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Entry version 134 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

5-azacytidine-induced protein 2

Gene

AZI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H6S1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H6S1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-azacytidine-induced protein 2
Alternative name(s):
NF-kappa-B-activating kinase-associated protein 1
Short name:
Nak-associated protein 1
TILP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AZI2
Synonyms:NAP1, TBKBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000163512.13

Human Gene Nomenclature Database

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HGNCi
HGNC:24002, AZI2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609916, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H6S1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64343

Open Targets

More...
OpenTargetsi
ENSG00000163512

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950985

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H6S1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AZI2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74718550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002806021 – 3925-azacytidine-induced protein 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei318PhosphoserineBy similarity1
Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H6S1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H6S1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H6S1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H6S1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H6S1

PeptideAtlas

More...
PeptideAtlasi
Q9H6S1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H6S1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
43401
81026 [Q9H6S1-1]
81027 [Q9H6S1-3]
9412

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H6S1

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H6S1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H6S1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Abundant expression seen in the pancreas and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163512, Expressed in testis and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H6S1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H6S1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163512, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with IKBKE (PubMed:14560022, PubMed:17568778).

Interacts with TBK1 (PubMed:14560022, PubMed:21931631, PubMed:29251827).

Interacts with TICAM1 (PubMed:15611223).

By similarity5 Publications

(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122142, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H6S1

Database of interacting proteins

More...
DIPi
DIP-27605N

Protein interaction database and analysis system

More...
IntActi
Q9H6S1, 15 interactors

Molecular INTeraction database

More...
MINTi
Q9H6S1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419371

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H6S1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H6S1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 197HomodimerizationBy similarityAdd BLAST197
Regioni216 – 257Interaction with TBK1 and IKBKEAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili40 – 76Sequence analysisAdd BLAST37
Coiled coili102 – 196Sequence analysisAdd BLAST95

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QV07, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000153704

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H6S1

Identification of Orthologs from Complete Genome Data

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OMAi
DAMFWEG

Database of Orthologous Groups

More...
OrthoDBi
1268120at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H6S1

TreeFam database of animal gene trees

More...
TreeFami
TF331289

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024581, TBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12845, TBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6S1-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDALVEDDIC ILNHEKAHKR DTVTPVSIYS GDESVASHFA LVTAYEDIKK
60 70 80 90 100
RLKDSEKENS LLKKRIRFLE EKLIARFEEE TSSVGREQVN KAYHAYREVC
110 120 130 140 150
IDRDNLKSKL DKMNKDNSES LKVLNEQLQS KEVELLQLRT EVETQQVMRN
160 170 180 190 200
LNPPSSNWEV EKLSCDLKIH GLEQELELMR KECSDLKIEL QKAKQTDPYQ
210 220 230 240 250
EDNLKSRDLQ KLSISSDNMQ HAYWELKREM SNLHLVTQVQ AELLRKLKTS
260 270 280 290 300
TAIKKACAPV GCSEDLGRDS TKLHLMNFTA TYTRHPPLLP NGKALCHTTS
310 320 330 340 350
SPLPGDVKVL SEKAILQSWT DNERSIPNDG TCFQEHSSYG RNSLEDNSWV
360 370 380 390
FPSPPKSSET AFGETKTKTL PLPNLPPLHY LDQHNQNCLY KN
Length:392
Mass (Da):44,935
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFDBDDA60C5CD624
GO
Isoform 2 (identifier: Q9H6S1-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     216-228: SDNMQHAYWELKR → TQPGVQWRNHGIA
     229-392: Missing.

Show »
Length:228
Mass (Da):26,510
Checksum:iA72E09E4DDF71599
GO
Isoform 3 (identifier: Q9H6S1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-243: SDNMQHAYWELKREMSNLHLVTQVQAEL → RQSICSTAWSAVAQSWDSMNFEDCSLFA
     244-392: Missing.

Show »
Length:243
Mass (Da):28,188
Checksum:i7AA3CF2551827226
GO
Isoform 4 (identifier: Q9H6S1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-232: SDNMQHAYWELKREMSN → RVSVAQPGVQWRNHGIA
     233-392: Missing.

Show »
Length:232
Mass (Da):26,921
Checksum:i5F5E73150C34543A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVK8C9JVK8_HUMAN
5-azacytidine-induced protein 2
AZI2
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGA2C9JGA2_HUMAN
5-azacytidine-induced protein 2
AZI2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1Z1H7C1Z1_HUMAN
5-azacytidine-induced protein 2
AZI2
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047087216 – 243SDNMQ…VQAEL → RQSICSTAWSAVAQSWDSMN FEDCSLFA in isoform 3. CuratedAdd BLAST28
Alternative sequenceiVSP_047088216 – 232SDNMQ…REMSN → RVSVAQPGVQWRNHGIA in isoform 4. CuratedAdd BLAST17
Alternative sequenceiVSP_023817216 – 228SDNMQ…WELKR → TQPGVQWRNHGIA in isoform 2. CuratedAdd BLAST13
Alternative sequenceiVSP_023818229 – 392Missing in isoform 2. CuratedAdd BLAST164
Alternative sequenceiVSP_047089233 – 392Missing in isoform 4. CuratedAdd BLAST160
Alternative sequenceiVSP_047090244 – 392Missing in isoform 3. CuratedAdd BLAST149

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY151386 mRNA Translation: AAO05967.1
AF044917 Genomic DNA Translation: AAF22368.1
AF044918 Genomic DNA Translation: AAF22369.1
AK025592 mRNA Translation: BAB15182.1
AK290637 mRNA Translation: BAF83326.1
AC092503 Genomic DNA No translation available.
AC098616 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64395.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2647.1 [Q9H6S1-1]
CCDS46782.1 [Q9H6S1-4]
CCDS46783.1 [Q9H6S1-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001127904.1, NM_001134432.1 [Q9H6S1-4]
NP_001127905.1, NM_001134433.1 [Q9H6S1-5]
NP_071906.1, NM_022461.4 [Q9H6S1-1]
XP_005265449.1, XM_005265392.2 [Q9H6S1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334100; ENSP00000335609; ENSG00000163512 [Q9H6S1-5]
ENST00000420543; ENSP00000391696; ENSG00000163512 [Q9H6S1-4]
ENST00000457172; ENSP00000389577; ENSG00000163512 [Q9H6S1-4]
ENST00000479665; ENSP00000419371; ENSG00000163512 [Q9H6S1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64343

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64343

UCSC genome browser

More...
UCSCi
uc003ceb.5, human [Q9H6S1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151386 mRNA Translation: AAO05967.1
AF044917 Genomic DNA Translation: AAF22368.1
AF044918 Genomic DNA Translation: AAF22369.1
AK025592 mRNA Translation: BAB15182.1
AK290637 mRNA Translation: BAF83326.1
AC092503 Genomic DNA No translation available.
AC098616 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64395.1
CCDSiCCDS2647.1 [Q9H6S1-1]
CCDS46782.1 [Q9H6S1-4]
CCDS46783.1 [Q9H6S1-5]
RefSeqiNP_001127904.1, NM_001134432.1 [Q9H6S1-4]
NP_001127905.1, NM_001134433.1 [Q9H6S1-5]
NP_071906.1, NM_022461.4 [Q9H6S1-1]
XP_005265449.1, XM_005265392.2 [Q9H6S1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EP6X-ray1.45A/C215-255[»]
5Z7GX-ray2.30C/D33-75[»]
5Z7LX-ray2.02C/D33-75[»]
SMRiQ9H6S1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122142, 26 interactors
CORUMiQ9H6S1
DIPiDIP-27605N
IntActiQ9H6S1, 15 interactors
MINTiQ9H6S1
STRINGi9606.ENSP00000419371

PTM databases

iPTMnetiQ9H6S1
MetOSiteiQ9H6S1
PhosphoSitePlusiQ9H6S1

Polymorphism and mutation databases

BioMutaiAZI2
DMDMi74718550

Proteomic databases

EPDiQ9H6S1
jPOSTiQ9H6S1
MassIVEiQ9H6S1
MaxQBiQ9H6S1
PaxDbiQ9H6S1
PeptideAtlasiQ9H6S1
PRIDEiQ9H6S1
ProteomicsDBi43401
81026 [Q9H6S1-1]
81027 [Q9H6S1-3]
9412

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27537, 114 antibodies

The DNASU plasmid repository

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DNASUi
64343

Genome annotation databases

EnsembliENST00000334100; ENSP00000335609; ENSG00000163512 [Q9H6S1-5]
ENST00000420543; ENSP00000391696; ENSG00000163512 [Q9H6S1-4]
ENST00000457172; ENSP00000389577; ENSG00000163512 [Q9H6S1-4]
ENST00000479665; ENSP00000419371; ENSG00000163512 [Q9H6S1-1]
GeneIDi64343
KEGGihsa:64343
UCSCiuc003ceb.5, human [Q9H6S1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64343
DisGeNETi64343
EuPathDBiHostDB:ENSG00000163512.13

GeneCards: human genes, protein and diseases

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GeneCardsi
AZI2
HGNCiHGNC:24002, AZI2
HPAiENSG00000163512, Low tissue specificity
MIMi609916, gene
neXtProtiNX_Q9H6S1
OpenTargetsiENSG00000163512
PharmGKBiPA134950985

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QV07, Eukaryota
GeneTreeiENSGT00940000153704
InParanoidiQ9H6S1
OMAiDAMFWEG
OrthoDBi1268120at2759
PhylomeDBiQ9H6S1
TreeFamiTF331289

Enzyme and pathway databases

PathwayCommonsiQ9H6S1
SignaLinkiQ9H6S1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64343, 43 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AZI2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AZI2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64343
PharosiQ9H6S1, Tdark

Protein Ontology

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PROi
PR:Q9H6S1
RNActiQ9H6S1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163512, Expressed in testis and 235 other tissues
ExpressionAtlasiQ9H6S1, baseline and differential
GenevisibleiQ9H6S1, HS

Family and domain databases

InterProiView protein in InterPro
IPR024581, TBD
PfamiView protein in Pfam
PF12845, TBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAZI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6S1
Secondary accession number(s): A8K3M2
, C9JB40, H7BXU6, Q86W99, Q9BQF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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