CLMP

Functionⁱ

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.3 Publications

GO - Biological processⁱ

digestive tract development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22155368

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CXADR-like membrane protein Alternative name(s): Adipocyte adhesion molecule Coxsackie- and adenovirus receptor-like membrane protein Short name: CAR-like membrane protein
Gene namesⁱ	Name:CLMP Synonyms:ACAM, ASAM ORF Names:UNQ318/PRO363
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166250.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24039 CLMP
MIMⁱ	611693 gene
neXtProtⁱ	NX_Q9H6B4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 235	ExtracellularSequence analysisAdd BLAST	217
Transmembraneⁱ	236 – 256	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	257 – 373	CytoplasmicSequence analysisAdd BLAST	117

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Congenital short bowel syndrome (CSBS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069713	124	V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587776967EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79827
MalaCards human disease database More...MalaCardsⁱ	CLMP
MIMⁱ	615237 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000166250
Orphanetⁱ	2301 Congenital short bowel syndrome

Polymorphism and mutation databases

BioMutaⁱ	CLMP
DMDMⁱ	74761472

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000293026	19 – 373	CXADR-like membrane proteinAdd BLAST		355

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	35 ↔ 111	PROSITE-ProRule annotation
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	153 ↔ 208	PROSITE-ProRule annotation
Glycosylationⁱ	197	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q9H6B4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H6B4
PaxDbⁱ	Q9H6B4
PeptideAtlas More...PeptideAtlasⁱ	Q9H6B4
PRIDEⁱ	Q9H6B4
ProteomicsDBⁱ	80973

PTM databases

iPTMnetⁱ	Q9H6B4
PhosphoSitePlusⁱ	Q9H6B4

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level).3 Publications

Developmental stageⁱ

At 7 and 8 weeks of development, it is highly abundant in the rapidly dividing cells of the central and peripheral nervous systems, the mesenchyme of the frontonasal and mandibular processes and the dermamyotome, and it is expressed in the endodermal derivatives of the foregut, midgut, and hindgut, as well as in the liver, lung, esophagus, and trachea. During midterm fetal stages, 18 and 23 weeks of development, increased expression is observed in the intestinal crypts. Midterm liver and kidney tissues strongly express CLMP in the parenchyma of the lobules and cortex, respectively.1 Publication

Inductionⁱ

Up-regulated in mature adipocytes and adipocyte tissue of obese individuals.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000166250 Expressed in 176 organ(s), highest expression level in cartilage tissue
Genevisibleⁱ	Q9H6B4 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122919, 8 interactors
IntActⁱ	Q9H6B4, 1 interactor
STRINGⁱ	9606.ENSP00000405577

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H6B4
SMRⁱ	Q9H6B4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 127	Ig-like C2-type 1Add BLAST		109
Domainⁱ	135 – 224	Ig-like C2-type 2Add BLAST		90

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	265 – 268	Poly-Glu		4
Compositional biasⁱ	288 – 314	Ser-richAdd BLAST		27

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEC5 Eukaryota ENOG4111I1J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119145
HOVERGENⁱ	HBG060225
InParanoidⁱ	Q9H6B4
KEGG Orthology (KO) More...KOⁱ	K06789
OMAⁱ	MVPAQTK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q9H6B4
TreeFamⁱ	TF330875

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13895 Ig_2, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9H6B4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLLLLLLLV SYYVGTLGTH TEIKRVAEEK VTLPCHHQLG LPEKDTLDIE 
        60         70         80         90        100
WLLTDNEGNQ KVVITYSSRH VYNNLTEEQK GRVAFASNFL AGDASLQIEP 
       110        120        130        140        150
LKPSDEGRYT CKVKNSGRYV WSHVILKVLV RPSKPKCELE GELTEGSDLT 
       160        170        180        190        200
LQCESSSGTE PIVYYWQRIR EKEGEDERLP PKSRIDYNHP GRVLLQNLTM 
       210        220        230        240        250
SYSGLYQCTA GNEAGKESCV VRVTVQYVQS IGMVAGAVTG IVAGALLIFL 
       260        270        280        290        300
LVWLLIRRKD KERYEEEERP NEIREDAEAP KARLVKPSSS SSGSRSSRSG 
       310        320        330        340        350
SSSTRSTANS ASRSQRTLST DAAPQPGLAT QAYSLVGPEV RGSEPKKVHH 
       360        370 
ANLTKAETTP SMIPSQSRAF QTV

Length:373

Mass (Da):41,281

Last modified:March 1, 2001 - v1

Checksum:ⁱFDA215EB3B3C4335

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049824	69	R → H. Corresponds to variant dbSNP:rs2276348Ensembl.		1
Natural variantⁱVAR_069713	124	V → D in CSBS; affects subcellular location; the mutant protein is localized in the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587776967EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY326422 mRNA Translation: AAP88386.1 AY358340 mRNA Translation: AAQ88706.1 AK026068 mRNA Translation: BAB15347.1 BC009371 mRNA Translation: AAH09371.1 BK001245 mRNA Translation: DAA01139.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8441.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079045.1, NM_024769.3
UniGeneⁱ	Hs.591949

Genome annotation databases

Ensemblⁱ	ENST00000448775; ENSP00000405577; ENSG00000166250
GeneIDⁱ	79827
KEGGⁱ	hsa:79827
UCSC genome browser More...UCSCⁱ	uc001pyt.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H6B4	CLMP isoform 1		PANTR		373	UniRef100_Q9H6B4
CXADR like membrane protein		PANPA		373
CXADR like membrane protein		GORGO		373

Protein	Similar proteins		Species	Score	Length	Source
Q9H6B4	CLMP isoform 1		PANTR		373	UniRef90_Q9H6B4
CXADR like membrane protein		PANPA		373
CXADR like membrane protein		GORGO		373
CXADR-like membrane protein		CAMFR		466
CXADR like membrane protein		MACMU		377
+32

Protein	Similar proteins		Species	Score	Length	Source
Q9H6B4	CLMP isoform 1		PANTR		373	UniRef50_Q9H6B4
CXADR like membrane protein		PANPA		373
CXADR like membrane protein		GORGO		373
CXADR-like membrane protein		CAMFR		466
CXADR like membrane protein		MACMU		377
+38

Entry informationⁱ

Entry nameⁱ	CLMP_HUMAN
Accessionⁱ	Q9H6B4Primary (citable) accession number: Q9H6B4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	March 1, 2001
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H6B4 (CLMP_HUMAN)

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CXADR-like membrane protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ