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Entry version 120 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein

XK-related protein 8

Gene

XKR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.1 Publication

Miscellaneous

Expression is repressed in PLB-985 leukemia and Raji lymphoma cells due to CpG methylation near the transcription start site of XKR8 gene, possibly explaining the inability of PLB-985 leukemia and Raji lymphoma cells to expose phosphatidylserine during apoptosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.112.1.13 the kx blood-group antigen (kxa) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
XK-related protein 8
Short name:
hXkr8
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XKR8
Synonyms:XRG8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25508 XKR8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H6D3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 47ExtracellularSequence analysisAdd BLAST14
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 158CytoplasmicSequence analysisAdd BLAST90
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 200ExtracellularSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 223CytoplasmicSequence analysis2
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 259ExtracellularSequence analysisAdd BLAST15
Transmembranei260 – 277HelicalSequence analysisAdd BLAST18
Topological domaini278 – 284CytoplasmicSequence analysis7
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 312ExtracellularSequence analysis7
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 395CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi352 – 355DQVD → AQVA: Abolishes cleavage by CASP3 and ability to promote phosphatidylserine exposure. 1 Publication4

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000158156

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670566

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H6D3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XKR8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752693

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001907921 – 395XK-related protein 8Add BLAST395
ChainiPRO_00004239841 – 355XK-related protein 8, processed formSequence analysisAdd BLAST355

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic processing by caspase-3 (CASP3), leading to its activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei355 – 356Cleavage; by caspase-3Sequence analysis2

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H6D3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H6D3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H6D3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H6D3

PeptideAtlas

More...
PeptideAtlasi
Q9H6D3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H6D3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80975

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H6D3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158156 Expressed in lymph node and 232 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H6D3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000158156 Tissue enriched (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120423, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H6D3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362991

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H6D3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4790 Eukaryota
ENOG410YRUD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182678

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028534_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H6D3

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYLYRCL

Database of Orthologous Groups

More...
OrthoDBi
1230316at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H6D3

TreeFam database of animal gene trees

More...
TreeFami
TF316454

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018629 XK-rel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09815 XK-related, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPWSSRGALL RDLVLGVLGT AAFLLDLGTD LWAAVQYALG GRYLWAALVL
60 70 80 90 100
ALLGLASVAL QLFSWLWLRA DPAGLHGSQP PRRCLALLHL LQLGYLYRCV
110 120 130 140 150
QELRQGLLVW QQEEPSEFDL AYADFLALDI SMLRLFETFL ETAPQLTLVL
160 170 180 190 200
AIMLQSGRAE YYQWVGICTS FLGISWALLD YHRALRTCLP SKPLLGLGSS
210 220 230 240 250
VIYFLWNLLL LWPRVLAVAL FSALFPSYVA LHFLGLWLVL LLWVWLQGTD
260 270 280 290 300
FMPDPSSEWL YRVTVATILY FSWFNVAEGR TRGRAIIHFA FLLSDSILLV
310 320 330 340 350
ATWVTHSSWL PSGIPLQLWL PVGCGCFFLG LALRLVYYHW LHPSCCWKPD
360 370 380 390
PDQVDGARSL LSPEGYQLPQ NRRMTHLAQK FFPKAKDEAA SPVKG
Length:395
Mass (Da):44,655
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23199BAEEA6964C6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY534246 mRNA Translation: AAT07095.1
AK026024 mRNA Translation: BAB15326.1
AL512288 Genomic DNA No translation available.
BC013379 mRNA Translation: AAH13379.1
BC028564 mRNA Translation: AAH28564.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS315.1

NCBI Reference Sequences

More...
RefSeqi
NP_060523.2, NM_018053.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373884; ENSP00000362991; ENSG00000158156

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55113

UCSC genome browser

More...
UCSCi
uc001bph.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY534246 mRNA Translation: AAT07095.1
AK026024 mRNA Translation: BAB15326.1
AL512288 Genomic DNA No translation available.
BC013379 mRNA Translation: AAH13379.1
BC028564 mRNA Translation: AAH28564.1
CCDSiCCDS315.1
RefSeqiNP_060523.2, NM_018053.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120423, 4 interactors
IntActiQ9H6D3, 1 interactor
STRINGi9606.ENSP00000362991

Protein family/group databases

TCDBi2.A.112.1.13 the kx blood-group antigen (kxa) family

PTM databases

iPTMnetiQ9H6D3

Polymorphism and mutation databases

BioMutaiXKR8
DMDMi74752693

Proteomic databases

EPDiQ9H6D3
jPOSTiQ9H6D3
MassIVEiQ9H6D3
PaxDbiQ9H6D3
PeptideAtlasiQ9H6D3
PRIDEiQ9H6D3
ProteomicsDBi80975

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
55125 68 antibodies

Genome annotation databases

EnsembliENST00000373884; ENSP00000362991; ENSG00000158156
GeneIDi55113
KEGGihsa:55113
UCSCiuc001bph.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55113

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XKR8
HGNCiHGNC:25508 XKR8
HPAiENSG00000158156 Tissue enriched (blood)
neXtProtiNX_Q9H6D3
OpenTargetsiENSG00000158156
PharmGKBiPA142670566

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4790 Eukaryota
ENOG410YRUD LUCA
GeneTreeiENSGT00950000182678
HOGENOMiCLU_028534_2_1_1
InParanoidiQ9H6D3
OMAiGYLYRCL
OrthoDBi1230316at2759
PhylomeDBiQ9H6D3
TreeFamiTF316454

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55113
PharosiQ9H6D3 Tbio

Protein Ontology

More...
PROi
PR:Q9H6D3
RNActiQ9H6D3 protein

Gene expression databases

BgeeiENSG00000158156 Expressed in lymph node and 232 other tissues
GenevisibleiQ9H6D3 HS

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXKR8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6D3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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