ANTXR1

Functionⁱ

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	52	Divalent metal cationBy similarity	1
Metal bindingⁱ	54	Divalent metal cationBy similarity	1
Metal bindingⁱ	118	Divalent metal cationBy similarity	1

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926
collagen binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926
metal ion binding Source: UniProtKB-KW
transmembrane signaling receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926
blood vessel development Source: Ensembl
negative regulation of extracellular matrix assembly Source: Ensembl
positive regulation of metallopeptidase activity Source: Ensembl
reproductive process Source: Ensembl
substrate adhesion-dependent cell spreading
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Ligand	Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5210891 Uptake and function of anthrax toxins

Reactomeⁱ

R-HSA-5210891 Uptake and function of anthrax toxins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Anthrax toxin receptor 1 Alternative name(s): Tumor endothelial marker 8
Gene namesⁱ	Name:ANTXR1 Synonyms:ATR, TEM8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169604.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21014 ANTXR1
MIMⁱ	606410 gene
neXtProtⁱ	NX_Q9H6X2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	33 – 321	ExtracellularSequence analysisAdd BLAST	289
Transmembraneⁱ	322 – 342	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	343 – 564	CytoplasmicSequence analysisAdd BLAST	222

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hemangioma, capillary infantile (HCI)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.

Keywords - Diseaseⁱ

Hypotrichosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84168
MalaCards human disease database More...MalaCardsⁱ	ANTXR1
MIMⁱ	230740 phenotype 602089 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000169604
Orphanetⁱ	91415 Familial capillary hemangioma 2067 GAPO syndrome
PharmGKBⁱ	PA134956382

Polymorphism and mutation databases

BioMutaⁱ	ANTXR1
DMDMⁱ	17366074

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000002692	33 – 564	Anthrax toxin receptor 1Add BLAST		532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	39 ↔ 220	1 Publication
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	262	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	362	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H6X2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H6X2
PaxDbⁱ	Q9H6X2
PeptideAtlas More...PeptideAtlasⁱ	Q9H6X2
PRIDEⁱ	Q9H6X2
ProteomicsDBⁱ	81048 81049 [Q9H6X2-2] 81050 [Q9H6X2-3] 81051 [Q9H6X2-4]

PTM databases

iPTMnetⁱ	Q9H6X2
PhosphoSitePlusⁱ	Q9H6X2
SwissPalmⁱ	Q9H6X2

Expressionⁱ

Tissue specificityⁱ

Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.1 Publication

Inductionⁱ

Up-regulated in cultured angiogenic umbilical vein endothelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000169604 Expressed in 215 organ(s), highest expression level in peritoneum
CleanExⁱ	HS_ANTXR1 HS_ATR
ExpressionAtlasⁱ	Q9H6X2 baseline and differential
Genevisibleⁱ	Q9H6X2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054785

HPAⁱ

HPA054785

Interactionⁱ

Subunit structureⁱ

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRP6	O75581	3	EBI-905643,EBI-910915
pagA	P13423	3	EBI-905659,EBI-456868	From Bacillus anthracis.

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16762926

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123924, 64 interactors
IntActⁱ	Q9H6X2, 14 interactors
STRINGⁱ	9606.ENSP00000301945

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	40 – 50	Combined sources	11
Helixⁱ	53 – 58	Combined sources	6
Helixⁱ	59 – 72	Combined sources	14
Beta strandⁱ	78 – 96	Combined sources	19
Helixⁱ	99 – 110	Combined sources	12
Helixⁱ	120 – 135	Combined sources	16
Beta strandⁱ	141 – 149	Combined sources	9
Helixⁱ	155 – 170	Combined sources	16
Beta strandⁱ	173 – 179	Combined sources	7
Helixⁱ	185 – 188	Combined sources	4
Turnⁱ	189 – 191	Combined sources	3
Beta strandⁱ	192 – 194	Combined sources	3
Helixⁱ	195 – 197	Combined sources	3
Beta strandⁱ	198 – 200	Combined sources	3
Helixⁱ	201 – 217	Combined sources	17

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H6X2
SMRⁱ	Q9H6X2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 215	VWFAPROSITE-ProRule annotationAdd BLAST		172

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	154 – 160	Interaction with PA		7

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	360 – 368	Asp/Glu-rich (highly acidic)		9
Compositional biasⁱ	506 – 564	Pro-richAdd BLAST		59

Domainⁱ

Binding to PA occurs through the VWA domain.

Sequence similaritiesⁱ

Belongs to the ATR family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IK1W Eukaryota ENOG410YC57 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00430000031214
HOGENOMⁱ	HOG000264249
HOVERGENⁱ	HBG050514
InParanoidⁱ	Q9H6X2
KEGG Orthology (KO) More...KOⁱ	K20909
OMAⁱ	FTVEDTY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08TW
PhylomeDBⁱ	Q9H6X2
TreeFamⁱ	TF328943

Family and domain databases

Gene3Dⁱ	3.40.50.410, 1 hit
InterProⁱ	View protein in InterPro IPR017360 Anthrax_toxin_rcpt IPR008399 Anthrax_toxin_rcpt_C IPR008400 Anthrax_toxin_rcpt_extracel IPR002035 VWF_A IPR036465 vWFA_dom_sf
PANTHERⁱ	PTHR16059 PTHR16059, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05586 Ant_C, 1 hit PF05587 Anth_Ig, 1 hit PF00092 VWA, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTⁱ	View protein in SMART SM00327 VWA, 1 hit
SUPFAMⁱ	SSF53300 SSF53300, 1 hit
PROSITEⁱ	View protein in PROSITE PS50234 VWFA, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H6X2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290        300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 
       310        320        330        340        350
DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI 
       360        370        380        390        400
IKEVPPPPAE ESEEEDDDGL PKKKWPTVDA SYYGGRGVGG IKRMEVRWGE 
       410        420        430        440        450
KGSTEEGAKL EKAKNARVKM PEQEYEFPEP RNLNNNMRRP SSPRKWYSPI 
       460        470        480        490        500
KGKLDALWVL LRKGYDRVSV MRPQPGDTGR CINFTRVKNN QPAKYPLNNA 
       510        520        530        540        550
YHTSSPPPAP IYTPPPPAPH CPPPPPSAPT PPIPSPPSTL PPPPQAPPPN 
       560 
RAPPPSRPPP RPSV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Length:564

Mass (Da):62,789

Last modified:November 2, 2001 - v2

Checksum:ⁱB118A00AD5DF2233

GO

Isoform 2 (identifier: Q9H6X2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
365-368: EDDD → NKIK
369-564: Missing.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290        300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 
       310        320        330        340        350
DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI 
       360 
IKEVPPPPAE ESEENKIK

Show »

Length:368

Mass (Da):41,157

Checksum:ⁱ8A87B13FFA7D8753

GO

Isoform 3 (identifier: Q9H6X2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
268-297: NEKPFSVEDTYLLCPAPILKEVGMKAALQV → SKSLQSPWVSSTSGFKEGNSHPCLPARPHT
298-564: Missing.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290 
NVDRVLCSFK INDSVTLSKS LQSPWVSSTS GFKEGNSHPC LPARPHT

Note: No experimental confirmation available.

Show »

Length:297

Mass (Da):33,280

Checksum:ⁱ96C8BB0E8EBB0C4A

GO

Isoform 4 (identifier: Q9H6X2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
319-333: DGSILAIALLILFLL → LHKIASGPTTAACME
334-564: Missing.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290        300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 
       310        320        330 
DGLSFISSSV IITTTHCSLH KIASGPTTAA CME

Show »

Length:333

Mass (Da):37,055

Checksum:ⁱF864586DEE043BBD

GO

Isoform 5 (identifier: Q9H6X2-5) [UniParc]FASTA Add to basket

Also known as: V4

The sequence of this isoform differs from the canonical sequence as follows:
522-557: Missing.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290        300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 
       310        320        330        340        350
DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI 
       360        370        380        390        400
IKEVPPPPAE ESEEEDDDGL PKKKWPTVDA SYYGGRGVGG IKRMEVRWGE 
       410        420        430        440        450
KGSTEEGAKL EKAKNARVKM PEQEYEFPEP RNLNNNMRRP SSPRKWYSPI 
       460        470        480        490        500
KGKLDALWVL LRKGYDRVSV MRPQPGDTGR CINFTRVKNN QPAKYPLNNA 
       510        520 
YHTSSPPPAP IYTPPPPAPH CPPPRPSV

Show »

Length:528

Mass (Da):59,205

Checksum:ⁱ28EC6D35E381197C

GO

Isoform 6 (identifier: Q9H6X2-6) [UniParc]FASTA Add to basket

Also known as: V5

The sequence of this isoform differs from the canonical sequence as follows:
315-358: THCSDGSILA...VIIKEVPPPP → FHPSPSSPGS...LGSLRNFRRC
359-564: Missing.

« Hide

        10         20         30         40         50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD 
        60         70         80         90        100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE 
       110        120        130        140        150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD 
       160        170        180        190        200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP 
       210        220        230        240        250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR 
       260        270        280        290        300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 
       310        320        330        340        350
DGLSFISSSV IITTFHPSPS SPGSTSQQGT SSLPPSSKAF CLEPKVPALG 

SLRNFRRC

Note: Prostate-specific.

Show »

Length:358

Mass (Da):39,742

Checksum:ⁱA1297D22F092C512

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YC24	H0YC24_HUMAN		Anthrax toxin receptor 1 Anthrax toxin receptor 1	ANTXR1	179	Annotation score:

Sequence cautionⁱ

The sequence BAA91707 differs from that shown. Erroneous initiation (Translation N-terminally extended) due to a conflict with the genome, including a frameshift.Curated

The sequence BAB15128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053015	7	R → K1 PublicationCorresponds to variant dbSNP:rs28365986Ensembl.		1
Natural variantⁱVAR_063146	326	A → T in HCI susceptibility; expression of FLT1 in hemangioma endothelial cells is markedly reduced compared to controls; low FLT1 expression in hemangioma cells is caused by reduced activity of a pathway involving ITGB1, ANTXR1, KDR and NFATC2IP; the mutation disrupts interaction of these molecules in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs119475040EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000446	268 – 297	NEKPF…AALQV → SKSLQSPWVSSTSGFKEGNS HPCLPARPHT in isoform 3. 1 PublicationAdd BLAST	30
Alternative sequenceⁱVSP_000447	298 – 564	Missing in isoform 3. 1 PublicationAdd BLAST	267
Alternative sequenceⁱVSP_047863	315 – 358	THCSD…VPPPP → FHPSPSSPGSTSQQGTSSLP PSSKAFCLEPKVPALGSLRN FRRC in isoform 6. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_000448	319 – 333	DGSIL…ILFLL → LHKIASGPTTAACME in isoform 4. 2 PublicationsAdd BLAST	15
Alternative sequenceⁱVSP_000449	334 – 564	Missing in isoform 4. 2 PublicationsAdd BLAST	231
Alternative sequenceⁱVSP_047864	359 – 564	Missing in isoform 6. 1 PublicationAdd BLAST	206
Alternative sequenceⁱVSP_000444	365 – 368	EDDD → NKIK in isoform 2. 1 Publication	4
Alternative sequenceⁱVSP_000445	369 – 564	Missing in isoform 2. 1 PublicationAdd BLAST	196
Alternative sequenceⁱVSP_047865	522 – 557	Missing in isoform 5. 1 PublicationAdd BLAST	36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279145 mRNA Translation: AAK52094.1 AF421380 mRNA Translation: AAL26496.1 JX424838 mRNA Translation: AFQ94038.1 JX424839 mRNA Translation: AFQ94039.1 AK001463 mRNA Translation: BAA91707.1 Sequence problems. AK025429 mRNA Translation: BAB15128.1 Different initiation. AK292113 mRNA Translation: BAF84802.1 AC112230 Genomic DNA Translation: AAX88860.1 AC114802 Genomic DNA Translation: AAY24067.1 BC012074 mRNA Translation: AAH12074.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1892.1 [Q9H6X2-1] CCDS46313.1 [Q9H6X2-2] CCDS46314.1 [Q9H6X2-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_060623.2, NM_018153.3 [Q9H6X2-4] NP_115584.1, NM_032208.2 [Q9H6X2-1] NP_444262.1, NM_053034.2 [Q9H6X2-2]
UniGeneⁱ	Hs.165859

Genome annotation databases

Ensemblⁱ	ENST00000303714; ENSP00000301945; ENSG00000169604 [Q9H6X2-1] ENST00000409349; ENSP00000386494; ENSG00000169604 [Q9H6X2-2] ENST00000409829; ENSP00000387058; ENSG00000169604 [Q9H6X2-4]
GeneIDⁱ	84168
KEGGⁱ	hsa:84168
UCSC genome browser More...UCSCⁱ	uc002sfe.4 human [Q9H6X2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H6X2	Uncharacterized protein		PANPA		564	UniRef100_Q9H6X2
Uncharacterized protein		NOMLE		564
Uncharacterized protein		PONAB		215
Q9H6X2-2	Uncharacterized protein		MACMU		369	UniRef100_F7C4E0
Uncharacterized protein		MACFA		369
Uncharacterized protein		MACNE		369
ANTXR1 isoform 4		PANTR		368
Uncharacterized protein		PANPA		368
+2
Q9H6X2-4	ANTXR1 isoform 2		PANTR		333	UniRef100_K7B8R2
ANTXR1 isoform 3		PONAB		333
Uncharacterized protein		PANPA		333
Anthrax toxin receptor 1		GORGO		333

Protein	Similar proteins		Species	Score	Length	Source
Q9H6X2	Anthrax toxin receptor 1		RAT		562	UniRef90_Q9H6X2
Anthrax toxin receptor 1		MOUSE		562
Uncharacterized protein		PANPA		564
Uncharacterized protein		NOMLE		564
Uncharacterized protein		PONAB		215
+115
Q9H6X2-2	Anthrax toxin receptor 1		OTOGA		345	UniRef90_H0X6C8
Anthrax toxin receptor/neuroblastoma fusion protein transcript variant 2		HUMAN		419
Anthrax toxin receptor 1 (Fragment)		NEOVI		390
Uncharacterized protein		COLAP		381
Uncharacterized protein		RHIRO		369
+36
Q9H6X2-3	Isoform 6 of Anthrax toxin receptor 1		HUMAN		358	UniRef90_Q9H6X2-6
anthrax toxin receptor 1 isoform X2		ODORO		321
UPI000C876294		PTEVA		327
UPI0004E00F11		URSMA		322
UPI0003315116		SORAR		321
+4
Q9H6X2-4	ANTXR1 isoform 2		PANTR		333	UniRef90_K7B8R2
ANTXR1 isoform 3		PONAB		333
Uncharacterized protein		PANPA		333
Anthrax toxin receptor 1		GORGO		333
anthrax toxin receptor 1-like		LIPVE		412
+21
Q9H6X2-6	anthrax toxin receptor 1 isoform X2		ODORO		321	UniRef90_Q9H6X2-6
Tumor endothelial marker 8 isoform 3 variant (Fragment)		HUMAN		317
UPI000C876294		PTEVA		327
UPI0004E00F11		URSMA		322
UPI0003315116		SORAR		321
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9H6X2	Anthrax toxin receptor 1		RAT		562	UniRef50_Q9H6X2
Anthrax toxin receptor 1		MOUSE		562
Uncharacterized protein		PANPA		564
Uncharacterized protein		NOMLE		564
Uncharacterized protein		PONAB		215
+530
Q9H6X2-2	Anthrax toxin receptor 1		OTOGA		345	UniRef50_H0X6C8
Anthrax toxin receptor/neuroblastoma fusion protein transcript variant 2		HUMAN		419
Anthrax toxin receptor 1 (Fragment)		NEOVI		390
Uncharacterized protein		COLAP		381
Uncharacterized protein		RHIRO		369
+46
Q9H6X2-3	Isoform 6 of Anthrax toxin receptor 1		HUMAN		358	UniRef50_Q9H6X2-6
anthrax toxin receptor 1 isoform X2		ODORO		321
anthrax toxin receptor 1 isoform X3		TURTR		312
Anthrax toxin receptor 1 (Fragment)		NOTFU		349
Anthrax toxin receptor 2a		PETMA		320
+24
Q9H6X2-4	Uncharacterized protein		NOMLE		333	UniRef50_A0A2I3HS32
anthrax toxin receptor 1-like		LIPVE		412
Uncharacterized protein		CALJA		335
Anthrax toxin receptor 1		SAIBB		335
Uncharacterized protein		AOTNA		335
+23
Q9H6X2-6	anthrax toxin receptor 1 isoform X2		ODORO		321	UniRef50_Q9H6X2-6
Tumor endothelial marker 8 isoform 3 variant (Fragment)		HUMAN		317
anthrax toxin receptor 1 isoform X3		TURTR		312
Anthrax toxin receptor 1 (Fragment)		NOTFU		349
Anthrax toxin receptor 2a		PETMA		320
+24

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF279145 mRNA Translation: AAK52094.1 AF421380 mRNA Translation: AAL26496.1 JX424838 mRNA Translation: AFQ94038.1 JX424839 mRNA Translation: AFQ94039.1 AK001463 mRNA Translation: BAA91707.1 Sequence problems. AK025429 mRNA Translation: BAB15128.1 Different initiation. AK292113 mRNA Translation: BAF84802.1 AC112230 Genomic DNA Translation: AAX88860.1 AC114802 Genomic DNA Translation: AAY24067.1 BC012074 mRNA Translation: AAH12074.1
CCDSⁱ	CCDS1892.1 [Q9H6X2-1] CCDS46313.1 [Q9H6X2-2] CCDS46314.1 [Q9H6X2-4]
RefSeqⁱ	NP_060623.2, NM_018153.3 [Q9H6X2-4] NP_115584.1, NM_032208.2 [Q9H6X2-1] NP_444262.1, NM_053034.2 [Q9H6X2-2]
UniGeneⁱ	Hs.165859

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3N2N	X-ray	1.80	A/B/C/D/E/F	38-220	[»]
ProteinModelPortalⁱ	Q9H6X2
SMRⁱ	Q9H6X2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123924, 64 interactors
IntActⁱ	Q9H6X2, 14 interactors
STRINGⁱ	9606.ENSP00000301945

PTM databases

iPTMnetⁱ	Q9H6X2
PhosphoSitePlusⁱ	Q9H6X2
SwissPalmⁱ	Q9H6X2

Polymorphism and mutation databases

BioMutaⁱ	ANTXR1
DMDMⁱ	17366074

Proteomic databases

EPDⁱ	Q9H6X2
MaxQBⁱ	Q9H6X2
PaxDbⁱ	Q9H6X2
PeptideAtlasⁱ	Q9H6X2
PRIDEⁱ	Q9H6X2
ProteomicsDBⁱ	81048 81049 [Q9H6X2-2] 81050 [Q9H6X2-3] 81051 [Q9H6X2-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84168
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000303714; ENSP00000301945; ENSG00000169604 [Q9H6X2-1] ENST00000409349; ENSP00000386494; ENSG00000169604 [Q9H6X2-2] ENST00000409829; ENSP00000387058; ENSG00000169604 [Q9H6X2-4]
GeneIDⁱ	84168
KEGGⁱ	hsa:84168
UCSCⁱ	uc002sfe.4 human [Q9H6X2-1]

Organism-specific databases

CTDⁱ	84168
DisGeNETⁱ	84168
EuPathDBⁱ	HostDB:ENSG00000169604.19
GeneCardsⁱ	ANTXR1
HGNCⁱ	HGNC:21014 ANTXR1
HPAⁱ	HPA054785
MalaCardsⁱ	ANTXR1
MIMⁱ	230740 phenotype 602089 phenotype 606410 gene
neXtProtⁱ	NX_Q9H6X2
OpenTargetsⁱ	ENSG00000169604
Orphanetⁱ	91415 Familial capillary hemangioma 2067 GAPO syndrome
PharmGKBⁱ	PA134956382
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK1W Eukaryota ENOG410YC57 LUCA
GeneTreeⁱ	ENSGT00430000031214
HOGENOMⁱ	HOG000264249
HOVERGENⁱ	HBG050514
InParanoidⁱ	Q9H6X2
KOⁱ	K20909
OMAⁱ	FTVEDTY
OrthoDBⁱ	EOG091G08TW
PhylomeDBⁱ	Q9H6X2
TreeFamⁱ	TF328943

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5210891 Uptake and function of anthrax toxins

Reactomeⁱ

R-HSA-5210891 Uptake and function of anthrax toxins

Miscellaneous databases

ChiTaRSⁱ	ANTXR1 human
GeneWikiⁱ	ANTXR1
GenomeRNAiⁱ	84168
Protein Ontology More...PROⁱ	PR:Q9H6X2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169604 Expressed in 215 organ(s), highest expression level in peritoneum
CleanExⁱ	HS_ANTXR1 HS_ATR
ExpressionAtlasⁱ	Q9H6X2 baseline and differential
Genevisibleⁱ	Q9H6X2 HS

Family and domain databases

Gene3Dⁱ	3.40.50.410, 1 hit
InterProⁱ	View protein in InterPro IPR017360 Anthrax_toxin_rcpt IPR008399 Anthrax_toxin_rcpt_C IPR008400 Anthrax_toxin_rcpt_extracel IPR002035 VWF_A IPR036465 vWFA_dom_sf
PANTHERⁱ	PTHR16059 PTHR16059, 1 hit
Pfamⁱ	View protein in Pfam PF05586 Ant_C, 1 hit PF05587 Anth_Ig, 1 hit PF00092 VWA, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTⁱ	View protein in SMART SM00327 VWA, 1 hit
SUPFAMⁱ	SSF53300 SSF53300, 1 hit
PROSITEⁱ	View protein in PROSITE PS50234 VWFA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANTR1_HUMAN
Accessionⁱ	Q9H6X2Primary (citable) accession number: Q9H6X2 Secondary accession number(s): A8K7U8 Q9NVP3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
	Last sequence update:	November 2, 2001
	Last modified:	October 10, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9H6X2 (ANTR1_HUMAN)

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Anthrax toxin receptor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

Proteomic databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ