BICC1

Functionⁱ

Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

determination of left/right symmetry Source: Ensembl
heart development Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21922595

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, RNA-binding

Molecular function

Developmental protein, RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein bicaudal C homolog 1 Short name: Bic-C
Gene namesⁱ	Name:BICC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122870.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19351 BICC1
MIMⁱ	614295 gene
neXtProtⁱ	NX_Q9H694

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Renal dysplasia, cystic (CYSRD)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionAn anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066760	932	E → G in CYSRD; may impair splicing; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387907124EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80114
MalaCards human disease database More...MalaCardsⁱ	BICC1
MIMⁱ	601331 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122870
Orphanetⁱ	730 Autosomal dominant polycystic kidney disease
PharmGKBⁱ	PA134878124

Polymorphism and mutation databases

BioMutaⁱ	BICC1
DMDMⁱ	119367815

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000267714	1 – 974	Protein bicaudal C homolog 1Add BLAST		974

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	26	PhosphoserineBy similarity	1
Modified residueⁱ	31	PhosphoserineBy similarity	1
Modified residueⁱ	43	PhosphoserineBy similarity	1
Modified residueⁱ	398	N6-acetyllysineCombined sources	1
Modified residueⁱ	576	PhosphoserineCombined sources	1
Modified residueⁱ	612	PhosphoserineBy similarity	1
Modified residueⁱ	679	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H694
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H694
PaxDbⁱ	Q9H694
PeptideAtlas More...PeptideAtlasⁱ	Q9H694
PRIDEⁱ	Q9H694
ProteomicsDBⁱ	80965 80966 [Q9H694-2]

PTM databases

iPTMnetⁱ	Q9H694
PhosphoSitePlusⁱ	Q9H694

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122870
CleanExⁱ	HS_BICC1
ExpressionAtlasⁱ	Q9H694 baseline and differential
Genevisibleⁱ	Q9H694 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045212

HPAⁱ

HPA045212

Interactionⁱ

Subunit structureⁱ

Interacts (via KH domains) with ANKS6 (via SAM domain) in an RNA-dependent manner (By similarity). Interacts with ANKS3 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	123119, 3 interactors
IntActⁱ	Q9H694, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q9H694
STRINGⁱ	9606.ENSP00000362993

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	875 – 877	Combined sources	3
Helixⁱ	878 – 884	Combined sources	7
Helixⁱ	888 – 890	Combined sources	3
Helixⁱ	891 – 896	Combined sources	6
Helixⁱ	901 – 904	Combined sources	4
Helixⁱ	909 – 915	Combined sources	7
Helixⁱ	920 – 935	Combined sources	16

3D structure databases

ProteinModelPortalⁱ	Q9H694
SMRⁱ	Q9H694
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	132 – 199	KH 1PROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	284 – 348	KH 2PROSITE-ProRule annotationAdd BLAST	65
Domainⁱ	873 – 936	SAMPROSITE-ProRule annotationAdd BLAST	64

Sequence similaritiesⁱ

Belongs to the BicC family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2208 Eukaryota KOG4374 Eukaryota ENOG410XQFV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140968
HOGENOMⁱ	HOG000068054
HOVERGENⁱ	HBG058964
InParanoidⁱ	Q9H694
KEGG Orthology (KO) More...KOⁱ	K18756
OMAⁱ	VRGSQNN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05A1
PhylomeDBⁱ	Q9H694
TreeFamⁱ	TF323767

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09520 SAM_BICC1, 1 hit
Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR037974 BICC1_SAM_dom IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR001660 SAM IPR013761 SAM/pointed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits PF00536 SAM_1, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 3 hits SM00454 SAM, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF54791 SSF54791, 3 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50105 SAM_DOMAIN, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9H694-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQGEPGYL AAQSDPGSNS ERSTDSPVPG SEDDLVAGAT LHSPEWSEER 
        60         70         80         90        100
FRVDRKKLEA MLQAAAEGKG RSGEDFFQKI MEETNTQIAW PSKLKIGAKS 
       110        120        130        140        150
KKDPHIKVSG KKEDVKEAKE MIMSVLDTKS NRVTLKMDVS HTEHSHVIGK 
       160        170        180        190        200
GGNNIKKVME ETGCHIHFPD SNRNNQAEKS NQVSIAGQPA GVESARVRIR 
       210        220        230        240        250
ELLPLVLMFE LPIAGILQPV PDPNSPSIQH ISQTYNISVS FKQRSRMYGA 
       260        270        280        290        300
TVIVRGSQNN TSAVKEGTAM LLEHLAGSLA SAIPVSTQLD IAAQHHLFMM 
       310        320        330        340        350
GRNGSNIKHI MQRTGAQIHF PDPSNPQKKS TVYLQGTIES VCLARQYLMG 
       360        370        380        390        400
CLPLVLMFDM KEEIEVDPQF IAQLMEQLDV FISIKPKPKQ PSKSVIVKSV 
       410        420        430        440        450
ERNALNMYEA RKCLLGLESS GVTIATSPSP ASCPAGLACP SLDILASAGL 
       460        470        480        490        500
GLTGLGLLGP TTLSLNTSTT PNSLLNALNS SVSPLQSPSS GTPSPTLWAP 
       510        520        530        540        550
PLANTSSATG FSAIPHLMIP STAQATLTNI LLSGVPTYGH TAPSPPPGLT 
       560        570        580        590        600
PVDVHINSMQ TEGKKISAAL NGHAQSPDIK YGAISTSSLG EKVLSANHGD 
       610        620        630        640        650
PSIQTSGSEQ TSPKSSPTEG CNDAFVEVGM PRSPSHSGNA GDLKQMMCPS 
       660        670        680        690        700
KVSCAKRQTV ELLQGTKNSH LHSTDRLLSD PELSATESPL ADKKAPGSER 
       710        720        730        740        750
AAERAAAAQQ NSERAHLAPR SSYVNMQAFD YEQKKLLATK AMLKKPVVTE 
       760        770        780        790        800
VRTPTNTWSG LGFSKSMPAE TIKELRRANH VSYKPTMTTT YEGSSMSLSR 
       810        820        830        840        850
SNSREHLGGG SESDNWRDRN GIGPGSHSEF AASIGSPKRK QNKSTEHYLS 
       860        870        880        890        900
SSNYMDCISS LTGSNGCNLN SSFKGSDLPE LFSKLGLGKY TDVFQQQEID 
       910        920        930        940        950
LQTFLTLTDQ DLKELGITTF GARRKMLLAI SELNKNRRKL FESPNARTSF 
       960        970 
LEGGASGRLP RQYHSDIASV SGRW

Length:974

Mass (Da):104,844

Last modified:December 12, 2006 - v2

Checksum:ⁱD2DB194BD3C8266D

GO

Isoform 2 (identifier: Q9H694-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
845-974: TEHYLSSSNY...SDIASVSGRW → SELCVLCTLL...CGLSDFKCLV

« Hide

        10         20         30         40         50
MAAQGEPGYL AAQSDPGSNS ERSTDSPVPG SEDDLVAGAT LHSPEWSEER 
        60         70         80         90        100
FRVDRKKLEA MLQAAAEGKG RSGEDFFQKI MEETNTQIAW PSKLKIGAKS 
       110        120        130        140        150
KKDPHIKVSG KKEDVKEAKE MIMSVLDTKS NRVTLKMDVS HTEHSHVIGK 
       160        170        180        190        200
GGNNIKKVME ETGCHIHFPD SNRNNQAEKS NQVSIAGQPA GVESARVRIR 
       210        220        230        240        250
ELLPLVLMFE LPIAGILQPV PDPNSPSIQH ISQTYNISVS FKQRSRMYGA 
       260        270        280        290        300
TVIVRGSQNN TSAVKEGTAM LLEHLAGSLA SAIPVSTQLD IAAQHHLFMM 
       310        320        330        340        350
GRNGSNIKHI MQRTGAQIHF PDPSNPQKKS TVYLQGTIES VCLARQYLMG 
       360        370        380        390        400
CLPLVLMFDM KEEIEVDPQF IAQLMEQLDV FISIKPKPKQ PSKSVIVKSV 
       410        420        430        440        450
ERNALNMYEA RKCLLGLESS GVTIATSPSP ASCPAGLACP SLDILASAGL 
       460        470        480        490        500
GLTGLGLLGP TTLSLNTSTT PNSLLNALNS SVSPLQSPSS GTPSPTLWAP 
       510        520        530        540        550
PLANTSSATG FSAIPHLMIP STAQATLTNI LLSGVPTYGH TAPSPPPGLT 
       560        570        580        590        600
PVDVHINSMQ TEGKKISAAL NGHAQSPDIK YGAISTSSLG EKVLSANHGD 
       610        620        630        640        650
PSIQTSGSEQ TSPKSSPTEG CNDAFVEVGM PRSPSHSGNA GDLKQMMCPS 
       660        670        680        690        700
KVSCAKRQTV ELLQGTKNSH LHSTDRLLSD PELSATESPL ADKKAPGSER 
       710        720        730        740        750
AAERAAAAQQ NSERAHLAPR SSYVNMQAFD YEQKKLLATK AMLKKPVVTE 
       760        770        780        790        800
VRTPTNTWSG LGFSKSMPAE TIKELRRANH VSYKPTMTTT YEGSSMSLSR 
       810        820        830        840        850
SNSREHLGGG SESDNWRDRN GIGPGSHSEF AASIGSPKRK QNKSSELCVL 
       860        870        880
CTLLGIPRLE CVYLGWSITD CGLSDFKCLV

Show »

Length:880

Mass (Da):94,288

Checksum:ⁱB9DA3F9F9AAEA61B

GO

Sequence cautionⁱ

The sequence BAB15369 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029658	8	G → D. Corresponds to variant dbSNP:rs7905025Ensembl.	1
Natural variantⁱVAR_072077	270	M → V Found in a family with atypical autism and severe epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753582128Ensembl.	1
Natural variantⁱVAR_066759	711	N → T1 PublicationCorresponds to variant dbSNP:rs138916713Ensembl.	1
Natural variantⁱVAR_066760	932	E → G in CYSRD; may impair splicing; hypomorphic mutation. 1 PublicationCorresponds to variant dbSNP:rs387907124EnsemblClinVar.	1
Natural variantⁱVAR_033542	943	S → P. Corresponds to variant dbSNP:rs4948550Ensembl.	1
Natural variantⁱVAR_060133	945	N → S. Corresponds to variant dbSNP:rs7895817Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021949	845 – 974	TEHYL…VSGRW → SELCVLCTLLGIPRLECVYL GWSITDCGLSDFKCLV in isoform 2. 1 PublicationAdd BLAST		130

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY726586 mRNA No translation available. AK026129 mRNA Translation: BAB15369.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31206.1 [Q9H694-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073981.1, NM_001080512.2 [Q9H694-1]
UniGeneⁱ	Hs.100261 Hs.158745 Hs.633222

Genome annotation databases

Ensemblⁱ	ENST00000373886; ENSP00000362993; ENSG00000122870 [Q9H694-1]
GeneIDⁱ	80114
KEGGⁱ	hsa:80114
UCSC genome browser More...UCSCⁱ	uc001jki.2 human [Q9H694-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9H694	BicC family RNA binding protein 1		PIG		1086
BicC family RNA binding protein 1		CALJA		1074
BicC family RNA binding protein 1		PANTR		1074
BicC family RNA binding protein 1		GORGO		974
BicC family RNA binding protein 1		PANPA		959
+265

Protein	Similar proteins		Species	Score	Length
Q9H694	BicC family RNA binding protein 1		PIG		1086
BicC family RNA binding protein 1		CALJA		1074
BicC family RNA binding protein 1		PANTR		1074
BicC family RNA binding protein 1		GORGO		974
BicC family RNA binding protein 1		PANPA		959
+426

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY726586 mRNA No translation available. AK026129 mRNA Translation: BAB15369.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31206.1 [Q9H694-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073981.1, NM_001080512.2 [Q9H694-1]
UniGeneⁱ	Hs.100261 Hs.158745 Hs.633222

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4RQM	X-ray	1.75	A/B/C	870-939	[»]
	4RQN	X-ray	2.00	A/B/C	870-939	[»]
ProteinModelPortalⁱ	Q9H694
SMRⁱ	Q9H694
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123119, 3 interactors
IntActⁱ	Q9H694, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q9H694
STRINGⁱ	9606.ENSP00000362993

PTM databases

iPTMnetⁱ	Q9H694
PhosphoSitePlusⁱ	Q9H694

Polymorphism and mutation databases

BioMutaⁱ	BICC1
DMDMⁱ	119367815

Proteomic databases

EPDⁱ	Q9H694
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H694
PaxDbⁱ	Q9H694
PeptideAtlas More...PeptideAtlasⁱ	Q9H694
PRIDEⁱ	Q9H694
ProteomicsDBⁱ	80965 80966 [Q9H694-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80114
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373886; ENSP00000362993; ENSG00000122870 [Q9H694-1]
GeneIDⁱ	80114
KEGGⁱ	hsa:80114
UCSC genome browser More...UCSCⁱ	uc001jki.2 human [Q9H694-1]

Organism-specific databases

CTDⁱ	80114
DisGeNET More...DisGeNETⁱ	80114
EuPathDBⁱ	HostDB:ENSG00000122870.11
GeneCardsⁱ	BICC1
H-InvDBⁱ	HIX0008843
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19351 BICC1
Human Protein Atlas More...HPAⁱ	HPA045212
MalaCards human disease database More...MalaCardsⁱ	BICC1
MIMⁱ	601331 phenotype 614295 gene
neXtProtⁱ	NX_Q9H694
Open Targets More...OpenTargetsⁱ	ENSG00000122870
Orphanetⁱ	730 Autosomal dominant polycystic kidney disease
PharmGKBⁱ	PA134878124
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2208 Eukaryota KOG4374 Eukaryota ENOG410XQFV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140968
HOGENOMⁱ	HOG000068054
HOVERGENⁱ	HBG058964
InParanoidⁱ	Q9H694
KEGG Orthology (KO) More...KOⁱ	K18756
OMAⁱ	VRGSQNN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05A1
PhylomeDBⁱ	Q9H694
TreeFamⁱ	TF323767

Miscellaneous databases

ChiTaRSⁱ	BICC1 human
GenomeRNAiⁱ	80114
Protein Ontology More...PROⁱ	PR:Q9H694
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122870
CleanExⁱ	HS_BICC1
ExpressionAtlasⁱ	Q9H694 baseline and differential
Genevisibleⁱ	Q9H694 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09520 SAM_BICC1, 1 hit
Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR037974 BICC1_SAM_dom IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR001660 SAM IPR013761 SAM/pointed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits PF00536 SAM_1, 1 hit
SMARTⁱ	View protein in SMART SM00322 KH, 3 hits SM00454 SAM, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF54791 SSF54791, 3 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50105 SAM_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BICC1_HUMAN
Accessionⁱ	Q9H694Primary (citable) accession number: Q9H694
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	December 12, 2006
	Last modified:	June 20, 2018
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9H694 (BICC1_HUMAN)

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Protein bicaudal C homolog 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ