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Entry version 146 (17 Jun 2020)
Sequence version 2 (24 May 2004)
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Protein

Rab GTPase-binding effector protein 2

Gene

RABEP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in membrane trafficking and in homotypic early endosome fusion (PubMed:9524116). Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking (PubMed:29425100). By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis (PubMed:27224062).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation, Endocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H5N1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab GTPase-binding effector protein 2
Alternative name(s):
Rabaptin-5beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RABEP2
Synonyms:RABPT5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177548.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24817 RABEP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611869 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H5N1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79874

Open Targets

More...
OpenTargetsi
ENSG00000177548

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952719

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H5N1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RABEP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606049

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001875592 – 569Rab GTPase-binding effector protein 2Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei189PhosphoserineBy similarity1
Modified residuei193PhosphoserineCombined sources1
Modified residuei200Phosphoserine; by GSK3-alpha1 Publication1
Modified residuei204Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H5N1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H5N1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H5N1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H5N1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H5N1

PeptideAtlas

More...
PeptideAtlasi
Q9H5N1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H5N1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80920 [Q9H5N1-1]
80921 [Q9H5N1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H5N1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H5N1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177548 Expressed in spleen and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H5N1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H5N1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177548 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with RABGEF1. The dimer binds RAB5A that has been activated by GTP-binding.

Interacts with SDCCAG8; this interaction is important for ciliogenesis regulation (PubMed:27224062).

Interacts with RAB4A; this interaction may mediate VEGFR2 cell surface expression (PubMed:29425100).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122962, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H5N1, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350934

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H5N1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H5N1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili34 – 187Sequence analysisAdd BLAST154
Coiled coili289 – 523Sequence analysisAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 113Poly-Gln5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rabaptin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0993 Eukaryota
ENOG410XSZ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035043_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H5N1

KEGG Orthology (KO)

More...
KOi
K20130

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICHTLLT

Database of Orthologous Groups

More...
OrthoDBi
1369937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H5N1

TreeFam database of animal gene trees

More...
TreeFami
TF329365

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003914 Rabaptin
IPR029882 Rabaptin-5beta
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR31179 PTHR31179, 1 hit
PTHR31179:SF6 PTHR31179:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09311 Rab5-bind, 1 hit
PF03528 Rabaptin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01432 RABAPTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H5N1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAPVAAD DDERRRRPGA ALEDSRSQEG ANGEAESGEL SRLRAELAGA
60 70 80 90 100
LAEMETMKAV AEVSESTKAE AVAAVQRQCQ EEVASLQAIL KDSISSYEAQ
110 120 130 140 150
ITALKQERQQ QQQDCEEKER ELGRLKQLLS RAYPLDSLEK QMEKAHEDSE
160 170 180 190 200
KLREIVLPME KEIEELKAKL LRAEELIQEI QRRPRHAPSL HGSTELLPLS
210 220 230 240 250
RDPSPPLEPL EELSGDGGPA AEAFAHNCDD SASISSFSLG GGVGSSSSLP
260 270 280 290 300
QSRQGLSPEQ EETASLVSTG TLVPEGIYLP PPGYQLVPDT QWEQLQTEGR
310 320 330 340 350
QLQKDLESVS RERDELQEGL RRSNEDCAKQ MQVLLAQVQN SEQLLRTLQG
360 370 380 390 400
TVSQAQERVQ LQMAELVTTH KCLHHEVKRL NEENQGLRAE QLPSSAPQGS
410 420 430 440 450
QQEQGEEESL PSSVPELQQL LCCTRQEARA RLQAQEHGAE RLRIEIVTLR
460 470 480 490 500
EALEEETVAR ASLEGQLRVQ REETEVLEAS LCSLRTEMER VQQEQSKAQL
510 520 530 540 550
PDLLSEQRAK VLRLQAELET SEQVQRDFVR LSQALQVRLE RIRQAETLEQ
560
VRSIMDEAPL TDVRDIKDT
Length:569
Mass (Da):63,543
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47451AAFA40CF23D
GO
Isoform 2 (identifier: Q9H5N1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-330: Missing.
     475-478: Missing.

Show »
Length:533
Mass (Da):59,316
Checksum:iD32A5480B6A261D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BT64H3BT64_HUMAN
Rab GTPase-binding effector protein...
RABEP2
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNR2H3BNR2_HUMAN
Rab GTPase-binding effector protein...
RABEP2
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHR0B4DHR0_HUMAN
Rab GTPase-binding effector protein...
RABEP2
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNR8H3BNR8_HUMAN
Rab GTPase-binding effector protein...
RABEP2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU67H3BU67_HUMAN
Rab GTPase-binding effector protein...
RABEP2
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMR7H3BMR7_HUMAN
Rab GTPase-binding effector protein...
RABEP2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15594 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010458299 – 330Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_010459475 – 478Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026935 mRNA Translation: BAB15594.1 Frameshift.
BC058900 mRNA Translation: AAH58900.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42140.1 [Q9H5N1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079092.2, NM_024816.2 [Q9H5N1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357573; ENSP00000350186; ENSG00000177548 [Q9H5N1-2]
ENST00000358201; ENSP00000350934; ENSG00000177548 [Q9H5N1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79874

UCSC genome browser

More...
UCSCi
uc002drq.4 human [Q9H5N1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026935 mRNA Translation: BAB15594.1 Frameshift.
BC058900 mRNA Translation: AAH58900.1
CCDSiCCDS42140.1 [Q9H5N1-1]
RefSeqiNP_079092.2, NM_024816.2 [Q9H5N1-1]

3D structure databases

SMRiQ9H5N1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122962, 39 interactors
IntActiQ9H5N1, 16 interactors
STRINGi9606.ENSP00000350934

PTM databases

iPTMnetiQ9H5N1
PhosphoSitePlusiQ9H5N1

Polymorphism and mutation databases

BioMutaiRABEP2
DMDMi47606049

Proteomic databases

EPDiQ9H5N1
jPOSTiQ9H5N1
MassIVEiQ9H5N1
MaxQBiQ9H5N1
PaxDbiQ9H5N1
PeptideAtlasiQ9H5N1
PRIDEiQ9H5N1
ProteomicsDBi80920 [Q9H5N1-1]
80921 [Q9H5N1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26625 113 antibodies

Genome annotation databases

EnsembliENST00000357573; ENSP00000350186; ENSG00000177548 [Q9H5N1-2]
ENST00000358201; ENSP00000350934; ENSG00000177548 [Q9H5N1-1]
GeneIDi79874
KEGGihsa:79874
UCSCiuc002drq.4 human [Q9H5N1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79874
DisGeNETi79874
EuPathDBiHostDB:ENSG00000177548.12

GeneCards: human genes, protein and diseases

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GeneCardsi
RABEP2
HGNCiHGNC:24817 RABEP2
HPAiENSG00000177548 Low tissue specificity
MIMi611869 gene
neXtProtiNX_Q9H5N1
OpenTargetsiENSG00000177548
PharmGKBiPA134952719

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0993 Eukaryota
ENOG410XSZ1 LUCA
GeneTreeiENSGT00530000063743
HOGENOMiCLU_035043_0_0_1
InParanoidiQ9H5N1
KOiK20130
OMAiICHTLLT
OrthoDBi1369937at2759
PhylomeDBiQ9H5N1
TreeFamiTF329365

Enzyme and pathway databases

SignaLinkiQ9H5N1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79874 3 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RABEP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79874
PharosiQ9H5N1 Tdark

Protein Ontology

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PROi
PR:Q9H5N1
RNActiQ9H5N1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000177548 Expressed in spleen and 195 other tissues
ExpressionAtlasiQ9H5N1 baseline and differential
GenevisibleiQ9H5N1 HS

Family and domain databases

InterProiView protein in InterPro
IPR003914 Rabaptin
IPR029882 Rabaptin-5beta
IPR018514 Rabaptin_coiled-coil
IPR015390 Rabaptin_Rab5-bd_dom
PANTHERiPTHR31179 PTHR31179, 1 hit
PTHR31179:SF6 PTHR31179:SF6, 1 hit
PfamiView protein in Pfam
PF09311 Rab5-bind, 1 hit
PF03528 Rabaptin, 1 hit
PRINTSiPR01432 RABAPTIN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRABE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H5N1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 17, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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