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Protein

IGF-like family receptor 1

Gene

IGFLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.1 Publication

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

SignaLinkiQ9H665

Names & Taxonomyi

Protein namesi
Recommended name:
IGF-like family receptor 1
Alternative name(s):
Transmembrane protein 149
U2 small nuclear RNA auxiliary factor 1-like 4
Gene namesi
Name:IGFLR1
Synonyms:TMEM149, U2AF1L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126246.9
HGNCiHGNC:23620 IGFLR1
MIMi614143 gene
neXtProtiNX_Q9H665

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 163ExtracellularSequence analysisAdd BLAST141
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 355CytoplasmicSequence analysisAdd BLAST171

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79713
OpenTargetsiENSG00000126246
PharmGKBiPA134884390

Chemistry databases

ChEMBLiCHEMBL2029192

Polymorphism and mutation databases

BioMutaiIGFLR1
DMDMi74718463

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029035723 – 355IGF-like family receptor 1Add BLAST333

Proteomic databases

PaxDbiQ9H665
PeptideAtlasiQ9H665
PRIDEiQ9H665
ProteomicsDBi80959
80960 [Q9H665-2]

PTM databases

iPTMnetiQ9H665
PhosphoSitePlusiQ9H665

Expressioni

Inductioni

Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.1 Publication

Gene expression databases

BgeeiENSG00000126246 Expressed in 87 organ(s), highest expression level in blood
CleanExiHS_TMEM149
HS_U2AF1L4
ExpressionAtlasiQ9H665 baseline and differential
GenevisibleiQ9H665 HS

Organism-specific databases

HPAiHPA012369

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IGFL1Q6UW325EBI-3870439,EBI-3870426

Protein-protein interaction databases

IntActiQ9H665, 3 interactors
STRINGi9606.ENSP00000246532

Chemistry databases

BindingDBiQ9H665

Structurei

3D structure databases

ProteinModelPortaliQ9H665
SMRiQ9H665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJZ Eukaryota
ENOG410YY5D LUCA
GeneTreeiENSGT00390000005702
HOVERGENiHBG099100
InParanoidiQ9H665
OMAiPYPGLVC
OrthoDBiEOG091G0H32
PhylomeDBiQ9H665
TreeFamiTF338761

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
SUPFAMiSSF47986 SSF47986, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H665-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGRCLLTA LLLLALAPPP EASQYCGRLE YWNPDNKCCS SCLQRFGPPP
60 70 80 90 100
CPDYEFRENC GLNDHGDFVT PPFRKCSSGQ CNPDGAELCS PCGGGAVTPT
110 120 130 140 150
PAAGGGRTPW RCRERPVPAK GHCPLTPGNP GAPSSQERSS PASSIAWRTP
160 170 180 190 200
EPVPQQAWPN FLPLVVLVLL LTLAVIAILL FILLWHLCWP KEKADPYPYP
210 220 230 240 250
GLVCGVPNTH TPSSSHLSSP GALETGDTWK EASLLPLLSR ELSSLASQPL
260 270 280 290 300
SRLLDELEVL EELIVLLDPE PGPGGGMAHG TTRHLAARYG LPAAWSTFAY
310 320 330 340 350
SLRPSRSPLR ALIEMVVARE PSASLGQLGT HLAQLGRADA LRVLSKLGSS

GVCWA
Length:355
Mass (Da):37,895
Last modified:March 1, 2001 - v1
Checksum:i52C41A73E673623C
GO
Isoform 2 (identifier: Q9H665-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-240: Missing.

Show »
Length:167
Mass (Da):17,816
Checksum:i14EC1AC3B47BC972
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EL86K7EL86_HUMAN
IGF-like family receptor 1
IGFLR1
187Annotation score:
K7ESC2K7ESC2_HUMAN
IGF-like family receptor 1
IGFLR1
138Annotation score:
K7ES44K7ES44_HUMAN
IGF-like family receptor 1
IGFLR1
132Annotation score:
S4R3Z9S4R3Z9_HUMAN
IGF-like family receptor 1
IGFLR1
60Annotation score:
U3KQL9U3KQL9_HUMAN
IGF-like family receptor 1
IGFLR1
74Annotation score:
K7EQI5K7EQI5_HUMAN
IGF-like family receptor 1
IGFLR1
16Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032775189W → R. Corresponds to variant dbSNP:rs34562867Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02614553 – 240Missing in isoform 2. 1 PublicationAdd BLAST188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026226 mRNA Translation: BAB15400.1
AD000671 Genomic DNA No translation available.
BC031329 mRNA Translation: AAH31329.1
BC126481 mRNA Translation: AAI26482.1
BC126483 mRNA Translation: AAI26484.1
CCDSiCCDS12472.1 [Q9H665-1]
CCDS86751.1 [Q9H665-2]
RefSeqiNP_001332933.1, NM_001346004.1 [Q9H665-2]
NP_001332934.1, NM_001346005.1 [Q9H665-2]
NP_078936.1, NM_024660.3 [Q9H665-1]
UniGeneiHs.352548

Genome annotation databases

EnsembliENST00000246532; ENSP00000246532; ENSG00000126246 [Q9H665-1]
ENST00000592537; ENSP00000466181; ENSG00000126246 [Q9H665-1]
ENST00000592889; ENSP00000467750; ENSG00000126246 [Q9H665-2]
GeneIDi79713
KEGGihsa:79713
UCSCiuc002obb.4 human [Q9H665-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026226 mRNA Translation: BAB15400.1
AD000671 Genomic DNA No translation available.
BC031329 mRNA Translation: AAH31329.1
BC126481 mRNA Translation: AAI26482.1
BC126483 mRNA Translation: AAI26484.1
CCDSiCCDS12472.1 [Q9H665-1]
CCDS86751.1 [Q9H665-2]
RefSeqiNP_001332933.1, NM_001346004.1 [Q9H665-2]
NP_001332934.1, NM_001346005.1 [Q9H665-2]
NP_078936.1, NM_024660.3 [Q9H665-1]
UniGeneiHs.352548

3D structure databases

ProteinModelPortaliQ9H665
SMRiQ9H665
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H665, 3 interactors
STRINGi9606.ENSP00000246532

Chemistry databases

BindingDBiQ9H665
ChEMBLiCHEMBL2029192

PTM databases

iPTMnetiQ9H665
PhosphoSitePlusiQ9H665

Polymorphism and mutation databases

BioMutaiIGFLR1
DMDMi74718463

Proteomic databases

PaxDbiQ9H665
PeptideAtlasiQ9H665
PRIDEiQ9H665
ProteomicsDBi80959
80960 [Q9H665-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246532; ENSP00000246532; ENSG00000126246 [Q9H665-1]
ENST00000592537; ENSP00000466181; ENSG00000126246 [Q9H665-1]
ENST00000592889; ENSP00000467750; ENSG00000126246 [Q9H665-2]
GeneIDi79713
KEGGihsa:79713
UCSCiuc002obb.4 human [Q9H665-1]

Organism-specific databases

CTDi79713
DisGeNETi79713
EuPathDBiHostDB:ENSG00000126246.9
GeneCardsiIGFLR1
HGNCiHGNC:23620 IGFLR1
HPAiHPA012369
MIMi614143 gene
neXtProtiNX_Q9H665
OpenTargetsiENSG00000126246
PharmGKBiPA134884390
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJZ Eukaryota
ENOG410YY5D LUCA
GeneTreeiENSGT00390000005702
HOVERGENiHBG099100
InParanoidiQ9H665
OMAiPYPGLVC
OrthoDBiEOG091G0H32
PhylomeDBiQ9H665
TreeFamiTF338761

Enzyme and pathway databases

SignaLinkiQ9H665

Miscellaneous databases

ChiTaRSiIGFLR1 human
GenomeRNAii79713
PROiPR:Q9H665
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126246 Expressed in 87 organ(s), highest expression level in blood
CleanExiHS_TMEM149
HS_U2AF1L4
ExpressionAtlasiQ9H665 baseline and differential
GenevisibleiQ9H665 HS

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
SUPFAMiSSF47986 SSF47986, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGFR1_HUMAN
AccessioniPrimary (citable) accession number: Q9H665
Secondary accession number(s): Q8N5X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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