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Protein

CXADR-like membrane protein

Gene

CLMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.3 Publications

GO - Biological processi

  • digestive tract development Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
CXADR-like membrane protein
Alternative name(s):
Adipocyte adhesion molecule
Coxsackie- and adenovirus receptor-like membrane protein
Short name:
CAR-like membrane protein
Gene namesi
Name:CLMP
Synonyms:ACAM, ASAM
ORF Names:UNQ318/PRO363
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166250.11
HGNCiHGNC:24039 CLMP
MIMi611693 gene
neXtProtiNX_Q9H6B4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 235ExtracellularSequence analysisAdd BLAST217
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 373CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Involvement in diseasei

Congenital short bowel syndrome (CSBS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.
See also OMIM:615237
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069713124V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587776967EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi79827
MalaCardsiCLMP
MIMi615237 phenotype
OpenTargetsiENSG00000166250
Orphaneti2301 Congenital short bowel syndrome

Polymorphism and mutation databases

BioMutaiCLMP
DMDMi74761472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000029302619 – 373CXADR-like membrane proteinAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 111PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 208PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H6B4
MaxQBiQ9H6B4
PaxDbiQ9H6B4
PeptideAtlasiQ9H6B4
PRIDEiQ9H6B4
ProteomicsDBi80973

PTM databases

iPTMnetiQ9H6B4
PhosphoSitePlusiQ9H6B4

Expressioni

Tissue specificityi

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).3 Publications

Developmental stagei

At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively.1 Publication

Inductioni

Up-regulated in mature adipocytes and adipocyte tissue of obese individuals.1 Publication

Gene expression databases

BgeeiENSG00000166250 Expressed in 176 organ(s), highest expression level in cartilage tissue
GenevisibleiQ9H6B4 HS

Interactioni

Protein-protein interaction databases

BioGridi122919, 8 interactors
IntActiQ9H6B4, 1 interactor
STRINGi9606.ENSP00000405577

Structurei

3D structure databases

ProteinModelPortaliQ9H6B4
SMRiQ9H6B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 127Ig-like C2-type 1Add BLAST109
Domaini135 – 224Ig-like C2-type 2Add BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi265 – 268Poly-Glu4
Compositional biasi288 – 314Ser-richAdd BLAST27

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC5 Eukaryota
ENOG4111I1J LUCA
GeneTreeiENSGT00760000119145
HOVERGENiHBG060225
InParanoidiQ9H6B4
KOiK06789
OMAiMVPAQTK
OrthoDBiEOG091G05PI
PhylomeDBiQ9H6B4
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H6B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE
60 70 80 90 100
WLLTDNEGNQ KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP
110 120 130 140 150
LKPSDEGRYT CKVKNSGRYV WSHVILKVLV RPSKPKCELE GELTEGSDLT
160 170 180 190 200
LQCESSSGTE PIVYYWQRIR EKEGEDERLP PKSRIDYNHP GRVLLQNLTM
210 220 230 240 250
SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG IVAGALLIFL
260 270 280 290 300
LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG
310 320 330 340 350
SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH
360 370
ANLTKAETTP SMIPSQSRAF QTV
Length:373
Mass (Da):41,281
Last modified:March 1, 2001 - v1
Checksum:iFDA215EB3B3C4335
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04982469R → H. Corresponds to variant dbSNP:rs2276348Ensembl.1
Natural variantiVAR_069713124V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587776967EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326422 mRNA Translation: AAP88386.1
AY358340 mRNA Translation: AAQ88706.1
AK026068 mRNA Translation: BAB15347.1
BC009371 mRNA Translation: AAH09371.1
BK001245 mRNA Translation: DAA01139.1
CCDSiCCDS8441.1
RefSeqiNP_079045.1, NM_024769.3
UniGeneiHs.591949

Genome annotation databases

EnsembliENST00000448775; ENSP00000405577; ENSG00000166250
GeneIDi79827
KEGGihsa:79827
UCSCiuc001pyt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLMP_HUMAN
AccessioniPrimary (citable) accession number: Q9H6B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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