Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H5U6 (ZCHC4_HUMAN)

Entry version 136 (18 Sep 2019)
Sequence version 3 (24 Jan 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

rRNA N6-adenosine-methyltransferase ZCCHC4

Gene

ZCCHC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri443 – 460CCHC-typeAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Methyltransferase, Transferase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
rRNA N6-adenosine-methyltransferase ZCCHC4Curated (EC:2.1.1.-1 Publication)
Alternative name(s):
Zinc finger CCHC domain-containing protein 4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCCHC41 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22917 ZCCHC4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611792 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H5U6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi276 – 279DPPF → AAAA: Loss of methyltransferase activity. 1 Publication4

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000168228

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134950003

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZCCHC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		85700439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509521 – 513rRNA N6-adenosine-methyltransferase ZCCHC4Add BLAST513

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H5U6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H5U6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H5U6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H5U6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H5U6

PeptideAtlas

More...PeptideAtlasi		Q9H5U6

PRoteomics IDEntifications database

More...PRIDEi		Q9H5U6

ProteomicsDB human proteome resource

More...ProteomicsDBi		80928 [Q9H5U6-1]
80929 [Q9H5U6-2]
80930 [Q9H5U6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H5U6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H5U6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168228 Expressed in 118 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H5U6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H5U6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035575
HPA035576

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9H5U6, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000303468

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H5U6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini395 – 447DHHCPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZCCHC4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 460CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4399 Eukaryota
ENOG410XTH9 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000230723

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H5U6

Identification of Orthologs from Complete Genome Data

More...OMAi		DPPFGGR

Database of Orthologous Groups

More...OrthoDBi		709190at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H5U6

TreeFam database of animal gene trees

More...TreeFami		TF313872

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR041370 Mlase_EEF1AKMT1/ZCCHC4
IPR039846 ZCCHC4
IPR010666 Znf_GRF

The PANTHER Classification System

More...PANTHERi		PTHR13493 PTHR13493, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10237 N6-adenineMlase, 1 hit
PF06839 zf-GRF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50216 DHHC, 1 hit
PS00092 N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H5U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRNGFEA VEAEGSAGCR GSSGMEVVLP LDPAVPAPLC PHGPTLLFVK 
        60         70         80         90        100
VTQGKEETRR FYACSACRDR KDCNFFQWED EKLSGARLAA REAHNRRCQP 
       110        120        130        140        150
PLSRTQCVER YLKFIELPLT QRKFCQTCQQ LLLPDDWGQH SEHQVLGNVS 
       160        170        180        190        200
ITQLRRPSQL LYPLENKKTN AQYLFADRSC QFLVDLLSAL GFRRVLCVGT 
       210        220        230        240        250
PRLHELIKLT ASGDKKSNIK SLLLDIDFRY SQFYMEDSFC HYNMFNHHFF 
       260        270        280        290        300
DGKTALEVCR AFLQEDKGEG IIMVTDPPFG GLVEPLAITF KKLIAMWKEG 
       310        320        330        340        350
QSQDDSHKEL PIFWIFPYFF ESRICQFFPS FQMLDYQVDY DNHALYKHGK 
       360        370        380        390        400
TGRKQSPVRI FTNIPPNKII LPTEEGYRFC SPCQRYVSLE NQHCELCNSC 
       410        420        430        440        450
TSKDGRKWNH CFLCKKCVKP SWIHCSICNH CAVPDHSCEG PKHGCFICGE 
       460        470        480        490        500
LDHKRSTCPN IATSKRANKA VRKQKQRKSN KMKMETTKGQ SMNHTSATRR 
       510 
KKRRERAHQY LGS
Length:513
Mass (Da):59,010
Last modified:January 24, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD74690827DC935F4
GO
Isoform 2 (identifier: Q9H5U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-513: Missing.

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):25,866
Checksum:i20D6F1827E273314
GO
Isoform 3 (identifier: Q9H5U6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     470-472: Missing.

Note: No experimental confirmation available.
Show »
Length:510
Mass (Da):58,683
Checksum:iA70B1ECBB327ED3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8V8H0Y8V8_HUMAN
rRNA N6-adenosine-methyltransferase...
ZCCHC4
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0K5A0A087X0K5_HUMAN
rRNA N6-adenosine-methyltransferase...
ZCCHC4
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16914 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15524 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti348H → R in BAG61250 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053751382P → L. Corresponds to variant dbSNP:rs3752873Ensembl.1
Natural variantiVAR_024925396L → H3 PublicationsCorresponds to variant dbSNP:rs315675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043359230 – 513Missing in isoform 2. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_043360470 – 472Missing in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY629351 mRNA Translation: AAV41218.1
CH471069 Genomic DNA Translation: EAW92837.1
AK299211 mRNA Translation: BAG61250.1
AK026677 mRNA Translation: BAB15524.1 Different initiation.
BC016914 mRNA Translation: AAH16914.1 Different initiation.
BC157834 mRNA Translation: AAI57835.1
BC171821 mRNA Translation: AAI71821.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43218.1 [Q9H5U6-1]

NCBI Reference Sequences

More...RefSeqi		NP_079212.2, NM_024936.2 [Q9H5U6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302874; ENSP00000303468; ENSG00000168228 [Q9H5U6-1]
ENST00000507760; ENSP00000422115; ENSG00000168228 [Q9H5U6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29063

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29063

UCSC genome browser

More...UCSCi		uc003grl.5 human [Q9H5U6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY629351 mRNA Translation: AAV41218.1
CH471069 Genomic DNA Translation: EAW92837.1
AK299211 mRNA Translation: BAG61250.1
AK026677 mRNA Translation: BAB15524.1 Different initiation.
BC016914 mRNA Translation: AAH16914.1 Different initiation.
BC157834 mRNA Translation: AAI57835.1
BC171821 mRNA Translation: AAI71821.1
CCDSiCCDS43218.1 [Q9H5U6-1]
RefSeqiNP_079212.2, NM_024936.2 [Q9H5U6-1]

3D structure databases

SMRiQ9H5U6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9H5U6, 1 interactor
STRINGi9606.ENSP00000303468

PTM databases

iPTMnetiQ9H5U6
PhosphoSitePlusiQ9H5U6

Polymorphism and mutation databases

BioMutaiZCCHC4
DMDMi85700439

Proteomic databases

EPDiQ9H5U6
jPOSTiQ9H5U6
MassIVEiQ9H5U6
MaxQBiQ9H5U6
PaxDbiQ9H5U6
PeptideAtlasiQ9H5U6
PRIDEiQ9H5U6
ProteomicsDBi80928 [Q9H5U6-1]
80929 [Q9H5U6-2]
80930 [Q9H5U6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302874; ENSP00000303468; ENSG00000168228 [Q9H5U6-1]
ENST00000507760; ENSP00000422115; ENSG00000168228 [Q9H5U6-2]
GeneIDi29063
KEGGihsa:29063
UCSCiuc003grl.5 human [Q9H5U6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29063

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZCCHC4
HGNCiHGNC:22917 ZCCHC4
HPAiHPA035575
HPA035576
MIMi611792 gene
neXtProtiNX_Q9H5U6
OpenTargetsiENSG00000168228
PharmGKBiPA134950003

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4399 Eukaryota
ENOG410XTH9 LUCA
GeneTreeiENSGT00390000012556
HOGENOMiHOG000230723
InParanoidiQ9H5U6
OMAiDPPFGGR
OrthoDBi709190at2759
PhylomeDBiQ9H5U6
TreeFamiTF313872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZCCHC4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29063

Pharos

More...Pharosi		Q9H5U6

Protein Ontology

More...PROi		PR:Q9H5U6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168228 Expressed in 118 organ(s), highest expression level in heart
ExpressionAtlasiQ9H5U6 baseline and differential
GenevisibleiQ9H5U6 HS

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR041370 Mlase_EEF1AKMT1/ZCCHC4
IPR039846 ZCCHC4
IPR010666 Znf_GRF
PANTHERiPTHR13493 PTHR13493, 1 hit
PfamiView protein in Pfam
PF10237 N6-adenineMlase, 1 hit
PF06839 zf-GRF, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
PS00092 N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCHC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5U6
Secondary accession number(s): B2RXF6
, B4DRD8, B7ZW20, Q5IW78, Q96AN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 24, 2006
Last modified: September 18, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again