UniProtKB - Q9H5L6 (THAP9_HUMAN)
Protein
DNA transposase THAP9
Gene
THAP9
Organism
Homo sapiens (Human)
Status
Functioni
Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.2 Publications
Miscellaneous
Able to mediate mobilization of P-elements when transfected in Drosophila.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 89 | THAP-typePROSITE-ProRule annotationAdd BLAST | 89 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- sequence-specific DNA binding Source: UniProtKB
- transferase activity Source: UniProtKB-KW
- transposase activity Source: UniProtKB
GO - Biological processi
- DNA integration Source: UniProtKB
- DNA recombination Source: UniProtKB
- transposition, DNA-mediated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Transferase |
Biological process | DNA integration, DNA recombination |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H5L6 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA transposase THAP9 (EC:2.7.7.-)Alternative name(s): THAP domain-containing protein 9 Short name: hTh9 |
Gene namesi | Name:THAP9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23192, THAP9 |
MIMi | 612537, gene |
neXtProti | NX_Q9H5L6 |
VEuPathDBi | HostDB:ENSG00000168152.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79725 |
OpenTargetsi | ENSG00000168152 |
PharmGKBi | PA134981371 |
Miscellaneous databases
Pharosi | Q9H5L6, Tbio |
Genetic variation databases
BioMutai | THAP9 |
DMDMi | 166987614 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317246 | 1 – 903 | DNA transposase THAP9Add BLAST | 903 |
Proteomic databases
EPDi | Q9H5L6 |
jPOSTi | Q9H5L6 |
MassIVEi | Q9H5L6 |
MaxQBi | Q9H5L6 |
PaxDbi | Q9H5L6 |
PeptideAtlasi | Q9H5L6 |
PRIDEi | Q9H5L6 |
ProteomicsDBi | 80918 |
PTM databases
iPTMneti | Q9H5L6 |
PhosphoSitePlusi | Q9H5L6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168152, Expressed in corpus callosum and 171 other tissues |
ExpressionAtlasi | Q9H5L6, baseline and differential |
Genevisiblei | Q9H5L6, HS |
Organism-specific databases
HPAi | ENSG00000168152, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122840, 5 interactors |
ELMi | Q9H5L6 |
IntActi | Q9H5L6, 4 interactors |
STRINGi | 9606.ENSP00000305533 |
Miscellaneous databases
RNActi | Q9H5L6, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 123 – 126 | HCFC1-binding motif (HBM)By similarity | 4 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 89 | THAP-typePROSITE-ProRule annotationAdd BLAST | 89 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QQSX, Eukaryota |
GeneTreei | ENSGT00940000161474 |
HOGENOMi | CLU_006886_4_0_1 |
InParanoidi | Q9H5L6 |
OMAi | KEDICQD |
OrthoDBi | 1000569at2759 |
PhylomeDBi | Q9H5L6 |
TreeFami | TF328542 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR006612, THAP_Znf IPR038441, THAP_Znf_sf IPR021896, Transposase_37 |
Pfami | View protein in Pfam PF05485, THAP, 1 hit PF12017, Tnp_P_element, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9H5L6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRSCSAVGC STRDTVLSRE RGLSFHQFPT DTIQRSKWIR AVNRVDPRSK
60 70 80 90 100
KIWIPGPGAI LCSKHFQESD FESYGIRRKL KKGAVPSVSL YKIPQGVHLK
110 120 130 140 150
GKARQKILKQ PLPDNSQEVA TEDHNYSLKT PLTIGAEKLA EVQQMLQVSK
160 170 180 190 200
KRLISVKNYR MIKKRKGLRL IDALVEEKLL SEETECLLRA QFSDFKWELY
210 220 230 240 250
NWRETDEYSA EMKQFACTLY LCSSKVYDYV RKILKLPHSS ILRTWLSKCQ
260 270 280 290 300
PSPGFNSNIF SFLQRRVENG DQLYQYCSLL IKSMPLKQQL QWDPSSHSLQ
310 320 330 340 350
GFMDFGLGKL DADETPLASE TVLLMAVGIF GHWRTPLGYF FVNRASGYLQ
360 370 380 390 400
AQLLRLTIGK LSDIGITVLA VTSDATAHSV QMAKALGIHI DGDDMKCTFQ
410 420 430 440 450
HPSSSSQQIA YFFDSCHLLR LIRNAFQNFQ SIQFINGIAH WQHLVELVAL
460 470 480 490 500
EEQELSNMER IPSTLANLKN HVLKVNSATQ LFSESVASAL EYLLSLDLPP
510 520 530 540 550
FQNCIGTIHF LRLINNLFDI FNSRNCYGKG LKGPLLPETY SKINHVLIEA
560 570 580 590 600
KTIFVTLSDT SNNQIIKGKQ KLGFLGFLLN AESLKWLYQN YVFPKVMPFP
610 620 630 640 650
YLLTYKFSHD HLELFLKMLR QVLVTSSSPT CMAFQKAYYN LETRYKFQDE
660 670 680 690 700
VFLSKVSIFD ISIARRKDLA LWTVQRQYGV SVTKTVFHEE GICQDWSHCS
710 720 730 740 750
LSEALLDLSD HRRNLICYAG YVANKLSALL TCEDCITALY ASDLKASKIG
760 770 780 790 800
SLLFVKKKNG LHFPSESLCR VINICERVVR THSRMAIFEL VSKQRELYLQ
810 820 830 840 850
QKILCELSGH INLFVDVNKH LFDGEVCAIN HFVKLLKDII ICFLNIRAKN
860 870 880 890 900
VAQNPLKHHS ERTDMKTLSR KHWSSVQDYK CSSFANTSSK FRHLLSNDGY
PFK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REM3 | D6REM3_HUMAN | DNA transposase THAP9 | THAP9 | 109 | Annotation score: | ||
F2Z371 | F2Z371_HUMAN | DNA transposase THAP9 | THAP9 | 102 | Annotation score: | ||
D6RCT5 | D6RCT5_HUMAN | DNA transposase THAP9 | THAP9 | 102 | Annotation score: | ||
H0Y9F3 | H0Y9F3_HUMAN | DNA transposase THAP9 | THAP9 | 121 | Annotation score: | ||
D6R957 | D6R957_HUMAN | DNA transposase THAP9 | THAP9 | 30 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 | L → I in BAB15609 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 491 | E → G in BAB15609 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 875 | S → P in BAG52354 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038486 | 284 | M → I1 PublicationCorresponds to variant dbSNP:rs1031639Ensembl. | 1 | |
Natural variantiVAR_038487 | 299 | L → F1 PublicationCorresponds to variant dbSNP:rs897945Ensembl. | 1 | |
Natural variantiVAR_038488 | 812 | N → D1 PublicationCorresponds to variant dbSNP:rs6535411Ensembl. | 1 | |
Natural variantiVAR_061842 | 833 | V → I. Corresponds to variant dbSNP:rs35532215Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026973 mRNA Translation: BAB15609.1 AK091412 mRNA Translation: BAG52354.1 AJ717666 Genomic DNA Translation: CAG30691.1 |
CCDSi | CCDS3598.1 |
RefSeqi | NP_078948.3, NM_024672.5 |
Genome annotation databases
Ensembli | ENST00000302236; ENSP00000305533; ENSG00000168152 |
GeneIDi | 79725 |
KEGGi | hsa:79725 |
UCSCi | uc003hnt.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026973 mRNA Translation: BAB15609.1 AK091412 mRNA Translation: BAG52354.1 AJ717666 Genomic DNA Translation: CAG30691.1 |
CCDSi | CCDS3598.1 |
RefSeqi | NP_078948.3, NM_024672.5 |
3D structure databases
SMRi | Q9H5L6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122840, 5 interactors |
ELMi | Q9H5L6 |
IntActi | Q9H5L6, 4 interactors |
STRINGi | 9606.ENSP00000305533 |
PTM databases
iPTMneti | Q9H5L6 |
PhosphoSitePlusi | Q9H5L6 |
Genetic variation databases
BioMutai | THAP9 |
DMDMi | 166987614 |
Proteomic databases
EPDi | Q9H5L6 |
jPOSTi | Q9H5L6 |
MassIVEi | Q9H5L6 |
MaxQBi | Q9H5L6 |
PaxDbi | Q9H5L6 |
PeptideAtlasi | Q9H5L6 |
PRIDEi | Q9H5L6 |
ProteomicsDBi | 80918 |
Protocols and materials databases
Antibodypediai | 52352, 43 antibodies |
DNASUi | 79725 |
Genome annotation databases
Ensembli | ENST00000302236; ENSP00000305533; ENSG00000168152 |
GeneIDi | 79725 |
KEGGi | hsa:79725 |
UCSCi | uc003hnt.3, human |
Organism-specific databases
CTDi | 79725 |
DisGeNETi | 79725 |
GeneCardsi | THAP9 |
HGNCi | HGNC:23192, THAP9 |
HPAi | ENSG00000168152, Low tissue specificity |
MIMi | 612537, gene |
neXtProti | NX_Q9H5L6 |
OpenTargetsi | ENSG00000168152 |
PharmGKBi | PA134981371 |
VEuPathDBi | HostDB:ENSG00000168152.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQSX, Eukaryota |
GeneTreei | ENSGT00940000161474 |
HOGENOMi | CLU_006886_4_0_1 |
InParanoidi | Q9H5L6 |
OMAi | KEDICQD |
OrthoDBi | 1000569at2759 |
PhylomeDBi | Q9H5L6 |
TreeFami | TF328542 |
Enzyme and pathway databases
PathwayCommonsi | Q9H5L6 |
Miscellaneous databases
BioGRID-ORCSi | 79725, 2 hits in 1013 CRISPR screens |
ChiTaRSi | THAP9, human |
GenomeRNAii | 79725 |
Pharosi | Q9H5L6, Tbio |
PROi | PR:Q9H5L6 |
RNActi | Q9H5L6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168152, Expressed in corpus callosum and 171 other tissues |
ExpressionAtlasi | Q9H5L6, baseline and differential |
Genevisiblei | Q9H5L6, HS |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR006612, THAP_Znf IPR038441, THAP_Znf_sf IPR021896, Transposase_37 |
Pfami | View protein in Pfam PF05485, THAP, 1 hit PF12017, Tnp_P_element, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THAP9_HUMAN | |
Accessioni | Q9H5L6Primary (citable) accession number: Q9H5L6 Secondary accession number(s): B3KRE2, Q59AC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot