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Entry version 118 (12 Aug 2020)
Sequence version 2 (29 Apr 2008)
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Protein

Pecanex-like protein 3

Gene

PCNX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H6A9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pecanex-like protein 3
Alternative name(s):
Pecanex homolog protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCNX3Imported
Synonyms:PCNXL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197136.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18760, PCNX3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617657, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H6A9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei790 – 812HelicalSequence analysisAdd BLAST23
Transmembranei819 – 836HelicalSequence analysisAdd BLAST18
Transmembranei852 – 872HelicalSequence analysisAdd BLAST21
Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21
Transmembranei946 – 968HelicalSequence analysisAdd BLAST23
Transmembranei980 – 1000HelicalSequence analysisAdd BLAST21
Transmembranei1053 – 1073HelicalSequence analysisAdd BLAST21
Transmembranei1078 – 1098HelicalSequence analysisAdd BLAST21
Transmembranei1244 – 1264HelicalSequence analysisAdd BLAST21
Transmembranei1280 – 1300HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
399909

Open Targets

More...
OpenTargetsi
ENSG00000197136

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38680

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H6A9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCNX3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187471100

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003315291 – 2034Pecanex-like protein 3Add BLAST2034

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineBy similarity1
Modified residuei129PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei370PhosphothreonineCombined sources1
Modified residuei392PhosphoserineCombined sources1
Modified residuei431PhosphoserineBy similarity1
Modified residuei505PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1697PhosphoserineCombined sources1
Glycosylationi1770N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1909PhosphoserineCombined sources1
Modified residuei1955PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H6A9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H6A9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H6A9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H6A9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H6A9

PeptideAtlas

More...
PeptideAtlasi
Q9H6A9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H6A9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80969 [Q9H6A9-1]
80970 [Q9H6A9-2]
80971 [Q9H6A9-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q9H6A9, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H6A9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H6A9

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9H6A9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197136, Expressed in testis and 112 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H6A9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197136, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
134447, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H6A9, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347931

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H6A9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi425 – 458Ser-richAdd BLAST34
Compositional biasi809 – 812Poly-Leu4
Compositional biasi1427 – 1430Poly-Cys4
Compositional biasi1824 – 1959Gly-richAdd BLAST136

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pecanex family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3604, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000602_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H6A9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHRDSHV

Database of Orthologous Groups

More...
OrthoDBi
63639at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H6A9

TreeFam database of animal gene trees

More...
TreeFami
TF313570

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039797, Pecanex
IPR007735, Pecanex_C

The PANTHER Classification System

More...
PANTHERi
PTHR12372, PTHR12372, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05041, Pecanex_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H6A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSQVLQILR QGVWASLTGG WFFDPHQSTF SNCFHLYVWI FLLIFPFLLY
60 70 80 90 100
MVLPPSLMVA GVYCLVVAVI FATIKTVNYR LHAMFDQGEI VEKRSSTMGE
110 120 130 140 150
LEEEPAQGDS NPPRDPGVEM TVFRKVSSTP PVRCSSQHSV FGFNQVSELL
160 170 180 190 200
PRMEDSGPLR DIKELVREQG SNNVIVTSAD REMLKLSSQE KLIGDLPQTP
210 220 230 240 250
PGAVPDPSLA STDSSEPSPL AGDGAPWSGS SMADTPMSPL LKGSLSQELS
260 270 280 290 300
KSFLTLTQPD RALVRTSSRR EQRRGAGGYQ PLDRRGSGEP TPQKAGSSDS
310 320 330 340 350
CFSGTDRETL SSFKSEKTNS THLDSPPGGP APEGSDTDPP SEAELPASPD
360 370 380 390 400
AGVPSDDTLR SFDTVIGAGT PPGLAEPLLV VRPKDLALLR PSKRQPPLRR
410 420 430 440 450
HSPPGRAPRR PLLEGGGFFE DEDTSEGSEL SPASSLRSQR RYSTDSSSST
460 470 480 490 500
SCYSPESSRG AAGGPRKRRA PHGAEEGTAV PPKRPYGTQR TPSTASAKTH
510 520 530 540 550
ARVLSMDGAG GDVLRPPLAG CKAELEAQVG VEQAASEPVV LPAEARRGPA
560 570 580 590 600
ANQPGWRGEL QEEGAVGGAA EETGRRDRSS SVRRTQAIRR RHNAGSNPTP
610 620 630 640 650
PASVMGSPPS SLQEAQRGRA ASHSRALTLP SALHFASSLL LTRAGANVHE
660 670 680 690 700
ACTFDDTSEG AVHYFYDESG VRRSYTFGLA GGGYENPVGQ QGEQTANGAW
710 720 730 740 750
DRHSHSSSFH SADVPEATGG LNLLQPRPVV LQGMQVRRVP LEIPEEQTLM
760 770 780 790 800
EEAPPRAQHS YKYWLLPGRW TSVRYERLAL LALLDRTRGV LENIFGVGLS
810 820 830 840 850
SLVAFLGYLL LLKGFFTDIW VFQFCLVIAS CQYSLLKSVQ PDAASPMHGH
860 870 880 890 900
NWVIAYSRPV YFCICCLLIW LLDALGSAQP FPPVSLYGLT LFSASFFFCA
910 920 930 940 950
RDVATVFTLC FPFVFLLGLL PQVNTCLMYL LEQIDMHGFG GTAATSPLTA
960 970 980 990 1000
VFSLSRSLLA AALLYGFCLG AIKTPWPEQH VPVLFSVFCG LLVALSYHLS
1010 1020 1030 1040 1050
RQSSDPTVLW SLIRSKLFPE LEERSLETAR AEPPDPLPDK MRQSVREVLH
1060 1070 1080 1090 1100
SDLVMCVVIA VLTFAISAST VFIALKSVLG FVLYALAGAV GFFTHYLLPQ
1110 1120 1130 1140 1150
LRKQLPWFCL SQPVLKPLEY SQYEVRGAAQ VMWFEKLYAG LQCVEKYLIY
1160 1170 1180 1190 1200
PAVVLNALTV DAHTVVSHPD KYCFYCRALL MTVAGLKLLR SAFCCPPQQY
1210 1220 1230 1240 1250
LTLAFTVLLF HFDYPRLSQG FLLDYFLMSL LCSKLWDLLY KLRFVLTYIA
1260 1270 1280 1290 1300
PWQITWGSAF HAFAQPFAVP HSAMLFVQAL LSGLFSTPLN PLLGSAVFIM
1310 1320 1330 1340 1350
SYARPLKFWE RDYNTKRVDH SNTRLVTQLD RNPGADDNNL NSIFYEHLTR
1360 1370 1380 1390 1400
SLQHTLCGDL VLGRWGNYGP GDCFVLASDY LNALVHLIEV GNGLVTFQLR
1410 1420 1430 1440 1450
GLEFRGTYCQ QREVEAITEG VEEDEGCCCC EPGHLPRVLS FNAAFGQRWL
1460 1470 1480 1490 1500
AWEVTASKYV LEGYSISDNN AASMLQVFDL RKILITYYVK SIIYYVSRSP
1510 1520 1530 1540 1550
KLEVWLSHEG ITAALRPVRV PGYADSDPTF SLSVDEDYDL RLSGLSLPSF
1560 1570 1580 1590 1600
CAVHLEWIQY CASRRSQPVD QDWNSPLVTL CFGLCVLGRR ALGTASHSMS
1610 1620 1630 1640 1650
ASLEPFLYGL HALFKGDFRI TSPRDEWVFA DMDLLHRVVA PGVRMALKLH
1660 1670 1680 1690 1700
QDHFTSPDEY EEPAALYDAI AANEERLVIS HEGDPAWRSA ILSNTPSLLA
1710 1720 1730 1740 1750
LRHVLDDASD EYKIIMLNRR HLSFRVIKVN RECVRGLWAG QQQELVFLRN
1760 1770 1780 1790 1800
RNPERGSIQN AKQALRNMIN SSCDQPLGYP IYVSPLTTSL AGSHPQLRAL
1810 1820 1830 1840 1850
WGGPISLGAI AHWLLRTWER LHKGCGAGCN SGGNVDDSDC SGGGGLTSLS
1860 1870 1880 1890 1900
NNPPVAHPTP ENTAGNGDQP LPPGPGWGPR SSLSGSGDGR PPPLLQWPPP
1910 1920 1930 1940 1950
RLPGPPPASP IPTEGPRTSR PPGPGLLSSE GPSGKWSLGG RKGLGGSDGE
1960 1970 1980 1990 2000
PASGSPKGGT PKSQAPLDLS LSLSLSLSPD VSTEASPPRA SQDIPCLDSS
2010 2020 2030
APESGTPMGA LGDWPAPIEE RESPAAQPLL EHQY
Length:2,034
Mass (Da):222,039
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC11C93DDFB2DA270
GO
Isoform 2 (identifier: Q9H6A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-982: LMYLLEQIDM...KTPWPEQHVP → PRPRSPPEAL...SKPLSGISLC
     983-2034: Missing.

Show »
Length:982
Mass (Da):106,000
Checksum:i2AE05D4E2DDD0F70
GO
Isoform 3 (identifier: Q9H6A9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1113: Missing.
     1114-1126: VLKPLEYSQYEVR → MWKPGAESWPLHT

Show »
Length:921
Mass (Da):101,308
Checksum:i60258D869E371D86
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15353 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042889258Q → R1 PublicationCorresponds to variant dbSNP:rs1151489Ensembl.1
Natural variantiVAR_042890458S → C. Corresponds to variant dbSNP:rs1193851Ensembl.1
Natural variantiVAR_061500564G → S. Corresponds to variant dbSNP:rs56232198Ensembl.1
Natural variantiVAR_042891813K → N. Corresponds to variant dbSNP:rs1144790Ensembl.1
Natural variantiVAR_0615011822H → Q. Corresponds to variant dbSNP:rs7114037Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0332441 – 1113Missing in isoform 3. 1 PublicationAdd BLAST1113
Alternative sequenceiVSP_033242927 – 982LMYLL…EQHVP → PRPRSPPEALPCLHICFALT QFGNSNCPAEVHSPDPFPTL VRVAGFSKPLSGISLC in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_033243983 – 2034Missing in isoform 2. 1 PublicationAdd BLAST1052
Alternative sequenceiVSP_0332451114 – 1126VLKPL…QYEVR → MWKPGAESWPLHT in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640978 mRNA Translation: CAE45990.2
AP001362 Genomic DNA No translation available.
AK026080 mRNA Translation: BAB15353.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44650.1 [Q9H6A9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_115599.2, NM_032223.3 [Q9H6A9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355703; ENSP00000347931; ENSG00000197136 [Q9H6A9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
399909

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:399909

UCSC genome browser

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UCSCi
uc001oey.3, human [Q9H6A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640978 mRNA Translation: CAE45990.2
AP001362 Genomic DNA No translation available.
AK026080 mRNA Translation: BAB15353.1 Different initiation.
CCDSiCCDS44650.1 [Q9H6A9-1]
RefSeqiNP_115599.2, NM_032223.3 [Q9H6A9-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi134447, 36 interactors
IntActiQ9H6A9, 26 interactors
STRINGi9606.ENSP00000347931

PTM databases

GlyGeniQ9H6A9, 2 sites
iPTMnetiQ9H6A9
PhosphoSitePlusiQ9H6A9
SwissPalmiQ9H6A9

Polymorphism and mutation databases

BioMutaiPCNX3
DMDMi187471100

Proteomic databases

EPDiQ9H6A9
jPOSTiQ9H6A9
MassIVEiQ9H6A9
MaxQBiQ9H6A9
PaxDbiQ9H6A9
PeptideAtlasiQ9H6A9
PRIDEiQ9H6A9
ProteomicsDBi80969 [Q9H6A9-1]
80970 [Q9H6A9-2]
80971 [Q9H6A9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
7459, 11 antibodies

Genome annotation databases

EnsembliENST00000355703; ENSP00000347931; ENSG00000197136 [Q9H6A9-1]
GeneIDi399909
KEGGihsa:399909
UCSCiuc001oey.3, human [Q9H6A9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
399909
DisGeNETi399909
EuPathDBiHostDB:ENSG00000197136.4

GeneCards: human genes, protein and diseases

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GeneCardsi
PCNX3
HGNCiHGNC:18760, PCNX3
HPAiENSG00000197136, Low tissue specificity
MIMi617657, gene
neXtProtiNX_Q9H6A9
OpenTargetsiENSG00000197136
PharmGKBiPA38680

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3604, Eukaryota
GeneTreeiENSGT00940000158735
HOGENOMiCLU_000602_0_1_1
InParanoidiQ9H6A9
OMAiQHRDSHV
OrthoDBi63639at2759
PhylomeDBiQ9H6A9
TreeFamiTF313570

Enzyme and pathway databases

PathwayCommonsiQ9H6A9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
399909, 93 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PCNX3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
399909
PharosiQ9H6A9, Tdark

Protein Ontology

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PROi
PR:Q9H6A9
RNActiQ9H6A9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197136, Expressed in testis and 112 other tissues
GenevisibleiQ9H6A9, HS

Family and domain databases

InterProiView protein in InterPro
IPR039797, Pecanex
IPR007735, Pecanex_C
PANTHERiPTHR12372, PTHR12372, 1 hit
PfamiView protein in Pfam
PF05041, Pecanex_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6A9
Secondary accession number(s): Q6MZN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: August 12, 2020
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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