UniProtKB - Q9H5J8 (TAF1D_HUMAN)
Protein
TATA box-binding protein-associated factor RNA polymerase I subunit D
Gene
TAF1D
Organism
Homo sapiens (Human)
Status
Functioni
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.2 Publications
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
GO - Biological processi
- positive regulation of gene expression, epigenetic Source: Reactome
- regulation of transcription, DNA-templated Source: InterPro
- termination of RNA polymerase I transcription Source: Reactome
- transcription elongation from RNA polymerase I promoter Source: Reactome
- transcription initiation from RNA polymerase I promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9H5J8 |
Reactomei | R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: TATA box-binding protein-associated factor RNA polymerase I subunit DAlternative name(s): RNA polymerase I-specific TBP-associated factor 41 kDa Short name: TAFI41 TATA box-binding protein-associated factor 1D Short name: TBP-associated factor 1D Transcription initiation factor SL1/TIF-IB subunit D |
Gene namesi | Name:TAF1D Synonyms:JOSD3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28759, TAF1D |
MIMi | 612823, gene |
neXtProti | NX_Q9H5J8 |
VEuPathDBi | HostDB:ENSG00000166012.14 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- centriolar satellite Source: HPA
- mitotic spindle Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- RNA polymerase transcription factor SL1 complex Source: InterPro
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79101 |
OpenTargetsi | ENSG00000166012 |
PharmGKBi | PA164726421 |
Miscellaneous databases
Pharosi | Q9H5J8, Tdark |
Genetic variation databases
BioMutai | TAF1D |
DMDMi | 74733586 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250717 | 1 – 278 | TATA box-binding protein-associated factor RNA polymerase I subunit DAdd BLAST | 278 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 138 | PhosphoserineCombined sources | 1 | |
Modified residuei | 234 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H5J8 |
jPOSTi | Q9H5J8 |
MassIVEi | Q9H5J8 |
MaxQBi | Q9H5J8 |
PaxDbi | Q9H5J8 |
PeptideAtlasi | Q9H5J8 |
PRIDEi | Q9H5J8 |
ProteomicsDBi | 80916 |
PTM databases
iPTMneti | Q9H5J8 |
PhosphoSitePlusi | Q9H5J8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166012, Expressed in body of pancreas and 235 other tissues |
ExpressionAtlasi | Q9H5J8, baseline and differential |
Genevisiblei | Q9H5J8, HS |
Organism-specific databases
HPAi | ENSG00000166012, Low tissue specificity |
Interactioni
Subunit structurei
Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D.
Interacts with UBTF.
1 PublicationBinary interactionsi
Hide detailsQ9H5J8
With | #Exp. | IntAct |
---|---|---|
CEP70 [Q8NHQ1] | 4 | EBI-716128,EBI-739624 |
NHLH2 [Q02577] | 3 | EBI-716128,EBI-5378683 |
POLB [P06746] | 4 | EBI-716128,EBI-713836 |
itself | 3 | EBI-716128,EBI-716128 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 122548, 58 interactors |
IntActi | Q9H5J8, 51 interactors |
MINTi | Q9H5J8 |
STRINGi | 9606.ENSP00000410409 |
Miscellaneous databases
RNActi | Q9H5J8, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502SQMW, Eukaryota |
GeneTreei | ENSGT00390000009061 |
InParanoidi | Q9H5J8 |
OMAi | RNPIYSL |
OrthoDBi | 1263117at2759 |
PhylomeDBi | Q9H5J8 |
TreeFami | TF335756 |
Family and domain databases
InterProi | View protein in InterPro IPR027976, TAF1D |
PANTHERi | PTHR14562, PTHR14562, 1 hit |
Pfami | View protein in Pfam PF15333, TAF1D, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q9H5J8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKSGIDSLD HVTSDAVELA NRSDNSSDSS LFKTQCIPYS PKGEKRNPIR
60 70 80 90 100
KFVRTPESVH ASDSSSDSSF EPIPLTIKAI FERFKNRKKR YKKKKKRRYQ
110 120 130 140 150
PTGRPRGRPE GRRNPIYSLI DKKKQFRSRG SGFPFLESEN EKNAPWRKIL
160 170 180 190 200
TFEQAVARGF FNYIEKLKYE HHLKESLKQM NVGEDLENED FDSRRYKFLD
210 220 230 240 250
DDGSISPIEE STAEDEDATH LEDNECDIKL AGDSFIVSSE FPVRLSVYLE
260 270
EEDITEEAAL SKKRATKAKN TGQRGLKM
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PM59 | E9PM59_HUMAN | TATA box-binding protein-associated... | TAF1D | 215 | Annotation score: | ||
H0YH71 | H0YH71_HUMAN | TATA box-binding protein-associated... | TAF1D | 26 | Annotation score: | ||
H0YCH2 | H0YCH2_HUMAN | TATA box-binding protein-associated... | TAF1D | 110 | Annotation score: | ||
E9PKU8 | E9PKU8_HUMAN | TATA box-binding protein-associated... | TAF1D | 36 | Annotation score: | ||
H0YG36 | H0YG36_HUMAN | TATA box-binding protein-associated... | TAF1D | 42 | Annotation score: | ||
H0Y3L3 | H0Y3L3_HUMAN | TATA box-binding protein-associated... | TAF1D | 44 | Annotation score: | ||
A0A1D5RMT6 | A0A1D5RMT6_HUMAN | TATA box-binding protein-associated... | TAF1D | 8 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | S → T in CAG33650 (Ref. 3) Curated | 1 | |
Sequence conflicti | 97 | R → G in CAG33650 (Ref. 3) Curated | 1 | |
Sequence conflicti | 278 | M → I in CAG33650 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027016 mRNA Translation: BAB15628.1 CR457369 mRNA Translation: CAG33650.1 BC001972 mRNA Translation: AAH01972.1 |
CCDSi | CCDS8293.1 |
RefSeqi | NP_077021.1, NM_024116.3 |
Genome annotation databases
Ensembli | ENST00000323981; ENSP00000314971; ENSG00000166012 ENST00000448108; ENSP00000410409; ENSG00000166012 ENST00000526015; ENSP00000435087; ENSG00000166012 |
GeneIDi | 79101 |
KEGGi | hsa:79101 |
UCSCi | uc001ped.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027016 mRNA Translation: BAB15628.1 CR457369 mRNA Translation: CAG33650.1 BC001972 mRNA Translation: AAH01972.1 |
CCDSi | CCDS8293.1 |
RefSeqi | NP_077021.1, NM_024116.3 |
3D structure databases
SMRi | Q9H5J8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122548, 58 interactors |
IntActi | Q9H5J8, 51 interactors |
MINTi | Q9H5J8 |
STRINGi | 9606.ENSP00000410409 |
PTM databases
iPTMneti | Q9H5J8 |
PhosphoSitePlusi | Q9H5J8 |
Genetic variation databases
BioMutai | TAF1D |
DMDMi | 74733586 |
Proteomic databases
EPDi | Q9H5J8 |
jPOSTi | Q9H5J8 |
MassIVEi | Q9H5J8 |
MaxQBi | Q9H5J8 |
PaxDbi | Q9H5J8 |
PeptideAtlasi | Q9H5J8 |
PRIDEi | Q9H5J8 |
ProteomicsDBi | 80916 |
Protocols and materials databases
Antibodypediai | 53987, 62 antibodies |
DNASUi | 79101 |
Genome annotation databases
Ensembli | ENST00000323981; ENSP00000314971; ENSG00000166012 ENST00000448108; ENSP00000410409; ENSG00000166012 ENST00000526015; ENSP00000435087; ENSG00000166012 |
GeneIDi | 79101 |
KEGGi | hsa:79101 |
UCSCi | uc001ped.5, human |
Organism-specific databases
CTDi | 79101 |
DisGeNETi | 79101 |
GeneCardsi | TAF1D |
HGNCi | HGNC:28759, TAF1D |
HPAi | ENSG00000166012, Low tissue specificity |
MIMi | 612823, gene |
neXtProti | NX_Q9H5J8 |
OpenTargetsi | ENSG00000166012 |
PharmGKBi | PA164726421 |
VEuPathDBi | HostDB:ENSG00000166012.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQMW, Eukaryota |
GeneTreei | ENSGT00390000009061 |
InParanoidi | Q9H5J8 |
OMAi | RNPIYSL |
OrthoDBi | 1263117at2759 |
PhylomeDBi | Q9H5J8 |
TreeFami | TF335756 |
Enzyme and pathway databases
PathwayCommonsi | Q9H5J8 |
Reactomei | R-HSA-427359, SIRT1 negatively regulates rRNA expression R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
Miscellaneous databases
BioGRID-ORCSi | 79101, 348 hits in 856 CRISPR screens |
ChiTaRSi | TAF1D, human |
GenomeRNAii | 79101 |
Pharosi | Q9H5J8, Tdark |
PROi | PR:Q9H5J8 |
RNActi | Q9H5J8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166012, Expressed in body of pancreas and 235 other tissues |
ExpressionAtlasi | Q9H5J8, baseline and differential |
Genevisiblei | Q9H5J8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027976, TAF1D |
PANTHERi | PTHR14562, PTHR14562, 1 hit |
Pfami | View protein in Pfam PF15333, TAF1D, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF1D_HUMAN | |
Accessioni | Q9H5J8Primary (citable) accession number: Q9H5J8 Secondary accession number(s): Q6I9Y6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot