UniProtKB - Q9H6X2 (ANTR1_HUMAN)
Anthrax toxin receptor 1
ANTXR1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 52 | Divalent metal cationBy similarity | 1 | |
Metal bindingi | 54 | Divalent metal cationBy similarity | 1 | |
Metal bindingi | 118 | Divalent metal cationBy similarity | 1 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- collagen binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- blood vessel development Source: Ensembl
- negative regulation of extracellular matrix assembly Source: Ensembl
- positive regulation of metallopeptidase activity Source: Ensembl
- reproductive process Source: Ensembl
- substrate adhesion-dependent cell spreading Source: UniProtKB
- toxin transport Source: GO_Central
Keywordsi
Molecular function | Receptor |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H6X2 |
Reactomei | R-HSA-5210891, Uptake and function of anthrax toxins |
Names & Taxonomyi
Protein namesi | Recommended name: Anthrax toxin receptor 1Alternative name(s): Tumor endothelial marker 8 |
Gene namesi | Name:ANTXR1 Synonyms:ATR, TEM8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21014, ANTXR1 |
MIMi | 606410, gene |
neXtProti | NX_Q9H6X2 |
VEuPathDBi | HostDB:ENSG00000169604.19 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
- lamellipodium membrane 1 Publication; Single-pass type I membrane protein 1 Publication
- filopodium membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
Endosome
- endosome membrane Source: Reactome
Plasma Membrane
- external side of plasma membrane Source: MGI
- filopodium membrane Source: UniProtKB
- lamellipodium membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 321 | ExtracellularSequence analysisAdd BLAST | 289 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 564 | CytoplasmicSequence analysisAdd BLAST | 222 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Involvement in diseasei
Hemangioma, capillary infantile (HCI)1 Publication
GAPO syndrome (GAPOS)1 Publication
Keywords - Diseasei
HypotrichosisOrganism-specific databases
DisGeNETi | 84168 |
MalaCardsi | ANTXR1 |
MIMi | 230740, phenotype 602089, phenotype |
OpenTargetsi | ENSG00000169604 |
Orphaneti | 2067, GAPO syndrome 464293, NON RARE IN EUROPE: Infantile capillary hemangioma |
PharmGKBi | PA134956382 |
Miscellaneous databases
Pharosi | Q9H6X2, Tbio |
Chemistry databases
DrugBanki | DB05945, MDX-1303 |
Genetic variation databases
BioMutai | ANTXR1 |
DMDMi | 17366074 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000002692 | 33 – 564 | Anthrax toxin receptor 1Add BLAST | 532 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 39 ↔ 220 | 1 Publication | ||
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9H6X2 |
jPOSTi | Q9H6X2 |
MassIVEi | Q9H6X2 |
MaxQBi | Q9H6X2 |
PaxDbi | Q9H6X2 |
PeptideAtlasi | Q9H6X2 |
PRIDEi | Q9H6X2 |
ProteomicsDBi | 81048 [Q9H6X2-1] 81049 [Q9H6X2-2] 81050 [Q9H6X2-3] 81051 [Q9H6X2-4] |
PTM databases
GlyGeni | Q9H6X2, 3 sites |
iPTMneti | Q9H6X2 |
PhosphoSitePlusi | Q9H6X2 |
SwissPalmi | Q9H6X2 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000169604, Expressed in stromal cell of endometrium and 225 other tissues |
ExpressionAtlasi | Q9H6X2, baseline and differential |
Genevisiblei | Q9H6X2, HS |
Organism-specific databases
HPAi | ENSG00000169604, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with gelatin and type 1 collagen.
Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.
5 PublicationsBinary interactionsi
Hide detailsQ9H6X2
With | #Exp. | IntAct |
---|---|---|
LRP6 [O75581] | 3 | EBI-905643,EBI-910915 |
Isoform 2 [Q9H6X2-2]
With | #Exp. | IntAct |
---|---|---|
pagA [P13423] from Bacillus anthracis. | 3 | EBI-905659,EBI-456868 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123924, 77 interactors |
IntActi | Q9H6X2, 51 interactors |
STRINGi | 9606.ENSP00000301945 |
Miscellaneous databases
RNActi | Q9H6X2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9H6X2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 215 | VWFAPROSITE-ProRule annotationAdd BLAST | 172 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 160 | Interaction with PA | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 360 – 368 | Asp/Glu-rich (highly acidic) | 9 | |
Compositional biasi | 506 – 564 | Pro-richAdd BLAST | 59 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSKR, Eukaryota |
GeneTreei | ENSGT00940000156522 |
HOGENOMi | CLU_029760_0_0_1 |
InParanoidi | Q9H6X2 |
OMAi | IYYENVH |
PhylomeDBi | Q9H6X2 |
TreeFami | TF328943 |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR017360, Anthrax_toxin_rcpt IPR008399, Anthrax_toxin_rcpt_C IPR008400, Anthrax_toxin_rcpt_extracel IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR16059:SF11, PTHR16059:SF11, 1 hit |
Pfami | View protein in Pfam PF05586, Ant_C, 1 hit PF05587, Anth_Ig, 1 hit PF00092, VWA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD
60 70 80 90 100
KSGSVLHHWN EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE
110 120 130 140 150
QIRQGLEELQ KVLPGGDTYM HEGFERASEQ IYYENRQGYR TASVIIALTD
160 170 180 190 200
GELHEDLFFY SEREANRSRD LGAIVYCVGV KDFNETQLAR IADSKDHVFP
210 220 230 240 250
VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV VRGNGFRHAR
260 270 280 290 300
NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN
310 320 330 340 350
DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI
360 370 380 390 400
IKEVPPPPAE ESEEEDDDGL PKKKWPTVDA SYYGGRGVGG IKRMEVRWGE
410 420 430 440 450
KGSTEEGAKL EKAKNARVKM PEQEYEFPEP RNLNNNMRRP SSPRKWYSPI
460 470 480 490 500
KGKLDALWVL LRKGYDRVSV MRPQPGDTGR CINFTRVKNN QPAKYPLNNA
510 520 530 540 550
YHTSSPPPAP IYTPPPPAPH CPPPPPSAPT PPIPSPPSTL PPPPQAPPPN
560
RAPPPSRPPP RPSV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YC24 | H0YC24_HUMAN | Anthrax toxin receptor 1 | ANTXR1 | 179 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053015 | 7 | R → K1 PublicationCorresponds to variant dbSNP:rs28365986Ensembl. | 1 | |
Natural variantiVAR_063146 | 326 | A → T in HCI susceptibility; expression of FLT1 in hemangioma endothelial cells is markedly reduced compared to controls; low FLT1 expression in hemangioma cells is caused by reduced activity of a pathway involving ITGB1, ANTXR1, KDR and NFATC2IP; the mutation disrupts interaction of these molecules in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs119475040EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000446 | 268 – 297 | NEKPF…AALQV → SKSLQSPWVSSTSGFKEGNS HPCLPARPHT in isoform 3. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_000447 | 298 – 564 | Missing in isoform 3. 1 PublicationAdd BLAST | 267 | |
Alternative sequenceiVSP_047863 | 315 – 358 | THCSD…VPPPP → FHPSPSSPGSTSQQGTSSLP PSSKAFCLEPKVPALGSLRN FRRC in isoform 6. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_000448 | 319 – 333 | DGSIL…ILFLL → LHKIASGPTTAACME in isoform 4. 2 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_000449 | 334 – 564 | Missing in isoform 4. 2 PublicationsAdd BLAST | 231 | |
Alternative sequenceiVSP_047864 | 359 – 564 | Missing in isoform 6. 1 PublicationAdd BLAST | 206 | |
Alternative sequenceiVSP_000444 | 365 – 368 | EDDD → NKIK in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_000445 | 369 – 564 | Missing in isoform 2. 1 PublicationAdd BLAST | 196 | |
Alternative sequenceiVSP_047865 | 522 – 557 | Missing in isoform 5. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279145 mRNA Translation: AAK52094.1 AF421380 mRNA Translation: AAL26496.1 JX424838 mRNA Translation: AFQ94038.1 JX424839 mRNA Translation: AFQ94039.1 AK001463 mRNA Translation: BAA91707.1 Sequence problems. AK025429 mRNA Translation: BAB15128.1 Different initiation. AK292113 mRNA Translation: BAF84802.1 AC112230 Genomic DNA Translation: AAX88860.1 AC114802 Genomic DNA Translation: AAY24067.1 BC012074 mRNA Translation: AAH12074.1 |
CCDSi | CCDS1892.1 [Q9H6X2-1] CCDS46313.1 [Q9H6X2-2] CCDS46314.1 [Q9H6X2-4] |
RefSeqi | NP_060623.2, NM_018153.3 [Q9H6X2-4] NP_115584.1, NM_032208.2 [Q9H6X2-1] NP_444262.1, NM_053034.2 [Q9H6X2-2] |
Genome annotation databases
Ensembli | ENST00000303714; ENSP00000301945; ENSG00000169604 [Q9H6X2-1] ENST00000409349; ENSP00000386494; ENSG00000169604 [Q9H6X2-2] ENST00000409829; ENSP00000387058; ENSG00000169604 [Q9H6X2-4] |
GeneIDi | 84168 |
KEGGi | hsa:84168 |
UCSCi | uc002sfe.4, human [Q9H6X2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF279145 mRNA Translation: AAK52094.1 AF421380 mRNA Translation: AAL26496.1 JX424838 mRNA Translation: AFQ94038.1 JX424839 mRNA Translation: AFQ94039.1 AK001463 mRNA Translation: BAA91707.1 Sequence problems. AK025429 mRNA Translation: BAB15128.1 Different initiation. AK292113 mRNA Translation: BAF84802.1 AC112230 Genomic DNA Translation: AAX88860.1 AC114802 Genomic DNA Translation: AAY24067.1 BC012074 mRNA Translation: AAH12074.1 |
CCDSi | CCDS1892.1 [Q9H6X2-1] CCDS46313.1 [Q9H6X2-2] CCDS46314.1 [Q9H6X2-4] |
RefSeqi | NP_060623.2, NM_018153.3 [Q9H6X2-4] NP_115584.1, NM_032208.2 [Q9H6X2-1] NP_444262.1, NM_053034.2 [Q9H6X2-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3N2N | X-ray | 1.80 | A/B/C/D/E/F | 38-220 | [»] | |
6ADL | electron microscopy | 3.08 | R | 38-220 | [»] | |
6ADM | electron microscopy | 2.84 | R | 38-220 | [»] | |
6ADR | electron microscopy | 3.38 | R | 38-220 | [»] | |
6CX1 | electron microscopy | 3.80 | E | 39-220 | [»] | |
SMRi | Q9H6X2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123924, 77 interactors |
IntActi | Q9H6X2, 51 interactors |
STRINGi | 9606.ENSP00000301945 |
Chemistry databases
DrugBanki | DB05945, MDX-1303 |
PTM databases
GlyGeni | Q9H6X2, 3 sites |
iPTMneti | Q9H6X2 |
PhosphoSitePlusi | Q9H6X2 |
SwissPalmi | Q9H6X2 |
Genetic variation databases
BioMutai | ANTXR1 |
DMDMi | 17366074 |
Proteomic databases
EPDi | Q9H6X2 |
jPOSTi | Q9H6X2 |
MassIVEi | Q9H6X2 |
MaxQBi | Q9H6X2 |
PaxDbi | Q9H6X2 |
PeptideAtlasi | Q9H6X2 |
PRIDEi | Q9H6X2 |
ProteomicsDBi | 81048 [Q9H6X2-1] 81049 [Q9H6X2-2] 81050 [Q9H6X2-3] 81051 [Q9H6X2-4] |
Protocols and materials databases
Antibodypediai | 16201, 615 antibodies |
DNASUi | 84168 |
Genome annotation databases
Ensembli | ENST00000303714; ENSP00000301945; ENSG00000169604 [Q9H6X2-1] ENST00000409349; ENSP00000386494; ENSG00000169604 [Q9H6X2-2] ENST00000409829; ENSP00000387058; ENSG00000169604 [Q9H6X2-4] |
GeneIDi | 84168 |
KEGGi | hsa:84168 |
UCSCi | uc002sfe.4, human [Q9H6X2-1] |
Organism-specific databases
CTDi | 84168 |
DisGeNETi | 84168 |
GeneCardsi | ANTXR1 |
HGNCi | HGNC:21014, ANTXR1 |
HPAi | ENSG00000169604, Low tissue specificity |
MalaCardsi | ANTXR1 |
MIMi | 230740, phenotype 602089, phenotype 606410, gene |
neXtProti | NX_Q9H6X2 |
OpenTargetsi | ENSG00000169604 |
Orphaneti | 2067, GAPO syndrome 464293, NON RARE IN EUROPE: Infantile capillary hemangioma |
PharmGKBi | PA134956382 |
VEuPathDBi | HostDB:ENSG00000169604.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSKR, Eukaryota |
GeneTreei | ENSGT00940000156522 |
HOGENOMi | CLU_029760_0_0_1 |
InParanoidi | Q9H6X2 |
OMAi | IYYENVH |
PhylomeDBi | Q9H6X2 |
TreeFami | TF328943 |
Enzyme and pathway databases
PathwayCommonsi | Q9H6X2 |
Reactomei | R-HSA-5210891, Uptake and function of anthrax toxins |
Miscellaneous databases
BioGRID-ORCSi | 84168, 10 hits in 992 CRISPR screens |
ChiTaRSi | ANTXR1, human |
GeneWikii | ANTXR1 |
GenomeRNAii | 84168 |
Pharosi | Q9H6X2, Tbio |
PROi | PR:Q9H6X2 |
RNActi | Q9H6X2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169604, Expressed in stromal cell of endometrium and 225 other tissues |
ExpressionAtlasi | Q9H6X2, baseline and differential |
Genevisiblei | Q9H6X2, HS |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR017360, Anthrax_toxin_rcpt IPR008399, Anthrax_toxin_rcpt_C IPR008400, Anthrax_toxin_rcpt_extracel IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR16059:SF11, PTHR16059:SF11, 1 hit |
Pfami | View protein in Pfam PF05586, Ant_C, 1 hit PF05587, Anth_Ig, 1 hit PF00092, VWA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANTR1_HUMAN | |
Accessioni | Q9H6X2Primary (citable) accession number: Q9H6X2 Secondary accession number(s): A8K7U8 Q9NVP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2001 |
Last sequence update: | November 2, 2001 | |
Last modified: | April 7, 2021 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families