM_007322.2 [Q9H6Z4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CRF | NMR | - | A | 380-516 | [»] | |
2Y8F | X-ray | 2.10 | A/B/C/D | 388-522 | [»] | |
2Y8G | X-ray | 1.61 | A/B | 388-522 | [»] | |
5XZX | X-ray | 3.00 | B | 99-128 | [»] | |
SMRi | Q9H6Z4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114070, 67 interactors |
IntActi | Q9H6Z4, 12 interactors |
MINTi | Q9H6Z4 |
STRINGi | 9606.ENSP00000341483 |
PTM databases
iPTMneti | Q9H6Z4 |
MetOSitei | Q9H6Z4 |
PhosphoSitePlusi | Q9H6Z4 |
Genetic variation databases
BioMutai | RANBP3 |
DMDMi | 51316528 |
Proteomic databases
EPDi | Q9H6Z4 |
jPOSTi | Q9H6Z4 |
MassIVEi | Q9H6Z4 |
MaxQBi | Q9H6Z4 |
PaxDbi | Q9H6Z4 |
PeptideAtlasi | Q9H6Z4 |
PRIDEi | Q9H6Z4 |
ProteomicsDBi | 81064 [Q9H6Z4-1] 81065 [Q9H6Z4-2] 81066 [Q9H6Z4-3] |
Protocols and materials databases
Antibodypediai | 24035, 260 antibodies |
Genome annotation databases
Ensembli | ENST00000034275; ENSP00000034275; ENSG00000031823 [Q9H6Z4-3] ENST00000340578; ENSP00000341483; ENSG00000031823 [Q9H6Z4-1] ENST00000439268; ENSP00000404837; ENSG00000031823 [Q9H6Z4-2] |
GeneIDi | 8498 |
KEGGi | hsa:8498 |
UCSCi | uc002mdw.4, human [Q9H6Z4-1] |
Organism-specific databases
CTDi | 8498 |
DisGeNETi | 8498 |
GeneCardsi | RANBP3 |
HGNCi | HGNC:9850, RANBP3 |
HPAi | ENSG00000031823, Low tissue specificity |
MIMi | 603327, gene |
neXtProti | NX_Q9H6Z4 |
OpenTargetsi | ENSG00000031823 |
PharmGKBi | PA34211 |
VEuPathDBi | HostDB:ENSG00000031823.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0866, Eukaryota |
GeneTreei | ENSGT00940000158588 |
InParanoidi | Q9H6Z4 |
OMAi | PHHGMGH |
OrthoDBi | 918488at2759 |
PhylomeDBi | Q9H6Z4 |
TreeFami | TF313181 |
Enzyme and pathway databases
PathwayCommonsi | Q9H6Z4 |
SignaLinki | Q9H6Z4 |
SIGNORi | Q9H6Z4 |
Miscellaneous databases
BioGRID-ORCSi | 8498, 133 hits in 1004 CRISPR screens |
ChiTaRSi | RANBP3, human |
EvolutionaryTracei | Q9H6Z4 |
GeneWikii | RANBP3 |
GenomeRNAii | 8498 |
Pharosi | Q9H6Z4, Tbio |
PROi | PR:Q9H6Z4 |
RNActi | Q9H6Z4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000031823, Expressed in testis and 234 other tissues |
ExpressionAtlasi | Q9H6Z4, baseline and differential |
Genevisiblei | Q9H6Z4, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR000156, Ran_bind_dom |
Pfami | View protein in Pfam PF00638, Ran_BP1, 1 hit |
SMARTi | View protein in SMART SM00160, RanBD, 1 hit |
PROSITEi | View protein in PROSITE PS50196, RANBD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RANB3_HUMAN | |
Accessioni | Q9H6Z4Primary (citable) accession number: Q9H6Z4 Secondary accession number(s): B2RAT8 Q9UG74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references