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Protein

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Gene

ACSS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.By similarity

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei539ATPBy similarity1
Binding sitei554ATPBy similarity1
Binding sitei565ATPBy similarity1
Binding sitei624Coenzyme ABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi425 – 427ATPBy similarity3
Nucleotide bindingi446 – 451ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-77111 Synthesis of Ketone Bodies

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC:6.2.1.1)
Alternative name(s):
Acyl-CoA synthetase short-chain family member 3
Gene namesi
Name:ACSS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111058.7
HGNCiHGNC:24723 ACSS3
MIMi614356 gene
neXtProtiNX_Q9H6R3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi79611
OpenTargetsiENSG00000111058
PharmGKBiPA162375534

Polymorphism and mutation databases

BioMutaiACSS3
DMDMi74752698

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000032062430 – 686Acyl-CoA synthetase short-chain family member 3, mitochondrialAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei518N6-succinyllysineBy similarity1
Modified residuei524N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H6R3
MaxQBiQ9H6R3
PaxDbiQ9H6R3
PeptideAtlasiQ9H6R3
PRIDEiQ9H6R3
ProteomicsDBi81014
81015 [Q9H6R3-2]
TopDownProteomicsiQ9H6R3-1 [Q9H6R3-1]

PTM databases

iPTMnetiQ9H6R3
PhosphoSitePlusiQ9H6R3

Expressioni

Gene expression databases

BgeeiENSG00000111058 Expressed in 173 organ(s), highest expression level in liver
CleanExiHS_ACSS3
ExpressionAtlasiQ9H6R3 baseline and differential
GenevisibleiQ9H6R3 HS

Organism-specific databases

HPAiHPA039353
HPA047956
HPA061517

Interactioni

Protein-protein interaction databases

BioGridi122745, 1 interactor
IntActiQ9H6R3, 1 interactor
STRINGi9606.ENSP00000449535

Structurei

3D structure databases

ProteinModelPortaliQ9H6R3
SMRiQ9H6R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 230Coenzyme A bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00930000150964
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ9H6R3
KOiK01908
OMAiYLYVMSR
OrthoDBiEOG091G03IL
PhylomeDBiQ9H6R3
TreeFamiTF354241

Family and domain databases

InterProiView protein in InterPro
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPSWLQCRK VTSAGGLGGP LPGSSPARGA GAALRALVVP GPRGGLGGRG
60 70 80 90 100
CRALSSGSGS EYKTHFAASV TDPERFWGKA AEQISWYKPW TKTLENKHSP
110 120 130 140 150
STRWFVEGML NICYNAVDRH IENGKGDKIA IIYDSPVTNT KATFTYKEVL
160 170 180 190 200
EQVSKLAGVL VKHGIKKGDT VVIYMPMIPQ AMYTMLACAR IGAIHSLIFG
210 220 230 240 250
GFASKELSSR IDHVKPKVVV TASFGIEPGR RVEYVPLVEE ALKIGQHKPD
260 270 280 290 300
KILIYNRPNM EAVPLAPGRD LDWDEEMAKA QSHDCVPVLS EHPLYILYTS
310 320 330 340 350
GTTGLPKGVI RPTGGYAVML HWSMSSIYGL QPGEVWWAAS DLGWVVGHSY
360 370 380 390 400
ICYGPLLHGN TTVLYEGKPV GTPDAGAYFR VLAEHGVAAL FTAPTAIRAI
410 420 430 440 450
RQQDPGAALG KQYSLTRFKT LFVAGERCDV ETLEWSKNVF RVPVLDHWWQ
460 470 480 490 500
TETGSPITAS CVGLGNSKTP PPGQAGKSVP GYNVMILDDN MQKLKARCLG
510 520 530 540 550
NIVVKLPLPP GAFSGLWKNQ EAFKHLYFEK FPGYYDTMDA GYMDEEGYLY
560 570 580 590 600
VMSRVDDVIN VAGHRISAGA IEESILSHGT VADCAVVGKE DPLKGHVPLA
610 620 630 640 650
LCVLRKDINA TEEQVLEEIV KHVRQNIGPV AAFRNAVFVK QLPKTRSGKI
660 670 680
PRSALSAIVN GKPYKITSTI EDPSIFGHVE EMLKQA
Length:686
Mass (Da):74,778
Last modified:March 1, 2001 - v1
Checksum:i3386338C6FFFD7E8
GO
Isoform 2 (identifier: Q9H6R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Show »
Length:368
Mass (Da):40,326
Checksum:i8DAB2F64E31A36A3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1R2A0A0B4J1R2_HUMAN
Acyl-CoA synthetase short-chain fam...
ACSS3 FLJ21963, hCG_23730
685Annotation score:
H0YII9H0YII9_HUMAN
Acyl-CoA synthetase short-chain fam...
ACSS3
75Annotation score:
F8VZB4F8VZB4_HUMAN
Acyl-CoA synthetase short-chain fam...
ACSS3
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428C → S in BAC11304 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0316921 – 318Missing in isoform 2. 1 PublicationAdd BLAST318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025616 mRNA Translation: BAB15190.1
AK074938 mRNA Translation: BAC11304.1
CH471054 Genomic DNA Translation: EAW97372.1
BC009317 mRNA Translation: AAH09317.1
BC015769 mRNA Translation: AAH15769.1
CCDSiCCDS9022.1 [Q9H6R3-1]
RefSeqiNP_001317171.1, NM_001330242.1
NP_001317172.1, NM_001330243.1 [Q9H6R3-2]
NP_078836.1, NM_024560.3 [Q9H6R3-1]
UniGeneiHs.259559

Genome annotation databases

EnsembliENST00000548058; ENSP00000449535; ENSG00000111058 [Q9H6R3-1]
GeneIDi79611
KEGGihsa:79611
UCSCiuc001szl.2 human [Q9H6R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025616 mRNA Translation: BAB15190.1
AK074938 mRNA Translation: BAC11304.1
CH471054 Genomic DNA Translation: EAW97372.1
BC009317 mRNA Translation: AAH09317.1
BC015769 mRNA Translation: AAH15769.1
CCDSiCCDS9022.1 [Q9H6R3-1]
RefSeqiNP_001317171.1, NM_001330242.1
NP_001317172.1, NM_001330243.1 [Q9H6R3-2]
NP_078836.1, NM_024560.3 [Q9H6R3-1]
UniGeneiHs.259559

3D structure databases

ProteinModelPortaliQ9H6R3
SMRiQ9H6R3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122745, 1 interactor
IntActiQ9H6R3, 1 interactor
STRINGi9606.ENSP00000449535

PTM databases

iPTMnetiQ9H6R3
PhosphoSitePlusiQ9H6R3

Polymorphism and mutation databases

BioMutaiACSS3
DMDMi74752698

Proteomic databases

EPDiQ9H6R3
MaxQBiQ9H6R3
PaxDbiQ9H6R3
PeptideAtlasiQ9H6R3
PRIDEiQ9H6R3
ProteomicsDBi81014
81015 [Q9H6R3-2]
TopDownProteomicsiQ9H6R3-1 [Q9H6R3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548058; ENSP00000449535; ENSG00000111058 [Q9H6R3-1]
GeneIDi79611
KEGGihsa:79611
UCSCiuc001szl.2 human [Q9H6R3-1]

Organism-specific databases

CTDi79611
DisGeNETi79611
EuPathDBiHostDB:ENSG00000111058.7
GeneCardsiACSS3
HGNCiHGNC:24723 ACSS3
HPAiHPA039353
HPA047956
HPA061517
MIMi614356 gene
neXtProtiNX_Q9H6R3
OpenTargetsiENSG00000111058
PharmGKBiPA162375534
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00930000150964
HOGENOMiHOG000229981
HOVERGENiHBG014401
InParanoidiQ9H6R3
KOiK01908
OMAiYLYVMSR
OrthoDBiEOG091G03IL
PhylomeDBiQ9H6R3
TreeFamiTF354241

Enzyme and pathway databases

ReactomeiR-HSA-77111 Synthesis of Ketone Bodies

Miscellaneous databases

ChiTaRSiACSS3 human
GenomeRNAii79611
PROiPR:Q9H6R3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111058 Expressed in 173 organ(s), highest expression level in liver
CleanExiHS_ACSS3
ExpressionAtlasiQ9H6R3 baseline and differential
GenevisibleiQ9H6R3 HS

Family and domain databases

InterProiView protein in InterPro
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACSS3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6R3
Secondary accession number(s): Q8NC66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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