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Entry version 150 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Ribonuclease P protein subunit p21

Gene

RPP21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi62ZincBy similarity1
Metal bindingi65ZincBy similarity1
Metal bindingi92ZincBy similarity1
Metal bindingi95ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.26.5, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H633

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease P protein subunit p21 (EC:3.1.26.51 Publication)
Short name:
RNaseP protein p21
Alternative name(s):
Ribonuclease P/MRP 21 kDa subunit
Ribonucleoprotein V
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPP21
Synonyms:C6orf135, CAT60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21300, RPP21

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612524, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H633

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000241370.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79897

Open Targets

More...
OpenTargetsi
ENSG00000241370

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134960979

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H633, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPP21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52001252

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001538452 – 154Ribonuclease P protein subunit p21Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H633

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H633

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H633

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H633

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H633

PeptideAtlas

More...
PeptideAtlasi
Q9H633

PRoteomics IDEntifications database

More...
PRIDEi
Q9H633

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63919
80953 [Q9H633-1]
80954 [Q9H633-2]
80955 [Q9H633-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H633

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H633

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000241370, Expressed in muscle tissue and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H633, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H633, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241370, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122981, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9H633

Protein interaction database and analysis system

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IntActi
Q9H633, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000409799

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H633, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H633

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 154DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi121 – 135Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4394, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003020

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_079140_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H633

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPKHLLW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H633

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007175, Rpr2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04032, Rpr2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H633-1) [UniParc]FASTAAdd to basket
Also known as: CAT60-V1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPVKDREA FQRLNFLYQA AHCVLAQDPE NQALARFYCY TERTIAKRLV
60 70 80 90 100
LRRDPSVKRT LCRGCSSLLV PGLTCTQRQR RCRGQRWTVQ TCLTCQRSQR
110 120 130 140 150
FLNDPGHLLW GDRPEAQLGS QADSKPLQPL PNTAHSISDR LPEEKMQTQG

SSNQ
Length:154
Mass (Da):17,570
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8BD15AA20AE695F
GO
Isoform 2 (identifier: Q9H633-2) [UniParc]FASTAAdd to basket
Also known as: CAT60-V3

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Q → QVSLRQGPHGDGARRPRVTAPLPQ

Show »
Length:177
Mass (Da):20,018
Checksum:i0FE5E6F3296602FB
GO
Isoform 3 (identifier: Q9H633-3) [UniParc]FASTAAdd to basket
Also known as: CAT60-V4

The sequence of this isoform differs from the canonical sequence as follows:
     123-154: DSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ → GERFQTTTTLAKHSPLHFRPPS

Show »
Length:144
Mass (Da):16,544
Checksum:iB037193A307F6F77
GO
Isoform 4 (identifier: Q9H633-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: R → RRPLSSSAP

Show »
Length:162
Mass (Da):18,366
Checksum:iE2CA143586B0B751
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP39A0A096LP39_HUMAN
Ribonuclease P protein subunit p21
RPP21 TRIM39-RPP21
503Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA46A0A140TA46_HUMAN
Ribonuclease P protein subunit p21
RPP21
503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JKY0A0A0G2JKY0_HUMAN
Ribonuclease P protein subunit p21
RPP21
503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJ52A0A0G2JJ52_HUMAN
Ribonuclease P protein subunit p21
RPP21
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJ26A0A0G2JJ26_HUMAN
Ribonuclease P protein subunit p21
RPP21
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9R9A0A140T9R9_HUMAN
RPP21
RPP21
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JHI3A0A0G2JHI3_HUMAN
Ribonuclease P protein subunit p21
RPP21
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JIT5A0A0G2JIT5_HUMAN
RPP21
RPP21
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JJY3A0A0G2JJY3_HUMAN
Ribonuclease P protein subunit p21
RPP21
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BI598757 differs from that shown. Reason: Erroneous termination. Extended C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9E → K in BI598757 (PubMed:15489334).Curated1
Sequence conflicti113R → Q in CAD44290 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01911677Q → H3 PublicationsCorresponds to variant dbSNP:rs6986Ensembl.1
Natural variantiVAR_045986149Q → K1 PublicationCorresponds to variant dbSNP:rs974963Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01069519Q → QVSLRQGPHGDGARRPRVTA PLPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_04490152R → RRPLSSSAP in isoform 4. 1 Publication1
Alternative sequenceiVSP_010696123 – 154DSKPL…GSSNQ → GERFQTTTTLAKHSPLHFRP PS in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF212152 mRNA Translation: AAK39955.2
AJ504713 mRNA Translation: CAD44289.1
AJ504714 mRNA Translation: CAD44290.1
AJ504715 mRNA Translation: CAD44291.1
AJ504716 mRNA Translation: CAD44292.1
AK026291 mRNA Translation: BAB15433.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX294158 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03287.1
CH471081 Genomic DNA Translation: EAX03288.1
CH471081 Genomic DNA Translation: EAX03289.1
BC011730 mRNA Translation: AAH11730.1
BI598757 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS4679.1 [Q9H633-1]
CCDS56409.1 [Q9H633-4]
CCDS56410.1 [Q9H633-3]

NCBI Reference Sequences

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RefSeqi
NP_001186049.1, NM_001199120.1 [Q9H633-4]
NP_001186050.1, NM_001199121.1 [Q9H633-3]
NP_079115.1, NM_024839.2 [Q9H633-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376642; ENSP00000365829; ENSG00000239927 [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863 [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009
ENST00000415583; ENSP00000403747; ENSG00000239927 [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779
ENST00000424616; ENSP00000399295; ENSG00000241863 [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927 [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370 [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927 [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370 [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726
ENST00000435318; ENSP00000411003; ENSG00000239865 [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370 [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863 [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370 [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863 [Q9H633-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79897

UCSC genome browser

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UCSCi
uc003nqd.3, human [Q9H633-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212152 mRNA Translation: AAK39955.2
AJ504713 mRNA Translation: CAD44289.1
AJ504714 mRNA Translation: CAD44290.1
AJ504715 mRNA Translation: CAD44291.1
AJ504716 mRNA Translation: CAD44292.1
AK026291 mRNA Translation: BAB15433.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX294158 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03287.1
CH471081 Genomic DNA Translation: EAX03288.1
CH471081 Genomic DNA Translation: EAX03289.1
BC011730 mRNA Translation: AAH11730.1
BI598757 mRNA No translation available.
CCDSiCCDS4679.1 [Q9H633-1]
CCDS56409.1 [Q9H633-4]
CCDS56410.1 [Q9H633-3]
RefSeqiNP_001186049.1, NM_001199120.1 [Q9H633-4]
NP_001186050.1, NM_001199121.1 [Q9H633-3]
NP_079115.1, NM_024839.2 [Q9H633-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AHRelectron microscopy3.92K1-154[»]
6AHUelectron microscopy3.66K1-154[»]
SMRiQ9H633
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122981, 13 interactors
CORUMiQ9H633
IntActiQ9H633, 11 interactors
STRINGi9606.ENSP00000409799

PTM databases

iPTMnetiQ9H633
PhosphoSitePlusiQ9H633

Genetic variation databases

BioMutaiRPP21
DMDMi52001252

Proteomic databases

EPDiQ9H633
jPOSTiQ9H633
MassIVEiQ9H633
MaxQBiQ9H633
PaxDbiQ9H633
PeptideAtlasiQ9H633
PRIDEiQ9H633
ProteomicsDBi63919
80953 [Q9H633-1]
80954 [Q9H633-2]
80955 [Q9H633-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34965, 50 antibodies

The DNASU plasmid repository

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DNASUi
79897

Genome annotation databases

EnsembliENST00000376642; ENSP00000365829; ENSG00000239927 [Q9H633-1]
ENST00000411784; ENSP00000412619; ENSG00000241863 [Q9H633-2]
ENST00000414187; ENSP00000398396; ENSG00000243009
ENST00000415583; ENSP00000403747; ENSG00000239927 [Q9H633-3]
ENST00000416977; ENSP00000404312; ENSG00000241779
ENST00000424616; ENSP00000399295; ENSG00000241863 [Q9H633-1]
ENST00000425575; ENSP00000405834; ENSG00000239927 [Q9H633-4]
ENST00000428040; ENSP00000394320; ENSG00000241370 [Q9H633-2]
ENST00000430900; ENSP00000415046; ENSG00000239927 [Q9H633-2]
ENST00000433076; ENSP00000409799; ENSG00000241370 [Q9H633-4]
ENST00000434282; ENSP00000414284; ENSG00000242726
ENST00000435318; ENSP00000411003; ENSG00000239865 [Q9H633-3]
ENST00000436442; ENSP00000397778; ENSG00000241370 [Q9H633-3]
ENST00000437470; ENSP00000408610; ENSG00000241863 [Q9H633-3]
ENST00000442966; ENSP00000403833; ENSG00000241370 [Q9H633-1]
ENST00000455025; ENSP00000409193; ENSG00000241863 [Q9H633-4]
GeneIDi79897
KEGGihsa:79897
UCSCiuc003nqd.3, human [Q9H633-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79897
DisGeNETi79897

GeneCards: human genes, protein and diseases

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GeneCardsi
RPP21
HGNCiHGNC:21300, RPP21
HPAiENSG00000241370, Low tissue specificity
MIMi612524, gene
neXtProtiNX_Q9H633
OpenTargetsiENSG00000241370
PharmGKBiPA134960979
VEuPathDBiHostDB:ENSG00000241370.5

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4394, Eukaryota
GeneTreeiENSGT00390000003020
HOGENOMiCLU_079140_2_1_1
InParanoidiQ9H633
OMAiDPKHLLW
PhylomeDBiQ9H633

Enzyme and pathway databases

BRENDAi3.1.26.5, 2681
PathwayCommonsiQ9H633
ReactomeiR-HSA-6784531, tRNA processing in the nucleus
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79897, 688 hits in 967 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79897
PharosiQ9H633, Tbio

Protein Ontology

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PROi
PR:Q9H633
RNActiQ9H633, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241370, Expressed in muscle tissue and 116 other tissues
ExpressionAtlasiQ9H633, baseline and differential
GenevisibleiQ9H633, HS

Family and domain databases

InterProiView protein in InterPro
IPR007175, Rpr2
PfamiView protein in Pfam
PF04032, Rpr2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPP21_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H633
Secondary accession number(s): A2AAZ8
, B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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