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Entry version 147 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

HAUS augmin-like complex subunit 4

Gene

HAUS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HAUS augmin-like complex subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAUS4
Synonyms:C14orf94
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20163 HAUS4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613431 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H6D7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000092036

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165478984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H6D7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAUS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33301114

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899011 – 363HAUS augmin-like complex subunit 4Add BLAST363

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H6D7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H6D7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H6D7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H6D7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H6D7

PeptideAtlas

More...
PeptideAtlasi
Q9H6D7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H6D7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80977 [Q9H6D7-1]
80978 [Q9H6D7-2]
80979 [Q9H6D7-3]
80980 [Q9H6D7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H6D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H6D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092036 Expressed in 93 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H6D7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H6D7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029803
HPA071195

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120270, 59 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1847 HAUS complex

Database of interacting proteins

More...
DIPi
DIP-48837N

Protein interaction database and analysis system

More...
IntActi
Q9H6D7, 48 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000206474

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H6D7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAUS4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFF7 Eukaryota
ENOG4111KUB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014634

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H6D7

KEGG Orthology (KO)

More...
KOi
K16587

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFPPCNL

Database of Orthologous Groups

More...
OrthoDBi
1168055at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H6D7

TreeFam database of animal gene trees

More...
TreeFami
TF330353

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029327 HAUS4
IPR026214 HAUS4_met

The PANTHER Classification System

More...
PANTHERi
PTHR16219 PTHR16219, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14735 HAUS4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02090 HAUSAUGMINL4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGDFCSPG EGMEILQQVC SKQLPPCNLS KEDLLQNPYF SKLLLNLSQH
60 70 80 90 100
VDESGLSLTL AKEQAQAWKE VRLHKTTWLR SEILHRVIQE LLVDYYVKIQ
110 120 130 140 150
DTNVTSEDKK FHETLEQRLL VTELMRLLGP SQEREIPPLL GLEKADLLEL
160 170 180 190 200
MPLSEDFVWM RARLQQEVEE QLKKKCFTLL CYYDPNSDAD SETVKAAKVW
210 220 230 240 250
KLAEVLVGEQ QQCQDAKSQQ KEQMLLLEKK SAAYSQVLLR CLTLLQRLLQ
260 270 280 290 300
EHRLKTQSEL DRINAQYLEV KCGAMILKLR MEELKILSDT YTVEKVEVHR
310 320 330 340 350
LIRDRLEGAI HLQEQDMENS RQVLNSYEVL GEEFDRLVKE YTVLKQATEN
360
KRWALQEFSK VYR
Length:363
Mass (Da):42,400
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAAFA1FFC25189C0
GO
Isoform 2 (identifier: Q9H6D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-236: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):27,791
Checksum:i7C6F4FB2CC6AD3B3
GO
Isoform 3 (identifier: Q9H6D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):28,119
Checksum:iC59E25891211506E
GO
Isoform 4 (identifier: Q9H6D7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-155: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):37,219
Checksum:iAC421A12072D246A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIZ6H0YIZ6_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5A5G3V5A5_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V541G3V541_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4X7G3V4X7_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5Z2G3V5Z2_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ09H0YJ09_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2I5G3V2I5_HUMAN
HAUS augmin-like complex subunit 4
HAUS4
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62584 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154S → T in BAA91161 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0078511 – 124Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_007853111 – 236Missing in isoform 2. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_007852111 – 155Missing in isoform 4. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026016 mRNA Translation: BAB15322.1
AK000431 mRNA Translation: BAA91161.1
BX247981 mRNA Translation: CAD62315.1
BX247995 mRNA Translation: CAD62328.1
BX248256 mRNA Translation: CAD62584.1 Different initiation.
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66207.1
CH471078 Genomic DNA Translation: EAW66206.1
CH471078 Genomic DNA Translation: EAW66209.1
CH471078 Genomic DNA Translation: EAW66210.1
CH471078 Genomic DNA Translation: EAW66213.1
BC001916 mRNA Translation: AAH01916.1
BC002554 mRNA Translation: AAH02554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53886.1 [Q9H6D7-4]
CCDS9580.1 [Q9H6D7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001159741.1, NM_001166269.1 [Q9H6D7-1]
NP_001159742.1, NM_001166270.1 [Q9H6D7-4]
NP_060285.2, NM_017815.2 [Q9H6D7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000206474; ENSP00000206474; ENSG00000092036 [Q9H6D7-1]
ENST00000342454; ENSP00000342776; ENSG00000092036 [Q9H6D7-4]
ENST00000347758; ENSP00000343473; ENSG00000092036 [Q9H6D7-2]
ENST00000490506; ENSP00000452260; ENSG00000092036 [Q9H6D7-3]
ENST00000541587; ENSP00000441026; ENSG00000092036 [Q9H6D7-1]
ENST00000555367; ENSP00000452239; ENSG00000092036 [Q9H6D7-4]
ENST00000555986; ENSP00000451018; ENSG00000092036 [Q9H6D7-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54930

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54930

UCSC genome browser

More...
UCSCi
uc001whq.4 human [Q9H6D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026016 mRNA Translation: BAB15322.1
AK000431 mRNA Translation: BAA91161.1
BX247981 mRNA Translation: CAD62315.1
BX247995 mRNA Translation: CAD62328.1
BX248256 mRNA Translation: CAD62584.1 Different initiation.
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66207.1
CH471078 Genomic DNA Translation: EAW66206.1
CH471078 Genomic DNA Translation: EAW66209.1
CH471078 Genomic DNA Translation: EAW66210.1
CH471078 Genomic DNA Translation: EAW66213.1
BC001916 mRNA Translation: AAH01916.1
BC002554 mRNA Translation: AAH02554.1
CCDSiCCDS53886.1 [Q9H6D7-4]
CCDS9580.1 [Q9H6D7-1]
RefSeqiNP_001159741.1, NM_001166269.1 [Q9H6D7-1]
NP_001159742.1, NM_001166270.1 [Q9H6D7-4]
NP_060285.2, NM_017815.2 [Q9H6D7-1]

3D structure databases

SMRiQ9H6D7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120270, 59 interactors
ComplexPortaliCPX-1847 HAUS complex
DIPiDIP-48837N
IntActiQ9H6D7, 48 interactors
STRINGi9606.ENSP00000206474

PTM databases

iPTMnetiQ9H6D7
PhosphoSitePlusiQ9H6D7

Polymorphism and mutation databases

BioMutaiHAUS4
DMDMi33301114

Proteomic databases

EPDiQ9H6D7
jPOSTiQ9H6D7
MassIVEiQ9H6D7
MaxQBiQ9H6D7
PaxDbiQ9H6D7
PeptideAtlasiQ9H6D7
PRIDEiQ9H6D7
ProteomicsDBi80977 [Q9H6D7-1]
80978 [Q9H6D7-2]
80979 [Q9H6D7-3]
80980 [Q9H6D7-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54930

Genome annotation databases

EnsembliENST00000206474; ENSP00000206474; ENSG00000092036 [Q9H6D7-1]
ENST00000342454; ENSP00000342776; ENSG00000092036 [Q9H6D7-4]
ENST00000347758; ENSP00000343473; ENSG00000092036 [Q9H6D7-2]
ENST00000490506; ENSP00000452260; ENSG00000092036 [Q9H6D7-3]
ENST00000541587; ENSP00000441026; ENSG00000092036 [Q9H6D7-1]
ENST00000555367; ENSP00000452239; ENSG00000092036 [Q9H6D7-4]
ENST00000555986; ENSP00000451018; ENSG00000092036 [Q9H6D7-4]
GeneIDi54930
KEGGihsa:54930
UCSCiuc001whq.4 human [Q9H6D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54930

GeneCards: human genes, protein and diseases

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GeneCardsi
HAUS4
HGNCiHGNC:20163 HAUS4
HPAiHPA029803
HPA071195
MIMi613431 gene
neXtProtiNX_Q9H6D7
OpenTargetsiENSG00000092036
PharmGKBiPA165478984

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFF7 Eukaryota
ENOG4111KUB LUCA
GeneTreeiENSGT00390000014634
InParanoidiQ9H6D7
KOiK16587
OMAiQFPPCNL
OrthoDBi1168055at2759
PhylomeDBiQ9H6D7
TreeFamiTF330353

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HAUS4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54930
PharosiQ9H6D7

Protein Ontology

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PROi
PR:Q9H6D7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000092036 Expressed in 93 organ(s), highest expression level in blood
ExpressionAtlasiQ9H6D7 baseline and differential
GenevisibleiQ9H6D7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029327 HAUS4
IPR026214 HAUS4_met
PANTHERiPTHR16219 PTHR16219, 1 hit
PfamiView protein in Pfam
PF14735 HAUS4, 1 hit
PRINTSiPR02090 HAUSAUGMINL4

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAUS4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6D7
Secondary accession number(s): B7WP17
, D3DS34, Q86T15, Q86T16, Q86U43, Q9NX59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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