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Protein

Nucleolar protein 6

Gene

NOL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: UniProtKB
  • tRNA export from nucleus Source: GO_Central

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 6
Alternative name(s):
Nucleolar RNA-associated protein
Short name:
Nrap
Gene namesi
Name:NOL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165271.16
HGNCiHGNC:19910 NOL6
MIMi611532 gene
neXtProtiNX_Q9H6R4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165271
PharmGKBiPA134979388

Polymorphism and mutation databases

BioMutaiNOL6
DMDMi62900709

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156471 – 1146Nucleolar protein 6Add BLAST1146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6R4
MaxQBiQ9H6R4
PaxDbiQ9H6R4
PeptideAtlasiQ9H6R4
PRIDEiQ9H6R4
ProteomicsDBi81016
81017 [Q9H6R4-2]
81018 [Q9H6R4-3]
81019 [Q9H6R4-4]

2D gel databases

SWISS-2DPAGEiQ9H6R4

PTM databases

iPTMnetiQ9H6R4
PhosphoSitePlusiQ9H6R4
SwissPalmiQ9H6R4

Expressioni

Gene expression databases

BgeeiENSG00000165271 Expressed in 216 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ9H6R4 baseline and differential
GenevisibleiQ9H6R4 HS

Organism-specific databases

HPAiHPA055891
HPA061002

Interactioni

Subunit structurei

Probably associated with rRNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-10307896,EBI-747107

Protein-protein interaction databases

BioGridi122391, 116 interactors
IntActiQ9H6R4, 19 interactors
MINTiQ9H6R4
STRINGi9606.ENSP00000297990

Structurei

3D structure databases

ProteinModelPortaliQ9H6R4
SMRiQ9H6R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 114Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the NRAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2054 Eukaryota
ENOG410XPP9 LUCA
GeneTreeiENSGT00390000018619
HOVERGENiHBG052644
InParanoidiQ9H6R4
KOiK14544
OMAiVWNQLAN
OrthoDBiEOG091G01Z2
PhylomeDBiQ9H6R4

Family and domain databases

InterProiView protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6R4-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL
60 70 80 90 100
QPVKLSRAEL YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK
110 120 130 140 150
KKDRIDAFLR EVNQRVVRVP SVPETELTDQ AWLPAGVRVP LHQVPYAVKG
160 170 180 190 200
CFRFLPPAQV TVVGSYLLGT CIRPDINVDV ALTMPREILQ DKDGLNQRYF
210 220 230 240 250
RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR PRGKDERLVT
260 270 280 290 300
VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW
310 320 330 340 350
VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF
360 370 380 390 400
LVSMLVVFLV STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP
410 420 430 440 450
SLPALADFHQ AFSVVFLDSS GHLNLCADVT ASTYHQVQHE ARLSMMLLDS
460 470 480 490 500
RADDGFHLLL MTPKPMIRAF DHVLHLRPLS RLQAACHRLK LWPELQDNGG
510 520 530 540 550
DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD PPKHKDSGTL
560 570 580 590 600
TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA
610 620 630 640 650
VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGGP LDALIQGLKE
660 670 680 690 700
TSSTGEEALV AAVRCYDDLS RLLWGLEGLP LTVSAVQGAH PVLRYTEVFP
710 720 730 740 750
PTPVRPAFSF YETLRERSSL LPRLDKPCPA YVEPMTVVCH LEGSGQWPQD
760 770 780 790 800
AEAVQRVRAA FQLRLAELLT QQHGLQCRAT ATHTDVLKDG FVFRIRVAYQ
810 820 830 840 850
REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA LHGLQQQHPA
860 870 880 890 900
FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEPF TPPSSPQVGF
910 920 930 940 950
LRFLFLVSTF DWKNNPLFVN LNNELTVEEQ VEIRSGFLAA RAQLPVMVIV
960 970 980 990 1000
TPQDRKNSVW TQDGPSAQIL QQLVVLAAEA LPMLEKQLMD PRGPGDIRTV
1010 1020 1030 1040 1050
FRPPLDIYDV LIRLSPRHIP RHRQAVDSPA ASFCRGLLSQ PGPSSLMPVL
1060 1070 1080 1090 1100
GYDPPQLYLT QLREAFGDLA LFFYDQHGGE VIGVLWKPTS FQPQPFKASS
1110 1120 1130 1140
TKGRMVMSRG GELVMVPNVE AILEDFAVLG EGLVQTVEAR SERWTV
Length:1,146
Mass (Da):127,593
Last modified:April 26, 2005 - v2
Checksum:i2E73D31BC3D4AF6B
GO
Isoform 2 (identifier: Q9H6R4-2) [UniParc]FASTAAdd to basket
Also known as: Beta, Mid

The sequence of this isoform differs from the canonical sequence as follows:
     999-1146: TVFRPPLDIY...VEARSERWTV → WDPAKMWPF

Show »
Length:1,007
Mass (Da):112,304
Checksum:i01D3B9CCAA02BCDA
GO
Isoform 3 (identifier: Q9H6R4-3) [UniParc]FASTAAdd to basket
Also known as: Gamma, Short

The sequence of this isoform differs from the canonical sequence as follows:
     651-1097: Missing.

Show »
Length:699
Mass (Da):77,638
Checksum:i75A45AF2E1FA4999
GO
Isoform 4 (identifier: Q9H6R4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-385: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):127,320
Checksum:i9645DBFD0F457291
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFX0A0A0C4DFX0_HUMAN
Nucleolar protein 6
NOL6
200Annotation score:
A0A0A0MRW6A0A0A0MRW6_HUMAN
Nucleolar protein 6
NOL6
1,008Annotation score:

Sequence cautioni

The sequence AAH08298 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15189 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15389 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1098A → T in AAL74405 (PubMed:11895476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05354152P → S. Corresponds to variant dbSNP:rs10971523Ensembl.1
Natural variantiVAR_053542723R → W. Corresponds to variant dbSNP:rs35135082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013530383 – 385Missing in isoform 4. 1 Publication3
Alternative sequenceiVSP_013531651 – 1097Missing in isoform 3. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_013532999 – 1146TVFRP…ERWTV → WDPAKMWPF in isoform 2. 1 PublicationAdd BLAST148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361079 mRNA Translation: AAL74403.1
AF361080 mRNA Translation: AAL74404.1
AF361081 mRNA Translation: AAL74405.1
AL356218 Genomic DNA No translation available.
BC008298 mRNA Translation: AAH08298.1 Different initiation.
BC008852 mRNA Translation: AAH08852.2
BC030139 mRNA Translation: AAH30139.1
AK025612 mRNA Translation: BAB15189.1 Different initiation.
AK026193 mRNA Translation: BAB15389.1 Sequence problems.
CCDSiCCDS6543.1 [Q9H6R4-1]
CCDS6544.1 [Q9H6R4-3]
RefSeqiNP_075068.2, NM_022917.4 [Q9H6R4-1]
NP_631981.2, NM_139235.3 [Q9H6R4-3]
UniGeneiHs.493709

Genome annotation databases

EnsembliENST00000297990; ENSP00000297990; ENSG00000165271 [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271 [Q9H6R4-3]
GeneIDi65083
KEGGihsa:65083
UCSCiuc003zsy.4 human [Q9H6R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361079 mRNA Translation: AAL74403.1
AF361080 mRNA Translation: AAL74404.1
AF361081 mRNA Translation: AAL74405.1
AL356218 Genomic DNA No translation available.
BC008298 mRNA Translation: AAH08298.1 Different initiation.
BC008852 mRNA Translation: AAH08852.2
BC030139 mRNA Translation: AAH30139.1
AK025612 mRNA Translation: BAB15189.1 Different initiation.
AK026193 mRNA Translation: BAB15389.1 Sequence problems.
CCDSiCCDS6543.1 [Q9H6R4-1]
CCDS6544.1 [Q9H6R4-3]
RefSeqiNP_075068.2, NM_022917.4 [Q9H6R4-1]
NP_631981.2, NM_139235.3 [Q9H6R4-3]
UniGeneiHs.493709

3D structure databases

ProteinModelPortaliQ9H6R4
SMRiQ9H6R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122391, 116 interactors
IntActiQ9H6R4, 19 interactors
MINTiQ9H6R4
STRINGi9606.ENSP00000297990

PTM databases

iPTMnetiQ9H6R4
PhosphoSitePlusiQ9H6R4
SwissPalmiQ9H6R4

Polymorphism and mutation databases

BioMutaiNOL6
DMDMi62900709

2D gel databases

SWISS-2DPAGEiQ9H6R4

Proteomic databases

EPDiQ9H6R4
MaxQBiQ9H6R4
PaxDbiQ9H6R4
PeptideAtlasiQ9H6R4
PRIDEiQ9H6R4
ProteomicsDBi81016
81017 [Q9H6R4-2]
81018 [Q9H6R4-3]
81019 [Q9H6R4-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297990; ENSP00000297990; ENSG00000165271 [Q9H6R4-1]
ENST00000353159; ENSP00000313978; ENSG00000165271 [Q9H6R4-3]
GeneIDi65083
KEGGihsa:65083
UCSCiuc003zsy.4 human [Q9H6R4-1]

Organism-specific databases

CTDi65083
EuPathDBiHostDB:ENSG00000165271.16
GeneCardsiNOL6
HGNCiHGNC:19910 NOL6
HPAiHPA055891
HPA061002
MIMi611532 gene
neXtProtiNX_Q9H6R4
OpenTargetsiENSG00000165271
PharmGKBiPA134979388
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2054 Eukaryota
ENOG410XPP9 LUCA
GeneTreeiENSGT00390000018619
HOVERGENiHBG052644
InParanoidiQ9H6R4
KOiK14544
OMAiVWNQLAN
OrthoDBiEOG091G01Z2
PhylomeDBiQ9H6R4

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiNOL6 human
GeneWikiiNOL6
GenomeRNAii65083
PROiPR:Q9H6R4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165271 Expressed in 216 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ9H6R4 baseline and differential
GenevisibleiQ9H6R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR005554 Nrap
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 1 hit
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOL6_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R4
Secondary accession number(s): Q5T5M3
, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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