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UniProtKB - Q9H6X4 (TM134_HUMAN)

Entry version 122 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Transmembrane protein 134

Gene

TMEM134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H6X4

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.232.1.8, the parkinson's disease tmem230 (tmem230) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 134
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM134
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26142, TMEM134

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H6X4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000172663.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 154ExtracellularSequence analysisAdd BLAST11
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 195CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80194

Open Targets

More...OpenTargetsi		ENSG00000172663

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485657

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H6X4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM134

Domain mapping of disease mutations (DMDM)

More...DMDMi		74718574

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794851 – 195Transmembrane protein 134Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H6X4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H6X4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H6X4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H6X4

PeptideAtlas

More...PeptideAtlasi		Q9H6X4

PRoteomics IDEntifications database

More...PRIDEi		Q9H6X4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81052 [Q9H6X4-1]
81053 [Q9H6X4-2]
81054 [Q9H6X4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H6X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H6X4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H6X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172663, Expressed in lower esophagus mucosa and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H6X4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H6X4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172663, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with Hepatitis E virus (HEV) ORF2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123167, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q9H6X4, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000312615

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H6X4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H6X4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni48 – 88DisorderedSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM134/TMEM230 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4753, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011766

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1427558_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H6X4

Identification of Orthologs from Complete Genome Data

More...OMAi		RSQFSID

Database of Orthologous Groups

More...OrthoDBi		1365914at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H6X4

TreeFam database of animal gene trees

More...TreeFami		TF323560

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039714, TMEM134
IPR008590, TMEM_230/134

The PANTHER Classification System

More...PANTHERi		PTHR13558, PTHR13558, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05915, DUF872, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAARPQFSI DDAFELSLED GGPGPESSGV ARFGPLHFER RARFEVADED 
        60         70         80         90        100
KQSRLRYQNL ENDEDGAQAS PEPDGGVGTR DSSRTSIRSS QWSFSTISSS 
       110        120        130        140        150
TQRSYNTCCS WTQHPLIQKN RRVVLASFLL LLLGLVLILV GVGLEATPSP 
       160        170        180        190 
GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK GHRGFQFFYL PYFEK
Length:195
Mass (Da):21,586
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD20FFFF9531DA68A
GO
Isoform 2 (identifier: Q9H6X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-150: Missing.

Show »
Length:180
Mass (Da):20,140
Checksum:i5C32079ADE6F27E0
GO
Isoform 3 (identifier: Q9H6X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: V → GPAQCLALETELGELPGEGLCLGHLQLRWWVSRAGGGSPRPHHCSCPHPRGSVCVQC
     137-195: Missing.

Show »
Length:192
Mass (Da):21,009
Checksum:iE16BF65C5DFA1304
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY65A0A087WY65_HUMAN
Transmembrane protein 134
TMEM134
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1M5G3V1M5_HUMAN
Transmembrane protein 134
TMEM134 hCG_21070
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X042A0A087X042_HUMAN
Transmembrane protein 134
TMEM134
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E0E3B4E0E3_HUMAN
Transmembrane protein 134
TMEM134
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023452136 – 150Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023453136V → GPAQCLALETELGELPGEGL CLGHLQLRWWVSRAGGGSPR PHHCSCPHPRGSVCVQC in isoform 3. 1 Publication1
Alternative sequenceiVSP_023454137 – 195Missing in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK025402 mRNA Translation: BAB15126.1
BC013883 mRNA Translation: AAH13883.1
BC125134 mRNA Translation: AAI25135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41678.1 [Q9H6X4-2]
CCDS8167.1 [Q9H6X4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001072118.1, NM_001078650.2 [Q9H6X4-2]
NP_001072119.1, NM_001078651.2
NP_079400.1, NM_025124.3 [Q9H6X4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308022; ENSP00000312615; ENSG00000172663 [Q9H6X4-1]
ENST00000393877; ENSP00000377455; ENSG00000172663 [Q9H6X4-2]
ENST00000545682; ENSP00000438439; ENSG00000172663 [Q9H6X4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80194

UCSC genome browser

More...UCSCi		uc001olq.3, human [Q9H6X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025402 mRNA Translation: BAB15126.1
BC013883 mRNA Translation: AAH13883.1
BC125134 mRNA Translation: AAI25135.1
CCDSiCCDS41678.1 [Q9H6X4-2]
CCDS8167.1 [Q9H6X4-1]
RefSeqiNP_001072118.1, NM_001078650.2 [Q9H6X4-2]
NP_001072119.1, NM_001078651.2
NP_079400.1, NM_025124.3 [Q9H6X4-1]

3D structure databases

SMRiQ9H6X4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123167, 13 interactors
IntActiQ9H6X4, 4 interactors
STRINGi9606.ENSP00000312615

Protein family/group databases

TCDBi9.B.232.1.8, the parkinson's disease tmem230 (tmem230) family

PTM databases

iPTMnetiQ9H6X4
PhosphoSitePlusiQ9H6X4
SwissPalmiQ9H6X4

Genetic variation databases

BioMutaiTMEM134
DMDMi74718574

Proteomic databases

jPOSTiQ9H6X4
MassIVEiQ9H6X4
MaxQBiQ9H6X4
PaxDbiQ9H6X4
PeptideAtlasiQ9H6X4
PRIDEiQ9H6X4
ProteomicsDBi81052 [Q9H6X4-1]
81053 [Q9H6X4-2]
81054 [Q9H6X4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30426, 69 antibodies

The DNASU plasmid repository

More...DNASUi		80194

Genome annotation databases

EnsembliENST00000308022; ENSP00000312615; ENSG00000172663 [Q9H6X4-1]
ENST00000393877; ENSP00000377455; ENSG00000172663 [Q9H6X4-2]
ENST00000545682; ENSP00000438439; ENSG00000172663 [Q9H6X4-3]
GeneIDi80194
KEGGihsa:80194
UCSCiuc001olq.3, human [Q9H6X4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80194
DisGeNETi80194

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM134
HGNCiHGNC:26142, TMEM134
HPAiENSG00000172663, Low tissue specificity
neXtProtiNX_Q9H6X4
OpenTargetsiENSG00000172663
PharmGKBiPA143485657
VEuPathDBiHostDB:ENSG00000172663.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4753, Eukaryota
GeneTreeiENSGT00390000011766
HOGENOMiCLU_1427558_0_0_1
InParanoidiQ9H6X4
OMAiRSQFSID
OrthoDBi1365914at2759
PhylomeDBiQ9H6X4
TreeFamiTF323560

Enzyme and pathway databases

PathwayCommonsiQ9H6X4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80194, 11 hits in 1005 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM134, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80194
PharosiQ9H6X4, Tdark

Protein Ontology

More...PROi		PR:Q9H6X4
RNActiQ9H6X4, protein

Gene expression databases

BgeeiENSG00000172663, Expressed in lower esophagus mucosa and 237 other tissues
ExpressionAtlasiQ9H6X4, baseline and differential
GenevisibleiQ9H6X4, HS

Family and domain databases

InterProiView protein in InterPro
IPR039714, TMEM134
IPR008590, TMEM_230/134
PANTHERiPTHR13558, PTHR13558, 1 hit
PfamiView protein in Pfam
PF05915, DUF872, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM134_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6X4
Secondary accession number(s): Q08AK4, Q6PJN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families
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