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UniProtKB - Q9H6U6 (BCAS3_HUMAN)

Entry version 173 (25 May 2022)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

BCAS3 microtubule associated cell migration factor

Gene

BCAS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity).

Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712).

Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H6U6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H6U6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCAS3 microtubule associated cell migration factorCurated
Alternative name(s):
Breast carcinoma-amplified sequence 3Imported
GAOB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCAS3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14347, BCAS3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607470, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H6U6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141376

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi350H → A: No effect on recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi370D → A: Decreases recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi372L → A: No effect on recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi377H → A: No effect on recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi400H → A: Decreases recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi401R → A: Almost abolishes recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi426R → A: Decreases recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi428T → A: Almost abolishes recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1
Mutagenesisi430H → A: Almost abolishes recruitment to preautophagosomal structure in response to mitophagy. No effect on interaction with PHAF1. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei824 – 825Breakpoint for translocation to form BCAS4-BCAS32

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		54828

Open Targets

More...OpenTargetsi		ENSG00000141376

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		528084, Non-specific syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25286

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H6U6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCAS3

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508831 – 928BCAS3 microtubule associated cell migration factorAdd BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei461PhosphoserineBy similarity1
Modified residuei480PhosphoserineCombined sources1
Modified residuei488PhosphoserineBy similarity1
Modified residuei838PhosphoserineBy similarity1
Modified residuei886PhosphoserineCombined sources1
Modified residuei898PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H6U6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H6U6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H6U6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H6U6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H6U6

PeptideAtlas

More...PeptideAtlasi		Q9H6U6

PRoteomics IDEntifications database

More...PRIDEi		Q9H6U6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81034 [Q9H6U6-1]
81035 [Q9H6U6-2]
81036 [Q9H6U6-3]
81037 [Q9H6U6-6]
81038 [Q9H6U6-7]
81039 [Q9H6U6-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H6U6

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H6U6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H6U6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Fetal.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By estrogen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141376, Expressed in corpus callosum and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H6U6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H6U6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141376, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3, ESR1, KAT2B and PELP1; the interactions occur in a estrogen-dependent manner.

Interacts with beta-tubulin and VIM.

Interacts (via C-terminal) with PHAF1; the interaction is requrired for the association with the phagophore (PubMed:33499712).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120182, 56 interactors

Protein interaction database and analysis system

More...IntActi		Q9H6U6, 37 interactors

Molecular INTeraction database

More...MINTi		Q9H6U6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375067

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H6U6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9H6U6

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati69 – 114WDSequence analysisAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni254 – 312Required for recruitment to preautophagosomal structure in response to mitophagy1 PublicationAdd BLAST59
Regioni437 – 560Required for recruitment to preautophagosomal structure in response to mitophagy1 PublicationAdd BLAST124
Regioni472 – 515DisorderedSequence analysisAdd BLAST44
Regioni755 – 777DisorderedSequence analysisAdd BLAST23
Regioni868 – 928DisorderedSequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi473 – 515Polar residuesSequence analysisAdd BLAST43
Compositional biasi755 – 773Polar residuesSequence analysisAdd BLAST19
Compositional biasi882 – 928Polar residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has been proposed to contain 7 WD repeats. This prediction could not be reproduced.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BCAS3 family.Curated

Keywords - Domaini

WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2109, Eukaryota
KOG4415, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006454

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H6U6

Identification of Orthologs from Complete Genome Data

More...OMAi		FHEIHGT

Database of Orthologous Groups

More...OrthoDBi		537714at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H6U6

TreeFam database of animal gene trees

More...TreeFami		TF105856

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022175, BCAS3
IPR045142, BCAS3-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13268, PTHR13268, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12490, BCAS3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9H6U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG 
        60         70         80         90        100
TPLTEEKEKI VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG 
       110        120        130        140        150
MQVWSIPISG EAQELFSVRH GPIRAARILP APQFGAQKCD NFAEKRPLLG 
       160        170        180        190        200
VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS IQFKTPIYDL HCNKRILVVV 
       210        220        230        240        250
LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL AYAENKLIRC 
       260        270        280        290        300
HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 
       310        320        330        340        350
DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH 
       360        370        380        390        400
EKPVCCMAFN TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH 
       410        420        430        440        450
RGETEAKVQD ICFSHDCRWV VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR 
       460        470        480        490        500
VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS PVPGLSSSPS GSPLHGKLNS 
       510        520        530        540        550
QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT ITKRTGPYLF 
       560        570        580        590        600
GAGCFSIKAP CKVKPPPQIS PSKSMGGEFC VAAIFGTSRS WFANNAGLKR 
       610        620        630        640        650
EKDQSKQVVV ESLYIISCYG TLVEHMMEPR PLSTAPKISD DTPLEMMTSP 
       660        670        680        690        700
RASWTLVRTP QWNELQPPFN ANHPLLLAAD AVQYYQFLLA GLVPPGSPGP 
       710        720        730        740        750
ITRHGSYDSL ASDHSGQEDE EWLSQVEIVT HTGPHRRLWM GPQFQFKTIH 
       760        770        780        790        800
PSGQTTVISS SSSVLQSHGP SDTPQPLLDF DTDDLDLNSL RIQPVRSDPV 
       810        820        830        840        850
SMPGSSRPVS DRRGVSTVID AASGTFDRSV TLLEVCGSWP EGFGLRHMSS 
       860        870        880        890        900
MEHTEEGLRE RLADAMAESP SRDVVGSGTE LQREGSIETL SNSSGSTSGS 
       910        920 
IPRNFDGYRS PLPTNESQPL SLFPTGFP
Length:928
Mass (Da):101,237
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00D82E2EDCD1E8D7
GO
Isoform 1 (identifier: Q9H6U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.

Show »
Length:913
Mass (Da):99,681
Checksum:i33A29CCC2357D75B
GO
Isoform 3 (identifier: Q9H6U6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Show »
Length:935
Mass (Da):102,107
Checksum:iC5012DE917714AAB
GO
Isoform 4 (identifier: Q9H6U6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Show »
Length:950
Mass (Da):103,662
Checksum:i1515C78689B7ABB1
GO
Isoform 5 (identifier: Q9H6U6-7) [UniParc]FASTAAdd to basket
Also known as: Maaab1

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     880-928: ELQREGSIET...PLSLFPTGFP → DTALDVAVKT...SARGKHRDSE

Show »
Length:928
Mass (Da):101,516
Checksum:iEAA80786E40CE757
GO
Isoform 6 (identifier: Q9H6U6-6) [UniParc]FASTAAdd to basket
Also known as: Maaab2

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     547-561: Missing.

Show »
Length:684
Mass (Da):74,240
Checksum:i2BA7C3218D9B40F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESE9K7ESE9_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
699Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIE2K7EIE2_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJH7K7EJH7_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJU7K7EJU7_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKB0K7EKB0_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EML5K7EML5_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELH0K7ELH0_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIR7K7EIR7_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQA6K7EQA6_HUMAN
BCAS3 microtubule-associated cell m...
BCAS3
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF70324 differs from that shown. Reason: Frameshift.Curated
The sequence AAL99634 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK225757 differs from that shown. Reason: Frameshift.Curated
The sequence BAA90966 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14078 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD54076 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29E → K in AAL99632 (PubMed:12378525).Curated1
Sequence conflicti127R → K in AAL99632 (PubMed:12378525).Curated1
Sequence conflicti199 – 200VV → II in BAB15156 (PubMed:14702039).Curated2
Sequence conflicti533K → E in BAB14078 (PubMed:14702039).Curated1
Sequence conflicti533K → E in BAB14380 (PubMed:14702039).Curated1
Sequence conflicti640D → G in BAB15156 (PubMed:14702039).Curated1
Sequence conflicti666Q → R in BAB14078 (PubMed:14702039).Curated1
Sequence conflicti806S → P in BAB15156 (PubMed:14702039).Curated1
Isoform 5 (identifier: Q9H6U6-7)
Sequence conflicti891G → R in CAD54076 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06509387N → S4 PublicationsCorresponds to variant dbSNP:rs2643103Ensembl.1
Natural variantiVAR_057583106I → V. Corresponds to variant dbSNP:rs34712615Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0401121 – 229Missing in isoform 6. 2 PublicationsAdd BLAST229
Alternative sequenceiVSP_007858547 – 561Missing in isoform 1, isoform 3, isoform 5 and isoform 6. 4 PublicationsAdd BLAST15
Alternative sequenceiVSP_007860879T → TDTALDVAVKTFPPERHVAV KCF in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_040113880 – 928ELQRE…PTGFP → DTALDVAVKTFPPERHVAVK CFGKKKGKKKQCQQPSVREQ PNSNKACVRDGGRTSARGKH RDSE in isoform 5. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF361219 mRNA Translation: AAL99632.1
AF361221 mRNA Translation: AAL99634.1 Different initiation.
AK000135 mRNA Translation: BAA90966.1 Different initiation.
AK022526 mRNA Translation: BAB14078.1 Different initiation.
AK023054 mRNA Translation: BAB14380.1
AK025510 mRNA Translation: BAB15156.1
AK225757 mRNA No translation available.
AC005746 Genomic DNA No translation available.
AC005856 Genomic DNA No translation available.
AC005884 Genomic DNA No translation available.
AC015876 Genomic DNA No translation available.
AC079005 Genomic DNA No translation available.
AC110602 Genomic DNA No translation available.
CH471179 Genomic DNA Translation: EAW51414.1
BC001250 mRNA Translation: AAH01250.2
BC117275 mRNA Translation: AAI17276.1
BC143386 mRNA Translation: AAI43387.1
AJ511332 mRNA Translation: CAD54076.1 Frameshift.
AJ518105 mRNA Translation: CAD57723.1
AL831895 mRNA Translation: CAD38568.1
AF260268 mRNA Translation: AAF70324.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11626.1 [Q9H6U6-2]
CCDS45749.1 [Q9H6U6-1]
CCDS82176.1 [Q9H6U6-8]
CCDS82177.1 [Q9H6U6-7]
CCDS82178.1 [Q9H6U6-3]

NCBI Reference Sequences

More...RefSeqi		NP_001092902.1, NM_001099432.1 [Q9H6U6-1]
NP_001307399.1, NM_001320470.1 [Q9H6U6-7]
NP_060149.3, NM_017679.3 [Q9H6U6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000390652.9; ENSP00000375067.4; ENSG00000141376.23
ENST00000407086.8; ENSP00000385323.2; ENSG00000141376.23 [Q9H6U6-2]
ENST00000408905.7; ENSP00000386173.2; ENSG00000141376.23 [Q9H6U6-3]
ENST00000588462.5; ENSP00000468592.1; ENSG00000141376.23 [Q9H6U6-8]
ENST00000588874.5; ENSP00000464825.1; ENSG00000141376.23 [Q9H6U6-6]
ENST00000589222.5; ENSP00000466078.1; ENSG00000141376.23 [Q9H6U6-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54828

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54828

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000407086.8; ENSP00000385323.2; NM_017679.5; NP_060149.3 [Q9H6U6-2]

UCSC genome browser

More...UCSCi		uc002iyu.5, human [Q9H6U6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361219 mRNA Translation: AAL99632.1
AF361221 mRNA Translation: AAL99634.1 Different initiation.
AK000135 mRNA Translation: BAA90966.1 Different initiation.
AK022526 mRNA Translation: BAB14078.1 Different initiation.
AK023054 mRNA Translation: BAB14380.1
AK025510 mRNA Translation: BAB15156.1
AK225757 mRNA No translation available.
AC005746 Genomic DNA No translation available.
AC005856 Genomic DNA No translation available.
AC005884 Genomic DNA No translation available.
AC015876 Genomic DNA No translation available.
AC079005 Genomic DNA No translation available.
AC110602 Genomic DNA No translation available.
CH471179 Genomic DNA Translation: EAW51414.1
BC001250 mRNA Translation: AAH01250.2
BC117275 mRNA Translation: AAI17276.1
BC143386 mRNA Translation: AAI43387.1
AJ511332 mRNA Translation: CAD54076.1 Frameshift.
AJ518105 mRNA Translation: CAD57723.1
AL831895 mRNA Translation: CAD38568.1
AF260268 mRNA Translation: AAF70324.1 Frameshift.
CCDSiCCDS11626.1 [Q9H6U6-2]
CCDS45749.1 [Q9H6U6-1]
CCDS82176.1 [Q9H6U6-8]
CCDS82177.1 [Q9H6U6-7]
CCDS82178.1 [Q9H6U6-3]
RefSeqiNP_001092902.1, NM_001099432.1 [Q9H6U6-1]
NP_001307399.1, NM_001320470.1 [Q9H6U6-7]
NP_060149.3, NM_017679.3 [Q9H6U6-2]

3D structure databases

AlphaFoldDBiQ9H6U6
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi120182, 56 interactors
IntActiQ9H6U6, 37 interactors
MINTiQ9H6U6
STRINGi9606.ENSP00000375067

PTM databases

iPTMnetiQ9H6U6
MetOSiteiQ9H6U6
PhosphoSitePlusiQ9H6U6

Genetic variation databases

BioMutaiBCAS3
DMDMi313104248

Proteomic databases

EPDiQ9H6U6
jPOSTiQ9H6U6
MassIVEiQ9H6U6
MaxQBiQ9H6U6
PaxDbiQ9H6U6
PeptideAtlasiQ9H6U6
PRIDEiQ9H6U6
ProteomicsDBi81034 [Q9H6U6-1]
81035 [Q9H6U6-2]
81036 [Q9H6U6-3]
81037 [Q9H6U6-6]
81038 [Q9H6U6-7]
81039 [Q9H6U6-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9303, 225 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		54828

Genome annotation databases

EnsembliENST00000390652.9; ENSP00000375067.4; ENSG00000141376.23
ENST00000407086.8; ENSP00000385323.2; ENSG00000141376.23 [Q9H6U6-2]
ENST00000408905.7; ENSP00000386173.2; ENSG00000141376.23 [Q9H6U6-3]
ENST00000588462.5; ENSP00000468592.1; ENSG00000141376.23 [Q9H6U6-8]
ENST00000588874.5; ENSP00000464825.1; ENSG00000141376.23 [Q9H6U6-6]
ENST00000589222.5; ENSP00000466078.1; ENSG00000141376.23 [Q9H6U6-7]
GeneIDi54828
KEGGihsa:54828
MANE-SelectiENST00000407086.8; ENSP00000385323.2; NM_017679.5; NP_060149.3 [Q9H6U6-2]
UCSCiuc002iyu.5, human [Q9H6U6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54828
DisGeNETi54828

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCAS3
HGNCiHGNC:14347, BCAS3
HPAiENSG00000141376, Low tissue specificity
MIMi607470, gene
neXtProtiNX_Q9H6U6
OpenTargetsiENSG00000141376
Orphaneti528084, Non-specific syndromic intellectual disability
PharmGKBiPA25286
VEuPathDBiHostDB:ENSG00000141376

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2109, Eukaryota
KOG4415, Eukaryota
GeneTreeiENSGT00390000006454
InParanoidiQ9H6U6
OMAiFHEIHGT
OrthoDBi537714at2759
PhylomeDBiQ9H6U6
TreeFamiTF105856

Enzyme and pathway databases

PathwayCommonsiQ9H6U6
SignaLinkiQ9H6U6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54828, 37 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCAS3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCAS3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54828
PharosiQ9H6U6, Tbio

Protein Ontology

More...PROi		PR:Q9H6U6
RNActiQ9H6U6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141376, Expressed in corpus callosum and 192 other tissues
ExpressionAtlasiQ9H6U6, baseline and differential
GenevisibleiQ9H6U6, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR022175, BCAS3
IPR045142, BCAS3-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13268, PTHR13268, 1 hit
PfamiView protein in Pfam
PF12490, BCAS3, 1 hit
SUPFAMiSSF50978, SSF50978, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6U6
Secondary accession number(s): Q17RM0
, Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H957, Q9H9Y9, Q9NXP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 30, 2010
Last modified: May 25, 2022
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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