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UniProtKB - Q9H5V8 (CDCP1_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 3 (11 Jan 2011)
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Protein

CUB domain-containing protein 1

Gene

CDCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.6 Publications

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H5V8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H5V8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUB domain-containing protein 1
Alternative name(s):
Membrane glycoprotein gp140
Subtractive immunization M plus HEp3-associated 135 kDa protein
Short name:
SIMA135
Transmembrane and associated with src kinases
CD_antigen: CD318
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDCP1
Synonyms:TRASK
ORF Names:UNQ2486/PRO5773
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24357, CDCP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611735, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H5V8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163814.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 667ExtracellularSequence analysisAdd BLAST638
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 836CytoplasmicSequence analysisAdd BLAST148

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi734Y → F: Impaired association with SRC. 1 Publication1
Mutagenesisi762Y → F: Impaired association with protein kinase PRKCG but not with SRC. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		64866

Open Targets

More...OpenTargetsi		ENSG00000163814

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672140

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H5V8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDCP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 292 PublicationsAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022624930 – 836CUB domain-containing protein 1Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi476 ↔ 499By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei734Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.4 Publications
N-glycosylated.3 Publications
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei368 – 369Cleavage; by ST14/MT-SP12

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-2211

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H5V8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H5V8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H5V8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H5V8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H5V8

PeptideAtlas

More...PeptideAtlasi		Q9H5V8

PRoteomics IDEntifications database

More...PRIDEi		Q9H5V8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80933 [Q9H5V8-1]
80934 [Q9H5V8-2]
80935 [Q9H5V8-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1160, 13 N-Linked glycans (8 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9H5V8, 10 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H5V8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H5V8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H5V8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163814, Expressed in squamous epithelium and 158 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H5V8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163814, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1.

Also interacts with SRC and PRKCG/protein kinase C gamma.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122336, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H5V8

Database of interacting proteins

More...DIPi		DIP-33861N

Protein interaction database and analysis system

More...IntActi		Q9H5V8, 26 interactors

Molecular INTeraction database

More...MINTi		Q9H5V8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H5V8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini417 – 544CUBAdd BLAST128

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVKN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007498_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H5V8

Identification of Orthologs from Complete Genome Data

More...OMAi		ISNCSPM

Database of Orthologous Groups

More...OrthoDBi		223122at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H5V8

TreeFam database of animal gene trees

More...TreeFami		TF331392

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038811, CDCP1
IPR035914, Sperma_CUB_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14477, PTHR14477, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H5V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT 
        60         70         80         90        100
LLAKPCYIVI SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM 
       110        120        130        140        150
SGPCPFGEVQ LQPSTSLLPT LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG 
       160        170        180        190        200
PGESCPDGVT HSISGRIDAT VVRIGTFCSN GTVSRIKMQE GVKMALHLPW 
       210        220        230        240        250
FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY PEGFPEDELM 
       260        270        280        290        300
TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK 
       310        320        330        340        350
QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS 
       360        370        380        390        400
NERAMSLTIE PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL 
       410        420        430        440        450
CDDLTRLWMN VEKTISCTDH RYCQRKSYSL QVPSDILHLP VELHDFSWKL 
       460        470        480        490        500
LVPKDRLSLV LVPAQKLQQH THEKPCNTSF SYLVASAIPS QDLYFGSFCP 
       510        520        530        540        550
GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY FKEEGVFTVT 
       560        570        580        590        600
PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ 
       610        620        630        640        650
TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ 
       660        670        680        690        700
LDLLFSVTLT PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK 
       710        720        730        740        750
GPAVGIYNDN INTEMPRQPK KFQKGRKDND SHVYAVIEDT MVYGHLLQDS 
       760        770        780        790        800
SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC SRAPTAKLAT EEPPPRSPPE 
       810        820        830 
SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE
Length:836
Mass (Da):92,932
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i544FFDBBDD371518
GO
Isoform 2 (identifier: Q9H5V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:649
Mass (Da):72,723
Checksum:iCA14C5F721CDCD49
GO
Isoform 3 (identifier: Q9H5V8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-343: NK → SE
     344-836: Missing.

Show »
Length:343
Mass (Da):37,818
Checksum:i3E4E13379DD94D1B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15388 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252W → C in BAB14695 (PubMed:14702039).Curated1
Sequence conflicti284Y → D in BAB15388 (PubMed:14702039).Curated1
Sequence conflicti434S → G in BAB14695 (PubMed:14702039).Curated1
Sequence conflicti466K → R in BAB15388 (PubMed:14702039).Curated1
Sequence conflicti827N → S in AAO33397 (PubMed:12660814).Curated1
Sequence conflicti827N → S in BAB15511 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025498525Q → R3 PublicationsCorresponds to variant dbSNP:rs3749191Ensembl.1
Natural variantiVAR_055095673A → V1 PublicationCorresponds to variant dbSNP:rs35428731Ensembl.1
Natural variantiVAR_025499709D → G3 PublicationsCorresponds to variant dbSNP:rs9874077Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0174321 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_017433342 – 343NK → SE in isoform 3. 2 Publications2
Alternative sequenceiVSP_017434344 – 836Missing in isoform 3. 2 PublicationsAdd BLAST493

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY026461 mRNA Translation: AAK02058.1
AF468010 mRNA Translation: AAO33397.1
AY167484 mRNA Translation: AAO34538.1
AY358779 mRNA Translation: AAQ89139.1
AK023834 mRNA Translation: BAB14695.1
AK026187 mRNA Translation: BAB15388.1 Different initiation.
AK026622 mRNA Translation: BAB15511.1
AC104165 Genomic DNA No translation available.
AC105902 Genomic DNA No translation available.
BC021099 mRNA Translation: AAH21099.1
BC069254 mRNA Translation: AAH69254.1
AY375452 mRNA Translation: AAR21289.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2727.1 [Q9H5V8-1]
CCDS46812.1 [Q9H5V8-3]

NCBI Reference Sequences

More...RefSeqi		NP_073753.3, NM_022842.4 [Q9H5V8-1]
NP_835488.1, NM_178181.2 [Q9H5V8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296129; ENSP00000296129; ENSG00000163814 [Q9H5V8-1]
ENST00000425231; ENSP00000399342; ENSG00000163814 [Q9H5V8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64866

UCSC genome browser

More...UCSCi		uc003com.5, human [Q9H5V8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026461 mRNA Translation: AAK02058.1
AF468010 mRNA Translation: AAO33397.1
AY167484 mRNA Translation: AAO34538.1
AY358779 mRNA Translation: AAQ89139.1
AK023834 mRNA Translation: BAB14695.1
AK026187 mRNA Translation: BAB15388.1 Different initiation.
AK026622 mRNA Translation: BAB15511.1
AC104165 Genomic DNA No translation available.
AC105902 Genomic DNA No translation available.
BC021099 mRNA Translation: AAH21099.1
BC069254 mRNA Translation: AAH69254.1
AY375452 mRNA Translation: AAR21289.1
CCDSiCCDS2727.1 [Q9H5V8-1]
CCDS46812.1 [Q9H5V8-3]
RefSeqiNP_073753.3, NM_022842.4 [Q9H5V8-1]
NP_835488.1, NM_178181.2 [Q9H5V8-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122336, 15 interactors
CORUMiQ9H5V8
DIPiDIP-33861N
IntActiQ9H5V8, 26 interactors
MINTiQ9H5V8
STRINGi9606.ENSP00000296129

PTM databases

GlyConnecti1160, 13 N-Linked glycans (8 sites)
GlyGeniQ9H5V8, 10 sites
iPTMnetiQ9H5V8
PhosphoSitePlusiQ9H5V8
SwissPalmiQ9H5V8

Genetic variation databases

BioMutaiCDCP1
DMDMi317373455

Proteomic databases

CPTACiCPTAC-2211
EPDiQ9H5V8
jPOSTiQ9H5V8
MassIVEiQ9H5V8
MaxQBiQ9H5V8
PaxDbiQ9H5V8
PeptideAtlasiQ9H5V8
PRIDEiQ9H5V8
ProteomicsDBi80933 [Q9H5V8-1]
80934 [Q9H5V8-2]
80935 [Q9H5V8-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9H5V8, 13 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2564, 802 antibodies

The DNASU plasmid repository

More...DNASUi		64866

Genome annotation databases

EnsembliENST00000296129; ENSP00000296129; ENSG00000163814 [Q9H5V8-1]
ENST00000425231; ENSP00000399342; ENSG00000163814 [Q9H5V8-3]
GeneIDi64866
KEGGihsa:64866
UCSCiuc003com.5, human [Q9H5V8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64866
DisGeNETi64866

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDCP1
HGNCiHGNC:24357, CDCP1
HPAiENSG00000163814, Low tissue specificity
MIMi611735, gene
neXtProtiNX_Q9H5V8
OpenTargetsiENSG00000163814
PharmGKBiPA142672140
VEuPathDBiHostDB:ENSG00000163814.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVKN, Eukaryota
GeneTreeiENSGT00390000010209
HOGENOMiCLU_007498_0_0_1
InParanoidiQ9H5V8
OMAiISNCSPM
OrthoDBi223122at2759
PhylomeDBiQ9H5V8
TreeFamiTF331392

Enzyme and pathway databases

PathwayCommonsiQ9H5V8
SIGNORiQ9H5V8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64866, 1 hit in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDCP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDCP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64866
PharosiQ9H5V8, Tbio

Protein Ontology

More...PROi		PR:Q9H5V8
RNActiQ9H5V8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163814, Expressed in squamous epithelium and 158 other tissues
GenevisibleiQ9H5V8, HS

Family and domain databases

InterProiView protein in InterPro
IPR038811, CDCP1
IPR035914, Sperma_CUB_dom_sf
PANTHERiPTHR14477, PTHR14477, 1 hit
SUPFAMiSSF49854, SSF49854, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDCP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5V8
Secondary accession number(s): Q49UB4
, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676, Q9H8C2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 11, 2011
Last modified: February 10, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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