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Protein

CUB domain-containing protein 1

Gene

CDCP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.6 Publications

Enzyme and pathway databases

SIGNORiQ9H5V8

Names & Taxonomyi

Protein namesi
Recommended name:
CUB domain-containing protein 1
Alternative name(s):
Membrane glycoprotein gp140
Subtractive immunization M plus HEp3-associated 135 kDa protein
Short name:
SIMA135
Transmembrane and associated with src kinases
CD_antigen: CD318
Gene namesi
Name:CDCP1
Synonyms:TRASK
ORF Names:UNQ2486/PRO5773
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163814.7
HGNCiHGNC:24357 CDCP1
MIMi611735 gene
neXtProtiNX_Q9H5V8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 667ExtracellularSequence analysisAdd BLAST638
Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 836CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi734Y → F: Impaired association with SRC. 1 Publication1
Mutagenesisi762Y → F: Impaired association with protein kinase PRKCG but not with SRC. 1 Publication1

Organism-specific databases

DisGeNETi64866
OpenTargetsiENSG00000163814
PharmGKBiPA142672140

Polymorphism and mutation databases

DMDMi317373455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 292 PublicationsAdd BLAST29
ChainiPRO_000022624930 – 836CUB domain-containing protein 1Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi476 ↔ 499By similarity
Modified residuei734Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.4 Publications
N-glycosylated.3 Publications
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei368 – 369Cleavage; by ST14/MT-SP12

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9H5V8
MaxQBiQ9H5V8
PaxDbiQ9H5V8
PeptideAtlasiQ9H5V8
PRIDEiQ9H5V8
ProteomicsDBi80933
80934 [Q9H5V8-2]
80935 [Q9H5V8-3]

PTM databases

iPTMnetiQ9H5V8
PhosphoSitePlusiQ9H5V8
SwissPalmiQ9H5V8

Expressioni

Tissue specificityi

Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.4 Publications

Gene expression databases

BgeeiENSG00000163814
CleanExiHS_CDCP1
GenevisibleiQ9H5V8 HS

Organism-specific databases

HPAiCAB025637
HPA010978
HPA010979

Interactioni

Subunit structurei

Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122336, 9 interactors
CORUMiQ9H5V8
DIPiDIP-33861N
IntActiQ9H5V8, 19 interactors
MINTiQ9H5V8
STRINGi9606.ENSP00000296129

Structurei

3D structure databases

ProteinModelPortaliQ9H5V8
SMRiQ9H5V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 544CUBAdd BLAST128

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJR2 Eukaryota
ENOG4110CXF LUCA
GeneTreeiENSGT00390000010209
HOVERGENiHBG081070
InParanoidiQ9H5V8
KOiK06732
OMAiKRLCIIE
OrthoDBiEOG091G01M3
PhylomeDBiQ9H5V8
TreeFamiTF331392

Family and domain databases

InterProiView protein in InterPro
IPR038811 CDCP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR14477 PTHR14477, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H5V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT
60 70 80 90 100
LLAKPCYIVI SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM
110 120 130 140 150
SGPCPFGEVQ LQPSTSLLPT LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG
160 170 180 190 200
PGESCPDGVT HSISGRIDAT VVRIGTFCSN GTVSRIKMQE GVKMALHLPW
210 220 230 240 250
FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY PEGFPEDELM
260 270 280 290 300
TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK
310 320 330 340 350
QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS
360 370 380 390 400
NERAMSLTIE PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL
410 420 430 440 450
CDDLTRLWMN VEKTISCTDH RYCQRKSYSL QVPSDILHLP VELHDFSWKL
460 470 480 490 500
LVPKDRLSLV LVPAQKLQQH THEKPCNTSF SYLVASAIPS QDLYFGSFCP
510 520 530 540 550
GGSIKQIQVK QNISVTLRTF APSFQQEASR QGLTVSFIPY FKEEGVFTVT
560 570 580 590 600
PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ
610 620 630 640 650
TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ
660 670 680 690 700
LDLLFSVTLT PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK
710 720 730 740 750
GPAVGIYNDN INTEMPRQPK KFQKGRKDND SHVYAVIEDT MVYGHLLQDS
760 770 780 790 800
SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC SRAPTAKLAT EEPPPRSPPE
810 820 830
SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE
Length:836
Mass (Da):92,932
Last modified:January 11, 2011 - v3
Checksum:i544FFDBBDD371518
GO
Isoform 2 (identifier: Q9H5V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Note: No experimental confirmation available.
Show »
Length:649
Mass (Da):72,723
Checksum:iCA14C5F721CDCD49
GO
Isoform 3 (identifier: Q9H5V8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-343: NK → SE
     344-836: Missing.

Show »
Length:343
Mass (Da):37,818
Checksum:i3E4E13379DD94D1B
GO

Sequence cautioni

The sequence BAB15388 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252W → C in BAB14695 (PubMed:14702039).Curated1
Sequence conflicti284Y → D in BAB15388 (PubMed:14702039).Curated1
Sequence conflicti434S → G in BAB14695 (PubMed:14702039).Curated1
Sequence conflicti466K → R in BAB15388 (PubMed:14702039).Curated1
Sequence conflicti827N → S in AAO33397 (PubMed:12660814).Curated1
Sequence conflicti827N → S in BAB15511 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025498525Q → R3 PublicationsCorresponds to variant dbSNP:rs3749191Ensembl.1
Natural variantiVAR_055095673A → V1 PublicationCorresponds to variant dbSNP:rs35428731Ensembl.1
Natural variantiVAR_025499709D → G3 PublicationsCorresponds to variant dbSNP:rs9874077Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0174321 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_017433342 – 343NK → SE in isoform 3. 2 Publications2
Alternative sequenceiVSP_017434344 – 836Missing in isoform 3. 2 PublicationsAdd BLAST493

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026461 mRNA Translation: AAK02058.1
AF468010 mRNA Translation: AAO33397.1
AY167484 mRNA Translation: AAO34538.1
AY358779 mRNA Translation: AAQ89139.1
AK023834 mRNA Translation: BAB14695.1
AK026187 mRNA Translation: BAB15388.1 Different initiation.
AK026622 mRNA Translation: BAB15511.1
AC104165 Genomic DNA No translation available.
AC105902 Genomic DNA No translation available.
BC021099 mRNA Translation: AAH21099.1
BC069254 mRNA Translation: AAH69254.1
AY375452 mRNA Translation: AAR21289.1
CCDSiCCDS2727.1 [Q9H5V8-1]
CCDS46812.1 [Q9H5V8-3]
RefSeqiNP_073753.3, NM_022842.4 [Q9H5V8-1]
NP_835488.1, NM_178181.2 [Q9H5V8-3]
UniGeneiHs.476093

Genome annotation databases

EnsembliENST00000296129; ENSP00000296129; ENSG00000163814 [Q9H5V8-1]
ENST00000425231; ENSP00000399342; ENSG00000163814 [Q9H5V8-3]
GeneIDi64866
KEGGihsa:64866
UCSCiuc003com.5 human [Q9H5V8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDCP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H5V8
Secondary accession number(s): Q49UB4
, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676, Q9H8C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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