UniProtKB - Q9H5X1 (CIA2A_HUMAN)
Cytosolic iron-sulfur assembly component 2A
CIAO2A
Functioni
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004).
As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004).
May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227).
By similarity2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 89 | Zinc 1; shared with dimeric partner | 1 | |
Metal bindingi | 89 | Zinc 2; shared with dimeric partner | 1 | |
Metal bindingi | 123 | Zinc 1; shared with dimeric partner | 1 | |
Metal bindingi | 123 | Zinc 2; shared with dimeric partner | 1 | |
Metal bindingi | 150 | Zinc 1; shared with dimeric partner | 1 | |
Metal bindingi | 150 | Zinc 2; shared with dimeric partner | 1 | |
Metal bindingi | 153 | Zinc 1; shared with dimeric partner | 1 | |
Metal bindingi | 153 | Zinc 2; shared with dimeric partner | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- chromosome segregation Source: UniProtKB-KW
- iron-sulfur cluster assembly Source: UniProtKB
- protein maturation by [4Fe-4S] cluster transfer Source: InterPro
- protein maturation by iron-sulfur cluster transfer Source: UniProtKB
Keywordsi
Biological process | Chromosome partition |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H5X1 |
SignaLinki | Q9H5X1 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytosolic iron-sulfur assembly component 2ACuratedAlternative name(s): MIP18 family protein FAM96A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26235, CIAO2A |
MIMi | 618382, gene |
neXtProti | NX_Q9H5X1 |
VEuPathDBi | HostDB:ENSG00000166797 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- CIA complex Source: UniProtKB
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 84191 |
OpenTargetsi | ENSG00000166797 |
PharmGKBi | PA142671829 |
Miscellaneous databases
Pharosi | Q9H5X1, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295943 |
Genetic variation databases
BioMutai | FAM96A |
DMDMi | 20455359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212689 | 1 – 160 | Cytosolic iron-sulfur assembly component 2AAdd BLAST | 160 |
Proteomic databases
EPDi | Q9H5X1 |
jPOSTi | Q9H5X1 |
MassIVEi | Q9H5X1 |
MaxQBi | Q9H5X1 |
PaxDbi | Q9H5X1 |
PeptideAtlasi | Q9H5X1 |
PRIDEi | Q9H5X1 |
ProteomicsDBi | 80937 [Q9H5X1-1] 80938 [Q9H5X1-2] |
PTM databases
iPTMneti | Q9H5X1 |
MetOSitei | Q9H5X1 |
PhosphoSitePlusi | Q9H5X1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166797, Expressed in liver and 215 other tissues |
ExpressionAtlasi | Q9H5X1, baseline and differential |
Genevisiblei | Q9H5X1, HS |
Organism-specific databases
HPAi | ENSG00000166797, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Binary interactionsi
Q9H5X1
Protein-protein interaction databases
BioGRIDi | 123939, 169 interactors |
IntActi | Q9H5X1, 24 interactors |
MINTi | Q9H5X1 |
STRINGi | 9606.ENSP00000300030 |
Miscellaneous databases
RNActi | Q9H5X1, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9H5X1 |
SMRi | Q9H5X1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3381, Eukaryota |
GeneTreei | ENSGT00390000017697 |
HOGENOMi | CLU_075876_4_0_1 |
InParanoidi | Q9H5X1 |
OMAi | YISEGAH |
OrthoDBi | 1408004at2759 |
PhylomeDBi | Q9H5X1 |
TreeFami | TF323934 |
Family and domain databases
Gene3Di | 3.30.300.130, 1 hit |
InterProi | View protein in InterPro IPR034904, FSCA_dom_sf IPR039796, MIP18 IPR002744, MIP18-like |
PANTHERi | PTHR12377, PTHR12377, 1 hit |
Pfami | View protein in Pfam PF01883, FeS_assembly_P, 1 hit |
SUPFAMi | SSF117916, SSF117916, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQRVSGLLSW TLSRVLWLSG LSEPGAARQP RIMEEKALEV YDLIRTIRDP
60 70 80 90 100
EKPNTLEELE VVSESCVEVQ EINEEEYLVI IRFTPTVPHC SLATLIGLCL
110 120 130 140 150
RVKLQRCLPF KHKLEIYISE GTHSTEEDIN KQINDKERVA AAMENPNLRE
160
IVEQCVLEPD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YKV4 | H0YKV4_HUMAN | Cytosolic iron-sulfur assembly comp... | CIAO2A FAM96A, hCG_33353 | 130 | Annotation score: | ||
H0YLH6 | H0YLH6_HUMAN | Cytosolic iron-sulfur assembly comp... | CIAO2A | 69 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042683 | 97 – 160 | GLCLR…VLEPD → VGNLHF in isoform 2. 1 PublicationAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026528 mRNA Translation: BAB15496.1 AK304202 mRNA Translation: BAH14131.1 AK312171 mRNA Translation: BAG35105.1 AC021541 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77661.1 CH471082 Genomic DNA Translation: EAW77662.1 BC008865 mRNA Translation: AAH08865.1 |
CCDSi | CCDS10189.1 [Q9H5X1-1] CCDS45278.1 [Q9H5X1-2] |
RefSeqi | NP_001014812.1, NM_001014812.2 [Q9H5X1-2] NP_001276037.1, NM_001289108.1 [Q9H5X1-2] NP_115607.1, NM_032231.5 [Q9H5X1-1] |
Genome annotation databases
Ensembli | ENST00000300030; ENSP00000300030; ENSG00000166797 ENST00000380290; ENSP00000369644; ENSG00000166797 [Q9H5X1-2] ENST00000557835; ENSP00000454079; ENSG00000166797 [Q9H5X1-2] |
GeneIDi | 84191 |
KEGGi | hsa:84191 |
MANE-Selecti | ENST00000300030.8; ENSP00000300030.3; NM_032231.7; NP_115607.1 |
UCSCi | uc002amt.3, human [Q9H5X1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026528 mRNA Translation: BAB15496.1 AK304202 mRNA Translation: BAH14131.1 AK312171 mRNA Translation: BAG35105.1 AC021541 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77661.1 CH471082 Genomic DNA Translation: EAW77662.1 BC008865 mRNA Translation: AAH08865.1 |
CCDSi | CCDS10189.1 [Q9H5X1-1] CCDS45278.1 [Q9H5X1-2] |
RefSeqi | NP_001014812.1, NM_001014812.2 [Q9H5X1-2] NP_001276037.1, NM_001289108.1 [Q9H5X1-2] NP_115607.1, NM_032231.5 [Q9H5X1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2M5H | NMR | - | A | 28-160 | [»] | |
3UX2 | X-ray | 1.80 | A | 31-157 | [»] | |
3UX3 | X-ray | 1.80 | A/B | 31-157 | [»] | |
BMRBi | Q9H5X1 | |||||
SMRi | Q9H5X1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123939, 169 interactors |
IntActi | Q9H5X1, 24 interactors |
MINTi | Q9H5X1 |
STRINGi | 9606.ENSP00000300030 |
Chemistry databases
ChEMBLi | CHEMBL4295943 |
PTM databases
iPTMneti | Q9H5X1 |
MetOSitei | Q9H5X1 |
PhosphoSitePlusi | Q9H5X1 |
Genetic variation databases
BioMutai | FAM96A |
DMDMi | 20455359 |
Proteomic databases
EPDi | Q9H5X1 |
jPOSTi | Q9H5X1 |
MassIVEi | Q9H5X1 |
MaxQBi | Q9H5X1 |
PaxDbi | Q9H5X1 |
PeptideAtlasi | Q9H5X1 |
PRIDEi | Q9H5X1 |
ProteomicsDBi | 80937 [Q9H5X1-1] 80938 [Q9H5X1-2] |
Protocols and materials databases
Antibodypediai | 25761, 113 antibodies from 17 providers |
DNASUi | 84191 |
Genome annotation databases
Ensembli | ENST00000300030; ENSP00000300030; ENSG00000166797 ENST00000380290; ENSP00000369644; ENSG00000166797 [Q9H5X1-2] ENST00000557835; ENSP00000454079; ENSG00000166797 [Q9H5X1-2] |
GeneIDi | 84191 |
KEGGi | hsa:84191 |
MANE-Selecti | ENST00000300030.8; ENSP00000300030.3; NM_032231.7; NP_115607.1 |
UCSCi | uc002amt.3, human [Q9H5X1-1] |
Organism-specific databases
CTDi | 84191 |
DisGeNETi | 84191 |
GeneCardsi | CIAO2A |
HGNCi | HGNC:26235, CIAO2A |
HPAi | ENSG00000166797, Tissue enhanced (liver) |
MIMi | 618382, gene |
neXtProti | NX_Q9H5X1 |
OpenTargetsi | ENSG00000166797 |
PharmGKBi | PA142671829 |
VEuPathDBi | HostDB:ENSG00000166797 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3381, Eukaryota |
GeneTreei | ENSGT00390000017697 |
HOGENOMi | CLU_075876_4_0_1 |
InParanoidi | Q9H5X1 |
OMAi | YISEGAH |
OrthoDBi | 1408004at2759 |
PhylomeDBi | Q9H5X1 |
TreeFami | TF323934 |
Enzyme and pathway databases
PathwayCommonsi | Q9H5X1 |
SignaLinki | Q9H5X1 |
Miscellaneous databases
BioGRID-ORCSi | 84191, 106 hits in 1044 CRISPR screens |
ChiTaRSi | FAM96A, human |
GenomeRNAii | 84191 |
Pharosi | Q9H5X1, Tbio |
PROi | PR:Q9H5X1 |
RNActi | Q9H5X1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166797, Expressed in liver and 215 other tissues |
ExpressionAtlasi | Q9H5X1, baseline and differential |
Genevisiblei | Q9H5X1, HS |
Family and domain databases
Gene3Di | 3.30.300.130, 1 hit |
InterProi | View protein in InterPro IPR034904, FSCA_dom_sf IPR039796, MIP18 IPR002744, MIP18-like |
PANTHERi | PTHR12377, PTHR12377, 1 hit |
Pfami | View protein in Pfam PF01883, FeS_assembly_P, 1 hit |
SUPFAMi | SSF117916, SSF117916, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CIA2A_HUMAN | |
Accessioni | Q9H5X1Primary (citable) accession number: Q9H5X1 Secondary accession number(s): A6NKS1, B2R5F8, B7Z8Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families