TAF1D

Functionⁱ

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of gene expression, epigenetic Source: Reactome
regulation of transcription, DNA-templated Source: InterPro
termination of RNA polymerase I transcription Source: Reactome
transcription initiation from RNA polymerase I promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-73863 RNA Polymerase I Transcription Termination

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TATA box-binding protein-associated factor RNA polymerase I subunit D Alternative name(s): RNA polymerase I-specific TBP-associated factor 41 kDa Short name: TAFI41 TATA box-binding protein-associated factor 1D Short name: TBP-associated factor 1D Transcription initiation factor SL1/TIF-IB subunit D
Gene namesⁱ	Name:TAF1D Synonyms:JOSD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166012.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28759 TAF1D
MIMⁱ	612823 gene
neXtProtⁱ	NX_Q9H5J8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79101
Open Targets More...OpenTargetsⁱ	ENSG00000166012
PharmGKBⁱ	PA164726421

Polymorphism and mutation databases

BioMutaⁱ	TAF1D
DMDMⁱ	74733586

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250717	1 – 278	TATA box-binding protein-associated factor RNA polymerase I subunit DAdd BLAST		278

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	23	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1
Modified residueⁱ	234	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H5J8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H5J8
PaxDbⁱ	Q9H5J8
PeptideAtlas More...PeptideAtlasⁱ	Q9H5J8
PRIDEⁱ	Q9H5J8
ProteomicsDBⁱ	80916

PTM databases

iPTMnetⁱ	Q9H5J8
PhosphoSitePlusⁱ	Q9H5J8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166012 Expressed in 227 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_TAF1D
ExpressionAtlasⁱ	Q9H5J8 baseline and differential
Genevisibleⁱ	Q9H5J8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055935 HPA060385

HPAⁱ

HPA055935
HPA060385

Interactionⁱ

Subunit structureⁱ

Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CEP70	Q8NHQ1	4	EBI-716128,EBI-739624
POLB	P06746	4	EBI-716128,EBI-713836

Protein-protein interaction databases

BioGridⁱ	122548, 56 interactors
IntActⁱ	Q9H5J8, 42 interactors
Molecular INTeraction database More...MINTⁱ	Q9H5J8
STRINGⁱ	9606.ENSP00000314971

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H5J8
SMRⁱ	Q9H5J8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IZI3 Eukaryota ENOG41124VA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009061
HOGENOMⁱ	HOG000154498
HOVERGENⁱ	HBG096071
InParanoidⁱ	Q9H5J8
KEGG Orthology (KO) More...KOⁱ	K15215
OMAⁱ	NEDFDSR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D0N
PhylomeDBⁱ	Q9H5J8
TreeFamⁱ	TF335756

Family and domain databases

InterProⁱ	View protein in InterPro IPR027976 TAF1D
PANTHERⁱ	PTHR14562 PTHR14562, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15333 TAF1D, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

Q9H5J8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR 
        60         70         80         90        100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ 
       110        120        130        140        150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL 
       160        170        180        190        200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD 
       210        220        230        240        250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE 
       260        270 
EEDITEEAAL SKKRATKAKN TGQRGLKM

Length:278

Mass (Da):32,058

Last modified:March 1, 2001 - v1

Checksum:ⁱ4BA37C73BB387446

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PM59	E9PM59_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	215	Annotation score:
E9PKU8	E9PKU8_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	36	Annotation score:
H0Y3L3	H0Y3L3_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	44	Annotation score:
H0YG36	H0YG36_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	42	Annotation score:
H0YCH2	H0YCH2_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	110	Annotation score:
H0YH71	H0YH71_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	26	Annotation score:
A0A1D5RMT6	A0A1D5RMT6_HUMAN	TATA box-binding protein-associated... TATA box-binding protein-associated factor RNA polymerase I subunit D	TAF1D	8	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	14	S → T in CAG33650 (Ref. 3) Curated	1
Sequence conflictⁱ	97	R → G in CAG33650 (Ref. 3) Curated	1
Sequence conflictⁱ	278	M → I in CAG33650 (Ref. 3) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027016 mRNA Translation: BAB15628.1 CR457369 mRNA Translation: CAG33650.1 BC001972 mRNA Translation: AAH01972.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8293.1
NCBI Reference Sequences More...RefSeqⁱ	NP_077021.1, NM_024116.3
UniGeneⁱ	Hs.355750 Hs.732267

Genome annotation databases

Ensemblⁱ	ENST00000323981; ENSP00000314971; ENSG00000166012 ENST00000448108; ENSP00000410409; ENSG00000166012 ENST00000526015; ENSP00000435087; ENSG00000166012
GeneIDⁱ	79101
KEGGⁱ	hsa:79101
UCSC genome browser More...UCSCⁱ	uc001ped.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H5J8	Josephin domain containing 3, isoform CRA_a		HUMAN		278	UniRef100_Q9H5J8
TAF1D isoform 13 (Fragment)		PANTR		42
TATA box-binding protein-associated factor RNA polymerase I subunit D (Fragment)		HUMAN		42

Protein	Similar proteins		Species	Score	Length	Source
Q9H5J8	TATA box-binding protein-associated factor RNA polymerase I subunit D		PONAB		278	UniRef90_Q9H5J8
Josephin domain containing 3, isoform CRA_a		HUMAN		278
TAF1D isoform 13 (Fragment)		PANTR		42
Uncharacterized protein		NOMLE		278
TATA box-binding protein-associated factor RNA polymerase I subunit D		MACMU		278
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9H5J8	TATA box-binding protein-associated factor RNA polymerase I subunit D		PONAB		278	UniRef50_Q9H5J8
Josephin domain containing 3, isoform CRA_a		HUMAN		278
TAF1D isoform 13 (Fragment)		PANTR		42
Uncharacterized protein		NOMLE		278
Uncharacterized protein		CHLSB		278
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK027016 mRNA Translation: BAB15628.1 CR457369 mRNA Translation: CAG33650.1 BC001972 mRNA Translation: AAH01972.1
CCDSⁱ	CCDS8293.1
RefSeqⁱ	NP_077021.1, NM_024116.3
UniGeneⁱ	Hs.355750 Hs.732267

3D structure databases

ProteinModelPortalⁱ	Q9H5J8
SMRⁱ	Q9H5J8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122548, 56 interactors
IntActⁱ	Q9H5J8, 42 interactors
MINTⁱ	Q9H5J8
STRINGⁱ	9606.ENSP00000314971

PTM databases

iPTMnetⁱ	Q9H5J8
PhosphoSitePlusⁱ	Q9H5J8

Polymorphism and mutation databases

BioMutaⁱ	TAF1D
DMDMⁱ	74733586

Proteomic databases

EPDⁱ	Q9H5J8
MaxQBⁱ	Q9H5J8
PaxDbⁱ	Q9H5J8
PeptideAtlasⁱ	Q9H5J8
PRIDEⁱ	Q9H5J8
ProteomicsDBⁱ	80916

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79101
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000323981; ENSP00000314971; ENSG00000166012 ENST00000448108; ENSP00000410409; ENSG00000166012 ENST00000526015; ENSP00000435087; ENSG00000166012
GeneIDⁱ	79101
KEGGⁱ	hsa:79101
UCSCⁱ	uc001ped.5 human

Organism-specific databases

CTDⁱ	79101
DisGeNETⁱ	79101
EuPathDBⁱ	HostDB:ENSG00000166012.14
GeneCardsⁱ	TAF1D
HGNCⁱ	HGNC:28759 TAF1D
HPAⁱ	HPA055935 HPA060385
MIMⁱ	612823 gene
neXtProtⁱ	NX_Q9H5J8
OpenTargetsⁱ	ENSG00000166012
PharmGKBⁱ	PA164726421
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZI3 Eukaryota ENOG41124VA LUCA
GeneTreeⁱ	ENSGT00390000009061
HOGENOMⁱ	HOG000154498
HOVERGENⁱ	HBG096071
InParanoidⁱ	Q9H5J8
KOⁱ	K15215
OMAⁱ	NEDFDSR
OrthoDBⁱ	EOG091G0D0N
PhylomeDBⁱ	Q9H5J8
TreeFamⁱ	TF335756

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427359 SIRT1 negatively regulates rRNA expression R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-73863 RNA Polymerase I Transcription Termination

Reactomeⁱ

R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-73863 RNA Polymerase I Transcription Termination

Miscellaneous databases

ChiTaRSⁱ	TAF1D human
GenomeRNAiⁱ	79101
Protein Ontology More...PROⁱ	PR:Q9H5J8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166012 Expressed in 227 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_TAF1D
ExpressionAtlasⁱ	Q9H5J8 baseline and differential
Genevisibleⁱ	Q9H5J8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027976 TAF1D
PANTHERⁱ	PTHR14562 PTHR14562, 1 hit
Pfamⁱ	View protein in Pfam PF15333 TAF1D, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF1D_HUMAN
Accessionⁱ	Q9H5J8Primary (citable) accession number: Q9H5J8 Secondary accession number(s): Q6I9Y6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q9H5J8 (TAF1D_HUMAN)

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TATA box-binding protein-associated factor RNA polymerase I subunit D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ