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Protein

Uncharacterized protein C6orf106

Gene

C6orf106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ubiquitin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf106
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196821.9
HGNCiHGNC:21215 C6orf106
MIMi612217 gene
neXtProtiNX_Q9H6K1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi64771
OpenTargetsiENSG00000196821
PharmGKBiPA134935866

Polymorphism and mutation databases

DMDMi88984085

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895191 – 298Uncharacterized protein C6orf106Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6K1
MaxQBiQ9H6K1
PaxDbiQ9H6K1
PeptideAtlasiQ9H6K1
PRIDEiQ9H6K1
ProteomicsDBi80993
80994 [Q9H6K1-2]

PTM databases

iPTMnetiQ9H6K1
PhosphoSitePlusiQ9H6K1

Expressioni

Gene expression databases

BgeeiENSG00000196821 Expressed in 232 organ(s), highest expression level in vagina
CleanExiHS_C6orf106
ExpressionAtlasiQ9H6K1 baseline and differential
GenevisibleiQ9H6K1 HS

Organism-specific databases

HPAiHPA034489
HPA034490

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122282, 10 interactors
IntActiQ9H6K1, 6 interactors
STRINGi9606.ENSP00000363135

Structurei

3D structure databases

ProteinModelPortaliQ9H6K1
SMRiQ9H6K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
ENOG410ZKCZ LUCA
GeneTreeiENSGT00490000043415
HOGENOMiHOG000236314
HOVERGENiHBG055075
InParanoidiQ9H6K1
OMAiQSKWRMM
OrthoDBiEOG091G0K92
PhylomeDBiQ9H6K1
TreeFamiTF105872

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd14349 UBA_CF106, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039517 C6orf106_UBA-like
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM
60 70 80 90 100
TNWNLQAAIG AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR
110 120 130 140 150
IQNSGAEAWP PGVCLKYVGG DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS
160 170 180 190 200
RAGMYQGQWR MCTATGLYYG DVIWVILSVE VGGLLGVTQQ LSSFETEFNT
210 220 230 240 250
QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK NTWAPAPDTW
260 270 280 290
APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS
Length:298
Mass (Da):32,872
Last modified:February 21, 2006 - v2
Checksum:i3BA3E7F7B4D26D76
GO
Isoform 2 (identifier: Q9H6K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-170: Missing.

Show »
Length:232
Mass (Da):25,673
Checksum:iC1380288B8EB3AF7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TH58Q5TH58_HUMAN
Uncharacterized protein C6orf106
C6orf106
224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54N → S in BAB71327 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017259105 – 170Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025848 mRNA Translation: BAB15258.1 Sequence problems.
AK056964 mRNA Translation: BAB71327.1
AK313410 mRNA Translation: BAG36204.1
AL031577 Genomic DNA No translation available.
AL451165 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03790.1
BC002328 mRNA Translation: AAH02328.1
BC010184 mRNA Translation: AAH10184.1
BC075810 mRNA Translation: AAH75810.1
CCDSiCCDS4795.1 [Q9H6K1-2]
CCDS4796.1 [Q9H6K1-1]
RefSeqiNP_073595.2, NM_022758.5 [Q9H6K1-2]
NP_077270.1, NM_024294.3 [Q9H6K1-1]
UniGeneiHs.643498
Hs.716193

Genome annotation databases

EnsembliENST00000374023; ENSP00000363135; ENSG00000196821 [Q9H6K1-1]
ENST00000374026; ENSP00000363138; ENSG00000196821 [Q9H6K1-2]
GeneIDi64771
KEGGihsa:64771
UCSCiuc003ojr.4 human [Q9H6K1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025848 mRNA Translation: BAB15258.1 Sequence problems.
AK056964 mRNA Translation: BAB71327.1
AK313410 mRNA Translation: BAG36204.1
AL031577 Genomic DNA No translation available.
AL451165 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03790.1
BC002328 mRNA Translation: AAH02328.1
BC010184 mRNA Translation: AAH10184.1
BC075810 mRNA Translation: AAH75810.1
CCDSiCCDS4795.1 [Q9H6K1-2]
CCDS4796.1 [Q9H6K1-1]
RefSeqiNP_073595.2, NM_022758.5 [Q9H6K1-2]
NP_077270.1, NM_024294.3 [Q9H6K1-1]
UniGeneiHs.643498
Hs.716193

3D structure databases

ProteinModelPortaliQ9H6K1
SMRiQ9H6K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122282, 10 interactors
IntActiQ9H6K1, 6 interactors
STRINGi9606.ENSP00000363135

PTM databases

iPTMnetiQ9H6K1
PhosphoSitePlusiQ9H6K1

Polymorphism and mutation databases

DMDMi88984085

Proteomic databases

EPDiQ9H6K1
MaxQBiQ9H6K1
PaxDbiQ9H6K1
PeptideAtlasiQ9H6K1
PRIDEiQ9H6K1
ProteomicsDBi80993
80994 [Q9H6K1-2]

Protocols and materials databases

DNASUi64771
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374023; ENSP00000363135; ENSG00000196821 [Q9H6K1-1]
ENST00000374026; ENSP00000363138; ENSG00000196821 [Q9H6K1-2]
GeneIDi64771
KEGGihsa:64771
UCSCiuc003ojr.4 human [Q9H6K1-1]

Organism-specific databases

CTDi64771
DisGeNETi64771
EuPathDBiHostDB:ENSG00000196821.9
GeneCardsiC6orf106
H-InvDBiHIX0005794
HGNCiHGNC:21215 C6orf106
HPAiHPA034489
HPA034490
MIMi612217 gene
neXtProtiNX_Q9H6K1
OpenTargetsiENSG00000196821
PharmGKBiPA134935866
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
ENOG410ZKCZ LUCA
GeneTreeiENSGT00490000043415
HOGENOMiHOG000236314
HOVERGENiHBG055075
InParanoidiQ9H6K1
OMAiQSKWRMM
OrthoDBiEOG091G0K92
PhylomeDBiQ9H6K1
TreeFamiTF105872

Miscellaneous databases

ChiTaRSiC6orf106 human
GenomeRNAii64771
PROiPR:Q9H6K1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196821 Expressed in 232 organ(s), highest expression level in vagina
CleanExiHS_C6orf106
ExpressionAtlasiQ9H6K1 baseline and differential
GenevisibleiQ9H6K1 HS

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd14349 UBA_CF106, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039517 C6orf106_UBA-like
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCF106_HUMAN
AccessioniPrimary (citable) accession number: Q9H6K1
Secondary accession number(s): B2R8K7
, Q5VV77, Q96MG5, Q9BUR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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