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Protein

Zinc finger protein 576

Gene

ZNF576

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Caution

Overlaps in opposite strand with ZNF428.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 57C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri71 – 93C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 576
Gene namesi
Name:ZNF576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000124444.15
HGNCiHGNC:28357 ZNF576
neXtProtiNX_Q9H609

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124444
PharmGKBiPA134950110

Polymorphism and mutation databases

BioMutaiZNF576
DMDMi74761466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476671 – 170Zinc finger protein 576Add BLAST170

Proteomic databases

EPDiQ9H609
MaxQBiQ9H609
PaxDbiQ9H609
PeptideAtlasiQ9H609
PRIDEiQ9H609
ProteomicsDBi80947

PTM databases

iPTMnetiQ9H609
PhosphoSitePlusiQ9H609

Expressioni

Gene expression databases

BgeeiENSG00000124444
CleanExiHS_ZNF576
ExpressionAtlasiQ9H609 baseline and differential
GenevisibleiQ9H609 HS

Organism-specific databases

HPAiHPA050064

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122594, 20 interactors
IntActiQ9H609, 11 interactors
STRINGi9606.ENSP00000337852

Structurei

3D structure databases

ProteinModelPortaliQ9H609
SMRiQ9H609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri34 – 57C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri71 – 93C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00730000111407
HOGENOMiHOG000120113
HOVERGENiHBG082912
InParanoidiQ9H609
OMAiQCTRCLI
OrthoDBiEOG091G0PJM
PhylomeDBiQ9H609
TreeFamiTF350821

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9H609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPNPEENM KQQDSPKERS PQSPGGNICH LGAPKCTRCL ITFADSKFQE
60 70 80 90 100
RHMKREHPAD FVAQKLQGVL FICFTCARSF PSSKALITHQ RSHGPAAKPT
110 120 130 140 150
LPVATTTAQP TFPCPDCGKT FGQAVSLRRH RQMHEVRAPP GTFACTECGQ
160 170
DFAQEAGLHQ HYIRHARGEL
Length:170
Mass (Da):18,890
Last modified:March 1, 2001 - v1
Checksum:i4EFAA311147613C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02395681P → L1 PublicationCorresponds to variant dbSNP:rs17849705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026353 mRNA Translation: BAB15458.1
AC006276 Genomic DNA No translation available.
BC002981 mRNA Translation: AAH02981.1
CCDSiCCDS12625.1
RefSeqiNP_001138819.1, NM_001145347.1
NP_077303.1, NM_024327.2
UniGeneiHs.11110

Genome annotation databases

EnsembliENST00000336564; ENSP00000337852; ENSG00000124444
ENST00000391965; ENSP00000375827; ENSG00000124444
ENST00000525771; ENSP00000436182; ENSG00000124444
ENST00000528387; ENSP00000435934; ENSG00000124444
ENST00000529930; ENSP00000435463; ENSG00000124444
ENST00000533118; ENSP00000435899; ENSG00000124444
GeneIDi79177
KEGGihsa:79177
UCSCiuc002owy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN576_HUMAN
AccessioniPrimary (citable) accession number: Q9H609
Secondary accession number(s): Q9BU03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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