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Entry version 160 (07 Apr 2021)
Sequence version 3 (15 Feb 2005)
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Protein

SLIT and NTRK-like protein 6

Gene

SLITRK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of neurite outgrowth required for normal hearing and vision.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing, Sensory transduction, Vision

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H5Y7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388844, Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLIT and NTRK-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLITRK6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23503, SLITRK6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609681, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H5Y7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000184564.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 608ExtracellularSequence analysisAdd BLAST582
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei609 – 629HelicalSequence analysisAdd BLAST21
Topological domaini630 – 841CytoplasmicSequence analysisAdd BLAST212

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness and myopia (DFNMYP)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by prelingual sensorineural hearing loss associated with high myopia.
Related information in OMIM

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
84189

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLITRK6

MalaCards human disease database

More...
MalaCardsi
SLITRK6
MIMi221200, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000184564

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
363396, High myopia-sensorineural deafness syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134928433

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H5Y7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLITRK6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
59803110

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003268327 – 841SLIT and NTRK-like protein 6Add BLAST815

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H5Y7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H5Y7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H5Y7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H5Y7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H5Y7

PeptideAtlas

More...
PeptideAtlasi
Q9H5Y7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H5Y7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80941

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H5Y7, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H5Y7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H5Y7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184564, Expressed in intestine and 161 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H5Y7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184564, Tissue enhanced (prostate, salivary gland, smooth muscle, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123937, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H5Y7, 24 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383143

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H5Y7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H5Y7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 67LRRNT 1Add BLAST41
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati89 – 110LRR 1Add BLAST22
Repeati113 – 134LRR 2Add BLAST22
Repeati137 – 158LRR 3Add BLAST22
Repeati161 – 182LRR 4Add BLAST22
Repeati184 – 205LRR 5Add BLAST22
Domaini218 – 269LRRCT 1Add BLAST52
Domaini320 – 361LRRNT 2Add BLAST42
Repeati364 – 385LRR 6Add BLAST22
Repeati388 – 409LRR 7Add BLAST22
Repeati412 – 433LRR 8Add BLAST22
Repeati436 – 457LRR 9Add BLAST22
Repeati460 – 481LRR 10Add BLAST22
Repeati483 – 504LRR 11Add BLAST22
Domaini517 – 568LRRCT 2Add BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLITRK family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QZTX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160718

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012706_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H5Y7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QADTNFI

Database of Orthologous Groups

More...
OrthoDBi
217854at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H5Y7

TreeFam database of animal gene trees

More...
TreeFami
TF326378

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR043326, Slitrk

The PANTHER Classification System

More...
PANTHERi
PTHR45773, PTHR45773, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 9 hits
SM00082, LRRCT, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H5Y7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLWIHLFYS SLLACISLHS QTPVLSSRGS CDSLCNCEEK DGTMLINCEA
60 70 80 90 100
KGIKMVSEIS VPPSRPFQLS LLNNGLTMLH TNDFSGLTNA ISIHLGFNNI
110 120 130 140 150
ADIEIGAFNG LGLLKQLHIN HNSLEILKED TFHGLENLEF LQADNNFITV
160 170 180 190 200
IEPSAFSKLN RLKVLILNDN AIESLPPNIF RFVPLTHLDL RGNQLQTLPY
210 220 230 240 250
VGFLEHIGRI LDLQLEDNKW ACNCDLLQLK TWLENMPPQS IIGDVVCNSP
260 270 280 290 300
PFFKGSILSR LKKESICPTP PVYEEHEDPS GSLHLAATSS INDSRMSTKT
310 320 330 340 350
TSILKLPTKA PGLIPYITKP STQLPGPYCP IPCNCKVLSP SGLLIHCQER
360 370 380 390 400
NIESLSDLRP PPQNPRKLIL AGNIIHSLMK SDLVEYFTLE MLHLGNNRIE
410 420 430 440 450
VLEEGSFMNL TRLQKLYLNG NHLTKLSKGM FLGLHNLEYL YLEYNAIKEI
460 470 480 490 500
LPGTFNPMPK LKVLYLNNNL LQVLPPHIFS GVPLTKVNLK TNQFTHLPVS
510 520 530 540 550
NILDDLDLLT QIDLEDNPWD CSCDLVGLQQ WIQKLSKNTV TDDILCTSPG
560 570 580 590 600
HLDKKELKAL NSEILCPGLV NNPSMPTQTS YLMVTTPATT TNTADTILRS
610 620 630 640 650
LTDAVPLSVL ILGLLIMFIT IVFCAAGIVV LVLHRRRRYK KKQVDEQMRD
660 670 680 690 700
NSPVHLQYSM YGHKTTHHTT ERPSASLYEQ HMVSPMVHVY RSPSFGPKHL
710 720 730 740 750
EEEEERNEKE GSDAKHLQRS LLEQENHSPL TGSNMKYKTT NQSTEFLSFQ
760 770 780 790 800
DASSLYRNIL EKERELQQLG ITEYLRKNIA QLQPDMEAHY PGAHEELKLM
810 820 830 840
ETLMYSRPRK VLVEQTKNEY FELKANLHAE PDYLEVLEQQ T
Length:841
Mass (Da):95,110
Last modified:February 15, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53B0D9293D53B9B5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13941 differs from that shown. Aberrant splicing.Curated
The sequence BAB13941 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15480 differs from that shown. Reason: Frameshift.Curated
The sequence BAB15480 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02775825L → F. Corresponds to variant dbSNP:rs12863734EnsemblClinVar.1
Natural variantiVAR_027759315P → R. Corresponds to variant dbSNP:rs9547378Ensembl.1
Natural variantiVAR_027760414Q → R. Corresponds to variant dbSNP:rs17080147EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK021931 mRNA Translation: BAB13941.1 Sequence problems.
AK026427 mRNA Translation: BAB15480.1 Sequence problems.
AK292793 mRNA Translation: BAF85482.1
AL137517 mRNA Translation: CAB70783.3
BX648640 mRNA Translation: CAH10557.1
AL162373 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80611.1
BC101070 mRNA Translation: AAI01071.1
BC101071 mRNA Translation: AAI01072.1
BC101072 mRNA Translation: AAI01073.1
BC101073 mRNA Translation: AAI01074.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41903.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46279

NCBI Reference Sequences

More...
RefSeqi
NP_115605.2, NM_032229.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000643778; ENSP00000496428; ENSG00000184564
ENST00000647374; ENSP00000495507; ENSG00000184564

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84189

UCSC genome browser

More...
UCSCi
uc001vll.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021931 mRNA Translation: BAB13941.1 Sequence problems.
AK026427 mRNA Translation: BAB15480.1 Sequence problems.
AK292793 mRNA Translation: BAF85482.1
AL137517 mRNA Translation: CAB70783.3
BX648640 mRNA Translation: CAH10557.1
AL162373 Genomic DNA No translation available.
CH471093 Genomic DNA Translation: EAW80611.1
BC101070 mRNA Translation: AAI01071.1
BC101071 mRNA Translation: AAI01072.1
BC101072 mRNA Translation: AAI01073.1
BC101073 mRNA Translation: AAI01074.1
CCDSiCCDS41903.1
PIRiT46279
RefSeqiNP_115605.2, NM_032229.2

3D structure databases

SMRiQ9H5Y7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123937, 3 interactors
IntActiQ9H5Y7, 24 interactors
STRINGi9606.ENSP00000383143

PTM databases

GlyGeniQ9H5Y7, 1 site
iPTMnetiQ9H5Y7
PhosphoSitePlusiQ9H5Y7

Genetic variation databases

BioMutaiSLITRK6
DMDMi59803110

Proteomic databases

EPDiQ9H5Y7
jPOSTiQ9H5Y7
MassIVEiQ9H5Y7
MaxQBiQ9H5Y7
PaxDbiQ9H5Y7
PeptideAtlasiQ9H5Y7
PRIDEiQ9H5Y7
ProteomicsDBi80941

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9H5Y7, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24756, 258 antibodies

The DNASU plasmid repository

More...
DNASUi
84189

Genome annotation databases

EnsembliENST00000643778; ENSP00000496428; ENSG00000184564
ENST00000647374; ENSP00000495507; ENSG00000184564
GeneIDi84189
KEGGihsa:84189
UCSCiuc001vll.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84189
DisGeNETi84189

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLITRK6
GeneReviewsiSLITRK6
HGNCiHGNC:23503, SLITRK6
HPAiENSG00000184564, Tissue enhanced (prostate, salivary gland, smooth muscle, urinary bladder)
MalaCardsiSLITRK6
MIMi221200, phenotype
609681, gene
neXtProtiNX_Q9H5Y7
OpenTargetsiENSG00000184564
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
363396, High myopia-sensorineural deafness syndrome
PharmGKBiPA134928433
VEuPathDBiHostDB:ENSG00000184564.8

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QZTX, Eukaryota
GeneTreeiENSGT00940000160718
HOGENOMiCLU_012706_1_0_1
InParanoidiQ9H5Y7
OMAiQADTNFI
OrthoDBi217854at2759
PhylomeDBiQ9H5Y7
TreeFamiTF326378

Enzyme and pathway databases

PathwayCommonsiQ9H5Y7
ReactomeiR-HSA-388844, Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84189, 6 hits in 982 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLITRK6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84189
PharosiQ9H5Y7, Tbio

Protein Ontology

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PROi
PR:Q9H5Y7
RNActiQ9H5Y7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000184564, Expressed in intestine and 161 other tissues
GenevisibleiQ9H5Y7, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR043326, Slitrk
PANTHERiPTHR45773, PTHR45773, 1 hit
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 9 hits
SM00082, LRRCT, 2 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIK6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5Y7
Secondary accession number(s): A8K9S8
, Q495Q0, Q6AW93, Q9HAA8, Q9NT60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: February 15, 2005
Last modified: April 7, 2021
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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