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Entry version 143 (13 Feb 2019)
Sequence version 2 (26 Apr 2005)
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Protein

Nucleolar protein 6

Gene

NOL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: UniProtKB
  • tRNA export from nucleus Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 6
Alternative name(s):
Nucleolar RNA-associated protein
Short name:
Nrap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOL6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165271.16

Human Gene Nomenclature Database

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HGNCi
HGNC:19910 NOL6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611532 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H6R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000165271

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134979388

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOL6

Domain mapping of disease mutations (DMDM)

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DMDMi
62900709

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002156471 – 1146Nucleolar protein 6Add BLAST1146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H6R4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H6R4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H6R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H6R4

PeptideAtlas

More...
PeptideAtlasi
Q9H6R4

PRoteomics IDEntifications database

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PRIDEi
Q9H6R4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81016
81017 [Q9H6R4-2]
81018 [Q9H6R4-3]
81019 [Q9H6R4-4]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q9H6R4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H6R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H6R4

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9H6R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165271 Expressed in 216 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H6R4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H6R4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055891
HPA061002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably associated with rRNA.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-10307896,EBI-747107

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122391, 120 interactors

Protein interaction database and analysis system

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IntActi
Q9H6R4, 22 interactors

Molecular INTeraction database

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MINTi
Q9H6R4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297990

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H6R4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H6R4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 114Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2054 Eukaryota
ENOG410XPP9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018619

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052644

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H6R4

KEGG Orthology (KO)

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KOi
K14544

Identification of Orthologs from Complete Genome Data

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OMAi
VWNQLAN

Database of Orthologous Groups

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OrthoDBi
176625at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H6R4

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6

The PANTHER Classification System

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PANTHERi
PTHR17972 PTHR17972, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6R4-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL
60 70 80 90 100
QPVKLSRAEL YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK
110 120 130 140 150
KKDRIDAFLR EVNQRVVRVP SVPETELTDQ AWLPAGVRVP LHQVPYAVKG
160 170 180 190 200
CFRFLPPAQV TVVGSYLLGT CIRPDINVDV ALTMPREILQ DKDGLNQRYF
210 220 230 240 250
RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR PRGKDERLVT
260 270 280 290 300
VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW
310 320 330 340 350
VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF
360 370 380 390 400
LVSMLVVFLV STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP
410 420 430 440 450
SLPALADFHQ AFSVVFLDSS GHLNLCADVT ASTYHQVQHE ARLSMMLLDS
460 470 480 490 500
RADDGFHLLL MTPKPMIRAF DHVLHLRPLS RLQAACHRLK LWPELQDNGG
510 520 530 540 550
DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD PPKHKDSGTL
560 570 580 590 600
TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA
610 620 630 640 650
VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGGP LDALIQGLKE
660 670 680 690 700
TSSTGEEALV AAVRCYDDLS RLLWGLEGLP LTVSAVQGAH PVLRYTEVFP
710 720 730 740 750
PTPVRPAFSF YETLRERSSL LPRLDKPCPA YVEPMTVVCH LEGSGQWPQD
760 770 780 790 800
AEAVQRVRAA FQLRLAELLT QQHGLQCRAT ATHTDVLKDG FVFRIRVAYQ
810 820 830 840 850
REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA LHGLQQQHPA
860 870 880 890 900
FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEPF TPPSSPQVGF
910 920 930 940 950
LRFLFLVSTF DWKNNPLFVN LNNELTVEEQ VEIRSGFLAA RAQLPVMVIV
960 970 980 990 1000
TPQDRKNSVW TQDGPSAQIL QQLVVLAAEA LPMLEKQLMD PRGPGDIRTV
1010 1020 1030 1040 1050
FRPPLDIYDV LIRLSPRHIP RHRQAVDSPA ASFCRGLLSQ PGPSSLMPVL
1060 1070 1080 1090 1100
GYDPPQLYLT QLREAFGDLA LFFYDQHGGE VIGVLWKPTS FQPQPFKASS
1110 1120 1130 1140
TKGRMVMSRG GELVMVPNVE AILEDFAVLG EGLVQTVEAR SERWTV
Length:1,146
Mass (Da):127,593
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E73D31BC3D4AF6B
GO
Isoform 2 (identifier: Q9H6R4-2) [UniParc]FASTAAdd to basket
Also known as: Beta, Mid

The sequence of this isoform differs from the canonical sequence as follows:
     999-1146: TVFRPPLDIY...VEARSERWTV → WDPAKMWPF

Show »
Length:1,007
Mass (Da):112,304
Checksum:i01D3B9CCAA02BCDA
GO
Isoform 3 (identifier: Q9H6R4-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, Short

The sequence of this isoform differs from the canonical sequence as follows:
     651-1097: Missing.

Show »
Length:699
Mass (Da):77,638
Checksum:i75A45AF2E1FA4999
GO
Isoform 4 (identifier: Q9H6R4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-385: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):127,320
Checksum:i9645DBFD0F457291
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFX0A0A0C4DFX0_HUMAN
Nucleolar protein 6
NOL6
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW6A0A0A0MRW6_HUMAN
Nucleolar protein 6
NOL6
1,008Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15189 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15389 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1098A → T in AAL74405 (PubMed:11895476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05354152P → S. Corresponds to variant dbSNP:rs10971523Ensembl.1
Natural variantiVAR_053542723R → W. Corresponds to variant dbSNP:rs35135082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013530383 – 385Missing in isoform 4. 1 Publication3
Alternative sequenceiVSP_013531651 – 1097Missing in isoform 3. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_013532999 – 1146TVFRP…ERWTV → WDPAKMWPF in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF361079 mRNA Translation: AAL74403.1
AF361080 mRNA Translation: AAL74404.1
AF361081 mRNA Translation: AAL74405.1
AL356218 Genomic DNA No translation available.
BC008298 mRNA Translation: AAH08298.1 Different initiation.
BC008852 mRNA Translation: AAH08852.2
BC030139 mRNA Translation: AAH30139.1
AK025612 mRNA Translation: BAB15189.1 Different initiation.
AK026193 mRNA Translation: BAB15389.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6543.1 [Q9H6R4-1]
CCDS6544.1 [Q9H6R4-3]

NCBI Reference Sequences

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RefSeqi
NP_075068.2, NM_022917.4 [Q9H6R4-1]
NP_631981.2, NM_139235.3 [Q9H6R4-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.493709

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297990; ENSP00000297990; ENSG00000165271 [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271 [Q9H6R4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
65083

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:65083

UCSC genome browser

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UCSCi
uc003zsy.4 human [Q9H6R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361079 mRNA Translation: AAL74403.1
AF361080 mRNA Translation: AAL74404.1
AF361081 mRNA Translation: AAL74405.1
AL356218 Genomic DNA No translation available.
BC008298 mRNA Translation: AAH08298.1 Different initiation.
BC008852 mRNA Translation: AAH08852.2
BC030139 mRNA Translation: AAH30139.1
AK025612 mRNA Translation: BAB15189.1 Different initiation.
AK026193 mRNA Translation: BAB15389.1 Sequence problems.
CCDSiCCDS6543.1 [Q9H6R4-1]
CCDS6544.1 [Q9H6R4-3]
RefSeqiNP_075068.2, NM_022917.4 [Q9H6R4-1]
NP_631981.2, NM_139235.3 [Q9H6R4-3]
UniGeneiHs.493709

3D structure databases

ProteinModelPortaliQ9H6R4
SMRiQ9H6R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122391, 120 interactors
IntActiQ9H6R4, 22 interactors
MINTiQ9H6R4
STRINGi9606.ENSP00000297990

PTM databases

iPTMnetiQ9H6R4
PhosphoSitePlusiQ9H6R4
SwissPalmiQ9H6R4

Polymorphism and mutation databases

BioMutaiNOL6
DMDMi62900709

2D gel databases

SWISS-2DPAGEiQ9H6R4

Proteomic databases

EPDiQ9H6R4
jPOSTiQ9H6R4
MaxQBiQ9H6R4
PaxDbiQ9H6R4
PeptideAtlasiQ9H6R4
PRIDEiQ9H6R4
ProteomicsDBi81016
81017 [Q9H6R4-2]
81018 [Q9H6R4-3]
81019 [Q9H6R4-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297990; ENSP00000297990; ENSG00000165271 [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271 [Q9H6R4-3]
GeneIDi65083
KEGGihsa:65083
UCSCiuc003zsy.4 human [Q9H6R4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
65083
EuPathDBiHostDB:ENSG00000165271.16

GeneCards: human genes, protein and diseases

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GeneCardsi
NOL6
HGNCiHGNC:19910 NOL6
HPAiHPA055891
HPA061002
MIMi611532 gene
neXtProtiNX_Q9H6R4
OpenTargetsiENSG00000165271
PharmGKBiPA134979388

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2054 Eukaryota
ENOG410XPP9 LUCA
GeneTreeiENSGT00390000018619
HOVERGENiHBG052644
InParanoidiQ9H6R4
KOiK14544
OMAiVWNQLAN
OrthoDBi176625at2759
PhylomeDBiQ9H6R4

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NOL6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NOL6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
65083

Protein Ontology

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PROi
PR:Q9H6R4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165271 Expressed in 216 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ9H6R4 baseline and differential
GenevisibleiQ9H6R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6R4
Secondary accession number(s): Q5T5M3
, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 13, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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