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UniProtKB - Q9H6Q4 (CIAO3_HUMAN)

Entry version 140 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Cytosolic iron-sulfur assembly component 3

Gene

CIAO3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi71Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi74Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi77Iron-sulfur 1 (4Fe-4S)Sequence analysis1
Metal bindingi190Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi246Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi395Iron-sulfur 2 (4Fe-4S)Sequence analysis1
Metal bindingi399Iron-sulfur 2 (4Fe-4S)Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: Ensembl
  • iron-sulfur cluster assembly Source: UniProtKB
  • oxygen homeostasis Source: HGNC
  • regulation of gene expression Source: BHF-UCL
  • response to hypoxia Source: HGNC
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2564830 Cytosolic iron-sulfur cluster assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic iron-sulfur assembly component 3Curated
Alternative name(s):
Cytosolic Fe-S cluster assembly factor NARFL
Iron-only hydrogenase-like protein 11 Publication
Short name:
IOP11 Publication
Nuclear prelamin A recognition factor-like protein
Protein related to Narf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CIAO3Imported
Synonyms:NARFLImported, PRN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000103245.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:14179 CIAO3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611118 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H6Q4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000103245

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394707

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NARFL

Domain mapping of disease mutations (DMDM)

More...DMDMi		74733617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884852 – 476Cytosolic iron-sulfur assembly component 3Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H6Q4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H6Q4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H6Q4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H6Q4

PeptideAtlas

More...PeptideAtlasi		Q9H6Q4

PRoteomics IDEntifications database

More...PRIDEi		Q9H6Q4

ProteomicsDB human proteome resource

More...ProteomicsDBi		81009
81010 [Q9H6Q4-2]
81011 [Q9H6Q4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H6Q4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H6Q4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103245 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H6Q4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H6Q4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA040851

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

External component of the CIA complex (PubMed:22678361, PubMed:22678362, PubMed:23585563). In the CIA complex, interacts directly with CIAO1 and MMS19 (PubMed:23585563).3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122176, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H6Q4

Protein interaction database and analysis system

More...IntActi		Q9H6Q4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000251588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9H6Q4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H6Q4

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NARF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2439 Eukaryota
COG4624 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153514

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000191744

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG055005

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H6Q4

Identification of Orthologs from Complete Genome Data

More...OMAi		QEHQTRD

Database of Orthologous Groups

More...OrthoDBi		705416at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H6Q4

TreeFam database of animal gene trees

More...TreeFami		TF106273

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00902 Fe_hyd_SSU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53920 SSF53920, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPFSGALQ LTDLDDFIGP SQECIKPVKV EKRAGSGVAK IRIEDDGSYF 
        60         70         80         90        100
QINQDGGTRR LEKAKVSLND CLACSGCITS AETVLITQQS HEELKKVLDA 
       110        120        130        140        150
NKMAAPSQQR LVVVSVSPQS RASLAARFQL NPTDTARKLT SFFKKIGVHF 
       160        170        180        190        200
VFDTAFSRHF SLLESQREFV RRFRGQADCR QALPLLASAC PGWICYAEKT 
       210        220        230        240        250
HGSFILPHIS TARSPQQVMG SLVKDFFAQQ QHLTPDKIYH VTVMPCYDKK 
       260        270        280        290        300
LEASRPDFFN QEHQTRDVDC VLTTGEVFRL LEEEGVSLPD LEPAPLDSLC 
       310        320        330        340        350
SGASAEEPTS HRGGGSGGYL EHVFRHAARE LFGIHVAEVT YKPLRNKDFQ 
       360        370        380        390        400
EVTLEKEGQV LLHFAMAYGF RNIQNLVQRL KRGRCPYHYV EVMACPSGCL 
       410        420        430        440        450
NGGGQLQAPD RPSRELLQHV ERLYGMVRAE APEDAPGVQE LYTHWLQGTD 
       460        470 
SECAGRLLHT QYHAVEKAST GLGIRW
Length:476
Mass (Da):53,020
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88A019DA4D7988EA
GO
Isoform 2 (identifier: Q9H6Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.

Show »
Length:233
Mass (Da):26,135
Checksum:iAA85FD01731E7051
GO
Isoform 3 (identifier: Q9H6Q4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:374
Mass (Da):42,010
Checksum:iD22B5E1FFD155545
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSH2H3BSH2_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2A3I3L2A3_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSJ7H3BSJ7_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DEE7B4DEE7_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPX8H3BPX8_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUF3H3BUF3_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ03H3BQ03_HUMAN
Cytosolic iron-sulfur assembly comp...
CIAO3
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK61251 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti205I → T in BAD96725 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05391138V → M. Corresponds to variant dbSNP:rs8045850Ensembl.1
Natural variantiVAR_053912444H → R. Corresponds to variant dbSNP:rs7188554Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0256941 – 243Missing in isoform 2. 1 PublicationAdd BLAST243
Alternative sequenceiVSP_0256951 – 102Missing in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY129231 mRNA Translation: AAM98737.1
AK025641 mRNA Translation: BAB15199.1
AK025861 mRNA Translation: BAB15261.1
AK095675 mRNA Translation: BAG53105.1
AK223005 mRNA Translation: BAD96725.1
AE006464 Genomic DNA Translation: AAK61251.1 Sequence problems.
Z98258 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85723.1
BC030248 mRNA Translation: AAH30248.1
BC129940 mRNA Translation: AAI29941.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10425.1 [Q9H6Q4-1]
CCDS76798.1 [Q9H6Q4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001291728.1, NM_001304799.1 [Q9H6Q4-3]
NP_071938.1, NM_022493.2 [Q9H6Q4-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.513247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000251588; ENSP00000251588; ENSG00000103245 [Q9H6Q4-1]
ENST00000540986; ENSP00000444008; ENSG00000103245 [Q9H6Q4-3]
ENST00000568545; ENSP00000457058; ENSG00000103245 [Q9H6Q4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64428

UCSC genome browser

More...UCSCi		uc002cjp.4 human [Q9H6Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129231 mRNA Translation: AAM98737.1
AK025641 mRNA Translation: BAB15199.1
AK025861 mRNA Translation: BAB15261.1
AK095675 mRNA Translation: BAG53105.1
AK223005 mRNA Translation: BAD96725.1
AE006464 Genomic DNA Translation: AAK61251.1 Sequence problems.
Z98258 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85723.1
BC030248 mRNA Translation: AAH30248.1
BC129940 mRNA Translation: AAI29941.1
CCDSiCCDS10425.1 [Q9H6Q4-1]
CCDS76798.1 [Q9H6Q4-3]
RefSeqiNP_001291728.1, NM_001304799.1 [Q9H6Q4-3]
NP_071938.1, NM_022493.2 [Q9H6Q4-1]
UniGeneiHs.513247

3D structure databases

ProteinModelPortaliQ9H6Q4
SMRiQ9H6Q4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122176, 15 interactors
CORUMiQ9H6Q4
IntActiQ9H6Q4, 1 interactor
STRINGi9606.ENSP00000251588

PTM databases

iPTMnetiQ9H6Q4
PhosphoSitePlusiQ9H6Q4

Polymorphism and mutation databases

BioMutaiNARFL
DMDMi74733617

Proteomic databases

EPDiQ9H6Q4
jPOSTiQ9H6Q4
MaxQBiQ9H6Q4
PaxDbiQ9H6Q4
PeptideAtlasiQ9H6Q4
PRIDEiQ9H6Q4
ProteomicsDBi81009
81010 [Q9H6Q4-2]
81011 [Q9H6Q4-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		64428
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251588; ENSP00000251588; ENSG00000103245 [Q9H6Q4-1]
ENST00000540986; ENSP00000444008; ENSG00000103245 [Q9H6Q4-3]
ENST00000568545; ENSP00000457058; ENSG00000103245 [Q9H6Q4-3]
GeneIDi64428
KEGGihsa:64428
UCSCiuc002cjp.4 human [Q9H6Q4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64428
EuPathDBiHostDB:ENSG00000103245.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CIAO3
HGNCiHGNC:14179 CIAO3
HPAiHPA040851
MIMi611118 gene
neXtProtiNX_Q9H6Q4
OpenTargetsiENSG00000103245
PharmGKBiPA128394707

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2439 Eukaryota
COG4624 LUCA
GeneTreeiENSGT00940000153514
HOGENOMiHOG000191744
HOVERGENiHBG055005
InParanoidiQ9H6Q4
OMAiQEHQTRD
OrthoDBi705416at2759
PhylomeDBiQ9H6Q4
TreeFamiTF106273

Enzyme and pathway databases

ReactomeiR-HSA-2564830 Cytosolic iron-sulfur cluster assembly

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NARFL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64428

Protein Ontology

More...PROi		PR:Q9H6Q4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103245 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9H6Q4 baseline and differential
GenevisibleiQ9H6Q4 HS

Family and domain databases

InterProiView protein in InterPro
IPR009016 Fe_hydrogenase
IPR004108 Fe_hydrogenase_lsu_C
IPR003149 Fe_hydrogenase_ssu
PfamiView protein in Pfam
PF02906 Fe_hyd_lg_C, 1 hit
PF02256 Fe_hyd_SSU, 1 hit
SMARTiView protein in SMART
SM00902 Fe_hyd_SSU, 1 hit
SUPFAMiSSF53920 SSF53920, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIAO3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6Q4
Secondary accession number(s): A1L385
, B3KTJ3, Q53GC6, Q96S10, Q9H6J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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