UniProtKB - Q9H6X4 (TM134_HUMAN)
Protein
Transmembrane protein 134
Gene
TMEM134
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9H6X4 |
Protein family/group databases
TCDBi | 9.B.232.1.8, the parkinson's disease tmem230 (tmem230) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 134 |
Gene namesi | Name:TMEM134 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26142, TMEM134 |
neXtProti | NX_Q9H6X4 |
VEuPathDBi | HostDB:ENSG00000172663.8 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- perinuclear region 1 Publication
Other locations
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 122 | CytoplasmicSequence analysisAdd BLAST | 122 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 154 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 195 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80194 |
OpenTargetsi | ENSG00000172663 |
PharmGKBi | PA143485657 |
Miscellaneous databases
Pharosi | Q9H6X4, Tdark |
Genetic variation databases
BioMutai | TMEM134 |
DMDMi | 74718574 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279485 | 1 – 195 | Transmembrane protein 134Add BLAST | 195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 93 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9H6X4 |
MaxQBi | Q9H6X4 |
PaxDbi | Q9H6X4 |
PeptideAtlasi | Q9H6X4 |
PRIDEi | Q9H6X4 |
ProteomicsDBi | 81052 [Q9H6X4-1] 81053 [Q9H6X4-2] 81054 [Q9H6X4-3] |
PTM databases
iPTMneti | Q9H6X4 |
PhosphoSitePlusi | Q9H6X4 |
SwissPalmi | Q9H6X4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172663, Expressed in lower esophagus mucosa and 236 other tissues |
ExpressionAtlasi | Q9H6X4, baseline and differential |
Genevisiblei | Q9H6X4, HS |
Organism-specific databases
HPAi | ENSG00000172663, Low tissue specificity |
Interactioni
Subunit structurei
(Microbial infection) Interacts with Hepatitis E virus (HEV) ORF2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 123167, 12 interactors |
IntActi | Q9H6X4, 4 interactors |
STRINGi | 9606.ENSP00000312615 |
Miscellaneous databases
RNActi | Q9H6X4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM134/TMEM230 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4753, Eukaryota |
GeneTreei | ENSGT00390000011766 |
HOGENOMi | CLU_1427558_0_0_1 |
InParanoidi | Q9H6X4 |
OMAi | RSQFSID |
OrthoDBi | 1365914at2759 |
PhylomeDBi | Q9H6X4 |
TreeFami | TF323560 |
Family and domain databases
InterProi | View protein in InterPro IPR039714, TMEM134 IPR008590, TMEM_230/134 |
PANTHERi | PTHR13558, PTHR13558, 1 hit |
Pfami | View protein in Pfam PF05915, DUF872, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H6X4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAARPQFSI DDAFELSLED GGPGPESSGV ARFGPLHFER RARFEVADED
60 70 80 90 100
KQSRLRYQNL ENDEDGAQAS PEPDGGVGTR DSSRTSIRSS QWSFSTISSS
110 120 130 140 150
TQRSYNTCCS WTQHPLIQKN RRVVLASFLL LLLGLVLILV GVGLEATPSP
160 170 180 190
GVSSAIFFVP GFLLLVPGVY HVIFIYCAVK GHRGFQFFYL PYFEK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WY65 | A0A087WY65_HUMAN | Transmembrane protein 134 | TMEM134 | 98 | Annotation score: | ||
G3V1M5 | G3V1M5_HUMAN | Transmembrane protein 134 | TMEM134 hCG_21070 | 119 | Annotation score: | ||
A0A087X042 | A0A087X042_HUMAN | Transmembrane protein 134 | TMEM134 | 41 | Annotation score: | ||
B4E0E3 | B4E0E3_HUMAN | Transmembrane protein 134 | TMEM134 | 110 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023452 | 136 – 150 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_023453 | 136 | V → GPAQCLALETELGELPGEGL CLGHLQLRWWVSRAGGGSPR PHHCSCPHPRGSVCVQC in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_023454 | 137 – 195 | Missing in isoform 3. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025402 mRNA Translation: BAB15126.1 BC013883 mRNA Translation: AAH13883.1 BC125134 mRNA Translation: AAI25135.1 |
CCDSi | CCDS41678.1 [Q9H6X4-2] CCDS8167.1 [Q9H6X4-1] |
RefSeqi | NP_001072118.1, NM_001078650.2 [Q9H6X4-2] NP_001072119.1, NM_001078651.2 NP_079400.1, NM_025124.3 [Q9H6X4-1] |
Genome annotation databases
Ensembli | ENST00000308022; ENSP00000312615; ENSG00000172663 [Q9H6X4-1] ENST00000393877; ENSP00000377455; ENSG00000172663 [Q9H6X4-2] ENST00000545682; ENSP00000438439; ENSG00000172663 [Q9H6X4-3] |
GeneIDi | 80194 |
KEGGi | hsa:80194 |
UCSCi | uc001olq.3, human [Q9H6X4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK025402 mRNA Translation: BAB15126.1 BC013883 mRNA Translation: AAH13883.1 BC125134 mRNA Translation: AAI25135.1 |
CCDSi | CCDS41678.1 [Q9H6X4-2] CCDS8167.1 [Q9H6X4-1] |
RefSeqi | NP_001072118.1, NM_001078650.2 [Q9H6X4-2] NP_001072119.1, NM_001078651.2 NP_079400.1, NM_025124.3 [Q9H6X4-1] |
3D structure databases
SMRi | Q9H6X4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123167, 12 interactors |
IntActi | Q9H6X4, 4 interactors |
STRINGi | 9606.ENSP00000312615 |
Protein family/group databases
TCDBi | 9.B.232.1.8, the parkinson's disease tmem230 (tmem230) family |
PTM databases
iPTMneti | Q9H6X4 |
PhosphoSitePlusi | Q9H6X4 |
SwissPalmi | Q9H6X4 |
Genetic variation databases
BioMutai | TMEM134 |
DMDMi | 74718574 |
Proteomic databases
jPOSTi | Q9H6X4 |
MaxQBi | Q9H6X4 |
PaxDbi | Q9H6X4 |
PeptideAtlasi | Q9H6X4 |
PRIDEi | Q9H6X4 |
ProteomicsDBi | 81052 [Q9H6X4-1] 81053 [Q9H6X4-2] 81054 [Q9H6X4-3] |
Protocols and materials databases
Antibodypediai | 30426, 68 antibodies |
Genome annotation databases
Ensembli | ENST00000308022; ENSP00000312615; ENSG00000172663 [Q9H6X4-1] ENST00000393877; ENSP00000377455; ENSG00000172663 [Q9H6X4-2] ENST00000545682; ENSP00000438439; ENSG00000172663 [Q9H6X4-3] |
GeneIDi | 80194 |
KEGGi | hsa:80194 |
UCSCi | uc001olq.3, human [Q9H6X4-1] |
Organism-specific databases
CTDi | 80194 |
DisGeNETi | 80194 |
GeneCardsi | TMEM134 |
HGNCi | HGNC:26142, TMEM134 |
HPAi | ENSG00000172663, Low tissue specificity |
neXtProti | NX_Q9H6X4 |
OpenTargetsi | ENSG00000172663 |
PharmGKBi | PA143485657 |
VEuPathDBi | HostDB:ENSG00000172663.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4753, Eukaryota |
GeneTreei | ENSGT00390000011766 |
HOGENOMi | CLU_1427558_0_0_1 |
InParanoidi | Q9H6X4 |
OMAi | RSQFSID |
OrthoDBi | 1365914at2759 |
PhylomeDBi | Q9H6X4 |
TreeFami | TF323560 |
Enzyme and pathway databases
PathwayCommonsi | Q9H6X4 |
Miscellaneous databases
BioGRID-ORCSi | 80194, 6 hits in 884 CRISPR screens |
ChiTaRSi | TMEM134, human |
GenomeRNAii | 80194 |
Pharosi | Q9H6X4, Tdark |
PROi | PR:Q9H6X4 |
RNActi | Q9H6X4, protein |
Gene expression databases
Bgeei | ENSG00000172663, Expressed in lower esophagus mucosa and 236 other tissues |
ExpressionAtlasi | Q9H6X4, baseline and differential |
Genevisiblei | Q9H6X4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039714, TMEM134 IPR008590, TMEM_230/134 |
PANTHERi | PTHR13558, PTHR13558, 1 hit |
Pfami | View protein in Pfam PF05915, DUF872, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM134_HUMAN | |
Accessioni | Q9H6X4Primary (citable) accession number: Q9H6X4 Secondary accession number(s): Q08AK4, Q6PJN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM