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UniProtKB - Q9H6Z4 (RANB3_HUMAN)

Entry version 172 (25 May 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Ran-binding protein 3

Gene

RANBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H6Z4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H6Z4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H6Z4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ran-binding protein 3
Short name:
RanBP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RANBP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9850, RANBP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603327, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H6Z4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000031823

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8498

Open Targets

More...OpenTargetsi		ENSG00000031823

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34211

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H6Z4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RANBP3

Domain mapping of disease mutations (DMDM)

More...DMDMi		51316528

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971652 – 567Ran-binding protein 3Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei219PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H6Z4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H6Z4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H6Z4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H6Z4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H6Z4

PeptideAtlas

More...PeptideAtlasi		Q9H6Z4

PRoteomics IDEntifications database

More...PRIDEi		Q9H6Z4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81064 [Q9H6Z4-1]
81065 [Q9H6Z4-2]
81066 [Q9H6Z4-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H6Z4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H6Z4

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H6Z4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H6Z4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high levels in testis and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000031823, Expressed in testis and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H6Z4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H6Z4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000031823, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHC1 in a Ran-stimulated manner.

Interacts with XPO1.

Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling.

Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114070, 77 interactors

Protein interaction database and analysis system

More...IntActi		Q9H6Z4, 14 interactors

Molecular INTeraction database

More...MINTi		Q9H6Z4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341483

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H6Z4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9H6Z4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H6Z4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9H6Z4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini378 – 518RanBD1PROSITE-ProRule annotationAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 263DisorderedSequence analysisAdd BLAST263
Regioni332 – 373DisorderedSequence analysisAdd BLAST42
Regioni515 – 567DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 57Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi70 – 86Pro residuesSequence analysisAdd BLAST17
Compositional biasi104 – 118Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi121 – 141Polar residuesSequence analysisAdd BLAST21
Compositional biasi181 – 199Polar residuesSequence analysisAdd BLAST19
Compositional biasi225 – 253Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi338 – 366Polar residuesSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0866, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158588

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H6Z4

Identification of Orthologs from Complete Genome Data

More...OMAi		HGMGHPE

Database of Orthologous Groups

More...OrthoDBi		918488at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H6Z4

TreeFam database of animal gene trees

More...TreeFami		TF313181

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR045255, RanBP1-like

The PANTHER Classification System

More...PANTHERi		PTHR23138, PTHR23138, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00638, Ran_BP1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00160, RanBD, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50196, RANBD1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH 
        60         70         80         90        100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS 
       110        120        130        140        150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI 
       160        170        180        190        200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP 
       210        220        230        240        250
ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE 
       260        270        280        290        300
KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL 
       310        320        330        340        350
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA 
       360        370        380        390        400
AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN 
       410        420        430        440        450
VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS 
       460        470        480        490        500
LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL 
       510        520        530        540        550
YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA 
       560 
TAAGAGDEGD GQTTGST
Length:567
Mass (Da):60,210
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i203B5A900512743C
GO
Isoform 2 (identifier: Q9H6Z4-2) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-a

The sequence of this isoform differs from the canonical sequence as follows:
     226-230: Missing.

Show »
Length:562
Mass (Da):59,694
Checksum:i453AF2CD380BA7F1
GO
Isoform 3 (identifier: Q9H6Z4-3) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-b

The sequence of this isoform differs from the canonical sequence as follows:
     27-94: Missing.

Show »
Length:499
Mass (Da):53,411
Checksum:i3356FC66E6A21796
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z7F3B7Z7F3_HUMAN
Ran-binding protein 3
RANBP3
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESQ0K7ESQ0_HUMAN
Ran-binding protein 3
RANBP3
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIJ4K7EIJ4_HUMAN
Ran-binding protein 3
RANBP3
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN31K7EN31_HUMAN
Ran-binding protein 3
RANBP3
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMT3K7EMT3_HUMAN
Ran-binding protein 3
RANBP3
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENB9K7ENB9_HUMAN
Ran-binding protein 3
RANBP3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EID7K7EID7_HUMAN
Ran-binding protein 3
RANBP3
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPW1K7EPW1_HUMAN
Ran-binding protein 3
RANBP3
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ17K7EJ17_HUMAN
Ran-binding protein 3
RANBP3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMH9K7EMH9_HUMAN
Ran-binding protein 3
RANBP3
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04349 differs from that shown. Aberrant splicing.Curated
The sequence CAB43293 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti358 – 359SS → PF in CAA69956 (PubMed:9637251).Curated2
Sequence conflicti367E → G in CAA69957 (PubMed:9637251).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051303314A → V. Corresponds to variant dbSNP:rs10417885EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01116327 – 94Missing in isoform 3. 3 PublicationsAdd BLAST68
Alternative sequenceiVSP_011162226 – 230Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y08697 mRNA Translation: CAA69956.1
Y08698 mRNA Translation: CAA69957.1
AK025300 mRNA Translation: BAB15106.1
AK314343 mRNA Translation: BAG36985.1
AL050149 mRNA Translation: CAB43293.1 Different initiation.
AC004602 Genomic DNA Translation: AAC14485.1
AC104532 Genomic DNA No translation available.
AC093050 Genomic DNA No translation available.
AC005784 Genomic DNA No translation available.
BC004349 mRNA Translation: AAH04349.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42477.1 [Q9H6Z4-3]
CCDS42478.1 [Q9H6Z4-1]
CCDS45935.1 [Q9H6Z4-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T08778

NCBI Reference Sequences

More...RefSeqi		NP_001287794.1, NM_001300865.1
NP_003615.2, NM_003624.2 [Q9H6Z4-2]
NP_015559.2, NM_007320.2 [Q9H6Z4-3]
NP_015561.1, NM_007322.2 [Q9H6Z4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000034275.12; ENSP00000034275.7; ENSG00000031823.14 [Q9H6Z4-3]
ENST00000340578.10; ENSP00000341483.5; ENSG00000031823.14
ENST00000439268.6; ENSP00000404837.1; ENSG00000031823.14 [Q9H6Z4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8498

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000340578.10; ENSP00000341483.5; NM_007322.3; NP_015561.1

UCSC genome browser

More...UCSCi		uc002mdw.4, human [Q9H6Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08697 mRNA Translation: CAA69956.1
Y08698 mRNA Translation: CAA69957.1
AK025300 mRNA Translation: BAB15106.1
AK314343 mRNA Translation: BAG36985.1
AL050149 mRNA Translation: CAB43293.1 Different initiation.
AC004602 Genomic DNA Translation: AAC14485.1
AC104532 Genomic DNA No translation available.
AC093050 Genomic DNA No translation available.
AC005784 Genomic DNA No translation available.
BC004349 mRNA Translation: AAH04349.1 Sequence problems.
CCDSiCCDS42477.1 [Q9H6Z4-3]
CCDS42478.1 [Q9H6Z4-1]
CCDS45935.1 [Q9H6Z4-2]
PIRiT08778
RefSeqiNP_001287794.1, NM_001300865.1
NP_003615.2, NM_003624.2 [Q9H6Z4-2]
NP_015559.2, NM_007320.2 [Q9H6Z4-3]
NP_015561.1, NM_007322.2 [Q9H6Z4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRFNMR-A380-516[»]
2Y8FX-ray2.10A/B/C/D388-522[»]
2Y8GX-ray1.61A/B388-522[»]
5XZXX-ray3.00B99-128[»]
AlphaFoldDBiQ9H6Z4
SMRiQ9H6Z4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114070, 77 interactors
IntActiQ9H6Z4, 14 interactors
MINTiQ9H6Z4
STRINGi9606.ENSP00000341483

PTM databases

GlyGeniQ9H6Z4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9H6Z4
MetOSiteiQ9H6Z4
PhosphoSitePlusiQ9H6Z4

Genetic variation databases

BioMutaiRANBP3
DMDMi51316528

Proteomic databases

EPDiQ9H6Z4
jPOSTiQ9H6Z4
MassIVEiQ9H6Z4
MaxQBiQ9H6Z4
PaxDbiQ9H6Z4
PeptideAtlasiQ9H6Z4
PRIDEiQ9H6Z4
ProteomicsDBi81064 [Q9H6Z4-1]
81065 [Q9H6Z4-2]
81066 [Q9H6Z4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24035, 263 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		8498

Genome annotation databases

EnsembliENST00000034275.12; ENSP00000034275.7; ENSG00000031823.14 [Q9H6Z4-3]
ENST00000340578.10; ENSP00000341483.5; ENSG00000031823.14
ENST00000439268.6; ENSP00000404837.1; ENSG00000031823.14 [Q9H6Z4-2]
GeneIDi8498
KEGGihsa:8498
MANE-SelectiENST00000340578.10; ENSP00000341483.5; NM_007322.3; NP_015561.1
UCSCiuc002mdw.4, human [Q9H6Z4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8498
DisGeNETi8498

GeneCards: human genes, protein and diseases

More...GeneCardsi		RANBP3
HGNCiHGNC:9850, RANBP3
HPAiENSG00000031823, Low tissue specificity
MIMi603327, gene
neXtProtiNX_Q9H6Z4
OpenTargetsiENSG00000031823
PharmGKBiPA34211
VEuPathDBiHostDB:ENSG00000031823

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0866, Eukaryota
GeneTreeiENSGT00940000158588
InParanoidiQ9H6Z4
OMAiHGMGHPE
OrthoDBi918488at2759
PhylomeDBiQ9H6Z4
TreeFamiTF313181

Enzyme and pathway databases

PathwayCommonsiQ9H6Z4
SignaLinkiQ9H6Z4
SIGNORiQ9H6Z4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8498, 138 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RANBP3, human
EvolutionaryTraceiQ9H6Z4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RANBP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8498
PharosiQ9H6Z4, Tbio

Protein Ontology

More...PROi		PR:Q9H6Z4
RNActiQ9H6Z4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000031823, Expressed in testis and 235 other tissues
ExpressionAtlasiQ9H6Z4, baseline and differential
GenevisibleiQ9H6Z4, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR045255, RanBP1-like
PANTHERiPTHR23138, PTHR23138, 1 hit
PfamiView protein in Pfam
PF00638, Ran_BP1, 1 hit
SMARTiView protein in SMART
SM00160, RanBD, 1 hit
PROSITEiView protein in PROSITE
PS50196, RANBD1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRANB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6Z4
Secondary accession number(s): B2RAT8
, O60405, O75759, O75760, Q9BT47, Q9UG74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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